PE20130149A1 - Derivados de la cromenona con actividad anti-tumoral - Google Patents

Derivados de la cromenona con actividad anti-tumoral

Info

Publication number
PE20130149A1
PE20130149A1 PE2012000578A PE2012000578A PE20130149A1 PE 20130149 A1 PE20130149 A1 PE 20130149A1 PE 2012000578 A PE2012000578 A PE 2012000578A PE 2012000578 A PE2012000578 A PE 2012000578A PE 20130149 A1 PE20130149 A1 PE 20130149A1
Authority
PE
Peru
Prior art keywords
ethyl
alkyl
halogen
chromenone
alcoxy
Prior art date
Application number
PE2012000578A
Other languages
English (en)
Inventor
Bernard Christophe Barlaam
Sebastien Louis Degorce
Der Brempt Christine Marie Paul Lambert-Van
Remy Robert Morgentin
Patrick Ple
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20130149A1 publication Critical patent/PE20130149A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CROMENONA DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI O ALCOXI(C1-C3); R2 ES ALQUILO(C1-C4) O ALCOXI(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI, ALQUENILO(C2-C3), ENTRE OTROS; R3 ES H O ALQUILO(C1-C3); R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALQUENILO(C2-C3), CN, ENTRE OTROS; R6, R7 Y R8 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALCOXI(C1-C3), ENTRE OTROS; R9 ES ALQUILO(C1-C3); n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-(2-(DIMETILAMINO)ETIL)-8-(1-(4-FLUOROFENILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA; N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-8-(1-(FENILAMINO)ETIL)-4H-CROMENO-6-CARBOXAMIDA; 8-(1-(3-CLORO-2-FLUOROFENILAMINO)ETIL)-N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFOINOSITIDA (PI) 3-QUINASA ? SIENDO UTILES EN EL TRATAMIENTO DE CANCER
PE2012000578A 2009-10-27 2010-10-25 Derivados de la cromenona con actividad anti-tumoral PE20130149A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27

Publications (1)

Publication Number Publication Date
PE20130149A1 true PE20130149A1 (es) 2013-03-10

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000578A PE20130149A1 (es) 2009-10-27 2010-10-25 Derivados de la cromenona con actividad anti-tumoral

Country Status (41)

