PL378372A1 - Tricykliczne związki jako inhibitory kinaz białkowych do wzmacniania skuteczności środków przeciwnowotworowych i radioterapii - Google Patents

Tricykliczne związki jako inhibitory kinaz białkowych do wzmacniania skuteczności środków przeciwnowotworowych i radioterapii

Info

Publication number
PL378372A1
PL378372A1 PL378372A PL37837204A PL378372A1 PL 378372 A1 PL378372 A1 PL 378372A1 PL 378372 A PL378372 A PL 378372A PL 37837204 A PL37837204 A PL 37837204A PL 378372 A1 PL378372 A1 PL 378372A1
Authority
PL
Poland
Prior art keywords
efectivenes
terapeutic
radiation
increasing
protein kinase
Prior art date
Application number
PL378372A
Other languages
English (en)
Inventor
Sacha Ninkovic
Michael John Bennett
Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of PL378372A1 publication Critical patent/PL378372A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
PL378372A 2003-01-09 2004-01-05 Tricykliczne związki jako inhibitory kinaz białkowych do wzmacniania skuteczności środków przeciwnowotworowych i radioterapii PL378372A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
PL378372A1 true PL378372A1 (pl) 2006-04-03

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
PL378372A PL378372A1 (pl) 2003-01-09 2004-01-05 Tricykliczne związki jako inhibitory kinaz białkowych do wzmacniania skuteczności środków przeciwnowotworowych i radioterapii

Country Status (35)

Country Link
US (3) US6967198B2 (pl)
EP (2) EP1585749B1 (pl)
JP (1) JP3990718B2 (pl)
KR (1) KR100697746B1 (pl)
CN (1) CN1759118B (pl)
AP (1) AP2048A (pl)
AT (1) ATE404564T1 (pl)
AU (1) AU2004203977B2 (pl)
BR (1) BRPI0406701A (pl)
CA (1) CA2512683C (pl)
CR (1) CR7899A (pl)
CY (1) CY1108408T1 (pl)
DE (1) DE602004015724D1 (pl)
DK (1) DK1585749T3 (pl)
EA (1) EA009337B1 (pl)
EC (1) ECSP055911A (pl)
ES (1) ES2309484T3 (pl)
GE (1) GEP20084367B (pl)
HK (1) HK1086257A1 (pl)
HR (1) HRP20050624A2 (pl)
IL (1) IL169082A (pl)
IS (1) IS7884A (pl)
MA (1) MA27703A1 (pl)
MX (1) MXPA05007352A (pl)
NO (1) NO20053775L (pl)
NZ (1) NZ540638A (pl)
OA (1) OA13017A (pl)
PL (1) PL378372A1 (pl)
PT (1) PT1585749E (pl)
RS (1) RS20050522A (pl)
SI (1) SI1585749T1 (pl)
TN (1) TNSN05176A1 (pl)
UA (1) UA80733C2 (pl)
WO (1) WO2004063198A1 (pl)
ZA (1) ZA200504674B (pl)

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ATE404564T1 (de) * 2003-01-09 2008-08-15 Pfizer Diazepinoindolderivate als kinaseinhibitoren
BRPI0607798A2 (pt) * 2005-02-18 2010-06-22 Astrazeneca Ab método para prognosticar uma responsividade do paciente a um inibidor de chk1, uso de um inibidor de chk1, e, kit para prognosticar uma resposta do paciente a um inibidor de chk1
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JP5576370B2 (ja) * 2008-08-06 2014-08-20 ファイザー・インク Ｃｈｋ−１阻害剤としての６置換２−ヘテロシクリルアミノピラジン化合物
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US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
EP2793882A4 (en) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA ACTIVATED DRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
MX2014008071A (es) 2011-12-31 2015-07-06 Beigene Ltd Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
NO2797921T3 (pl) * 2011-12-31 2018-02-03
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
WO2015069489A1 (en) 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
PT3157566T (pt) 2014-06-17 2019-07-11 Vertex Pharma Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr
MX2018002322A (es) 2015-08-25 2018-04-11 Beigene Ltd Procedimiento para la preparacion de un inhibidor de poli(adp-ribosa)polimerasa, formas cristalinas, y usos del mismo.
CA3000684A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
WO2018059437A1 (en) 2016-09-27 2018-04-05 Beigene, Ltd. Treatment cancers using combination comprising parp inhibitors
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
WO2018157794A1 (en) 2017-02-28 2018-09-07 Beigene, Ltd. Crystalline forms of salts of fused tera or penta-cyclic dihydrodiazepinocarazolones, and uses thereof
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
NZ762985A (en) * 2017-09-22 2024-03-22 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN113631179A (zh) * 2019-01-25 2021-11-09 努梅迪公司 用于治疗特发性肺纤维化的方法
WO2021018298A1 (zh) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 作为parp抑制剂吲哚并七元酰肟化合物
CN114746413B (zh) 2019-11-29 2024-02-23 南京明德新药研发有限公司 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用
CA3184988A1 (en) * 2020-07-13 2022-01-20 Ahmed Mamai Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
US20230331739A1 (en) * 2020-07-31 2023-10-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Indolo heptamyl oxime analog crystal as parp inhibitor and method for preparing same

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ATE404564T1 (de) * 2003-01-09 2008-08-15 Pfizer Diazepinoindolderivate als kinaseinhibitoren

Also Published As

Publication number Publication date
US20050075499A1 (en) 2005-04-07
JP2006516274A (ja) 2006-06-29
NO20053775D0 (no) 2005-08-08
US7132533B2 (en) 2006-11-07
DE602004015724D1 (de) 2008-09-25
IS7884A (is) 2005-06-09
ZA200504674B (en) 2006-07-26
EA200500893A1 (ru) 2006-02-24
AP2005003353A0 (en) 2005-09-30
US20070135415A1 (en) 2007-06-14
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13
HRP20050624A2 (en) 2006-02-28
MA27703A1 (fr) 2006-01-02
IL169082A (en) 2011-02-28
CN1759118A (zh) 2006-04-12
ECSP055911A (es) 2005-11-22
DK1585749T3 (da) 2008-09-22
NO20053775L (no) 2005-09-16
WO2004063198A1 (en) 2004-07-29
EA009337B1 (ru) 2007-12-28
NZ540638A (en) 2007-12-21
CR7899A (es) 2005-08-05
UA80733C2 (en) 2007-10-25
EP1585749A1 (en) 2005-10-19
MXPA05007352A (es) 2006-02-17
KR20050092397A (ko) 2005-09-21
CA2512683C (en) 2010-03-16
CA2512683A1 (en) 2004-07-29
KR100697746B1 (ko) 2007-03-22
CN1759118B (zh) 2010-12-08
BRPI0406701A (pt) 2005-12-20
TNSN05176A1 (fr) 2007-06-11
OA13017A (en) 2006-11-10
ATE404564T1 (de) 2008-08-15
US7462713B2 (en) 2008-12-09
AU2004203977B2 (en) 2010-06-17
ES2309484T3 (es) 2008-12-16
AP2048A (en) 2009-09-24
GEP20084367B (en) 2008-05-13
US6967198B2 (en) 2005-11-22
CY1108408T1 (el) 2014-02-12
PT1585749E (pt) 2008-10-23
HK1086257A1 (en) 2006-09-15
RS20050522A (en) 2007-12-31
EP1947102A1 (en) 2008-07-23
SI1585749T1 (sl) 2008-10-31
JP3990718B2 (ja) 2007-10-17
US20060004052A1 (en) 2006-01-05

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