ATE446366T1 - Agonistische monoklonale antikörper gegen trkc - Google Patents
Agonistische monoklonale antikörper gegen trkcInfo
- Publication number
- ATE446366T1 ATE446366T1 AT01950429T AT01950429T ATE446366T1 AT E446366 T1 ATE446366 T1 AT E446366T1 AT 01950429 T AT01950429 T AT 01950429T AT 01950429 T AT01950429 T AT 01950429T AT E446366 T1 ATE446366 T1 AT E446366T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibodies
- trkc
- antibodies against
- agonistic monoclonal
- antibodies
- Prior art date
Links
- 102100029166 NT-3 growth factor receptor Human genes 0.000 title 1
- 101150117329 NTRK3 gene Proteins 0.000 title 1
- 230000001270 agonistic effect Effects 0.000 title 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000047459 trkC Receptor Human genes 0.000 abstract 1
- 108010064892 trkC Receptor Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21314100P | 2000-06-22 | 2000-06-22 | |
| US23831900P | 2000-10-05 | 2000-10-05 | |
| PCT/US2001/020153 WO2001098361A2 (en) | 2000-06-22 | 2001-06-22 | Agonist anti-trk-c monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446366T1 true ATE446366T1 (de) | 2009-11-15 |
Family
ID=26907807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01950429T ATE446366T1 (de) | 2000-06-22 | 2001-06-22 | Agonistische monoklonale antikörper gegen trkc |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7384632B2 (de) |
| EP (1) | EP1292680B1 (de) |
| JP (1) | JP2004500873A (de) |
| KR (1) | KR100823764B1 (de) |
| CN (1) | CN100519749C (de) |
| AT (1) | ATE446366T1 (de) |
| AU (2) | AU2001271422B2 (de) |
| BR (1) | BR0112272A (de) |
| CA (1) | CA2412494C (de) |
| DE (1) | DE60140252D1 (de) |
| DK (1) | DK1292680T3 (de) |
| HU (1) | HU228310B1 (de) |
| IL (2) | IL153375A0 (de) |
| MX (1) | MXPA02012602A (de) |
| NZ (1) | NZ523105A (de) |
| PL (1) | PL208113B1 (de) |
| WO (1) | WO2001098361A2 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| ES2540102T3 (es) | 2000-06-05 | 2015-07-08 | The Brigham & Women's Hospital, Inc. | Un gen que codifica un homólogo de glicoproteína P humana multifármaco-resistente en el cromosoma 7p15-21 y usos del mismo |
| PL208113B1 (pl) * | 2000-06-22 | 2011-03-31 | Genentech Inc | Agonistyczne przeciwciało monoklonalne anty-trkC, mysie agonistyczne przeciwciało monoklonalne, ludzkie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca mysie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca ludzkie przeciwciało anty-trkC, cząsteczka kwasu nukleinowego, linia komórek gospodarza, linia komórek hybrydomy, przeciwciało wytwarzane przez tę linię komórek hybrydomy, wyizolowana cząsteczka kwasu nukleinowego i wektor zawierający tę cząsteczkę kwasu nukleinowego, przeciwciało, polipeptyd, kompozycja |
| GB0210783D0 (en) * | 2002-05-10 | 2002-06-19 | Polonelli Luciano | Anti-microbial polypeptides |
| WO2004044584A1 (en) * | 2002-11-13 | 2004-05-27 | Micromet Ag | Method for identifying antigen specific b cells |
| ATE431157T1 (de) * | 2002-12-23 | 2009-05-15 | Rinat Neuroscience Corp | Verfahren zur behandlung von durch taxol induzierter sensorischer neuropathie |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| JP2006520806A (ja) * | 2003-03-20 | 2006-09-14 | ライナット ニューロサイエンス コーポレイション | タキソール誘導性腸障害を処置する方法 |
| WO2005062955A2 (en) * | 2003-12-23 | 2005-07-14 | Rinat Neuroscience Corp. | Agonist anti-trkc antibodies and methods using same |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| NZ563941A (en) * | 2005-06-06 | 2011-09-30 | Wyeth Corp | Anti-TRKB monoclonal antibodies and uses thereof |
| BRPI0611714A2 (pt) * | 2005-06-30 | 2009-01-13 | Abbott Lab | proteÍnas de ligaÇço a il-12/p40 |
| CA2628703C (en) | 2005-11-30 | 2019-10-29 | Abbott Laboratories | Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| RU2008131939A (ru) | 2006-02-02 | 2010-02-10 | Ринат Ньюросайенс Корп. (Us) | Способы лечения нежелательной потери веса или нарушений приема пищи агонистами trkb |
