IS7884A - Díasepínóindól afleiður sem kínasa hindrar - Google Patents

Díasepínóindól afleiður sem kínasa hindrar

Info

Publication number
IS7884A
IS7884A IS7884A IS7884A IS7884A IS 7884 A IS7884 A IS 7884A IS 7884 A IS7884 A IS 7884A IS 7884 A IS7884 A IS 7884A IS 7884 A IS7884 A IS 7884A
Authority
IS
Iceland
Prior art keywords
inhibit kinase
diazepinoindole
derivatives
diazepinoindole derivatives
kinase
Prior art date
Application number
IS7884A
Other languages
English (en)
Inventor
Ninkovic Sacha
John Bennett Michael
Yuanjin Rui Eugene
Wang Fen
Pritchett Benedict Suzanne
Teng Min
Wang Yong
Zhu Jinjiang
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of IS7884A publication Critical patent/IS7884A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
IS7884A 2003-01-09 2005-06-09 Díasepínóindól afleiður sem kínasa hindrar IS7884A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
IS7884A true IS7884A (is) 2005-06-09

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7884A IS7884A (is) 2003-01-09 2005-06-09 Díasepínóindól afleiður sem kínasa hindrar

Country Status (35)

Country Link
US (3) US6967198B2 (is)
EP (2) EP1585749B1 (is)
JP (1) JP3990718B2 (is)
KR (1) KR100697746B1 (is)
CN (1) CN1759118B (is)
AP (1) AP2048A (is)
AT (1) ATE404564T1 (is)
AU (1) AU2004203977B2 (is)
BR (1) BRPI0406701A (is)
CA (1) CA2512683C (is)
CR (1) CR7899A (is)
CY (1) CY1108408T1 (is)
DE (1) DE602004015724D1 (is)
DK (1) DK1585749T3 (is)
EA (1) EA009337B1 (is)
EC (1) ECSP055911A (is)
ES (1) ES2309484T3 (is)
GE (1) GEP20084367B (is)
HK (1) HK1086257A1 (is)
HR (1) HRP20050624A2 (is)
IL (1) IL169082A (is)
IS (1) IS7884A (is)
MA (1) MA27703A1 (is)
MX (1) MXPA05007352A (is)
NO (1) NO20053775L (is)
NZ (1) NZ540638A (is)
OA (1) OA13017A (is)
PL (1) PL378372A1 (is)
PT (1) PT1585749E (is)
RS (1) RS20050522A (is)
SI (1) SI1585749T1 (is)
TN (1) TNSN05176A1 (is)
UA (1) UA80733C2 (is)
WO (1) WO2004063198A1 (is)
ZA (1) ZA200504674B (is)

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JP4745609B2 (ja) * 2002-01-22 2011-08-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア グルココルチコイドレセプターのための非ステロイド性リガンド、その組成物および使用
AU2004203977B2 (en) * 2003-01-09 2010-06-17 Pfizer Inc. Diazepinoindole derivatives as kinase inhibitors
EP1853721B1 (en) * 2005-02-18 2010-04-14 AstraZeneca AB Method for determining responsiveness to chk1 inhibitors
AU2006230337B2 (en) 2005-03-29 2011-10-27 Icos Corporation Heteroaryl urea derivatives useful for inhibiting Chk1
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
RU2414475C2 (ru) 2005-06-29 2011-03-20 Трешолд Фармасьютикалз, Инк. Пролекарства фосфорамидатных алкилаторов
CA2619048A1 (en) * 2005-08-15 2007-02-22 The Regents Of The University Of California Vegf-activated fas ligands
WO2007023948A1 (ja) 2005-08-25 2007-03-01 Ube Industries, Ltd. 光学活性（Ｓ又はＲ）－α－アミノ酸及び光学活性（Ｒ又はＳ）－α－アミノ酸エステルの製造方法
AU2006282767A1 (en) * 2005-08-26 2007-03-01 The Regents Of The University Of California Non-steroidal antiandrogens
AU2007232279B2 (en) * 2006-04-04 2010-05-06 Pfizer Products Inc. Combination therapy of (2R)-2-amino-2-cyclohexyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-6- oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide
CA2648369A1 (en) * 2006-04-04 2007-10-11 Pfizer Products Inc. Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4?l)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide
EP2086644A2 (en) * 2006-11-17 2009-08-12 Schering Corporation Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders
US8158656B2 (en) * 2008-05-16 2012-04-17 Shenzhen Chipscreen Biosciences Ltd. 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
US8518952B2 (en) * 2008-08-06 2013-08-27 Pfizer Inc. 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
EP2346881A1 (en) * 2008-10-10 2011-07-27 Priaxon AG Novel compounds which modulate kinase activity
US8314108B2 (en) 2008-12-17 2012-11-20 Eli Lilly And Company 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
EP2705036B1 (en) 2011-05-06 2015-08-12 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
EP2793882A4 (en) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA ACTIVATED DRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
WO2013097225A1 (en) 2011-12-31 2013-07-04 Beigene, Ltd. Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
MX2014008071A (es) 2011-12-31 2015-07-06 Beigene Ltd Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
WO2015069489A1 (en) 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
RU2736219C2 (ru) 2014-06-17 2020-11-12 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации ингибиторов снк1 и atr
MX2018002322A (es) * 2015-08-25 2018-04-11 Beigene Ltd Procedimiento para la preparacion de un inhibidor de poli(adp-ribosa)polimerasa, formas cristalinas, y usos del mismo.
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
CN110087730B (zh) 2016-09-27 2023-03-28 百济神州(苏州)生物科技有限公司 使用包含parp抑制剂的组合产品治疗癌症
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
WO2018157794A1 (en) 2017-02-28 2018-09-07 Beigene, Ltd. Crystalline forms of salts of fused tera or penta-cyclic dihydrodiazepinocarazolones, and uses thereof
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
AU2018336171B2 (en) * 2017-09-22 2023-01-05 Jubilant Epipad LLC Heterocyclic compounds as PAD inhibitors
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
EP3914284A4 (en) * 2019-01-25 2022-10-26 Numedii, Inc. METHOD FOR THE TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS
CN114072410B (zh) * 2019-08-01 2023-08-01 正大天晴药业集团股份有限公司 作为parp抑制剂吲哚并七元酰肟化合物
WO2021104461A1 (zh) 2019-11-29 2021-06-03 南京明德新药研发有限公司 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用
WO2022011458A1 (en) * 2020-07-13 2022-01-20 Ontario Institute For Cancer Research (Oicr) Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
TW202214649A (zh) * 2020-07-31 2022-04-16 大陸商正大天晴藥業集團股份有限公司 用作ｐａｒｐ抑制劑的吲哚并七員醯肟類似物的結晶及其製備方法

