AR039648A1 - Compuestos de aril cetona pirrolo triazina utiles como inhibidores de cinasa y las composiciones farmaceuticas que las contienen - Google Patents

Compuestos de aril cetona pirrolo triazina utiles como inhibidores de cinasa y las composiciones farmaceuticas que las contienen

Info

Publication number
AR039648A1
AR039648A1 ARP030101400A ARP030101400A AR039648A1 AR 039648 A1 AR039648 A1 AR 039648A1 AR P030101400 A ARP030101400 A AR P030101400A AR P030101400 A ARP030101400 A AR P030101400A AR 039648 A1 AR039648 A1 AR 039648A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently selected
cyano
halogen
substituted
Prior art date
Application number
ARP030101400A
Other languages
English (en)
Inventor
Alaric Dyckman
Katerina Leftheris
John Hynes
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR039648A1 publication Critical patent/AR039648A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Derivados de aril pirrolo triazina, caracterizados porque tienen la fórmula (1) o una sal farmacéuticamente aceptable, profármaco o solvato del mismo en donde; X1, X2 y X3 son independientemente seleccionados de N y CH, en donde cuando X1, X2 y/o X3 es CH, el átomo de H de X1, X2 y/o X3 es opcionalmente reemplazado con un sustituyente R5 o un enlace unido al anillo W a C*; R1 y R4 son independientemente seleccionados de H, alquilo, alquilo sustituido, -OR8, -SR8, -OC(=O)R8, -CO2R8, -C(=O)NR8R9, -NR8R9, -S(=O)R8, -SO2R8, -SO2NR8R9, -NR10SO2NR8R9, -NR10SO2R8,-NR8C(=O)R9, -NR8CO2R9, -NR10C(=O)NR8R9, halógeno, nitro y ciano; R2 es H o alquilo C1-4; R3 es H, metilo, perfluorometilo, metoxi, halógeno, ciano, NH2,o NH(CH3); el R5 está unido a cualquier átomo de C disponible del anillo W arilo o heteroarilo y cada que se presenta es independientemente seleccionado de alquilo, halógeno, trifluorometoxi, trifluorometilo, hidroxi, alcoxi, alcanoilo, alcanoiloxi, amino, alquilamino, aralquilamino, dialquilamino, alcanoilamino, tiol, alquiltio, ureido, nitro, ciano, carboxi, carboxialquilo, carbamilo, alcoxicarbonilo, alquiltiono, ariltiono, arilsulfonilamina, alquilsulfonilamina, ácido sulfónico, alquilsulfonilo, sulfonamido, fenilo, bencilo, ariloxi, y benciloxi, y/o dos de los grupos R5 pueden ser tomados juntos para formar un anillo carbocíclico, heterocíclico o heteroarilo fusionado de 5 o 6 miembros, en donde cada grupo R5 y/o cada anillo fusionado formado por dos grupos R5 a su vez opcionalmente pueden ser sustituidos hasta con dos R11; El R6 está unido a cualquier átomo de C disponible del anillo fenilo A y cada que se presenta es independientemente seleccionado de alquilo, halógeno, trifluorometoxi, trifluorometilo, hidroxi, alcoxi, alcanoilo, alcanoiloxi, amino, alquilamino, aralquilamino, dialquilamino, alcanoilamino, tiol, alquiltio, ureido, nitro, ciano, carboxi, carboxialquilo, carbamilo, alcoxicarbonilo, alquiltiono, ariltiono, arilsulfonilamina, alquilsulfonilamino, ácido sulfónico, alquilsulfonilo, sulfonamido, fenilo, bencilo, ariloxi, y benciloxi, en donde cada grupo R6 a su vez opcionalmente pueden ser sustituidos hasta por dos R12; R8, R9, y R10 son seleccionados independientemente de H, alquilo, alquilo sustituido, arilo, heteroarilo, cicloalquilo y heterociclo, R11 y R12 son seleccionados independientemente de H, alquilo, alquilo sustituido, alcoxi, arilo, aralquilo, y arilo sustituido con 0 a 3 de alquilo C1-4, alquenilo C2-6, halógeno, trifluorometilo, trifluorometoxi, ciano, nitro, amino, alquilamino C1-4, aminoalquilo C1-4, hidroxi, hidroxialquilo C1-4, alcoxi y C1-4alquiltio; y m y n son 0, 1, 2 o 3:
ARP030101400A 2002-04-23 2003-04-23 Compuestos de aril cetona pirrolo triazina utiles como inhibidores de cinasa y las composiciones farmaceuticas que las contienen AR039648A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37490702P 2002-04-23 2002-04-23

Publications (1)

Publication Number Publication Date
AR039648A1 true AR039648A1 (es) 2005-03-02

Family

ID=29270567

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101400A AR039648A1 (es) 2002-04-23 2003-04-23 Compuestos de aril cetona pirrolo triazina utiles como inhibidores de cinasa y las composiciones farmaceuticas que las contienen

Country Status (14)

Country Link
US (1) US7314876B2 (es)
EP (1) EP1503996B1 (es)
JP (1) JP2005529890A (es)
AR (1) AR039648A1 (es)
AT (1) ATE418546T1 (es)
AU (1) AU2003221753A1 (es)
DE (1) DE60325469D1 (es)
ES (1) ES2318122T3 (es)
IS (1) IS7504A (es)
NO (1) NO20044592L (es)
PE (1) PE20040411A1 (es)
PL (1) PL373371A1 (es)
TW (1) TW200306841A (es)
WO (1) WO2003091229A1 (es)

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Also Published As

Publication number Publication date
IS7504A (is) 2004-10-14
DE60325469D1 (de) 2009-02-05
EP1503996A1 (en) 2005-02-09
PL373371A1 (en) 2005-08-22
WO2003091229A1 (en) 2003-11-06
JP2005529890A (ja) 2005-10-06
US20030232831A1 (en) 2003-12-18
NO20044592L (no) 2004-11-19
ATE418546T1 (de) 2009-01-15
AU2003221753A1 (en) 2003-11-10
ES2318122T3 (es) 2009-05-01
EP1503996B1 (en) 2008-12-24
EP1503996A4 (en) 2006-05-17
TW200306841A (en) 2003-12-01
US7314876B2 (en) 2008-01-01
PE20040411A1 (es) 2004-07-14

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