| DK2035549T3 (da) | 2006-05-31 | 2014-10-13 | Childrens Medical Center | Abcb5-positive mesenkymale stamceller som immunmodulatorer |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| CN101657212B (zh) * | 2006-12-05 | 2014-03-19 | 皇家学习促进会/麦吉尔大学 | Trk受体调节剂的使用方法 |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| HUE027593T2 (en) | 2007-04-12 | 2016-11-28 | Brigham & Womens Hospital Inc | ABCB5 targeting cancer therapy |
| US8168757B2 (en) * | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
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| PT2725028T (pt) | 2008-10-22 | 2016-08-31 | Array Biopharma Inc | Compostos de pirazolo[1,5-]pirimidina substituídos como intermediários na síntese de inibidores de cinase trk |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
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| CA2746778C (en) | 2008-12-19 | 2019-04-23 | University Of Zurich | Human anti-alpha-synuclein autoantibodies |
| EP2421900A1 (de) | 2009-04-24 | 2012-02-29 | Alper Biotech, Llc | Monoklonale antikörper gegen pcbp-1-antigene, und anwendungen davon |
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| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
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| WO2012027821A1 (en) * | 2010-09-03 | 2012-03-08 | The Royal Institution For The Advancement Of Learning / Mcgill University | A trkc receptor agonist antibody to treat neurodegenerative and motor neuron diseases |
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| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
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| EP2847700B1 (de) * | 2012-05-09 | 2022-12-07 | Koninklijke Philips N.V. | Medizinische verfolgungsschnittstelle mit informationsvermittlung für eingriffe |
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| BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
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| EP4095161A1 (de) * | 2017-03-15 | 2022-11-30 | Tsinghua University | Neuartige anti-trkb-antikörper |
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| CN117281803A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
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| JP2022515197A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | がんを治療するためのfgfr阻害剤としての7-((3,5-ジメトキシフェニル)アミノ)キノキサリン誘導体 |
| EP3898626A1 (de) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituierte pyrazolo[1,5-a]pyridin-verbindungen als inhibitoren von fgfr-tyrosinkinasen |
| EP4041290A4 (de) | 2019-09-23 | 2024-02-07 | The Trustees of the University of Pennsylvania | Monoklonaler antikörper gegen fibroblasten-aktivierungsprotein des hundes, das mit fibroblasten-aktivierungsprotein (fap) der maus und des menschen kreuzreagiert |
| JP7621344B2 (ja) | 2019-09-23 | 2025-01-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 線維芽細胞活性化タンパク質(fap)を標的とすることによる腫瘍組織の破壊の方法 |
| CN117447602B (zh) * | 2023-12-22 | 2024-03-19 | 北京索莱宝科技有限公司 | 猪IgM的抗体及其应用 |
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| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL95511A (en) * | 1989-08-30 | 2000-10-31 | Max Planck Gesellschaft | Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor |
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| US5364769A (en) | 1990-09-25 | 1994-11-15 | Genentech, Inc. | Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production |
| US5348856A (en) * | 1991-07-08 | 1994-09-20 | E. R. Squibb & Sons, Inc. | DNA encoding TRKC protein |
| DE69330809T2 (de) | 1992-06-08 | 2002-05-16 | Takeda Chemical Industries, Ltd. | Therapeutisches Agens für Neutropenie |
| US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| US5659791A (en) * | 1993-04-26 | 1997-08-19 | Microsoft Corporation | Encapsulation of extracted portions of documents into objects |
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| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物am5221 |
| WO1996036361A1 (en) * | 1995-05-18 | 1996-11-21 | The Regents Of The University Of Michigan | Dna binding antibodies |
