NO20053775L - Diazepinoindol derivater som kinaseinhibitorer. - Google Patents
Diazepinoindol derivater som kinaseinhibitorer.Info
- Publication number
- NO20053775L NO20053775L NO20053775A NO20053775A NO20053775L NO 20053775 L NO20053775 L NO 20053775L NO 20053775 A NO20053775 A NO 20053775A NO 20053775 A NO20053775 A NO 20053775A NO 20053775 L NO20053775 L NO 20053775L
- Authority
- NO
- Norway
- Prior art keywords
- kinase inhibitors
- diazepinoindole
- derivatives
- compounds
- diazepinoindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43939603P | 2003-01-09 | 2003-01-09 | |
| PCT/IB2004/000026 WO2004063198A1 (en) | 2003-01-09 | 2004-01-05 | Diazepinoindole derivatives as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053775D0 NO20053775D0 (no) | 2005-08-08 |
| NO20053775L true NO20053775L (no) | 2005-09-16 |
Family
ID=32713475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053775A NO20053775L (no) | 2003-01-09 | 2005-08-08 | Diazepinoindol derivater som kinaseinhibitorer. |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6967198B2 (pl) |
| EP (2) | EP1947102A1 (pl) |
| JP (1) | JP3990718B2 (pl) |
| KR (1) | KR100697746B1 (pl) |
| CN (1) | CN1759118B (pl) |
| AP (1) | AP2048A (pl) |
| AT (1) | ATE404564T1 (pl) |
| AU (1) | AU2004203977B2 (pl) |
| BR (1) | BRPI0406701A (pl) |
| CA (1) | CA2512683C (pl) |
| CR (1) | CR7899A (pl) |
| CY (1) | CY1108408T1 (pl) |
| DE (1) | DE602004015724D1 (pl) |
| DK (1) | DK1585749T3 (pl) |
| EA (1) | EA009337B1 (pl) |
| EC (1) | ECSP055911A (pl) |
| ES (1) | ES2309484T3 (pl) |
| GE (1) | GEP20084367B (pl) |
| HK (1) | HK1086257A1 (pl) |
| HR (1) | HRP20050624A2 (pl) |
| IL (1) | IL169082A (pl) |
| IS (1) | IS7884A (pl) |
| MA (1) | MA27703A1 (pl) |
| MX (1) | MXPA05007352A (pl) |
| NO (1) | NO20053775L (pl) |
| NZ (1) | NZ540638A (pl) |
| OA (1) | OA13017A (pl) |
| PL (1) | PL378372A1 (pl) |
| PT (1) | PT1585749E (pl) |
| RS (1) | RS20050522A (pl) |
| SI (1) | SI1585749T1 (pl) |
| TN (1) | TNSN05176A1 (pl) |
| UA (1) | UA80733C2 (pl) |
| WO (1) | WO2004063198A1 (pl) |
| ZA (1) | ZA200504674B (pl) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1467730A4 (en) * | 2002-01-22 | 2010-03-10 | Univ California | Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof |
| AU2004203977B2 (en) * | 2003-01-09 | 2010-06-17 | Pfizer Inc. | Diazepinoindole derivatives as kinase inhibitors |
| WO2006087557A1 (en) * | 2005-02-18 | 2006-08-24 | Astrazeneca Ab | METHOD FOR DETERMINING RESPONSIVENESS TO CHKl INHIBITORS |
| MX2007012116A (es) | 2005-03-29 | 2008-04-08 | Icos Corp | Derivados de heteroaril urea utiles para inhibir chk1. |
| GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| AU2006263433B8 (en) | 2005-06-29 | 2011-06-09 | Immunogenesis, Inc. | Phosphoramidate alkylator prodrugs |
| CA2619048A1 (en) | 2005-08-15 | 2007-02-22 | The Regents Of The University Of California | Vegf-activated fas ligands |
| JP4935675B2 (ja) | 2005-08-25 | 2012-05-23 | 宇部興産株式会社 | 光学活性（Ｓ又はＲ）−α−アミノ酸及び光学活性（Ｒ又はＳ）−α−アミノ酸エステルの製造方法 |
| CA2620275A1 (en) * | 2005-08-26 | 2007-03-01 | Thomas S. Scanlan | Non-steroidal antiandrogens |
| EP2004655A1 (en) * | 2006-04-04 | 2008-12-24 | Pfizer Products Incorporated | Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4 l)-1-oxo-2,6-dihydro-1h-ý1,2¨diazepinoý4,5,6-cd¨indol-8-yl)acetamide |
| KR20080100838A (ko) * | 2006-04-04 | 2008-11-19 | 화이자 프로덕츠 인코포레이티드 | (2ｒ,ｚ)-2-아미노-2-사이클로헥실-ｎ-(5-(1-메틸-1ｈ-피라졸-4-일)-1-옥소-2,6-다이하이드로-1ｈ-[1,2]다이아제피노[4,5,6-ｃｄ]인돌-8-일)아세트아미드의 복합 요법 |
