MX2011008549A - [1, 2, 4] triazolo [1 ,5 -a] piridinas como inhibidores de cinasa. - Google Patents

[1, 2, 4] triazolo [1 ,5 -a] piridinas como inhibidores de cinasa.

Info

Publication number
MX2011008549A
MX2011008549A MX2011008549A MX2011008549A MX2011008549A MX 2011008549 A MX2011008549 A MX 2011008549A MX 2011008549 A MX2011008549 A MX 2011008549A MX 2011008549 A MX2011008549 A MX 2011008549A MX 2011008549 A MX2011008549 A MX 2011008549A
Authority
MX
Mexico
Prior art keywords
methods
kinase
diseases
ameliorating
treating
Prior art date
Application number
MX2011008549A
Other languages
English (en)
Inventor
Eric Auclair
David Middlemiss
Caroline Leriche
Jacques Le Roux
Original Assignee
Fovea Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42229029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011008549(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fovea Pharmaceuticals filed Critical Fovea Pharmaceuticals
Publication of MX2011008549A publication Critical patent/MX2011008549A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención está dirigida a ciertos compuestos novedosos, métodos para producirlos y métodos para tratar o mejorar un trastorno mediado por cinasa. Más particularmente, esta invención está dirigida a compuestos de triazolopiridina sustituidos útiles como inhibidores de cinasa selectivos, métodos para producir tales compuestos y métodos para tratar o mejorar un trastorno mediado por cinasa, En particular, los métodos se relacionan con el tratamiento o la mejora de un trastorno mediado por cinasa que incluye enfermedades cardiovasculares, diabetes, trastornos asociados con diabetes, enfermedades inflamatorias, trastornos inmunológicos, cáncer y enfermedades de los ojos tales como retinopatias o degeneración macular u otras enfermedades vitreorretinianas, y similares.
MX2011008549A 2009-02-13 2010-02-09 [1, 2, 4] triazolo [1 ,5 -a] piridinas como inhibidores de cinasa. MX2011008549A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09360013 2009-02-13
PCT/EP2010/051556 WO2010092041A1 (en) 2009-02-13 2010-02-09 [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2011008549A true MX2011008549A (es) 2011-12-06

Family

ID=42229029

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008549A MX2011008549A (es) 2009-02-13 2010-02-09 [1, 2, 4] triazolo [1 ,5 -a] piridinas como inhibidores de cinasa.

Country Status (24)

Country Link
US (1) US20120041195A1 (es)
EP (1) EP2396324A1 (es)
JP (1) JP2012517971A (es)
KR (1) KR20110116160A (es)
CN (1) CN102317288A (es)
AR (1) AR075411A1 (es)
BR (1) BRPI1008850A2 (es)
CA (1) CA2751517A1 (es)
CL (1) CL2011001947A1 (es)
CO (1) CO6420343A2 (es)
CR (1) CR20110386A (es)
DO (1) DOP2011000248A (es)
EA (1) EA201101188A1 (es)
EC (1) ECSP11011250A (es)
HN (1) HN2011002095A (es)
IL (1) IL214426A0 (es)
MX (1) MX2011008549A (es)
NI (1) NI201100151A (es)
NZ (1) NZ594508A (es)
PE (1) PE20120110A1 (es)
SG (1) SG173610A1 (es)
TN (1) TN2011000379A1 (es)
WO (1) WO2010092041A1 (es)
ZA (1) ZA201105896B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141796A2 (en) 2009-06-05 2010-12-09 Cephalon, Inc. PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES
EP2343294A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
UY33452A (es) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
AR081960A1 (es) * 2010-06-22 2012-10-31 Fovea Pharmaceuticals Sa Compuestos heterociclicos, su preparacion y su aplicacion terapeutica
PT2699575E (pt) 2011-04-21 2015-07-29 Bayer Ip Gmbh Triazolopiridinas
WO2012160029A1 (en) 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
KR20130091464A (ko) 2012-02-08 2013-08-19 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체
EP2825540B1 (en) 2012-03-14 2016-09-14 Bayer Intellectual Property GmbH Substituted imidazopyridazines
SG11201408419QA (en) 2012-07-10 2015-01-29 Bayer Pharma AG Method for preparing substituted triazolopyridines
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
CN105377848A (zh) 2013-06-11 2016-03-02 拜耳制药股份公司 取代的三唑并吡啶的前体药物衍生物
JP2023503931A (ja) * 2019-11-22 2023-02-01 メッドシャイン ディスカバリー インコーポレイテッド Ｄｎａ－ｐｋ阻害剤としてのピリミドピロール系スピロ化合物及びその誘導体

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US4271143A (en) 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4407792A (en) 1979-05-09 1983-10-04 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
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US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
CA2386955A1 (en) 1999-11-22 2001-05-31 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
JP4817661B2 (ja) * 2002-12-18 2011-11-16 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとしてのトリアゾロピリダジン
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CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
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MX2007002208A (es) 2004-08-25 2007-05-08 Targegen Inc Compuestos hetrociclicos y metodos de uso.
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CN101155799A (zh) 2005-03-16 2008-04-02 塔格根公司 嘧啶化合物和使用方法
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JP2008543775A (ja) 2005-06-08 2008-12-04 ターゲジェン インコーポレーティッド 眼の障害を治療するための方法および組成物
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CN103641829A (zh) * 2006-08-30 2014-03-19 塞尔佐姆有限公司 作为激酶抑制剂的三唑衍生物
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Also Published As

Publication number Publication date
ZA201105896B (en) 2012-03-28
WO2010092041A1 (en) 2010-08-19
CO6420343A2 (es) 2012-04-16
EP2396324A1 (en) 2011-12-21
NZ594508A (en) 2013-12-20
US20120041195A1 (en) 2012-02-16
HN2011002095A (es) 2014-01-06
KR20110116160A (ko) 2011-10-25
PE20120110A1 (es) 2012-02-20
SG173610A1 (en) 2011-09-29
EA201101188A1 (ru) 2012-04-30
AR075411A1 (es) 2011-03-30
IL214426A0 (en) 2011-09-27
CR20110386A (es) 2011-12-02
CL2011001947A1 (es) 2012-03-16
CN102317288A (zh) 2012-01-11
ECSP11011250A (es) 2011-10-31
NI201100151A (es) 2012-10-03
TN2011000379A1 (en) 2013-03-27
BRPI1008850A2 (pt) 2016-03-15
DOP2011000248A (es) 2011-10-31
CA2751517A1 (en) 2010-08-19
JP2012517971A (ja) 2012-08-09

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