AR068657A1 - Derivados de piperidina y piperazina - Google Patents
Derivados de piperidina y piperazinaInfo
- Publication number
- AR068657A1 AR068657A1 ARP080104328A ARP080104328A AR068657A1 AR 068657 A1 AR068657 A1 AR 068657A1 AR P080104328 A ARP080104328 A AR P080104328A AR P080104328 A ARP080104328 A AR P080104328A AR 068657 A1 AR068657 A1 AR 068657A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- atoms
- hal
- nhet
- mono
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la formula (1), en donde R1 es un heterociclo insaturado o aromático bicíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con A, Hal, NR2, (CR2)nCN, OR5 y/u =O (oxígeno del carbonilo); D es C o S; G es N o C, en caso de que G = N, R2 está ausente; en caso de que G = O, R2 es H o Ar1 o también junto con el átomo de C al que está unido el R2 y con E-W un radical espirocíclico seleccionado del grupo de formulas (2); Q es alquileno no ramificado o ramificado con 1, 2, 3 o 4 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por A, (CR2)n[X(CR2)n]p-Y, F y/o Cl; R3 es H, A, Ar, OR, SR, NR2, Hal, No2, CN, o (CR2)n[X(CR2)n]p-Y; X es O, NR o CR2; Y es OR o NR2; R5 es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por F y/o Cl; E es COO(CR2)n, COO(CRR4), CO(CR2)mO, CONH(CR2)n, C(=S)NH(CR2)n, S(O)qNH(CR2)n, S(O)q(CR2)n, CO(CR2)n, (CR2)n, CO(CR2)mO(CR2)n, CO(CR2)mNH(CR2)n, CO(CH2)nCO, COCHR6CHR7, C(=S)O(CR2)n, CO(CRR4)(CR2)n, COO(CRR4), (CRR4)(CR2)n, S(O)qCR=CR, COCR=CR, (CR2)mCO, CONH(CR2)mCRR4 O (CR2)mCONR; R4 es COOR5, Ar1, (CR2)nNR2, OH, NRCOOR8 o NRCOOA; R6, R7 son juntos (CH2)1-4; R8 es fenilo, naftilo o fluorenilo; R es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de carbono; W es Ar o Het; Ar es fenilo, indanilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, A, (CR2)nOR, O(CR2)n, Ar1, (CR2)nNR2, SR, No2, CN, COOR, CONR2, NRCOA, NRSo2A, So2NR2, S(O)qA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, CR5=CR5Ar1, So2Het, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, OCONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet y/o COA; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, (CR2)nAr1, O(CR2)nAr1, (CR2)nOR, (CR2)nNR2, SR, No2, CN, COOR, CONR2, NRCOA, NRSo2A, So2NR2, S(O)qA, CO-Het1, (CR2)nHet1, O(CR2)nNR2, O(CR2)nHet1, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet1, NHCONH(CR2)nNR2, NHCONH(CR2)nHet1, OCONH(CR2)nNR2, OCONH(CR2)nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo); Het1 es un heterociclo saturado monocíclico con 1 a 2 N y/o átomos de O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo); Ar1 es fenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, CN, A y/o (CR2)nOR; A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OR, CN, NR2, F y/o Cl y/o en donde uno o dos grupos CH2 no adyacentes pueden estar reemplazados por O, NH, s, so, so2 y/o por grupos CH=CH, o alquilo cíclico con 3-7 átomos de C; m es 1, 2, 3, 4, 5 o 6; n es 0, 1, 2, 3, 4, 5, 6, 7 u 8; p es 1, 2, 3, 4, 5 o 6; q es 0, 1 o 2; Hal es F, Cl, Br o l; así como sus tautomeros, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones, se pueden utilizar para el tratamiento de tumores. Medicamento en base al compuesto (y uso de este para preparar los medicamentos) y procedimiento de preparacion del compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007047737A DE102007047737A1 (de) | 2007-10-05 | 2007-10-05 | Piperidin- und Piperazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068657A1 true AR068657A1 (es) | 2009-11-25 |
Family
ID=40089983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104328A AR068657A1 (es) | 2007-10-05 | 2008-10-03 | Derivados de piperidina y piperazina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8791111B2 (es) |