| WO2008063558A2 (en) * | 2006-11-17 | 2008-05-29 | Schering Corporation | Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders |
| US8158656B2 (en) * | 2008-05-16 | 2012-04-17 | Shenzhen Chipscreen Biosciences Ltd. | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
| CA2731368C (en) * | 2008-08-06 | 2013-05-14 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
| EP2346881A1 (en) * | 2008-10-10 | 2011-07-27 | Priaxon AG | Novel compounds which modulate kinase activity |
| US8314108B2 (en) | 2008-12-17 | 2012-11-20 | Eli Lilly And Company | 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
| CN101906076B (zh) | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
| CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| WO2013096687A1 (en) * | 2011-12-22 | 2013-06-27 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer |
| EP2797919B1 (en) | 2011-12-31 | 2017-03-29 | BeiGene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
| EA027533B1 (ru) | 2011-12-31 | 2017-08-31 | Бейджен, Лтд. | Конденсированные тетра- или пентациклические дигидродиазепинокарбазолоны в качестве ингибиторов parps |
| CN102746211B (zh) * | 2012-06-27 | 2015-05-27 | 上海泰坦化学有限公司 | 一种取代吲哚-3-甲醛类化合物的制备方法 |
| TWI633107B (zh) * | 2013-05-22 | 2018-08-21 | 開曼群島商百濟神州生物科技有限公司 | 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮 |
| KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| DK3157566T3 (da) | 2014-06-17 | 2019-07-22 | Vertex Pharma | Fremgangsmåde til behandling af cancer under anvendelse af en kombination chk1- og atr-inhibitorer |
| IL257442B2 (en) | 2015-08-25 | 2023-03-01 | Beigene Ltd | Process for preparing parp inhibitor, crystalline forms and their uses |
| RU2768621C1 (ru) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr |
| WO2018059437A1 (en) | 2016-09-27 | 2018-04-05 | Beigene, Ltd. | Treatment cancers using combination comprising parp inhibitors |
| JP6541635B2 (ja) * | 2016-10-28 | 2019-07-10 | ベイジーン リミテッド | Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン |
| CN110392687B (zh) | 2017-02-28 | 2022-08-02 | 百济神州(苏州)生物科技有限公司 | 稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式及其用途 |
| US11661581B2 (en) * | 2017-05-25 | 2023-05-30 | University Of Massachusetts | Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells |
| KR20200094734A (ko) * | 2017-09-22 | 2020-08-07 | 주빌런트 에피파드 엘엘씨 | Pad 억제제로서의 헤테로사이클릭 화합물 |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| CN113631179A (zh) * | 2019-01-25 | 2021-11-09 | 努梅迪公司 | 用于治疗特发性肺纤维化的方法 |
| CN114072410B (zh) * | 2019-08-01 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
| EP4067351A4 (en) | 2019-11-29 | 2023-11-22 | Medshine Discovery Inc. | DIAZAINDOLE DERIVATIVE AND ITS USE AS CHK1 INHIBITOR |
| US20230330244A1 (en) * | 2020-07-13 | 2023-10-19 | Ontario Institute For Cancer Research (Oicr) | Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof |
| CN115698019A (zh) * | 2020-07-31 | 2023-02-03 | 正大天晴药业集团股份有限公司 | 用作parp抑制剂的吲哚并七元酰肟类似物的结晶及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9722320D0 (en) | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
| US6383744B1 (en) | 1998-07-10 | 2002-05-07 | Incyte Genomics, Inc. | Human checkpoint kinase |
| WO2000016781A1 (en) | 1998-09-18 | 2000-03-30 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| PL210415B1 (pl) * | 1999-01-11 | 2012-01-31 | Agouron Pharma | Pochodne indolu, środek farmaceutyczny i zastosowanie pochodnych indolu |
