AR059778A1 - Compuestos de pirrolotriazina inhibidores de quinasas p38,composiciones farmaceuticas que los contienen y usos en gran variedad de procesos inflamatorios. - Google Patents

Compuestos de pirrolotriazina inhibidores de quinasas p38,composiciones farmaceuticas que los contienen y usos en gran variedad de procesos inflamatorios.

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Publication number
AR059778A1
AR059778A1 ARP070100944A ARP070100944A AR059778A1 AR 059778 A1 AR059778 A1 AR 059778A1 AR P070100944 A ARP070100944 A AR P070100944A AR P070100944 A ARP070100944 A AR P070100944A AR 059778 A1 AR059778 A1 AR 059778A1
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Argentina
Prior art keywords
optionally substituted
independently selected
alkyl
cycloalkyl
hydrogen
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ARP070100944A
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English (en)
Inventor
Vivekananda Y Vrudhula
James Lin
Chunjian Liu
Katerina Leftheris
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Bristol Myers Squibb Co
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Publication of AR059778A1 publication Critical patent/AR059778A1/es

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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract

Reivindicacion 1: Compuesto de la formula (1) o sales del mismo farmacéuticamente aceptables, caracterizado porque al menos un de X1, X2 o X3 escomo se muestra en formula (2) y cualquier X1, X2 o X3 restante es hidrogeno; A1 y A2 son cada uno independientemente seleccionados de alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heterociclo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R1, R3 y R5 son cada uno independientemente seleccionados de hidrogeno, alquilo opcionalmente sustituido, -OR14. -C(=O)NR14R14a, -NR14R14a, SO2NR14R14a, -NR14SO2NR14aR14b, -NR14aSO2R14, -NR14C(=O)R14a, -NR14CO2R14a, -NR14C(O)NR14aR14b, halogeno, ciano, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R2 es independientemente seleccionado de hidrogeno y alquilo opcionalmente sustituido; R4 es independientemente seleccionado del grupo de formulas (3), R6 se une a cualquier átomo de carbono disponible del anillo fenilo y en cada caso es independientemente seleccionado de alquilo opcionalmente sustituido, halogeno, trifluorometoxi, trifluorometilo, hidroxi, alcoxi, alcanoilo, alcanoiloxi, tiol, alquiltio, ureido, nitro, ciano, carboxi, carboxialquilo, carbamilo, alcoxicarbonilo, alquiltiono, ariltiono, arilsulfonilamina, alquilsulfonilamina, ácido sulfonico, alquilsulfonilo, sulfonamido, fenilo, bencilo, ariloxi y benciloxi, en donde cada grupo R6 a su vez puede ser adicionalmente sustituido por uno o dos R18; R14, R14a y R14b se seleccionan independientemente de hidrogeno, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, y heteroarilo opcionalmente sustituido, excepto cuando R14 se une a un grupo sulfonilo, como en -S(=O)R14, -SO2R14, y - NR14aSO2R14, entonces R14 no es hidrogeno; R18 se selecciona independientemente de alquilo de C1-6, alquenilo C2-6, halogeno, haloalquilo, haloalcoxi, ciano, nitro, amino, alquilamino C1-4, aminoalquilo C1-4, hidroxi, hidroxialquilo C1-4, alcoxi, alquiltio C1-4, arilo, heterociclo, (aril)alquilo, ariloxi, y (aril)alcoxi; R27 y R28 se seleccionan independientemente de hidrogeno, alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heterociclo opcionalmente sustituido y heteroarilo opcionalmente sustituido; uno de D, E, G, J o L es =N- y cada D, E, G, J o L, restante es =C-; m es 0, 1, 2 o 3; n es 0 o 1;y k es 0, 1 o 2.
ARP070100944A 2006-03-07 2007-03-07 Compuestos de pirrolotriazina inhibidores de quinasas p38,composiciones farmaceuticas que los contienen y usos en gran variedad de procesos inflamatorios. AR059778A1 (es)

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US (2) US7572795B2 (es)
EP (1) EP2001886A2 (es)
JP (1) JP2009535295A (es)
KR (1) KR20080107408A (es)
CN (1) CN101395158A (es)
AR (1) AR059778A1 (es)
AU (1) AU2007223342A1 (es)
BR (1) BRPI0708644A2 (es)
CA (1) CA2645031A1 (es)
EA (1) EA200801945A1 (es)
IL (1) IL193653A0 (es)
MX (1) MX2008011136A (es)
NO (1) NO20083717L (es)
PE (1) PE20080139A1 (es)
TW (1) TW200804390A (es)
WO (1) WO2007103839A2 (es)
ZA (1) ZA200807459B (es)

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