AR079636A1 - Antagonistas del receptor ccr2 y usos de los mismos - Google Patents
Antagonistas del receptor ccr2 y usos de los mismosInfo
- Publication number
- AR079636A1 AR079636A1 ARP100104699A ARP100104699A AR079636A1 AR 079636 A1 AR079636 A1 AR 079636A1 AR P100104699 A ARP100104699 A AR P100104699A AR P100104699 A ARP100104699 A AR P100104699A AR 079636 A1 AR079636 A1 AR 079636A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- heterocyclyl
- optionally substituted
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Antagonistas para el CCR2 (receptor 2 de quimiocina CC) y a su uso para proporcionar medicamentos para tratar afecciones y enfermedades, en especial enfermedades pulmonares tales como asma y EPOC. Reivindicacion 1: Compuestos caracterizados porque tienen la formula (1), en la que R1 es un grupo seleccionado entre -H, -halogeno, -CN, -O-alquilo C1-4, -alquilo C1-4, -CH=CH2, -C:::CH, -CF3, -OCF3, -OCF2H y -OCFH2; en la que R7 es un anillo seleccionado entre -cicloalquilo C3-8, -heterociclilo C3-8, -arilo C5-10 y -heteroarilo C5-10, donde el anillo R7 está opcionalmente sustituido con uno o más grupos seleccionados entre -CF3, -O-CF3, -S-CF3, -CN, -alquilo C1-6, -C(CH3)2-CN y -halogeno, o donde el anillo R7 está opcionalmente sustituido con uno o más grupos seleccionados entre -alquilo C1-6, -O-alquilo C1-6, -arilo C5-10, -heteroarilo C5-10, -cicloalquilo C3-8, -heterociclilo C3-8, -alquenilo C2-6 y -alquinilo C2-6, estando opcionalmente sustituido con uno o más grupos seleccionados entre -OH, -NH2, -alquilo C1-3, -O-alquilo C1-6, -CN, -CF3, -OCF3, halogeno, -metilo y =O, o donde el anillo R7 está adicionalmente opcionalmente sustituido bi-valentemente en dos átomos adyacentes en el anillo, de tal forma que se forma un anillo anelado con uno o más grupos seleccionados entre -alquileno C1-6, -alquenileno C2-6 y -alquinileno C4-6 en la que uno, dos o tres centros de carbono pueden reemplazarse opcionalmente por 1, 2 á 3 heteroátomos seleccionados entre N, O y S, estando el grupo bivalente opcionalmente sustituido con uno o más grupos seleccionados entre - OH, -NH2, -alquilo C1-3, -O-alquilo C1-6, -CN, -CF3, -OCF3, halogeno y =O; donde R2 se selecciona entre -H, -halogeno, -CN, -O-alquilo C2-4, -alquilo C1-4, -CH=CH2, -C:::CH, -CF3, -OCF3, -OCF2H y -OCFH2; en la que R3 se selecciona entre -H, -metilo, -etilo, -propilo, -i-propilo, -ciclopropilo, -OCH3, -CF3 y -CN; en la que n es 1, 2 o 3; en la que G y E se seleccionan independientemente entre C-H o N; en la que Z es C, y R4 y R5 se seleccionan independientemente entre -H, -alquilo C1-6, -NH2, -cicloalquilo C3-8, -heterociclilo C3-8, -arilo C5-10, -heteroarilo C5-10 y -C(O)N(R8,R8'), estando R8 y R8' independientemente seleccionados entre -H y -alquilo C1-6, o en la que Z es N, y R4 representa un par de electrones y R5 se selecciona entre -H, -alquilo C1-6, -NH2, -cicloalquilo C3-8, -heterociclilo C3-8, -arilo C5-10, -heteroarilo C5-10 y -C(O)-N(R8,R8'), estando R8 y R8' seleccionados independientemente entre -H y -alquilo C1-6, y en la que R4 y R5, si son diferentes de un par de electrones o son -H, están opcionalmente sustituidos independientemente con uno o más grupos seleccionados entre -halogeno, -OH, -CF3, -CN, -alquilo C1-6, -O-alquilo C1-6, -O-cicloalquilo C3-8, -O-heterociclilo C3-8, -O-arilo C5-10, -O-heteroarilo C5-10, -alquilen C0-6-CN, -alquilen C0-4-O-alquilo C1-4, -alquilen C0-4-O-cicloalquilo C3-8, -alquilen C0-4-O-heterociclilo C3-8, -alquilen C0-4-O-arilo C5-10, -alquilen C0-4-O-heteroarilo C5-10, -alquilen C0-4-Q-alquil C0-4-N(R9,R9'), -alquilen