| DE60038220T2 (de) | 1999-08-27 | 2009-03-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Chimerische antisense-oligonukleotide und zelltransfektions-zusammensetzungen davon |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
| EP1218494B1 (en) | 1999-09-22 | 2005-04-06 | Canbas Co., Ltd. | Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents |
| US6211164B1 (en) | 2000-03-10 | 2001-04-03 | Abbott Laboratories | Antisense oligonucleotides of the human chk1 gene and uses thereof |
| CA2430363C (en) | 2000-12-01 | 2010-04-13 | Guilford Pharmaceuticals Inc. | Compounds and their uses |
| UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| AU2004203977B2 (en) * | 2003-01-09 | 2010-06-17 | Pfizer Inc. | Diazepinoindole derivatives as kinase inhibitors |
-
2004
- 2004-01-05 AU AU2004203977A patent/AU2004203977B2/en not_active Ceased
- 2004-01-05 WO PCT/IB2004/000026 patent/WO2004063198A1/en active IP Right Grant
- 2004-01-05 PT PT04700145T patent/PT1585749E/pt unknown
- 2004-01-05 SI SI200430830T patent/SI1585749T1/sl unknown
- 2004-01-05 KR KR1020057012806A patent/KR100697746B1/ko not_active IP Right Cessation
- 2004-01-05 AP AP2005003353A patent/AP2048A/xx active
- 2004-01-05 PL PL378372A patent/PL378372A1/pl not_active Application Discontinuation
- 2004-01-05 EP EP08155745A patent/EP1947102A1/en not_active Withdrawn
- 2004-01-05 AT AT04700145T patent/ATE404564T1/de not_active IP Right Cessation
- 2004-01-05 ES ES04700145T patent/ES2309484T3/es not_active Expired - Lifetime
- 2004-01-05 OA OA1200500197A patent/OA13017A/en unknown
- 2004-01-05 DE DE602004015724T patent/DE602004015724D1/de not_active Expired - Lifetime
- 2004-01-05 MX MXPA05007352A patent/MXPA05007352A/es active IP Right Grant
- 2004-01-05 EP EP04700145A patent/EP1585749B1/en not_active Expired - Lifetime
- 2004-01-05 GE GEAP20048886A patent/GEP20084367B/en unknown
- 2004-01-05 RS YUP-2005/0522A patent/RS20050522A/sr unknown
- 2004-01-05 BR BR0406701-0A patent/BRPI0406701A/pt not_active IP Right Cessation
- 2004-01-05 DK DK04700145T patent/DK1585749T3/da active
- 2004-01-05 CA CA2512683A patent/CA2512683C/en not_active Expired - Fee Related
- 2004-01-05 EA EA200500893A patent/EA009337B1/ru not_active IP Right Cessation
- 2004-01-05 JP JP2006500278A patent/JP3990718B2/ja not_active Expired - Fee Related
- 2004-01-05 NZ NZ540638A patent/NZ540638A/en unknown
- 2004-01-05 CN CN2004800063838A patent/CN1759118B/zh not_active Expired - Fee Related
- 2004-01-09 US US10/754,171 patent/US6967198B2/en not_active Expired - Fee Related
- 2004-05-01 UA UAA200506730A patent/UA80733C2/uk unknown
-
2005
- 2005-06-08 ZA ZA200504674A patent/ZA200504674B/en unknown
- 2005-06-08 IL IL169082A patent/IL169082A/en not_active IP Right Cessation
- 2005-06-09 IS IS7884A patent/IS7884A/is unknown
- 2005-07-07 HR HR20050624A patent/HRP20050624A2/hr not_active Application Discontinuation
- 2005-07-08 TN TNP2005000176A patent/TNSN05176A1/fr unknown
- 2005-07-08 MA MA28375A patent/MA27703A1/fr unknown
- 2005-07-08 CR CR7899A patent/CR7899A/es unknown
- 2005-07-08 EC EC2005005911A patent/ECSP055911A/es unknown
- 2005-07-22 US US11/187,089 patent/US7132533B2/en not_active Expired - Fee Related
- 2005-08-08 NO NO20053775A patent/NO20053775L/no unknown
-
2006
- 2006-05-26 HK HK06106153.4A patent/HK1086257A1/xx not_active IP Right Cessation
- 2006-06-23 US US11/426,132 patent/US7462713B2/en not_active Expired - Fee Related
-
2008
- 2008-10-13 CY CY20081101127T patent/CY1108408T1/el unknown
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