Country Link
US (5) US8399460B2 (es)
EP (1) EP2493870B1 (es)
JP (2) JP5657010B2 (es)
KR (1) KR101738195B1 (es)
CN (2) CN104447657B (es)
AR (1) AR078786A1 (es)
AU (1) AU2010311107B9 (es)
BR (1) BR112012010124B8 (es)
CA (1) CA2776994C (es)
CL (1) CL2012001056A1 (es)
CO (1) CO6541528A2 (es)
CR (1) CR20120217A (es)
CU (1) CU20120069A7 (es)
CY (1) CY1116143T1 (es)
DK (1) DK2493870T3 (es)
DO (1) DOP2012000124A (es)
EA (1) EA020523B9 (es)
EC (1) ECSP12011838A (es)
ES (1) ES2530943T3 (es)
GT (1) GT201200126A (es)
HK (2) HK1174027A1 (es)
HN (1) HN2012000889A (es)
HR (1) HRP20150146T1 (es)
IL (1) IL219191A0 (es)
IN (1) IN2012DN03328A (es)
ME (1) ME02050B (es)
MX (1) MX2012005027A (es)
MY (1) MY179833A (es)
NI (1) NI201200081A (es)
NZ (1) NZ599457A (es)
PE (1) PE20130149A1 (es)
PL (1) PL2493870T3 (es)
PT (1) PT2493870E (es)
RS (1) RS53813B1 (es)
SA (1) SA110310808B1 (es)
SI (1) SI2493870T1 (es)
SM (1) SMT201500036B (es)
TW (1) TWI483939B (es)
UA (1) UA107474C2 (es)
UY (1) UY32978A (es)
WO (1) WO2011051704A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2474147T3 (es) 2008-05-30 2014-07-08 Amgen, Inc Inhibidores de PI3 cinasa
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
US8530470B2 (en) 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
MA38287B1 (fr) 2013-01-23 2018-08-31 Astrazeneca Ab Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer
CA2900136C (en) * 2013-03-04 2021-05-04 Astrazeneca Ab Combination treatment
MX2016016516A (es) 2014-06-13 2017-05-01 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-cinasa.
KR20170010063A (ko) 2014-06-13 2017-01-25 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제
CA2952018A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
NZ726360A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
US9499523B2 (en) 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
KR101766731B1 (ko) 2015-06-23 2017-08-10 충남대학교산학협력단 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물
KR102630111B1 (ko) * 2015-10-09 2024-01-25 얀센 파마슈티카 엔브이 PI3Kβ 저해제로서의 퀴녹살린 및 피리도피라진 유도체
WO2018057808A1 (en) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
AR121719A1 (es) * 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) * 2020-05-15 2021-11-23 제이투에이치바이오텍 (주) 3원환 화합물 및 이의 의약 용도
KR20240016938A (ko) * 2021-02-01 2024-02-06 지오드 테라퓨틱스 인크. 포스포이노시티드 3 키나아제 베타 억제제 및 그 조성물 및 방법
JP2024516993A (ja) * 2021-05-03 2024-04-18 ペトラ・ファーマ・コーポレイション 疾患の治療のためのホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤
CR20230517A (es) * 2021-05-03 2023-11-28 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
BR112023022890A2 (pt) 2021-05-27 2024-01-23 Petra Pharma Corp Inibidores de cromenona alostéricos de fosfoinositídio 3-cinase (pi3k), composições farmacêuticas que os compreendem e usos dos mesmos
WO2023104111A1 (en) * 2021-12-08 2023-06-15 Nanjing Zenshine Pharmaceuticals Co., Ltd. Fused heterocyclic compounds as pi3kalpha inhibitors
WO2024003241A1 (en) 2022-06-30 2024-01-04 Astrazeneca Ab Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4
WO2024081904A1 (en) * 2022-10-14 2024-04-18 Genesis Therapeutics, Inc. Methods for treating cancer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027A (en) * 1849-01-09 Rotary blacksmith s twyer
JPH04502322A (ja) 1988-12-21 1992-04-23 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化症性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類
EP0525123B1 (en) 1990-06-20 1997-09-17 PHARMACIA & UPJOHN COMPANY Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
DE4318756A1 (de) 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
SI0880508T1 (en) 1996-02-13 2003-10-31 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
CA2674803C (en) 1999-02-10 2012-10-09 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors
CA2398163C (en) 2000-01-24 2011-02-22 Kinacia Pty Ltd. Therapeutic morpholino-substituted compounds
CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
CA2411160A1 (en) 2000-07-07 2002-01-17 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
AU2001266232B2 (en) 2000-07-07 2005-09-15 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
CA2495661C (en) 2002-08-16 2011-06-14 Kinacia Pty Ltd. Inhibition of phosphoinositide 3-kinase beta
AR054438A1 (es) * 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
WO2007045876A1 (en) 2005-10-21 2007-04-26 Merz Pharma Gmbh & Co. Kgaa Chromenones and their use as modulators of metabotropic glutamate receptors
CN101448505A (zh) * 2006-04-04 2009-06-03 加利福尼亚大学董事会 Pi3激酶拮抗剂
WO2008064244A2 (en) 2006-11-20 2008-05-29 The Trustees Of Columbia University In The City Of New York Phosphoinositide modulation for the treatment of neurodegenerative diseases
EP2112145A1 (en) 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenone derivatives useful for the treatment of neurodegenerative diseases
WO2010134082A1 (en) 2009-05-21 2010-11-25 Proteologics Ltd Chromenone derivatives for treatment of cancer
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives

Also Published As

Publication number Publication date
BR112012010124B1 (pt) 2021-02-17
CN104447657B (zh) 2016-08-17
AU2010311107B2 (en) 2014-03-27
SMT201500036B (it) 2015-05-05
CR20120217A (es) 2012-06-28
CA2776994A1 (en) 2011-05-05
AU2010311107B9 (en) 2014-06-19
CN102712615B (zh) 2014-12-17
SI2493870T1 (sl) 2015-03-31
NZ599457A (en) 2014-04-30
SA110310808B1 (ar) 2013-11-24
US9029374B2 (en) 2015-05-12
BR112012010124A2 (pt) 2016-06-07
GT201200126A (es) 2014-03-03
DOP2012000124A (es) 2012-07-15
DK2493870T3 (en) 2015-02-23
IN2012DN03328A (es) 2015-10-23
JP5872016B2 (ja) 2016-03-01
BR112012010124B8 (pt) 2021-05-25
MY179833A (en) 2020-11-17
AU2010311107A1 (en) 2012-05-03
JP2013508449A (ja) 2013-03-07
ES2530943T3 (es) 2015-03-09
CL2012001056A1 (es) 2012-10-05
HRP20150146T1 (hr) 2015-05-22
US9718800B2 (en) 2017-08-01
JP5657010B2 (ja) 2015-01-21
CN104447657A (zh) 2015-03-25
RS53813B1 (en) 2015-06-30
ECSP12011838A (es) 2012-06-29
JP2015078202A (ja) 2015-04-23
TW201121960A (en) 2011-07-01
CU20120069A7 (es) 2012-10-15
US20110098271A1 (en) 2011-04-28
UA107474C2 (uk) 2015-01-12
HN2012000889A (es) 2015-08-03
TWI483939B (zh) 2015-05-11
EA020523B1 (ru) 2014-11-28
HK1174027A1 (en) 2013-05-31
WO2011051704A1 (en) 2011-05-05
KR20120098724A (ko) 2012-09-05
CY1116143T1 (el) 2017-02-08
US20140194419A1 (en) 2014-07-10
UY32978A (es) 2011-05-31
CN102712615A (zh) 2012-10-03
US8673906B2 (en) 2014-03-18
US8399460B2 (en) 2013-03-19
US20160060240A1 (en) 2016-03-03
HK1206335A1 (zh) 2016-01-08
PL2493870T3 (pl) 2015-04-30
US20130158026A1 (en) 2013-06-20
CA2776994C (en) 2017-10-31
KR101738195B1 (ko) 2017-05-19
ME02050B (me) 2015-05-20
US20160272607A1 (en) 2016-09-22
EA020523B9 (ru) 2015-01-30
EP2493870A1 (en) 2012-09-05
NI201200081A (es) 2012-11-07
AR078786A1 (es) 2011-11-30
EA201200618A1 (ru) 2012-12-28
CO6541528A2 (es) 2012-10-16
MX2012005027A (es) 2012-09-07
IL219191A0 (en) 2012-06-28
PT2493870E (pt) 2015-02-18
EP2493870B1 (en) 2014-12-17

Similar Documents

Publication Publication Date Title
PE20130149A1 (es) Derivados de la cromenona con actividad anti-tumoral
PE20071322A1 (es) Derivados de 2-morfolinopirimidina como inhibidores de fosfatidinoinositol(pi) 3-quinasa
CY1118969T1 (el) Ενωσεις πυριμιδινο-2-αμινης και η χρηση τους ως αναστολεις των κινασων jak
PE20221264A1 (es) Inhibidores de egfr
AR076460A1 (es) Antagonistas del receptor cxcr3
PE20170268A1 (es) Compuestos de heteroarilo para la inhibicion de cinasa
PE20141598A1 (es) Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina
PE20091561A1 (es) Compuestos inhibidores de raf y metodos para su uso
AR059957A1 (es) DERIVADOS DE ESPIROINDOLINONA, MÉTODOS PARA SU PREPARACIoN, UNA COMPOSICIoN FARMACÉUTICA QUE LOS CONTIENE Y SU USO EN LA FABRICACIoN DE MEDICAMENTOS PARA EL TRATAMIENTO DEL CÁNCER.
PE20141404A1 (es) Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas
PE20151981A1 (es) Pontenciador de inhibidores del homologo de zeste
AR079327A1 (es) Derivados de 2-amino-5,5-difluor -5,6-dihidro-4h-(1,3) oxazin-4-il) fenil)-amida
CO6321276A2 (es) Derivados de tiazol usados como inhibidores de pi3- cinasa
ECSP15012804A (es) Alcoxipirazoles como activadores de guanilato ciclasa soluble
CO2017000438A2 (es) Ácidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble
EA201071370A1 (ru) Серосодержащее гетероциклическое производное, обладающее активностью ингибитора бета-секретазы
AR075729A1 (es) Derivados de benzofuranilo, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad y/o diabetes.
PE20140192A1 (es) Derivados de bencimidazol como inhibidores de cinasa pi3
ECSP11011560A (es) Derivados amino-propiónicos sustituidos como inhibidores de neprilisina
SV2011004077A (es) Derivados aminobutiricos sustituidos como inhibidores de neprilisina
UY31254A1 (es) Derivados sutituidos de n4-(5-metil-1h-pirazol-3-il)- 1,3,5-triazina-2,4-diamina, sus enantiómeros, sales farmacéuticamente aceptables de los mismos, composiciones, procesos de preparación y aplicaciones
PE20091201A1 (es) AMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON (Btk)
PE20061106A1 (es) Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida
PE20120062A1 (es) Derivados de 1-bencil-2-amino-tetralina como inhibidores del transportador de glicina glyt1
NI201300111A (es) Derivados de pirazoloespirocetona para uso como inhibidores de acetil-coa carboxilasa

Legal Events

Date Code Title Description
FG Grant, registration