AR068658A1 - Derivados de tiazol - Google Patents
Derivados de tiazolInfo
- Publication number
- AR068658A1 AR068658A1 ARP080104329A ARP080104329A AR068658A1 AR 068658 A1 AR068658 A1 AR 068658A1 AR P080104329 A ARP080104329 A AR P080104329A AR P080104329 A ARP080104329 A AR P080104329A AR 068658 A1 AR068658 A1 AR 068658A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- atoms
- hal
- nhet
- nhet1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de formula (1) en donde R1 es un heterociclo insaturado o aromático bicíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con A, Ar, SR, NR2, Hal, NO2, CN, (CR2)n[X(CR2)n)]p-Y, CONR2, OR5 y/u =O (oxígeno del carbonilo); R2 y R3 son en cada caso, de modo independiente entre sí, H, A, Ar, OR, SR, NR2, Hal, NO2, CN o (CR2)n[X(CR2)n)]p-Y; R4 es H, Hal, A, OR, NR2 o (CR2)n[X(CR2)n)]p-Y; X es O, NR o CR2; Y es OR o NR2; R5 es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por F y/o Cl; K es C=O, CR2CO, o CR2; E es COO(CR2)n, CO(CR2)mO, CONH(CR2)n, S(O)q(CR2)n, CO(CR2)n, (CR2)n, CO(CR2)mO(CR2)p, CO(CR2)mNH(CR2)p o C(=S)O(CR2)n; R es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C; W es Ar o Het; G es CH o N; Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, A, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, OCONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet y/o COA; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het1, (CR2)nHet1, O(CR2)nNR2, O(CR2)nHet1, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet1, NHCONH(CR2)NR2, NHCONH(CR2)nHet1, OCONH(CR2)nNR2, OCONH(CR2)nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo); Het1 es un heterociclo saturado monocíclico con 1 a 2 N y/o átomos de O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo); A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OR, CN, NR2, F y/o Cl y/o en donde uno o dos grupos CH2 no adyacentes pueden estar reemplazados por O, NH, S, SO, SO2 y/o por grupos CH=CH, o alquilo cíclico con 3-7 átomos de C; m es 1, 2, 3, 4, 5 o 6; n es 0, 1, 2, 3, 4, 5, 6, 7 u 8, p es 0, 1, 2, 3, 4, 5 o 6; q es 0, 1 o 2; Hal es F, Cl, Br o I; así como sus derivados, solvatos, tautomeros, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Se pueden utilizar para el tratamiento de tumores. También se reivindica medicamento y proceso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007047735A DE102007047735A1 (de) | 2007-10-05 | 2007-10-05 | Thiazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068658A1 true AR068658A1 (es) | 2009-11-25 |
Family
ID=40418145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104329A AR068658A1 (es) | 2007-10-05 | 2008-10-03 | Derivados de tiazol |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8557824B2 (es) |
| EP (1) | EP2209777B1 (es) |
| JP (2) | JP2010540580A (es) |
| KR (1) | KR20100080836A (es) |
| CN (1) | CN101815714A (es) |
| AR (1) | AR068658A1 (es) |
| AU (1) | AU2008310068B2 (es) |
| BR (1) | BRPI0817579A2 (es) |
| CA (1) | CA2701525C (es) |
| DE (1) | DE102007047735A1 (es) |
| EA (1) | EA201000550A1 (es) |
| ES (1) | ES2548525T3 (es) |
| IL (1) | IL204563A (es) |
| MX (1) | MX2010003365A (es) |
| WO (1) | WO2009046842A2 (es) |
| ZA (1) | ZA201003123B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5337711B2 (ja) * | 2007-01-25 | 2013-11-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺菌性アミド |