| EP (2) | EP2193118B1 (es) |
| JP (2) | JP5597538B2 (es) |
| KR (1) | KR20100075601A (es) |
| CN (1) | CN101808988A (es) |
| AR (1) | AR068657A1 (es) |
| AU (1) | AU2008310067B2 (es) |
| BR (1) | BRPI0817644A2 (es) |
| CA (1) | CA2701519C (es) |
| CY (2) | CY1113757T1 (es) |
| DE (1) | DE102007047737A1 (es) |
| DK (2) | DK2426106T3 (es) |
| EA (1) | EA017787B1 (es) |
| ES (2) | ES2392475T3 (es) |
| HR (2) | HRP20120802T1 (es) |
| IL (1) | IL204562A0 (es) |
| MX (1) | MX2010003366A (es) |
| PL (2) | PL2193118T3 (es) |
| PT (2) | PT2193118E (es) |
| SI (2) | SI2193118T1 (es) |
| WO (1) | WO2009046841A2 (es) |
| ZA (1) | ZA201003124B (es) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| EA201101399A1 (ru) | 2009-04-02 | 2012-08-30 | Мерк Патент Гмбх | Гетероциклические соединения в качестве ингибиторов аутотаксина |
| DE102009049211A1 (de) | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| EP2687531B1 (en) | 2011-03-18 | 2016-07-13 | ONO Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| US8828874B2 (en) * | 2011-03-28 | 2014-09-09 | Sinmat, Inc. | Chemical mechanical polishing of group III-nitride surfaces |
| US9273011B2 (en) * | 2011-10-28 | 2016-03-01 | Inhibitaxin Limited | Substituted pyridazines for the treatment of pain |
| WO2013070879A1 (en) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| KR20220123339A (ko) * | 2012-04-13 | 2022-09-06 | 에피자임, 인코포레이티드 | 인간 히스톤 메틸트랜스퍼라제 ｅｚｈ２ 억제제의 염 형태 |
| TWI633087B (zh) | 2012-06-13 | 2018-08-21 | 赫孚孟拉羅股份公司 | 新穎二氮雜螺環烷及氮雜螺環烷 |
| SI2900669T1 (sl) * | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| KR20150095888A (ko) * | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | 오토탁신 억제제 |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| JP2016530210A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ヘテロ環式ビニルオートタキシン阻害剤化合物 |
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| CN104557739B (zh) | 2013-10-25 | 2016-11-09 | 山东先达农化股份有限公司 | 三酮类化合物及其制备方法和应用 |
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| US9926318B2 (en) | 2013-11-22 | 2018-03-27 | Pharmakea, Inc. | Tetracyclic autotaxin inhibitors |
| SI3074400T1 (en) | 2013-11-26 | 2018-03-30 | F. Hoffmann-La Roche Ag | Octahydro-cyclobut (1,2-c, 3,4-cy) dipyrrole derivatives as autoantaxine inhibitors |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| AU2015238541B2 (en) | 2014-03-26 | 2019-09-19 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| TW201623239A (zh) | 2014-04-24 | 2016-07-01 | 田邊三菱製藥股份有限公司 | 新穎２－胺基－吡啶及２－胺基－嘧啶衍生物及其醫藥用途 |
| EP3134398A1 (en) | 2014-04-24 | 2017-03-01 | Novartis Ag | Autotaxin inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| CN104758286B (zh) * | 2015-03-05 | 2016-09-14 | 南京工业大学 | 1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| JP6873919B2 (ja) | 2015-05-27 | 2021-05-19 | セイバー セラピューティクス エルエルシー | オートタキシン阻害剤とその使用 |
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| PE20180479A1 (es) | 2015-09-04 | 2018-03-07 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
| MA42919A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
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| JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
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| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
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| CN113461640B (zh) * | 2021-06-17 | 2023-08-11 | 中央民族大学 | Lpar1抑制剂、医药用途及其制备方法 |
| CN117980300A (zh) * | 2021-09-21 | 2024-05-03 | 明斯特大学 | 自分泌运动因子抑制剂 |
| CN114378108B (zh) * | 2022-03-24 | 2022-07-22 | 神美科技有限公司 | 一种重金属螯合剂及其在去除生活垃圾中重金属中的用途 |
