ATE446366T1 - Agonistische monoklonale antikörper gegen trkc - Google Patents
Agonistische monoklonale antikörper gegen trkcInfo
- Publication number
- ATE446366T1 ATE446366T1 AT01950429T AT01950429T ATE446366T1 AT E446366 T1 ATE446366 T1 AT E446366T1 AT 01950429 T AT01950429 T AT 01950429T AT 01950429 T AT01950429 T AT 01950429T AT E446366 T1 ATE446366 T1 AT E446366T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibodies
- trkc
- antibodies against
- agonistic monoclonal
- antibodies
- Prior art date
Links
- 102100029166 NT-3 growth factor receptor Human genes 0.000 title 1
- 101150117329 NTRK3 gene Proteins 0.000 title 1
- 230000001270 agonistic effect Effects 0.000 title 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000047459 trkC Receptor Human genes 0.000 abstract 1
- 108010064892 trkC Receptor Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21314100P | 2000-06-22 | 2000-06-22 | |
| US23831900P | 2000-10-05 | 2000-10-05 | |
| PCT/US2001/020153 WO2001098361A2 (en) | 2000-06-22 | 2001-06-22 | Agonist anti-trk-c monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446366T1 true ATE446366T1 (de) | 2009-11-15 |
Family
ID=26907807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01950429T ATE446366T1 (de) | 2000-06-22 | 2001-06-22 | Agonistische monoklonale antikörper gegen trkc |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7384632B2 (de) |
| EP (1) | EP1292680B1 (de) |
| JP (1) | JP2004500873A (de) |
| KR (1) | KR100823764B1 (de) |
| CN (1) | CN100519749C (de) |
| AT (1) | ATE446366T1 (de) |
| AU (2) | AU7142201A (de) |
| BR (1) | BR0112272A (de) |
| CA (1) | CA2412494C (de) |
| DE (1) | DE60140252D1 (de) |
| DK (1) | DK1292680T3 (de) |
| HU (1) | HU228310B1 (de) |
| IL (2) | IL153375A0 (de) |
| MX (1) | MXPA02012602A (de) |
| NZ (1) | NZ523105A (de) |
| PL (1) | PL208113B1 (de) |
| WO (1) | WO2001098361A2 (de) |
Families Citing this family (88)
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| GB0210783D0 (en) * | 2002-05-10 | 2002-06-19 | Polonelli Luciano | Anti-microbial polypeptides |
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| US20070014786A1 (en) * | 2003-03-20 | 2007-01-18 | Rinat Neuroscience Corp. | Methods for treating taxol-induced gut disorder |
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| ES2527661T3 (es) | 2005-11-30 | 2015-01-28 | Abbvie Inc. | Método de exploración, proceso para purificar oligómeros Abeta no difundibles, anticuerpos selectivos contra dichos oligómeros Abeta no difundibles y un proceso para fabricar dichos anticuerpos |
| CN101400367A (zh) | 2006-02-02 | 2009-04-01 | 瑞纳神经科学公司 | 施用trkb激动剂治疗不希望的重量减轻或进食障碍的方法 |
| PT2035549E (pt) | 2006-05-31 | 2014-10-06 | Childrens Medical Center | Células estaminais mesenquimais abcb5 positivas como imunomoduladores |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008070132A2 (en) * | 2006-12-05 | 2008-06-12 | The Royal Institution For The Advancement Of Learning/ Mcgill University | Methods of use of trk receptor modulators |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
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| EP3898626A1 (de) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituierte pyrazolo[1,5-a]pyridin-verbindungen als inhibitoren von fgfr-tyrosinkinasen |
| EP3898615A1 (de) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)chinoxalin-derivate als fgfr-inhibitoren zur behandlung von krebs |
| JP7603670B2 (ja) | 2019-09-23 | 2024-12-20 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | マウスおよびヒト線維芽細胞活性化タンパク質(fap)と交差反応するイヌ線維芽細胞活性化タンパク質に対するモノクローナル抗体 |
| AU2020353000A1 (en) * | 2019-09-23 | 2022-04-07 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| CN117447602B (zh) * | 2023-12-22 | 2024-03-19 | 北京索莱宝科技有限公司 | 猪IgM的抗体及其应用 |
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| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL95511A (en) * | 1989-08-30 | 2000-10-31 | Max Planck Gesellschaft | Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor |
| CA2040099A1 (en) | 1990-05-01 | 1991-11-02 | Mariano Barbacid | Tyrosine kinase negative trkb |
| US5364769A (en) | 1990-09-25 | 1994-11-15 | Genentech, Inc. | Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production |
| US5348856A (en) | 1991-07-08 | 1994-09-20 | E. R. Squibb & Sons, Inc. | DNA encoding TRKC protein |