| JP3946256B2 (ja) * | 1995-09-11 | 2007-07-18 | 協和醗酵工業株式会社 | ヒトインターロイキン5受容体α鎖に対する抗体 |
| GB9525180D0 (en) * | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| AU7154698A (en) * | 1997-04-25 | 1998-11-24 | Genentech Inc. | Ngf variants |
| CA2348835A1 (en) | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methods for regulating angiogenesis and vascular integrity using trk receptor ligands |
| US6656474B1 (en) * | 1999-01-15 | 2003-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
| PL208113B1 (pl) * | 2000-06-22 | 2011-03-31 | Genentech Inc | Agonistyczne przeciwciało monoklonalne anty-trkC, mysie agonistyczne przeciwciało monoklonalne, ludzkie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca mysie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca ludzkie przeciwciało anty-trkC, cząsteczka kwasu nukleinowego, linia komórek gospodarza, linia komórek hybrydomy, przeciwciało wytwarzane przez tę linię komórek hybrydomy, wyizolowana cząsteczka kwasu nukleinowego i wektor zawierający tę cząsteczkę kwasu nukleinowego, przeciwciało, polipeptyd, kompozycja |
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2001
- 2001-06-22 PL PL359926A patent/PL208113B1/pl unknown
- 2001-06-22 AT AT01950429T patent/ATE446366T1/de not_active IP Right Cessation
- 2001-06-22 HU HU0300841A patent/HU228310B1/hu unknown
- 2001-06-22 DK DK01950429.9T patent/DK1292680T3/da active
- 2001-06-22 JP JP2002504316A patent/JP2004500873A/ja active Pending
- 2001-06-22 CA CA2412494A patent/CA2412494C/en not_active Expired - Lifetime
- 2001-06-22 AU AU2001271422A patent/AU2001271422B2/en not_active Ceased
- 2001-06-22 BR BR0112272-0A patent/BR0112272A/pt not_active IP Right Cessation
- 2001-06-22 US US10/312,316 patent/US7384632B2/en not_active Expired - Lifetime
- 2001-06-22 WO PCT/US2001/020153 patent/WO2001098361A2/en not_active Ceased
- 2001-06-22 KR KR1020027017506A patent/KR100823764B1/ko not_active Expired - Lifetime
- 2001-06-22 AU AU7142201A patent/AU7142201A/xx active Pending
- 2001-06-22 NZ NZ523105A patent/NZ523105A/en not_active IP Right Cessation
- 2001-06-22 IL IL15337501A patent/IL153375A0/xx unknown
- 2001-06-22 DE DE60140252T patent/DE60140252D1/de not_active Expired - Lifetime
- 2001-06-22 EP EP01950429A patent/EP1292680B1/de not_active Expired - Lifetime
- 2001-06-22 CN CNB018144217A patent/CN100519749C/zh not_active Expired - Lifetime
- 2001-06-22 MX MXPA02012602A patent/MXPA02012602A/es active IP Right Grant
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2002
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- 2006-10-16 US US11/581,865 patent/US7615383B2/en not_active Expired - Lifetime
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- 2009-06-04 US US12/478,501 patent/US20100003261A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| CN100519749C (zh) | 2009-07-29 |
| EP1292680A2 (de) | 2003-03-19 |
| AU7142201A (en) | 2002-01-02 |
| CA2412494C (en) | 2012-10-23 |
| KR20030036240A (ko) | 2003-05-09 |
| EP1292680B1 (de) | 2009-10-21 |
| WO2001098361A9 (en) | 2003-03-06 |
| JP2004500873A (ja) | 2004-01-15 |
| US20120045443A1 (en) | 2012-02-23 |
| KR100823764B1 (ko) | 2008-04-21 |
| AU2001271422B2 (en) | 2005-12-22 |
| HUP0300841A3 (en) | 2005-11-28 |
| WO2001098361A3 (en) | 2002-05-02 |
| BR0112272A (pt) | 2003-05-06 |
| NZ523105A (en) | 2004-07-30 |
| DK1292680T3 (da) | 2010-03-08 |
| US7384632B2 (en) | 2008-06-10 |
| US20100003261A1 (en) | 2010-01-07 |
| DE60140252D1 (de) | 2009-12-03 |
| CA2412494A1 (en) | 2001-12-27 |
| WO2001098361A2 (en) | 2001-12-27 |
| US20040137513A1 (en) | 2004-07-15 |
| IL153375A0 (en) | 2003-07-06 |
| HU228310B1 (en) | 2013-03-28 |
| CN1447857A (zh) | 2003-10-08 |
| HUP0300841A2 (hu) | 2004-06-28 |
| MXPA02012602A (es) | 2003-05-14 |
| US7615383B2 (en) | 2009-11-10 |
| US20070036794A1 (en) | 2007-02-15 |
| IL153375A (en) | 2009-06-15 |
| PL359926A1 (en) | 2004-09-06 |
| PL208113B1 (pl) | 2011-03-31 |
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