AR046046A1 - Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas. - Google Patents

Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.

Info

Publication number
AR046046A1
AR046046A1 ARP040103584A ARP040103584A AR046046A1 AR 046046 A1 AR046046 A1 AR 046046A1 AR P040103584 A ARP040103584 A AR P040103584A AR P040103584 A ARP040103584 A AR P040103584A AR 046046 A1 AR046046 A1 AR 046046A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
het
substituted
dialkylamino
Prior art date
Application number
ARP040103584A
Other languages
English (en)
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of AR046046A1 publication Critical patent/AR046046A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Métodos de uso de estos compuestos como inmunomoduladores, para inducir o inhibir la biosíntesis de citocinas en animales y en el tratamiento de enfermedades, incluyendo virales y neoplásticas. Composiciones farmacéuticas. Reivindicación 1: Un compuesto de fórmula (1), donde: R3 se selecciona del grupo formado por: -Z-Y-R4; -Z-Y-X-Y-R4; -Z-R5; -Z-Het; -Z-Het'-R4; y -Z-Het'-Y-R4; Z se selecciona del grupo formado por alquileno, alquenileno, y alquinileno, donde alquileno, alquenileno, y alquinileno pueden estar interrumpidos en forma opcional con uno o más grupos -O-; Y se selecciona del grupo formado por: -S(O)-0-2-; -S(O)2-N(R8)-; -C(R6)-; -C(R6)-O-; -O-C(R6)-; -O-C(O)-O-; -N(R8)-Q-; -C(R6)-N(R8)-; -O-C(R6)-N(R8)-; -C(R10)-N(OR9)- ; o un grupo de fórmulas (2) a (6); X se selecciona del grupo formado por alquileno, alquenileno, alquinileno, arileno, heteroarileno, y heterociclileno donde los grupos alquileno, alquenilo, y alquinileno pueden estar, en forma opcional, interrumpidos o terminados con arileno, heteroarileno, o heterociclileno, e interrumpidos, en forma opcional, por uno o más grupos -O-; R4 se selecciona del grupo formado por hidrógeno, alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo donde los grupos alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo pueden no estar sustituidos o estar sustituidos con uno o más sustituyentes seleccionados, en forma independiente, del grupo formado por alquilo, alcoxi, hidroxialquilo, haloalquilo, haloalcoxi, halógeno, nitro, hidroxi, mercapto, ciano, arilo, ariloxi, arilalquilenoxi, heteroarilo, heteroariloxi, heteroarilalquilenoxi, heterociclilo, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi, y en el caso del alquilo, alquenilo, alquinilo, y heterociclilo, oxo; R5 se selecciona del grupo formado por las fórmulas (7) a (10); R6 se selecciona del grupo formado por =O y =S; R7 es alquileno C2-7; R8 se selecciona del grupo formado por hidrógeno, alquilo, alcoxialquilenilo, y arilalquilenilo; R9 se selecciona del grupo formado por hidrógeno y alquilo; R10 es alquileno C3-8; A se selecciona del grupo formado por -O-, -C(O)-, -S(O)0-2-, y -N(R4)-; Het es heterociclilo que puede no estar sustituido o estar sustituido con uno o más sustituyentes seleccionados, en forma independiente, del grupo formado por alquilo, alcoxi, haloalquilo, haloalcoxi, halógeno, nitro, hidroxi, hidroxialquilo, mercapto, ciano, ariloxi, arilalquilenoxi, heteroariloxi, heteroarilalquilenoxi, heterociclilo, hidroxialquilenoxialquilenilo, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi, y oxo; Het' es heterociclileno que puede no estar sustituido o estar sustituido con uno o más sustituyentes seleccionados, en forma independiente, del grupo formado por alquilo, alcoxi, haloalquilo, haloalcoxi, halógeno, nitro, hidroxi, hidroxialquilo, mercapto, ciano, ariloxi, arilalquilenoxi, heteroariloxi, heteroarilalquilenoxi, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi, y oxo; Q se selecciona del grupo formado por un enlace, -C(R6)-, -C(R6)-C(R6)-, -S(O)2-, -C(R6)-N(R8)-W, -S(O)2-N(R8)-, -C(R6)-O-, y -C(R6)-N(OR9)-; V se selecciona del grupo formado por -C(R6)-, -O-C(R6)-, -N(R8)-C(R6)-, y -S(O)2-; W se selecciona del grupo formado por un enlace, -C(O)-, y -S(O)2-; a y b son, en forma independiente, números enteros desde 1 hasta 6 con la salvedad de que a + b es =< 7; R se selecciona del grupo formado por alquilo, alcoxi, hidroxi, halógeno, y trifluorometilo; n es 0 ó 1; y R y R se seleccionan en forma independiente del grupo formado por hidrógeno y sustituyentes no interferentes; con la salvedad de que Z puede ser también un enlace cuando: R3 es -Z-Het, -Z-Het'-R4, O -Z-Het'-Y-R4; o R3 es -Z-Y-R4 o -Z-Y-X-Y-R4, e Y se selecciona de -S(O)-0-2-, -S(O)2-N(R8)-, -C(R6)-, -C(R6)-O-, -C(R6)-N(R8)-, o las fórmulas (2) y (6); o R3 es -Z-R5 y R5 es el grupo de fórmula (10); o una de sus sales aceptables desde el punto de vista farmacéutico.
ARP040103584A 2003-10-03 2004-10-01 Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas. AR046046A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50863403P 2003-10-03 2003-10-03

Publications (1)

Publication Number Publication Date
AR046046A1 true AR046046A1 (es) 2005-11-23

Family

ID=34421769

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Application Number Title Priority Date Filing Date
ARP040103584A AR046046A1 (es) 2003-10-03 2004-10-01 Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.

Country Status (17)

Country Link
US (3) US8871782B2 (es)
EP (1) EP1673087B1 (es)
JP (1) JP5043435B2 (es)
KR (1) KR101154101B1 (es)
CN (1) CN1897948A (es)
AR (1) AR046046A1 (es)
AU (1) AU2004278014B2 (es)
BR (1) BRPI0414856A (es)
CA (1) CA2540541C (es)
ES (1) ES2544477T3 (es)
IL (1) IL174654A0 (es)
MX (1) MXPA06003705A (es)
NZ (1) NZ546273A (es)
RU (1) RU2412942C2 (es)
SG (1) SG149828A1 (es)
WO (1) WO2005032484A2 (es)
ZA (1) ZA200603474B (es)

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JP2007507542A (ja) 2007-03-29
WO2005032484A9 (en) 2006-05-18
CN1897948A (zh) 2007-01-17
MXPA06003705A (es) 2006-06-20
KR101154101B1 (ko) 2012-06-11
ES2544477T3 (es) 2015-08-31
WO2005032484A3 (en) 2005-06-30
RU2006110186A (ru) 2007-11-10
US8871782B2 (en) 2014-10-28
AU2004278014B2 (en) 2011-04-28
CA2540541A1 (en) 2005-04-14
KR20060118453A (ko) 2006-11-23
US20160280707A1 (en) 2016-09-29
US20150023990A1 (en) 2015-01-22
EP1673087A4 (en) 2009-04-08
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EP1673087A2 (en) 2006-06-28
AU2004278014A1 (en) 2005-04-14
US20070060754A1 (en) 2007-03-15
JP5043435B2 (ja) 2012-10-10
NZ546273A (en) 2009-05-31
RU2412942C2 (ru) 2011-02-27
EP1673087B1 (en) 2015-05-13
WO2005032484A2 (en) 2005-04-14
ZA200603474B (en) 2008-05-28
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