MX2013006748A - Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi. - Google Patents

Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi.

Info

Publication number
MX2013006748A
MX2013006748A MX2013006748A MX2013006748A MX2013006748A MX 2013006748 A MX2013006748 A MX 2013006748A MX 2013006748 A MX2013006748 A MX 2013006748A MX 2013006748 A MX2013006748 A MX 2013006748A MX 2013006748 A MX2013006748 A MX 2013006748A
Authority
MX
Mexico
Prior art keywords
vivo
data store
targeting
pharmacokinetic modulator
polynucleotides
Prior art date
Application number
MX2013006748A
Other languages
English (en)
Other versions
MX346144B (es
Inventor
David L Lewis
Eric A Kitas
David B Rozema
Darren H Wakefield
Peter Mohr
Philipp Hadwiger
Torsten Hoffmann
Ingo Roehl
Linda Valis
Original Assignee
Arrowhead Res Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Res Corp filed Critical Arrowhead Res Corp
Publication of MX2013006748A publication Critical patent/MX2013006748A/es
Publication of MX346144B publication Critical patent/MX346144B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

La presente invención está dirigida a composiciones para el suministro activado de polinucleátidos de interferencia de ARN (iARN) a células in vivo. El modulador farmacocinético mejora la activación in vivo comparado con el ligado activador solo. El ligando activador y la porción activante del modulador activador que activan los polinucleátidos de iARN pueden administrarse in vivo solos o en combinación con polímeros de suministro co-activados.
MX2013006748A 2010-12-17 2011-12-15 Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi. MX346144B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061424195P 2010-12-17 2010-12-17
PCT/US2011/065210 WO2012083046A2 (en) 2010-12-17 2011-12-15 Galactose cluster-pharmacokinetic modulator targeting moiety for sirna

Publications (2)

Publication Number Publication Date
MX2013006748A true MX2013006748A (es) 2013-07-17
MX346144B MX346144B (es) 2017-03-09

Family

ID=46235176

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006748A MX346144B (es) 2010-12-17 2011-12-15 Porcion activadora del modulador farmacocinetico del agregado de galactosa para arnsi.

Country Status (12)

Country Link
US (2) US9249179B2 (es)
EP (2) EP2652134B1 (es)
JP (2) JP2014504295A (es)
KR (1) KR20130132475A (es)
CN (1) CN103492568B (es)
AU (2) AU2011343664B2 (es)
BR (1) BR112013013434A2 (es)
CA (1) CA2816155C (es)
MX (1) MX346144B (es)
RU (1) RU2013117288A (es)
SG (1) SG189474A1 (es)
WO (1) WO2012083046A2 (es)

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Also Published As

Publication number Publication date
EP2652134A2 (en) 2013-10-23
AU2016200000A1 (en) 2016-01-28
AU2016200000B2 (en) 2018-01-04
EP3192800A1 (en) 2017-07-19
MX346144B (es) 2017-03-09
CA2816155C (en) 2020-10-27
EP2652134B1 (en) 2017-03-01
EP2652134A4 (en) 2014-05-21
CA2816155A1 (en) 2012-06-21
US20120157509A1 (en) 2012-06-21
KR20130132475A (ko) 2013-12-04
CN103492568A (zh) 2014-01-01
AU2011343664B2 (en) 2015-10-08
AU2011343664A1 (en) 2013-05-09
RU2013117288A (ru) 2015-01-27
WO2012083046A2 (en) 2012-06-21
US9249179B2 (en) 2016-02-02
US9796756B2 (en) 2017-10-24
SG189474A1 (en) 2013-05-31
JP6261144B2 (ja) 2018-01-17
BR112013013434A2 (pt) 2016-08-16
US20160102120A1 (en) 2016-04-14
WO2012083046A3 (en) 2012-09-27
CN103492568B (zh) 2017-04-12
JP2016185968A (ja) 2016-10-27
JP2014504295A (ja) 2014-02-20

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