PE20180552A1 - Nuevos compuestos biciclicos como inhibidores duales de atx/ca - Google Patents

Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Info

Publication number
PE20180552A1
PE20180552A1 PE2018000079A PE2018000079A PE20180552A1 PE 20180552 A1 PE20180552 A1 PE 20180552A1 PE 2018000079 A PE2018000079 A PE 2018000079A PE 2018000079 A PE2018000079 A PE 2018000079A PE 20180552 A1 PE20180552 A1 PE 20180552A1
Authority
PE
Peru
Prior art keywords
inhibitors
compounds
substituted phenyl
substituted
atx
Prior art date
Application number
PE2018000079A
Other languages
English (en)
Inventor
Giorgio Patrick Di
Jerôme Hert
Daniel Hunziker
Patrizio Mattei
Markus Rudolph
Petra Schmitz
Christoph Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20180552A1 publication Critical patent/PE20180552A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Referido a compuestos de la formula (I), en donde R1 fenilo sustituido, fenil-alquilo C1-6 sustituido, entre otros; R2 es fenilo sustituido, piridinilo sustituido o tiofenilo sustituido, entre otros; Y es un -OC(O)- o -C(O)-; W es -C(O)-, -S(O)2- o -CR6R7-; m, n, p y q se eligen con independencia entre 1 y 2. Estos son compuestos organicos inhibidores daules de la autotaxina (ATX)/ la anhidrasa carbonica, que son inhibidores de la produccion de acido lisofosfatidico (LPA), por ello moduladores de los niveles de LPA y de la senalizacion asociada. Siendo util en el tratamiento de estados patologicos inflamatorios, del sistema nervioso, vasculares entre otros.
PE2018000079A 2015-09-24 2016-09-21 Nuevos compuestos biciclicos como inhibidores duales de atx/ca PE20180552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186633 2015-09-24

Publications (1)

Publication Number Publication Date
PE20180552A1 true PE20180552A1 (es) 2018-04-02

Family

ID=54199035

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000079A PE20180552A1 (es) 2015-09-24 2016-09-21 Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Country Status (21)

Country Link
US (2) US10647719B2 (es)
EP (1) EP3353178B1 (es)
JP (1) JP6877413B2 (es)
KR (1) KR20180054634A (es)
CN (1) CN107922415B (es)
AR (1) AR106099A1 (es)
AU (1) AU2016328436B2 (es)
BR (1) BR112018006080A2 (es)
CA (1) CA2991612A1 (es)
CL (1) CL2018000685A1 (es)
CO (1) CO2018000668A2 (es)
CR (1) CR20180057A (es)
HK (1) HK1252995A1 (es)
IL (1) IL256724A (es)
MA (1) MA42923A (es)
MX (1) MX2018001430A (es)
PE (1) PE20180552A1 (es)
RU (1) RU2724899C2 (es)
TW (1) TW201720823A (es)
WO (1) WO2017050791A1 (es)
ZA (1) ZA201800480B (es)

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UA123362C2 (uk) 2015-09-04 2021-03-24 Ф. Хоффманн-Ля Рош Аг Феноксиметильні похідні
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