| DE102009049211A1 (de) * | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| US9353113B2 (en) | 2011-03-18 | 2016-05-31 | Ono Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| MY182095A (en) | 2013-11-22 | 2021-01-18 | Sabre Therapeutics Llc | Autotaxin inhibitor compounds |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MX2017015225A (es) | 2015-05-27 | 2018-02-19 | Pharmakea Inc | Inhibidores de la autotaxina y sus usos. |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| TW202110831A (zh) * | 2019-06-04 | 2021-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吡啶酮類衍生物、其製備方法及其在醫藥上的應用 |
| TW202116754A (zh) | 2019-07-11 | 2021-05-01 | 美商Ｅ 斯蓋普生物股份有限公司 | 作為ｌｒｒｋ２抑制劑之吲唑及氮雜吲唑 |
| CN113493453B (zh) * | 2020-04-07 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 稠合芳香环类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| CA2229617A1 (en) | 1995-10-20 | 1997-05-01 | Dr. Karl Thomae Gmbh | 5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| GB0230162D0 (en) | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005116653A2 (en) * | 2004-04-13 | 2005-12-08 | Arena Pharmaceuticals, Inc. | Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders |
| EP1637529A1 (en) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| US7601745B2 (en) * | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| AU2006281435A1 (en) | 2005-08-18 | 2007-02-22 | F. Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as H3 receptor modulators |
| CN101395107A (zh) | 2006-02-28 | 2009-03-25 | 出光兴产株式会社 | 并四苯衍生物以及应用该衍生物的有机电致发光元件 |
| EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
| CN101405278A (zh) * | 2006-03-15 | 2009-04-08 | 4Sc股份公司 | 新颖的杂环NF-κB抑制剂 |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
-
2007
- 2007-10-05 DE DE102007047735A patent/DE102007047735A1/de not_active Withdrawn
-
2008
- 2008-09-19 BR BRPI0817579 patent/BRPI0817579A2/pt not_active IP Right Cessation
- 2008-09-19 AU AU2008310068A patent/AU2008310068B2/en not_active Ceased
- 2008-09-19 MX MX2010003365A patent/MX2010003365A/es not_active Application Discontinuation
- 2008-09-19 JP JP2010527350A patent/JP2010540580A/ja active Pending
- 2008-09-19 CA CA2701525A patent/CA2701525C/en not_active Expired - Fee Related
- 2008-09-19 EP EP08802403.9A patent/EP2209777B1/de not_active Not-in-force
- 2008-09-19 WO PCT/EP2008/007894 patent/WO2009046842A2/de active Application Filing
- 2008-09-19 KR KR1020107009914A patent/KR20100080836A/ko not_active Application Discontinuation
- 2008-09-19 CN CN200880110188A patent/CN101815714A/zh active Pending
- 2008-09-19 US US12/681,724 patent/US8557824B2/en active Active
- 2008-09-19 ES ES08802403.9T patent/ES2548525T3/es active Active
- 2008-09-19 EA EA201000550A patent/EA201000550A1/ru unknown
- 2008-10-03 AR ARP080104329A patent/AR068658A1/es unknown
-
2010
- 2010-03-16 IL IL204563A patent/IL204563A/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03123A patent/ZA201003123B/en unknown
-
2014
- 2014-07-14 JP JP2014144141A patent/JP5843930B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009046842A2 (de) | 2009-04-16 |
| ZA201003123B (en) | 2011-04-28 |
| CN101815714A (zh) | 2010-08-25 |
| EA201000550A1 (ru) | 2010-10-29 |
| JP5843930B2 (ja) | 2016-01-13 |
| BRPI0817579A2 (pt) | 2015-04-07 |
| MX2010003365A (es) | 2010-04-30 |
| EP2209777B1 (de) | 2015-07-29 |
| IL204563A (en) | 2017-03-30 |
| AU2008310068A1 (en) | 2009-04-16 |
| ES2548525T3 (es) | 2015-10-19 |
| US8557824B2 (en) | 2013-10-15 |
| DE102007047735A1 (de) | 2009-04-09 |
| CA2701525C (en) | 2016-06-28 |
| JP2010540580A (ja) | 2010-12-24 |
| KR20100080836A (ko) | 2010-07-12 |
| WO2009046842A3 (de) | 2009-06-25 |
| CA2701525A1 (en) | 2009-04-16 |
| IL204563A0 (en) | 2010-11-30 |
| EP2209777A2 (de) | 2010-07-28 |
| AU2008310068B2 (en) | 2014-05-01 |
| JP2014240392A (ja) | 2014-12-25 |
| US20100240676A1 (en) | 2010-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |