PE20200401A1 - Nuevos compuestos como inhibidores de autotaxina y composiciones farmaceuticas que comprenden a los mismos - Google Patents

Nuevos compuestos como inhibidores de autotaxina y composiciones farmaceuticas que comprenden a los mismos

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Publication number
PE20200401A1
PE20200401A1 PE2019002408A PE2019002408A PE20200401A1 PE 20200401 A1 PE20200401 A1 PE 20200401A1 PE 2019002408 A PE2019002408 A PE 2019002408A PE 2019002408 A PE2019002408 A PE 2019002408A PE 20200401 A1 PE20200401 A1 PE 20200401A1
Authority
PE
Peru
Prior art keywords
refers
autotaxin
compound
inhibitors
same
Prior art date
Application number
PE2019002408A
Other languages
English (en)
Inventor
Dae Yon Lee
Sang Eun Chae
Eun Mi Jung
Eun Hye Yang
Yoon Jeong Choi
Chul-Woong Chung
Ju Hyun Shin
Yun Ki Kim
Hyun Jin Kwon
Jeong Hee Ryu
Eun Hye Ban
Yong Zu Kim
Yeong Soo Oh
Jeiwook Chae
Original Assignee
Legochem Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legochem Biosciences Inc filed Critical Legochem Biosciences Inc
Publication of PE20200401A1 publication Critical patent/PE20200401A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se refiere a un compuesto de formula quimica 1, en donde: X e Y son CR' o N; R' es hidrogeno, alquilo C1-C10, o arilo C6-C12; R es indanilo, arC6-C12alquilo C1-C10, entre otros; A es heteroarilo C2-C12, carboxil alquilo C1-C10 sustituido, entre otros; L es un enlace unico, -(CR3R4)aC(=O)-,entre otros; Q es carbonilo, heterocicloalquileno C2-C12, entre otros. Tambien se refiere a un profarmaco, hidrato, solvato, isomero, o una sal farmaceuticamente aceptable del mismo. Son compuestos preferidos los compuestos de formula i, ii, iii, entre otros. Tambien se refiere a una composicion farmaceutica que comprende dicho compuesto. Dicho compuesto inhibe la autotaxina (ATX) y tambien inhibe simultaneamente la produccion de acido lisofosfatidico (LPA) siendo util en el tratamiento y profilaxis de un trastorno mediado por ATX, por ejemplo, trastorno cardiovascular, cancer, trastorno del sistema nervioso, entre otros.
PE2019002408A 2017-05-17 2018-05-15 Nuevos compuestos como inhibidores de autotaxina y composiciones farmaceuticas que comprenden a los mismos PE20200401A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170060940A KR101798840B1 (ko) 2017-05-17 2017-05-17 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
PCT/KR2018/005516 WO2018212534A1 (en) 2017-05-17 2018-05-15 Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

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PE20200401A1 true PE20200401A1 (es) 2020-02-26

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US (1) US11548883B2 (es)
EP (1) EP3442973B1 (es)
JP (1) JP6800325B2 (es)
KR (1) KR101798840B1 (es)
CN (1) CN109476664B (es)
AU (2) AU2018270685C1 (es)
BR (1) BR112018076327A2 (es)
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IL (1) IL263082B (es)
JO (1) JOP20190217B1 (es)
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MY (1) MY201524A (es)
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PE (1) PE20200401A1 (es)
PH (1) PH12018502364A1 (es)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020119896A1 (en) * 2018-12-11 2020-06-18 F. Hoffmann-La Roche Ag Heterocyclic inhibitors of atx
EP3873473A4 (en) * 2018-12-11 2022-06-29 F. Hoffmann-La Roche AG Aminoazine amides
US11485727B2 (en) * 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
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