MA46054A - Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci - Google Patents

Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Info

Publication number
MA46054A
MA46054A MA046054A MA46054A MA46054A MA 46054 A MA46054 A MA 46054A MA 046054 A MA046054 A MA 046054A MA 46054 A MA46054 A MA 46054A MA 46054 A MA46054 A MA 46054A
Authority
MA
Morocco
Prior art keywords
pyrazolo
pyrimidines
salts
preparation
Prior art date
Application number
MA046054A
Other languages
English (en)
Inventor
Charles Todd Eary
Julia Haas
Yutong Jiang
Stacey Spencer
Qian Zhao
Original Assignee
Array Biopharma Inc
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62023982&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46054(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2016/058951 external-priority patent/WO2017075107A1/fr
Application filed by Array Biopharma Inc, Loxo Oncology Inc filed Critical Array Biopharma Inc
Publication of MA46054A publication Critical patent/MA46054A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA046054A 2016-10-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci MA46054A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2016/058951 WO2017075107A1 (fr) 2015-10-26 2016-10-26 Mutations ponctuelles dans le cancer résistant aux inhibiteurs de trk et méthodes associées
US201762524801P 2017-06-26 2017-06-26

Publications (1)

Publication Number Publication Date
MA46054A true MA46054A (fr) 2019-07-03

Family

ID=62023982

Family Applications (2)

Application Number Title Priority Date Filing Date
MA45802A MA45802A1 (fr) 2017-06-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci
MA046054A MA46054A (fr) 2016-10-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA45802A MA45802A1 (fr) 2017-06-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Country Status (28)

Country Link
US (1) US11091486B2 (fr)
EP (1) EP3532475A2 (fr)
JP (1) JP2019532089A (fr)
KR (1) KR20190082808A (fr)
CN (1) CN110267958A (fr)
AR (1) AR112207A1 (fr)
AU (1) AU2017348259B2 (fr)
BR (1) BR112019008341A2 (fr)
CA (1) CA3041316A1 (fr)
CL (2) CL2019001094A1 (fr)
CO (1) CO2019004123A2 (fr)
CR (1) CR20190255A (fr)
DO (1) DOP2019000109A (fr)
EA (1) EA201991055A1 (fr)
EC (1) ECSP19036765A (fr)
IL (1) IL266170A (fr)
JO (1) JOP20190092A1 (fr)
MA (2) MA45802A1 (fr)
MX (1) MX2019004951A (fr)
NI (1) NI201900037A (fr)
PE (1) PE20191543A1 (fr)
PH (1) PH12019500930A1 (fr)
SG (1) SG11201903487SA (fr)
TN (2) TN2019000133A1 (fr)
TW (1) TW201906840A (fr)
UA (1) UA124271C2 (fr)
UY (1) UY37781A (fr)
WO (2) WO2018081417A2 (fr)

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HUE057625T2 (hu) 2008-10-22 2022-05-28 Array Biopharma Inc TRK kináz inhibitor szubsztituált pirazolo[1,5-a]pirimidin vegyületek
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2011146336A1 (fr) 2010-05-20 2011-11-24 Array Biopharma Inc. Composés macrocycliques en tant qu'inhibiteurs de kinase trk
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
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US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
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JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
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JP6986789B2 (ja) * 2017-11-10 2021-12-22 エンジェクス ファーマシューティカル インコーポレイテッド 化合物、その薬学的に許容される塩、化合物の使用および医薬組成物
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WO2019233461A1 (fr) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 Inhibiteur du récepteur de kinase a lié à la tropomyosine, son procédé de préparation et son utilisation
EP3858834A4 (fr) * 2018-09-29 2022-06-22 Shandong Luye Pharmaceutical Co., Ltd. Dérivé de pyrazolopyrimidine en tant qu'inhibiteur de trk sélectif
CN113490664A (zh) 2018-10-22 2021-10-08 埃斯克疗法股份有限公司 Tyk2抑制剂和其用途
CN113166155A (zh) * 2018-11-09 2021-07-23 山东轩竹医药科技有限公司 大环类酪氨酸激酶抑制剂及其用途
CN111253402B (zh) * 2018-11-30 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 一种trk激酶抑制剂化合物的中间体化合物及制备方法
US20220177486A1 (en) * 2019-03-11 2022-06-09 Esker Therapeutics, Inc. Tyk2 inhibitors and uses thereof
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN113135938B (zh) * 2020-01-19 2022-06-14 山东轩竹医药科技有限公司 取代的大环类酪氨酸激酶抑制剂及其用途
WO2022208370A1 (fr) 2021-03-31 2022-10-06 Pi Industries Ltd. Composés hétérocycliques condensés et leur utilisation en tant qu'agents de lutte antiparasitaire
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