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| JPS60130573A (ja) | 1983-12-15 | 1985-07-12 | Otsuka Pharmaceut Co Ltd | ベンゾチアゾ−ル誘導体 |
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| FR2643634A1 (fr) | 1989-02-28 | 1990-08-31 | Adir | Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
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| CN100384836C (zh) * | 2000-02-29 | 2008-04-30 | 三菱制药株式会社 | 新型环状酰胺衍生物 |
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| CA2381630A1 (en) * | 2001-04-23 | 2002-10-23 | Leonard Theodore Meltzer | Method for preventing dyskinesias |
| DE10120159A1 (de) | 2001-04-25 | 2002-10-31 | Merck Patent Gmbh | NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen |
| EP1409477B1 (en) * | 2001-07-24 | 2008-09-17 | Richter Gedeon NYRT | Piperidine derivatives as nmda receptor antagonists |
| GB0320244D0 (en) * | 2003-05-06 | 2003-10-01 | Aventis Pharma Inc | Pyrazoles as inhibitors of tumour necrosis factor |
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| US7777037B2 (en) * | 2004-10-27 | 2010-08-17 | Dr. Reddy's Laboratories Limited | Ziprasidone process |
| TWI415845B (zh) * | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
-
2007
- 2007-10-05 DE DE102007047737A patent/DE102007047737A1/de not_active Withdrawn
-
2008
- 2008-09-19 DK DK11007349.1T patent/DK2426106T3/da active
- 2008-09-19 PT PT08802402T patent/PT2193118E/pt unknown
- 2008-09-19 SI SI200830792T patent/SI2193118T1/sl unknown
- 2008-09-19 CA CA2701519A patent/CA2701519C/en not_active Expired - Fee Related
- 2008-09-19 WO PCT/EP2008/007893 patent/WO2009046841A2/de active Application Filing
- 2008-09-19 CN CN200880109583A patent/CN101808988A/zh active Pending
- 2008-09-19 KR KR1020107009776A patent/KR20100075601A/ko not_active Application Discontinuation
- 2008-09-19 PT PT110073491T patent/PT2426106E/pt unknown
- 2008-09-19 ES ES08802402T patent/ES2392475T3/es active Active
- 2008-09-19 SI SI200831052T patent/SI2426106T1/sl unknown
- 2008-09-19 EP EP08802402A patent/EP2193118B1/de not_active Not-in-force
- 2008-09-19 BR BRPI0817644 patent/BRPI0817644A2/pt not_active IP Right Cessation
- 2008-09-19 MX MX2010003366A patent/MX2010003366A/es not_active Application Discontinuation
- 2008-09-19 DK DK08802402.1T patent/DK2193118T3/da active
- 2008-09-19 PL PL08802402T patent/PL2193118T3/pl unknown
- 2008-09-19 AU AU2008310067A patent/AU2008310067B2/en not_active Ceased
- 2008-09-19 PL PL11007349T patent/PL2426106T3/pl unknown
- 2008-09-19 EA EA201000549A patent/EA017787B1/ru not_active IP Right Cessation
- 2008-09-19 EP EP11007349.1A patent/EP2426106B1/de not_active Not-in-force
- 2008-09-19 ES ES11007349T patent/ES2429843T3/es active Active
- 2008-09-19 US US12/681,440 patent/US8791111B2/en not_active Expired - Fee Related
- 2008-09-19 JP JP2010527349A patent/JP5597538B2/ja not_active Expired - Fee Related
- 2008-10-03 AR ARP080104328A patent/AR068657A1/es unknown
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2010
- 2010-03-16 IL IL204562A patent/IL204562A0/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03124A patent/ZA201003124B/en unknown
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2012
- 2012-08-22 US US13/591,765 patent/US8754097B2/en not_active Expired - Fee Related
- 2012-10-05 HR HRP20120802AT patent/HRP20120802T1/hr unknown
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-
2013
- 2013-10-03 HR HRP20130929AT patent/HRP20130929T1/hr unknown
- 2013-10-25 CY CY20131100944T patent/CY1114574T1/el unknown
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2014
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