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GB9722320D0 (en) 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
US6383744B1 (en) 1998-07-10 2002-05-07 Incyte Genomics, Inc. Human checkpoint kinase
EP1135135A4 (en) 1998-09-18 2006-08-09 Smithkline Beecham Corp CHK1 KINASE INHIBITORS
AU781711B2 (en) * 1999-01-11 2005-06-09 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(ADP-ribose) polymerases
JP4652648B2 (ja) 1999-08-27 2011-03-16 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド キメラアンチセンスオリゴヌクレオチド、およびその細胞トランスフェクション処方物
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
DK1218494T3 (da) 1999-09-22 2005-08-08 Canbas Co Ltd Præparater og fremgangsmåder til inhibering af C2-cellecyklusstandsning og sensibilisering af celler til DNA-beskadigende midler
US6211164B1 (en) 2000-03-10 2001-04-03 Abbott Laboratories Antisense oligonucleotides of the human chk1 gene and uses thereof
DE60142921D1 (de) 2000-12-01 2010-10-07 Eisai Inc Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2004203977B2 (en) * 2003-01-09 2010-06-17 Pfizer Inc. Diazepinoindole derivatives as kinase inhibitors

Also Published As

Publication number Publication date
NO20053775D0 (no) 2005-08-08
CR7899A (es) 2005-08-05
DK1585749T3 (da) 2008-09-22
NO20053775L (no) 2005-09-16
CN1759118A (zh) 2006-04-12
SI1585749T1 (sl) 2008-10-31
DE602004015724D1 (de) 2008-09-25
KR20050092397A (ko) 2005-09-21
CA2512683A1 (en) 2004-07-29
NZ540638A (en) 2007-12-21
EA009337B1 (ru) 2007-12-28
AP2005003353A0 (en) 2005-09-30
BRPI0406701A (pt) 2005-12-20
RS20050522A (en) 2007-12-31
PT1585749E (pt) 2008-10-23
PL378372A1 (pl) 2006-04-03
EP1585749A1 (en) 2005-10-19
MA27703A1 (fr) 2006-01-02
CY1108408T1 (el) 2014-02-12
UA80733C2 (en) 2007-10-25
AP2048A (en) 2009-09-24
US20050075499A1 (en) 2005-04-07
AU2004203977B2 (en) 2010-06-17
EA200500893A1 (ru) 2006-02-24
US7132533B2 (en) 2006-11-07
US20070135415A1 (en) 2007-06-14
JP2006516274A (ja) 2006-06-29
CA2512683C (en) 2010-03-16
US20060004052A1 (en) 2006-01-05
GEP20084367B (en) 2008-05-13
TNSN05176A1 (fr) 2007-06-11
US7462713B2 (en) 2008-12-09
HRP20050624A2 (en) 2006-02-28
IL169082A (en) 2011-02-28
CN1759118B (zh) 2010-12-08
WO2004063198A1 (en) 2004-07-29
EP1947102A1 (en) 2008-07-23
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13
JP3990718B2 (ja) 2007-10-17
US6967198B2 (en) 2005-11-22
OA13017A (en) 2006-11-10
ATE404564T1 (de) 2008-08-15
KR100697746B1 (ko) 2007-03-22
ZA200504674B (en) 2006-07-26
MXPA05007352A (es) 2006-02-17
ECSP055911A (es) 2005-11-22
ES2309484T3 (es) 2008-12-16
HK1086257A1 (en) 2006-09-15

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