SMT201500036B - Derivati di cromenone con attivita' antitumorale - Google Patents

Derivati di cromenone con attivita' antitumorale

Info

Publication number
SMT201500036B
SMT201500036B SM201500036T SM201500036T SMT201500036B SM T201500036 B SMT201500036 B SM T201500036B SM 201500036 T SM201500036 T SM 201500036T SM 201500036 T SM201500036 T SM 201500036T SM T201500036 B SMT201500036 B SM T201500036B
Authority
SM
San Marino
Prior art keywords
cromenone
derivatives
antitumor activity
antitumor
activity
Prior art date
Application number
SM201500036T
Other languages
English (en)
Inventor
Bernard Christophe Barlaam
Sebastien Louis Degorce
Der Brempt Christine Marie Paul Lambert-Van
Remy Robert Morgentin
Patrick Ple
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SMT201500036B publication Critical patent/SMT201500036B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SM201500036T 2009-10-27 2015-02-12 Derivati di cromenone con attivita' antitumorale SMT201500036B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27
PCT/GB2010/051788 WO2011051704A1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti-tumour activity

Publications (1)

Publication Number Publication Date
SMT201500036B true SMT201500036B (it) 2015-05-05

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500036T SMT201500036B (it) 2009-10-27 2015-02-12 Derivati di cromenone con attivita' antitumorale

Country Status (41)