C0-4-N(R10)-Q-alquilo C1-4, -alquilen C0-4-N(R10)-Q-cicloalquilo C3-8, -alquilen C0-4-N(R10)-Q-heterociclilo C3-8, -alquilen C0-4-N(R10)-Q-arilo C5-10, -alquilen C0-4-N(R10)-Q-heteroarilo C5-10, -alquilen C0-4-Q-N(R11,R11'), -alquilen C0-4-N(R12)-Q-N(R13,R13'), -alquilen C0-4-R14, -alquilen C0-4-(R20, R20'), -alquilen C0-4-Q-alquilo C1-6, -alquilen C0-4-Q-cicloalquilo C3-8, -alquilen C0-4-Q-heterociclilo C3-8, -alquilen C0-4-Q-arilo C5-10, -alquilen C0-4-Q-heteroarilo C5-10, -alquilen C0-4-O-Q-N(R15,R15') y -alquilen C0-4-N(R16)-Q-O-(R17), donde Q se selecciona entre -C(O)- y -SO2-, donde R10, R12, R16, se seleccionan independientemente entre -H, -alquilo C1-6 y -cicloalquilo C3-6, donde R9, R9', R11, R11', R13, R13', R15, R15', se seleccionan independientemente entre -H, -alquilo C1-6 y -cicloalquilo C3-6, o donde R9 y R9', R11 y R11', R13 y R13', R15 y R15' juntos forman un grupo -alquileno C2-6, donde R14 y R17 se seleccionan independientemente entre -H, -alquilo C1-6, -arilo C5-10, -heteroarilo C5-10, -cicloalquilo C3-8 y -heterociclilo C3-8, donde dicho -heterociclilo C3-8 comprende opcionalmente nitrogeno y/o -SO2- en el anillo, y donde R14 y R17 están opcionalmente sustituidos con uno o más grupos seleccionados entre -OH, -OCH3, -CF3, -COOH, -OCF3, -CN, -halogeno, -alquilo C1-4, =O y -SO2-alquilo C1-4, donde R20 y R20' juntos forman un espiro-carbociclo C3-8 o un espiro-heterociclo C3-8 que comprende uno o más grupos seleccionados entre O en el anillo, y donde dicho espirociclo está adicionalmente opcionalmente sustituido bivalentemente por un grupo de formacion de anillos anelados seleccionados entre -alquileno C1-6, -alquenileno C2-6 y -alquinileno C4-6, y donde dicho espirociclo está adicionalmente opcionalmente sustituido con uno o más grupos seleccionados entre -OH, -OCH3, - CF3, -COOH, -OCF3, -CN, -halogeno, o donde Z es C, y R4 representa -H, y R5 es un grupo de la estructura -L1-R18, donde L1 se selecciona entre -NH-, -N(alquil C1-4)- y un enlace, donde R18 se selecciona entre -arilo C5-10, -heteroarilo C5-10, -cicloalquilo C3-8 y -heterociclilo C3-C8, donde R18 está opcionalmente sustituido con uno o más grupos seleccionados entre halogeno, -CF3, -OCF3, -CN, -OH, -O-alquilo C1-4, -alquilo C1-6, -NH-C(O)-alquilo C1-6, -N(alquil C1-4)-C(O)-alquilo C1-6, -C(O)-alquilo C1-6, -S(O)2-alquilo C1-6, -NH-S(O)2-alquilo C1-6, -N(alquil C1-4)-S(O)2-alquilo C1-6 y -C(O)-O-alquilo C1-6, y donde R4, R5 y R18 están adicionalmente opcionalmente sustituidos con espirocicloalquilo C3-8 o espiro-heterociclilo C3-8 de tal forma que junto con R4, R5 y/o R18 se forma un espirociclo, donde dicho espiro-heterociclilo C3-8 comprende opcionalmente uno o más grupos seleccionados entre nitrogeno, -C(O)-, -SO2- y - N(SO2-alquilo C1-4)- en el anillo, o donde R4, R5 y R18 están adicionalmente opcionalmente sustituidos bivalentemente por uno o más grupos de formacion espirociclicos o de anillos anelados seleccionados entre -alquileno C1-6, -alquenileno C2-6 y -alquinileno C4-6, donde uno o dos centros de carbono pueden reemplazarse opcionalmente por uno o dos heteroátomos seleccionados entre N, O y S y que pueden estar opcionalmente sustituidos con uno o más grupos en un átomo del anillo o en dos átomos adyacentes en el anillo seleccionados entre -OH, -NH2, -alquilo C1-3, -O-alquilo C1-6, -CN, -CF3, -OCF3 y halogeno; donde R6 se selecciona entre -H, -alquilo C1-4, -OH, -O-alquilo C1-4, -halogeno, -CN, -CF3 y -OCF3 así como en forma de sus sales de adicion de ácidos con ácidos farmacologicamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09179555 | 2009-12-17 | ||
