PE20120110A1 - [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa - Google Patents

[1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa

Info

Publication number
PE20120110A1
PE20120110A1 PE2011001470A PE2011001470A PE20120110A1 PE 20120110 A1 PE20120110 A1 PE 20120110A1 PE 2011001470 A PE2011001470 A PE 2011001470A PE 2011001470 A PE2011001470 A PE 2011001470A PE 20120110 A1 PE20120110 A1 PE 20120110A1
Authority
PE
Peru
Prior art keywords
triazolo
pyridines
kinase inhibitors
phenylamine
pyridin
Prior art date
Application number
PE2011001470A
Other languages
English (en)
Inventor
Caroline Leriche
Eric Auclair
Jacques Le Roux
David Middlemiss
Original Assignee
Fovea Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42229029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fovea Pharmaceuticals filed Critical Fovea Pharmaceuticals
Publication of PE20120110A1 publication Critical patent/PE20120110A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE [1,2,4]TRIAZOLO[1,5-a]PIRIDINAS DE FORMULA (I) DONDE A1 Y A2 SON CADA UNO N O C; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C4), ARILO, HALOGENO, ENTRE OTROS; R3 ES H, ALQUILO(C1-C4), CICLOALQUILO, ARILO, CN, ENTRE OTROS; X ES UN ENLACE O (CH2)aW(CH2)b, (CH2)aW(CH2)bY(CH2)c, ENTRE OTROS, EN DONDE a, b Y c SON CADA UNO DE 0 A 3; W E Y SON CADA UNO -CO-, -O-, -SO2-, -CH2-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 4-CLORO-3-{2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; CLORHIDRATO DE 4-CLORO-3-{8-METIL-2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; 4-CLORO-3-{2-[4-(2-MORFOLIN-4-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA SIENDO UTILES EN EL TRATAMIENTO DE INFARTO DE MIOCARDIO, CANCER, ARTRITIS, RETINOPATIA, GLAUCOMA
PE2011001470A 2009-02-13 2010-02-09 [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa PE20120110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09360013 2009-02-13

Publications (1)

Publication Number Publication Date
PE20120110A1 true PE20120110A1 (es) 2012-02-20

Family

ID=42229029

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001470A PE20120110A1 (es) 2009-02-13 2010-02-09 [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa

Country Status (24)

Country Link
US (1) US20120041195A1 (es)
EP (1) EP2396324A1 (es)
JP (1) JP2012517971A (es)
KR (1) KR20110116160A (es)
CN (1) CN102317288A (es)
AR (1) AR075411A1 (es)
BR (1) BRPI1008850A2 (es)
CA (1) CA2751517A1 (es)
CL (1) CL2011001947A1 (es)
CO (1) CO6420343A2 (es)
CR (1) CR20110386A (es)
DO (1) DOP2011000248A (es)
EA (1) EA201101188A1 (es)
EC (1) ECSP11011250A (es)
HN (1) HN2011002095A (es)
IL (1) IL214426A0 (es)
MX (1) MX2011008549A (es)
NI (1) NI201100151A (es)
NZ (1) NZ594508A (es)
PE (1) PE20120110A1 (es)
SG (1) SG173610A1 (es)
TN (1) TN2011000379A1 (es)
WO (1) WO2010092041A1 (es)
ZA (1) ZA201105896B (es)

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US8501936B2 (en) 2009-06-05 2013-08-06 Cephalon, Inc. Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
UY33452A (es) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
TW201204723A (en) * 2010-06-22 2012-02-01 Fovea Pharmaceuticals Heterocyclic compounds, their preparation and their therapeutic application
US20140120087A1 (en) * 2011-04-21 2014-05-01 Bayer Intellectual Property Gmbh Triazolopyridines
WO2012160029A1 (en) 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
KR20130091464A (ko) 2012-02-08 2013-08-19 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체
ES2605946T3 (es) 2012-03-14 2017-03-17 Bayer Intellectual Property Gmbh Imidazopiridazinas sustituidas
IN2015DN00085A (es) 2012-07-10 2015-05-29 Bayer Pharma AG
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
CN105377848A (zh) 2013-06-11 2016-03-02 拜耳制药股份公司 取代的三唑并吡啶的前体药物衍生物
EP4063371A1 (en) * 2019-11-22 2022-09-28 Medshine Discovery Inc. Pyrimidopyrrole spiro compounds and derivatives thereof as dna-pk inhibitors

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Also Published As

Publication number Publication date
ECSP11011250A (es) 2011-10-31
US20120041195A1 (en) 2012-02-16
MX2011008549A (es) 2011-12-06
KR20110116160A (ko) 2011-10-25
JP2012517971A (ja) 2012-08-09
CN102317288A (zh) 2012-01-11
IL214426A0 (en) 2011-09-27
CO6420343A2 (es) 2012-04-16
EA201101188A1 (ru) 2012-04-30
NI201100151A (es) 2012-10-03
BRPI1008850A2 (pt) 2016-03-15
EP2396324A1 (en) 2011-12-21
AR075411A1 (es) 2011-03-30
TN2011000379A1 (en) 2013-03-27
DOP2011000248A (es) 2011-10-31
HN2011002095A (es) 2014-01-06
CA2751517A1 (en) 2010-08-19
SG173610A1 (en) 2011-09-29
ZA201105896B (en) 2012-03-28
WO2010092041A1 (en) 2010-08-19
CL2011001947A1 (es) 2012-03-16
NZ594508A (en) 2013-12-20
CR20110386A (es) 2011-12-02

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