Country Link
US (5) US8399460B2 (it)
EP (1) EP2493870B1 (it)
JP (2) JP5657010B2 (it)
KR (1) KR101738195B1 (it)
CN (2) CN104447657B (it)
AR (1) AR078786A1 (it)
AU (1) AU2010311107B9 (it)
BR (1) BR112012010124B8 (it)
CA (1) CA2776994C (it)
CL (1) CL2012001056A1 (it)
CO (1) CO6541528A2 (it)
CR (1) CR20120217A (it)
CU (1) CU20120069A7 (it)
CY (1) CY1116143T1 (it)
DK (1) DK2493870T3 (it)
DO (1) DOP2012000124A (it)
EA (1) EA020523B9 (it)
EC (1) ECSP12011838A (it)
ES (1) ES2530943T3 (it)
GT (1) GT201200126A (it)
HK (2) HK1174027A1 (it)
HN (1) HN2012000889A (it)
HR (1) HRP20150146T1 (it)
IL (1) IL219191A0 (it)
IN (1) IN2012DN03328A (it)
ME (1) ME02050B (it)
MX (1) MX2012005027A (it)
MY (1) MY179833A (it)
NI (1) NI201200081A (it)
NZ (1) NZ599457A (it)
PE (1) PE20130149A1 (it)
PL (1) PL2493870T3 (it)
PT (1) PT2493870E (it)
RS (1) RS53813B1 (it)
SA (1) SA110310808B1 (it)
SI (1) SI2493870T1 (it)
SM (1) SMT201500036B (it)
TW (1) TWI483939B (it)
UA (1) UA107474C2 (it)
UY (1) UY32978A (it)
WO (1) WO2011051704A1 (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5599783B2 (ja) 2008-05-30 2014-10-01 アムジエン・インコーポレーテツド Pi3キナーゼの阻害薬
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
US8530470B2 (en) 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
RU2644769C2 (ru) 2013-01-23 2018-02-14 Астразенека Аб Химические соединения
KR102222346B1 (ko) * 2013-03-04 2021-03-02 아스트라제네카 아베 조합 치료
BR112016028819A2 (pt) 2014-06-13 2017-08-22 Gilead Sciences Inc composição farmacêutica, métodos para tratar uma doença ou condição em um ser humano e para inibir a atividade de um polipeptídeo de fosfatidilinositol 3-quinase e reações imunológicas excessivas ou destrutivas ou o crescimento ou a proliferação de células cancerosas, kit, composto, sal farmaceuticamente aceitável, isômero ou mistura dos mesmos, e, uso de um composto, sal farmaceuticamente aceitável ou mistura dos mesmos.
EP3154962B1 (en) 2014-06-13 2019-08-07 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
NZ726360A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
EP3154958B1 (en) 2014-06-13 2020-10-07 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
JP6383810B2 (ja) 2014-06-13 2018-08-29 ギリアード サイエンシーズ, インコーポレイテッド ホスファチジルイノシトール3−キナーゼ阻害剤としてのキナゾリノン誘導体
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
KR101766731B1 (ko) 2015-06-23 2017-08-10 충남대학교산학협력단 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물
JP6912460B2 (ja) * 2015-10-09 2021-08-04 ヤンセン ファーマシューティカ エヌ.ベー. PI3Kβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体
WO2018057808A1 (en) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
AR121719A1 (es) * 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) * 2020-05-15 2021-11-23 제이투에이치바이오텍 (주) 3원환 화합물 및 이의 의약 용도
WO2022164812A1 (en) * 2021-02-01 2022-08-04 Geode Therapeutics Inc. Phosphoinositide 3 kinase beta inhibitors and compositions and methods thereof
CR20230517A (es) * 2021-05-03 2023-11-28 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
TW202309011A (zh) * 2021-05-03 2023-03-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑
US11878970B2 (en) 2021-05-27 2024-01-23 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
CA3237760A1 (en) * 2021-12-08 2023-06-15 Xiaolin Hao Fused heterocyclic compounds as pi3kalpha inhibitors
WO2024003241A1 (en) 2022-06-30 2024-01-04 Astrazeneca Ab Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4
WO2024081904A1 (en) * 2022-10-14 2024-04-18 Genesis Therapeutics, Inc. Methods for treating cancer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027A (en) * 1849-01-09 Rotary blacksmith s twyer
WO1990006921A1 (en) 1988-12-21 1990-06-28 The Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH05509302A (ja) 1990-06-20 1993-12-22 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化性および抗血栓性1―ベンゾピラン―4―オン類および2―アミノ―1,3―ベンゾオキサジン―4―オン類
DE4318756A1 (de) 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
SK285141B6 (sk) 1996-02-13 2006-07-07 Astrazeneca Uk Limited Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
HU228964B1 (en) 1999-02-10 2013-07-29 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors, process for their preparation and medicaments containing them
WO2001053266A1 (en) 2000-01-24 2001-07-26 Kinacia Pty Ltd. Therapeutic morpholino-substituted compounds
WO2001092224A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
MXPA02012903A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como inhibidores de angiogenesis.
CA2411160A1 (en) 2000-07-07 2002-01-17 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
EP1537102A4 (en) 2002-08-16 2010-12-08 Astrazeneca Ab INHIBITORS OF PHOSPHOINOSITIDE-3-KINASE BETA
AR054438A1 (es) * 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
AU2006303037A1 (en) 2005-10-21 2007-04-26 Merz Pharma Gmbh & Co Kgaa Chromenones and their use as modulators of metabotropic glutamate receptors
CN101448505A (zh) * 2006-04-04 2009-06-03 加利福尼亚大学董事会 Pi3激酶拮抗剂
WO2008064244A2 (en) 2006-11-20 2008-05-29 The Trustees Of Columbia University In The City Of New York Phosphoinositide modulation for the treatment of neurodegenerative diseases
EP2112145A1 (en) 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenone derivatives useful for the treatment of neurodegenerative diseases
WO2010134082A1 (en) 2009-05-21 2010-11-25 Proteologics Ltd Chromenone derivatives for treatment of cancer
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives

Also Published As

Publication number Publication date
CU20120069A7 (es) 2012-10-15
BR112012010124B8 (pt) 2021-05-25
US20160272607A1 (en) 2016-09-22
CN104447657A (zh) 2015-03-25
SA110310808B1 (ar) 2013-11-24
AU2010311107A1 (en) 2012-05-03
NZ599457A (en) 2014-04-30
HN2012000889A (es) 2015-08-03
AU2010311107B2 (en) 2014-03-27
CY1116143T1 (el) 2017-02-08
PL2493870T3 (pl) 2015-04-30
JP2013508449A (ja) 2013-03-07
HRP20150146T1 (hr) 2015-05-22
BR112012010124B1 (pt) 2021-02-17
US8399460B2 (en) 2013-03-19
SI2493870T1 (sl) 2015-03-31
HK1174027A1 (en) 2013-05-31
MX2012005027A (es) 2012-09-07
TW201121960A (en) 2011-07-01
CO6541528A2 (es) 2012-10-16
KR20120098724A (ko) 2012-09-05
US20130158026A1 (en) 2013-06-20
EP2493870A1 (en) 2012-09-05
ME02050B (me) 2015-05-20
DOP2012000124A (es) 2012-07-15
KR101738195B1 (ko) 2017-05-19
HK1206335A1 (zh) 2016-01-08
CR20120217A (es) 2012-06-28
US20110098271A1 (en) 2011-04-28
ECSP12011838A (es) 2012-06-29
AU2010311107B9 (en) 2014-06-19
CN104447657B (zh) 2016-08-17
IN2012DN03328A (it) 2015-10-23
DK2493870T3 (en) 2015-02-23
CA2776994C (en) 2017-10-31
CN102712615B (zh) 2014-12-17
EA020523B1 (ru) 2014-11-28
EA020523B9 (ru) 2015-01-30
US9029374B2 (en) 2015-05-12
US20140194419A1 (en) 2014-07-10
RS53813B1 (en) 2015-06-30
US9718800B2 (en) 2017-08-01
CA2776994A1 (en) 2011-05-05
US8673906B2 (en) 2014-03-18
AR078786A1 (es) 2011-11-30
CN102712615A (zh) 2012-10-03
PT2493870E (pt) 2015-02-18
US20160060240A1 (en) 2016-03-03
WO2011051704A1 (en) 2011-05-05
JP2015078202A (ja) 2015-04-23
JP5872016B2 (ja) 2016-03-01
EA201200618A1 (ru) 2012-12-28
TWI483939B (zh) 2015-05-11
JP5657010B2 (ja) 2015-01-21
EP2493870B1 (en) 2014-12-17
UY32978A (es) 2011-05-31
UA107474C2 (uk) 2015-01-12
IL219191A0 (en) 2012-06-28
CL2012001056A1 (es) 2012-10-05
GT201200126A (es) 2014-03-03
ES2530943T3 (es) 2015-03-09
PE20130149A1 (es) 2013-03-10
MY179833A (en) 2020-11-17
BR112012010124A2 (pt) 2016-06-07
NI201200081A (es) 2012-11-07

Similar Documents

Publication Publication Date Title
SMT201500036B (it) Derivati di cromenone con attivita' antitumorale
SMT201600198B (it) Derivati di 1,2,4-triazina-4-ammina
BRPI1013246A2 (pt) derivados de benzofuralina
BR112012002828A2 (pt) derivados de 5-fluorpirimidinona
BRPI1010924A2 (pt) retração montada em pacientes
ECSP12011999A (es) Derivados benzamida sustituidos
BRPI1013844A2 (pt) derivados de piridina-isoxazol
DK2397480T3 (da) Diazepindionderivat
BRPI1014454A2 (pt) derivados de isoxazol-pirazol
BR112012010242A2 (pt) derivados de heteroarilpiperidina e heteroarilpiperazina
SMT201400080B (it) Derivati di pirazinoossazepina
DK2387580T3 (da) Deoxyactagardinderivater
DK2391349T3 (da) Farmaceutisk sammensætning omfattende 2-oco-1-pyrrolidin-derivater
SMT201400185B (it) Derivati di 3,4,4A, 10B-tetraidro-1H-tiopirano-[4,3-C]isochinolina
BR112012002810A2 (pt) derivados de n1-acil-5-fluoropirimidinona
BRPI1011416A2 (pt) derivados de antraquinova novos
BRPI1008173A2 (pt) "derivados de piridina espiroindolinona"
SMT201500113B (it) Processp per preparare derivati di alfa-carbossammide
DK2380892T3 (da) Imidazothiazolderivat med prolinringstruktur
SMT201500067B (it) Derivati di acilbenzene
BRPI1010720A2 (pt) artigo
SMT201300010B (it) Derivati di piridazinoni
ES1071322Y (es) Mueble con zocalo
BRPI0924828A2 (pt) Ingrediente oligossacarídeo
TH104960B (th) อนุพันธ์ซับสทิทิวเต็ดอะริลลาไมด์ออกซาเซพิโนไพริมิโดน