NO20053775L - Diazepinoindol derivater som kinaseinhibitorer. - Google Patents

Diazepinoindol derivater som kinaseinhibitorer.

Info

Publication number
NO20053775L
NO20053775L NO20053775A NO20053775A NO20053775L NO 20053775 L NO20053775 L NO 20053775L NO 20053775 A NO20053775 A NO 20053775A NO 20053775 A NO20053775 A NO 20053775A NO 20053775 L NO20053775 L NO 20053775L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
diazepinoindole
derivatives
compounds
diazepinoindole derivatives
Prior art date
Application number
NO20053775A
Other languages
English (en)
Other versions
NO20053775D0 (no
Inventor
Min Teng
Sacha Ninkovic
Michael John Bennett
Yuanjin Eugene Rui
Fen Wang
Suzanne Pritchett Benedict
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20053775D0 publication Critical patent/NO20053775D0/no
Publication of NO20053775L publication Critical patent/NO20053775L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Proteinkinase, slik som CHK-1, som inhiberer tricykliske forbindelser med følgende formel (hvori R2, R3 og R4 er som definert i beskrivelsen) farmasøytiske sammensetninger som inneholder effektive mengder av nevnte forbindelser eller deres salter er anvendelse som et enkelt middel eller i kombinasjon med et anti-neoplastisk middel eller terapeutisk bestråling som har en anti-neoplastisk effekt for behandling av sykdommer eller tilstander, slik som kreft.
NO20053775A 2003-01-09 2005-08-08 Diazepinoindol derivater som kinaseinhibitorer. NO20053775L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20053775D0 NO20053775D0 (no) 2005-08-08
NO20053775L true NO20053775L (no) 2005-09-16

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053775A NO20053775L (no) 2003-01-09 2005-08-08 Diazepinoindol derivater som kinaseinhibitorer.

Country Status (35)

Country Link
US (3) US6967198B2 (no)
EP (2) EP1947102A1 (no)
JP (1) JP3990718B2 (no)
KR (1) KR100697746B1 (no)
CN (1) CN1759118B (no)
AP (1) AP2048A (no)
AT (1) ATE404564T1 (no)
AU (1) AU2004203977B2 (no)
BR (1) BRPI0406701A (no)
CA (1) CA2512683C (no)
CR (1) CR7899A (no)
CY (1) CY1108408T1 (no)
DE (1) DE602004015724D1 (no)
DK (1) DK1585749T3 (no)
EA (1) EA009337B1 (no)
EC (1) ECSP055911A (no)
ES (1) ES2309484T3 (no)
GE (1) GEP20084367B (no)
HK (1) HK1086257A1 (no)
HR (1) HRP20050624A2 (no)
IL (1) IL169082A (no)
IS (1) IS7884A (no)
MA (1) MA27703A1 (no)
MX (1) MXPA05007352A (no)
NO (1) NO20053775L (no)
NZ (1) NZ540638A (no)
OA (1) OA13017A (no)
PL (1) PL378372A1 (no)
PT (1) PT1585749E (no)
RS (1) RS20050522A (no)
SI (1) SI1585749T1 (no)
TN (1) TNSN05176A1 (no)
UA (1) UA80733C2 (no)
WO (1) WO2004063198A1 (no)
ZA (1) ZA200504674B (no)

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US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
US9254299B2 (en) 2011-12-22 2016-02-09 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer
DK2797921T3 (en) * 2011-12-31 2017-10-02 Beigene Ltd FUSED TETRA- OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARB INHIBITORS
EA027241B1 (ru) 2011-12-31 2017-07-31 Бейджен, Лтд. Конденсированные тетра- или пентациклические пиридофталазиноны в качестве ингибиторов parp
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
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Also Published As

Publication number Publication date
MA27703A1 (fr) 2006-01-02
CA2512683C (en) 2010-03-16
EP1585749B1 (en) 2008-08-13
HRP20050624A2 (en) 2006-02-28
ECSP055911A (es) 2005-11-22
DE602004015724D1 (de) 2008-09-25
US7462713B2 (en) 2008-12-09
EA009337B1 (ru) 2007-12-28
ZA200504674B (en) 2006-07-26
AP2005003353A0 (en) 2005-09-30
KR20050092397A (ko) 2005-09-21
DK1585749T3 (da) 2008-09-22
EP1585749A1 (en) 2005-10-19
SI1585749T1 (sl) 2008-10-31
AU2004203977B2 (en) 2010-06-17
EP1947102A1 (en) 2008-07-23
US7132533B2 (en) 2006-11-07
CY1108408T1 (el) 2014-02-12
NO20053775D0 (no) 2005-08-08
UA80733C2 (en) 2007-10-25
JP3990718B2 (ja) 2007-10-17
ES2309484T3 (es) 2008-12-16
US6967198B2 (en) 2005-11-22
GEP20084367B (en) 2008-05-13
AU2004203977A1 (en) 2004-07-29
MXPA05007352A (es) 2006-02-17
CA2512683A1 (en) 2004-07-29
IS7884A (is) 2005-06-09
RS20050522A (en) 2007-12-31
CN1759118A (zh) 2006-04-12
CN1759118B (zh) 2010-12-08
EA200500893A1 (ru) 2006-02-24
ATE404564T1 (de) 2008-08-15
IL169082A (en) 2011-02-28
WO2004063198A1 (en) 2004-07-29
US20060004052A1 (en) 2006-01-05
BRPI0406701A (pt) 2005-12-20
US20050075499A1 (en) 2005-04-07
AP2048A (en) 2009-09-24
OA13017A (en) 2006-11-10
KR100697746B1 (ko) 2007-03-22
CR7899A (es) 2005-08-05
HK1086257A1 (en) 2006-09-15
PT1585749E (pt) 2008-10-23
PL378372A1 (pl) 2006-04-03
NZ540638A (en) 2007-12-21
US20070135415A1 (en) 2007-06-14
JP2006516274A (ja) 2006-06-29
TNSN05176A1 (fr) 2007-06-11

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