| EP0573904B1 (de) | 1992-06-08 | 2001-09-26 | Takeda Chemical Industries, Ltd. | Therapeutisches Agens für Neutropenie |
| US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| US5659791A (en) * | 1993-04-26 | 1997-08-19 | Microsoft Corporation | Encapsulation of extracted portions of documents into objects |
| CA2175893C (en) | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| DE69408541T2 (de) | 1993-11-23 | 1998-08-06 | Genentech, Inc., South San Francisco, Calif. | Kinaserezeptoraktivierungstest |
| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物am5221 |
| WO1996036361A1 (en) * | 1995-05-18 | 1996-11-21 | The Regents Of The University Of Michigan | Dna binding antibodies |
| ATE283926T1 (de) * | 1995-09-11 | 2004-12-15 | Kyowa Hakko Kogyo Kk | Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor |
| GB9525180D0 (en) * | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| AU7154698A (en) | 1997-04-25 | 1998-11-24 | Genentech Inc. | Ngf variants |
| ES2316194T3 (es) | 1998-10-28 | 2009-04-01 | Cornell Research Foundation, Inc. | Metodos para la regulacion de la angiogenesis y la integridad vascular utilizando los ligandos bdnf, nt-3 y nt-4. |
| US6656474B1 (en) * | 1999-01-15 | 2003-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
| ATE446366T1 (de) * | 2000-06-22 | 2009-11-15 | Genentech Inc | Agonistische monoklonale antikörper gegen trkc |
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2001
- 2001-06-22 AT AT01950429T patent/ATE446366T1/de not_active IP Right Cessation
- 2001-06-22 MX MXPA02012602A patent/MXPA02012602A/es active IP Right Grant
- 2001-06-22 US US10/312,316 patent/US7384632B2/en not_active Expired - Lifetime
- 2001-06-22 NZ NZ523105A patent/NZ523105A/en not_active IP Right Cessation
- 2001-06-22 HU HU0300841A patent/HU228310B1/hu unknown
- 2001-06-22 KR KR1020027017506A patent/KR100823764B1/ko not_active Expired - Lifetime
- 2001-06-22 WO PCT/US2001/020153 patent/WO2001098361A2/en not_active Ceased
- 2001-06-22 EP EP01950429A patent/EP1292680B1/de not_active Expired - Lifetime
- 2001-06-22 PL PL359926A patent/PL208113B1/pl unknown
- 2001-06-22 AU AU7142201A patent/AU7142201A/xx active Pending
- 2001-06-22 IL IL15337501A patent/IL153375A0/xx unknown
- 2001-06-22 AU AU2001271422A patent/AU2001271422B2/en not_active Ceased
- 2001-06-22 BR BR0112272-0A patent/BR0112272A/pt not_active IP Right Cessation
- 2001-06-22 JP JP2002504316A patent/JP2004500873A/ja active Pending
- 2001-06-22 DK DK01950429.9T patent/DK1292680T3/da active
- 2001-06-22 CA CA2412494A patent/CA2412494C/en not_active Expired - Lifetime
- 2001-06-22 DE DE60140252T patent/DE60140252D1/de not_active Expired - Lifetime
- 2001-06-22 CN CNB018144217A patent/CN100519749C/zh not_active Expired - Lifetime
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2002
- 2002-12-11 IL IL153375A patent/IL153375A/en active IP Right Grant
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2006
- 2006-10-16 US US11/581,865 patent/US7615383B2/en not_active Expired - Lifetime
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2009
- 2009-06-04 US US12/478,501 patent/US20100003261A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| DK1292680T3 (da) | 2010-03-08 |
| PL208113B1 (pl) | 2011-03-31 |
| BR0112272A (pt) | 2003-05-06 |
| HU228310B1 (en) | 2013-03-28 |
| AU2001271422B2 (en) | 2005-12-22 |
| WO2001098361A2 (en) | 2001-12-27 |
| WO2001098361A3 (en) | 2002-05-02 |
| CA2412494A1 (en) | 2001-12-27 |
| US20100003261A1 (en) | 2010-01-07 |
| MXPA02012602A (es) | 2003-05-14 |
| WO2001098361A9 (en) | 2003-03-06 |
| US20120045443A1 (en) | 2012-02-23 |
| IL153375A (en) | 2009-06-15 |
| CN1447857A (zh) | 2003-10-08 |
| AU7142201A (en) | 2002-01-02 |
| CA2412494C (en) | 2012-10-23 |
| US20040137513A1 (en) | 2004-07-15 |
| JP2004500873A (ja) | 2004-01-15 |
| EP1292680A2 (de) | 2003-03-19 |
| IL153375A0 (en) | 2003-07-06 |
| DE60140252D1 (de) | 2009-12-03 |
| PL359926A1 (en) | 2004-09-06 |
| EP1292680B1 (de) | 2009-10-21 |
| US7384632B2 (en) | 2008-06-10 |
| CN100519749C (zh) | 2009-07-29 |
| KR100823764B1 (ko) | 2008-04-21 |
| NZ523105A (en) | 2004-07-30 |
| KR20030036240A (ko) | 2003-05-09 |
| US20070036794A1 (en) | 2007-02-15 |
| HUP0300841A2 (hu) | 2004-06-28 |
| US7615383B2 (en) | 2009-11-10 |
| HUP0300841A3 (en) | 2005-11-28 |
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