SG11201609981RA - Mth1 inhibitors for treatment of inflammatory and autoimmune conditions - Google Patents

Mth1 inhibitors for treatment of inflammatory and autoimmune conditions

Info

Publication number
SG11201609981RA
SG11201609981RA SG11201609981RA SG11201609981RA SG11201609981RA SG 11201609981R A SG11201609981R A SG 11201609981RA SG 11201609981R A SG11201609981R A SG 11201609981RA SG 11201609981R A SG11201609981R A SG 11201609981RA SG 11201609981R A SG11201609981R A SG 11201609981RA
Authority
SG
Singapore
Prior art keywords
inflammatory
treatment
autoimmune conditions
mth1 inhibitors
mth1
Prior art date
Application number
SG11201609981RA
Inventor
Martin Scobie
Olov Wallner
Tobias Koolmeister
Karl Sven Axel Vallin
Carl Martin Henriksson
Evert Homan
Thomas Helleday
Sylvain Jacques
Matthieu Desroses
Marie-Caroline Jacques-Cordonnier
Roland Julius Yu Fiskesund
Original Assignee
Thomas Helledays Stiftelse För Medicinsk Forskning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Helledays Stiftelse För Medicinsk Forskning filed Critical Thomas Helledays Stiftelse För Medicinsk Forskning
Publication of SG11201609981RA publication Critical patent/SG11201609981RA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SG11201609981RA 2014-06-04 2015-06-04 Mth1 inhibitors for treatment of inflammatory and autoimmune conditions SG11201609981RA (en)

Applications Claiming Priority (2)

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SE1450681 2014-06-04
PCT/SE2015/050654 WO2015187089A1 (en) 2014-06-04 2015-06-04 Mth1 inhibitors for treatment of inflammatory and autoimmune conditions

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US (2) US10064869B2 (en)
EP (1) EP3151833A4 (en)
JP (1) JP6635949B2 (en)
CN (1) CN106794181A (en)
AU (1) AU2015268962A1 (en)
CA (1) CA2948601A1 (en)
IL (1) IL249223A0 (en)
RU (1) RU2016151390A (en)
SG (1) SG11201609981RA (en)
WO (1) WO2015187089A1 (en)

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EP3152195A4 (en) * 2014-06-04 2017-12-13 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of cancer
WO2015187089A1 (en) * 2014-06-04 2015-12-10 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
ES2954453T3 (en) * 2014-06-13 2023-11-22 Yuma Therapeutics Inc Pyrimidine compounds and methods using the same
CR20180323A (en) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd DERIVATIVES OF INDOL N-SUBSTITUTES AS MODULATORS OF PGE2 RECEIVERS
EP3416648A4 (en) * 2016-02-17 2019-09-18 Merck Sharp & Dohme Corp. Processes for the preparation of a bace inhibitor
CN109153649B (en) 2016-03-22 2022-04-19 默沙东公司 Allosteric modulators of nicotinic acetylcholine receptors
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