EP10162621 | 2010-05-12 |
Publications (1)
Publication Number | Publication Date |
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AR079636A1 true AR079636A1 (es) | 2012-02-08 |
Family
ID=43533115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104699A AR079636A1 (es) | 2009-12-17 | 2010-12-16 | Antagonistas del receptor ccr2 y usos de los mismos |
Country Status (36)
Country | Link |
---|---|
US (6) | US8765949B2 (es) |
EP (3) | EP2513093B1 (es) |
JP (1) | JP5632014B2 (es) |
KR (1) | KR101530234B1 (es) |
CN (1) | CN102933579B (es) |
AP (1) | AP3170A (es) |
AR (1) | AR079636A1 (es) |
AU (1) | AU2010332969B2 (es) |
BR (1) | BR112012015873B1 (es) |
CA (1) | CA2782464C (es) |
CL (1) | CL2012001311A1 (es) |
CO (1) | CO6650336A2 (es) |
CY (1) | CY1115873T1 (es) |
DK (1) | DK2513093T3 (es) |
EA (1) | EA024397B1 (es) |
EC (1) | ECSP12012010A (es) |
ES (2) | ES2524829T3 (es) |
GE (1) | GEP20146124B (es) |
HK (1) | HK1178147A1 (es) |
HR (1) | HRP20141143T1 (es) |
IL (1) | IL219421A (es) |
MA (1) | MA33818B1 (es) |
ME (1) | ME01908B (es) |
MX (2) | MX2012006964A (es) |
MY (1) | MY160471A (es) |
NZ (1) | NZ599770A (es) |
PE (1) | PE20121614A1 (es) |
PL (2) | PL3091012T3 (es) |
PT (2) | PT3091012T (es) |
RS (1) | RS53555B1 (es) |
SG (1) | SG181722A1 (es) |
SI (1) | SI2513093T1 (es) |
TN (1) | TN2012000300A1 (es) |
TW (1) | TWI473800B (es) |
UY (1) | UY33109A (es) |
WO (1) | WO2011073154A1 (es) |
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CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
EA020548B1 (ru) * | 2008-12-19 | 2014-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл |
NZ599770A (en) | 2009-12-17 | 2014-06-27 | Boehringer Ingelheim Int | New ccr2 receptor antagonists and uses thereof |
WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
JP5786257B2 (ja) * | 2011-06-16 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の選択的ccr2拮抗薬 |
JP5786258B2 (ja) * | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なccr2拮抗薬 |
EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
US8877185B2 (en) | 2012-05-10 | 2014-11-04 | Stan S. Sastry | Managing and treating keloids |
WO2016081801A1 (en) * | 2014-11-21 | 2016-05-26 | Millennium Pharmaceuticals, Inc. | Use of an anti-ccr2 antagonist in the treatment of an infectious disease |
DK3297438T3 (da) * | 2015-05-21 | 2022-01-17 | Chemocentryx Inc | Ccr2-modulatorer |
BR112017028492B1 (pt) * | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
BR112018074452A2 (pt) * | 2016-06-03 | 2019-03-19 | Chemocentryx, Inc. | método de tratamento de fibrose hepática |
AU2017283491B2 (en) * | 2016-06-13 | 2021-06-03 | Chemocentryx, Inc. | Methods of treating pancreatic cancer |
US10195188B2 (en) | 2016-06-13 | 2019-02-05 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
CN108017599B (zh) * | 2016-11-04 | 2020-03-03 | 上海爱科百发生物医药技术有限公司 | [3-(胺甲基)-氧杂环丁烷-3-基]氨基甲酸对甲氧基苄酯对氯苯甲酸盐合成方法 |
RU2765737C2 (ru) | 2016-11-23 | 2022-02-02 | Хемоцентрикс, Инк. | Способ лечения фокально-сегментарного гломерулосклероза |
SG11202002119QA (en) | 2017-09-25 | 2020-04-29 | Chemocentryx Inc | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
BR112020007183A2 (pt) | 2017-10-11 | 2020-09-24 | Chemocentryx, Inc. | tratamento de glomeruloesclerose focal segmentado com antagonistas de ccr2 |
WO2019136368A2 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
US20210322412A1 (en) * | 2020-04-20 | 2021-10-21 | Centrexion Therapeutics Corporation | Methods and compositions for treating a coronavirus infection |
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