PT3091012T - Antagonistas do receptor ccr2 e suas utilizações - Google Patents

Antagonistas do receptor ccr2 e suas utilizações

Info

Publication number
PT3091012T
PT3091012T PT161570270T PT16157027T PT3091012T PT 3091012 T PT3091012 T PT 3091012T PT 161570270 T PT161570270 T PT 161570270T PT 16157027 T PT16157027 T PT 16157027T PT 3091012 T PT3091012 T PT 3091012T
Authority
PT
Portugal
Prior art keywords
receptor antagonists
ccr2 receptor
ccr2
antagonists
receptor
Prior art date
Application number
PT161570270T
Other languages
English (en)
Inventor
Hoenke Christoph
Giovannini Riccardo
Ebel Heiner
Frattini Sara
Gerlach Kai
Mazzaferro Rocco
Santagostino Marco
Tautermann Christofer
Trieselmann Thomas
Original Assignee
Centrexion Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrexion Therapeutics Corp filed Critical Centrexion Therapeutics Corp
Publication of PT3091012T publication Critical patent/PT3091012T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
PT161570270T 2009-12-17 2010-12-13 Antagonistas do receptor ccr2 e suas utilizações PT3091012T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09179555 2009-12-17
EP10162621 2010-05-12

Publications (1)

Publication Number Publication Date
PT3091012T true PT3091012T (pt) 2018-06-27

Family

ID=43533115

Family Applications (2)

Application Number Title Priority Date Filing Date
PT161570270T PT3091012T (pt) 2009-12-17 2010-12-13 Antagonistas do receptor ccr2 e suas utilizações
PT107963365T PT2513093E (pt) 2009-12-17 2010-12-13 Novos antagonistas do receptor ccr2 e suas utilizações

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT107963365T PT2513093E (pt) 2009-12-17 2010-12-13 Novos antagonistas do receptor ccr2 e suas utilizações

Country Status (36)

Country Link
US (6) US8765949B2 (pt)
EP (3) EP2513093B1 (pt)
JP (1) JP5632014B2 (pt)
KR (1) KR101530234B1 (pt)
CN (1) CN102933579B (pt)
AP (1) AP3170A (pt)
AR (1) AR079636A1 (pt)
AU (1) AU2010332969B2 (pt)
BR (1) BR112012015873B1 (pt)
CA (1) CA2782464C (pt)
CL (1) CL2012001311A1 (pt)
CO (1) CO6650336A2 (pt)
CY (1) CY1115873T1 (pt)
DK (1) DK2513093T3 (pt)
EA (1) EA024397B1 (pt)
EC (1) ECSP12012010A (pt)
ES (2) ES2524829T3 (pt)
GE (1) GEP20146124B (pt)
HK (1) HK1178147A1 (pt)
HR (1) HRP20141143T1 (pt)
IL (1) IL219421A (pt)
MA (1) MA33818B1 (pt)
ME (1) ME01908B (pt)
MX (2) MX346393B (pt)
MY (1) MY160471A (pt)
NZ (1) NZ599770A (pt)
PE (1) PE20121614A1 (pt)
PL (2) PL2513093T3 (pt)
PT (2) PT3091012T (pt)
RS (1) RS53555B1 (pt)
SG (1) SG181722A1 (pt)
SI (1) SI2513093T1 (pt)
TN (1) TN2012000300A1 (pt)
TW (1) TWI473800B (pt)
UY (1) UY33109A (pt)
WO (1) WO2011073154A1 (pt)

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ES2524829T3 (es) 2009-12-17 2014-12-12 Boehringer Ingelheim International Gmbh Nuevos antagonistas del receptor CCR2 y usos de los mismos
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
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WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
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CN108017599B (zh) * 2016-11-04 2020-03-03 上海爱科百发生物医药技术有限公司 [3-(胺甲基)-氧杂环丁烷-3-基]氨基甲酸对甲氧基苄酯对氯苯甲酸盐合成方法
KR20190088513A (ko) 2016-11-23 2019-07-26 케모센트릭스, 인크. 국소 분절 사구체경화증의 치료 방법
JP7453139B2 (ja) 2017-09-25 2024-03-19 ケモセントリックス，インコーポレイティド ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法
JP2020536919A (ja) 2017-10-11 2020-12-17 ケモセントリックス， インコーポレイテッド Ｃｃｒ２アンタゴニストによる巣状分節性糸球体硬化症の治療
JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス，インコーポレイティド Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法
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