ES2606137T3 - Derivados de aminas espirocíclicas como moduladores de S1P - Google Patents
Derivados de aminas espirocíclicas como moduladores de S1P Download PDFInfo
- Publication number
- ES2606137T3 ES2606137T3 ES11730314.9T ES11730314T ES2606137T3 ES 2606137 T3 ES2606137 T3 ES 2606137T3 ES 11730314 T ES11730314 T ES 11730314T ES 2606137 T3 ES2606137 T3 ES 2606137T3
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- Prior art keywords
- optionally substituted
- alkyl
- halogen
- substituted
- fluoro atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Abstract
Un derivado de amina espiro-cíclica de la fórmula (I)**Fórmula** en donde R1 se selecciona de ciano, (2-4C)alquenilo, (2-4C)alquinilo, (1-4C)alquilo cada uno opcionalmente sustituido con CN o uno o más átomos de fluoro, (3-6C)cicloalquilo, (4-6C)cicloalquenilo o un grupo (8-10C)bicíclico, cada uno opcionalmente sustituido con halógeno o (1-4C)alquilo, fenilo, bifenilo, naftilo, cada uno opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de halógeno, ciano, (1-6C)alquilo opcionalmente sustituido con uno o más átomos de fluoro, (1-6C)alcoxi opcionalmente sustituido con uno o más átomos de fluoro, amino, di(1-4C)alquilamino y (3- 6C)cicloalquilo opcionalmente sustituido con fenilo que puede estar sustituido con (1-4C)alquilo o halógeno, fenilo sustituido con fenoxi, bencilo, benciloxi, feniletilo o heterociclo monocíclico, cada uno opcionalmente sustituido con (1-4C)alquilo opcionalmente sustituido con uno o más átomos de fluoro, heterociclo monocíclico opcionalmente independientemente sustituido con halógeno, (1-6C)alquilo opcionalmente sustituido con uno o más átomos de fluoro, (3-6C)cicloalquilo, o fenilo opcionalmente sustituido con (1-4C)alquilo o halógeno, y heterociclo bicíclico opcionalmente sustituido con halógeno o (1-4C)alquilo opcionalmente sustituido con uno o más átomos de fluoro; -Y-(Cn-alquilen)-X- es un grupo enlazante en donde Y está unido a R1 y seleccionado de un enlace, -O-, -CO-, -S-, -SO-, -SO2-, -NH-, -CH>=CH-, -C(CF3)>=CH-, - C≡C-, -CH2-O-, -O-CO-, -CO-O-, -CO-NH-, -NH-CO-, y trans-ciclopropileno; n es un entero de 0 a 10; y X está unido a la unidad estructural fenileno/piridilo y seleccionado de un enlace, -O-, -S-, -SO-,-SO2-, -NH-, - CO-, -CH>=CH-, y trans-ciclopropileno; R2 es H o seleccionados independientemente de uno o más sustituyentes seleccionados de halógeno, (1-4C)alcoxi y (1-4C)alquilo opcionalmente sustituido con uno o más átomos de flúor; y R3 es (1-4C)alquilen-R4 en donde el grupo alquileno puede estar sustituido con uno o más átomos de halógeno o con (CH2)2 para formar una unidad estructural ciclopropilo, o R3 es (3-6C)cicloalquilen-R4, -CH2-(3- 6C)cicloalquilen-R4, (3-6C)cicloalquilen-CH2-R4 o -CO-CH2-R4, en donde R4 es -PO3H2, -OPO3H2, -COOH, - COO(1-4C)alquilo o tetrazol-5-ilo; Q es un enlace; -W-T- se selecciona de -CH>=CH-, -O-CH2-CH2-, -CO-O-, -CH2-CH2-, -CH2-O- y -O-CH2-; R5 es H o independientemente seleccionado de uno o más halógenos; Z es CH, CR2 o N; y A representa una estructura de anillo de morfolina o una amina cíclica de 5, 6 o 7 miembros; o una sal, un solvato o hidrato farmacéuticamente aceptable del mismo o uno o más N-óxidos del mismo
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36278210P | 2010-07-09 | 2010-07-09 | |
EP10169104 | 2010-07-09 | ||
EP10169104 | 2010-07-09 | ||
US362782P | 2010-07-09 | ||
US201161444186P | 2011-02-18 | 2011-02-18 | |
US201161444186P | 2011-02-18 | ||
EP11154961 | 2011-02-18 | ||
EP11154961 | 2011-02-18 | ||
PCT/EP2011/061599 WO2012004378A1 (en) | 2010-07-09 | 2011-07-08 | Spiro-cyclic amine derivatives as s1p modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2606137T3 true ES2606137T3 (es) | 2017-03-22 |
Family
ID=44315247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11730314.9T Active ES2606137T3 (es) | 2010-07-09 | 2011-07-08 | Derivados de aminas espirocíclicas como moduladores de S1P |
Country Status (23)
Country | Link |
---|---|
US (4) | US10179791B2 (es) |
EP (2) | EP3144312A1 (es) |
JP (1) | JP5922115B2 (es) |
KR (1) | KR101889695B1 (es) |
CN (1) | CN103097364B (es) |
AR (1) | AR082135A1 (es) |
AU (1) | AU2011275760B2 (es) |
BR (1) | BR112013000629B1 (es) |
CA (1) | CA2804143C (es) |
DK (1) | DK2590955T3 (es) |
ES (1) | ES2606137T3 (es) |
HK (1) | HK1184153A1 (es) |
IL (1) | IL224049B (es) |
MX (1) | MX347423B (es) |
NZ (1) | NZ605486A (es) |
PL (1) | PL2590955T3 (es) |
PT (1) | PT2590955T (es) |
RU (2) | RU2016140266A (es) |
SG (1) | SG186926A1 (es) |
TW (2) | TW201643169A (es) |
UY (1) | UY33497A (es) |
WO (1) | WO2012004378A1 (es) |
ZA (1) | ZA201300153B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE48301E1 (en) | 2010-07-09 | 2020-11-10 | Abbvie B.V. | Fused heterocyclic derivatives as S1P modulators |
TW201643169A (zh) * | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
CN102250035A (zh) * | 2011-06-10 | 2011-11-23 | 北京富卡生物技术有限公司 | 二芳基取代-1,3,4-噁二唑化合物的合成方法和其药物用途 |
US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
US8809376B2 (en) | 2012-04-30 | 2014-08-19 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
EP2928886B1 (en) | 2012-12-07 | 2016-11-02 | Boehringer Ingelheim International GmbH | New indanyloxydihydrobenzofuranylacetic acids |
KR101598612B1 (ko) * | 2013-08-29 | 2016-02-26 | 재단법인 아산사회복지재단 | Dpp-4 억제제를 포함하는 혈관 또는 심장판막 석회화의 예방 또는 치료용 조성물 |
CN107253903B (zh) * | 2016-06-20 | 2020-11-24 | 北京海步医药科技股份有限公司 | 制备一种能够结合s1p受体化合物及其中间体的方法 |
WO2018083171A1 (en) | 2016-11-02 | 2018-05-11 | AbbVie Deutschland GmbH & Co. KG | Spiro-compounds as s1p modulators |
JP7023969B2 (ja) | 2017-01-26 | 2022-02-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルアミノピリジルシクロプロパンカルボン酸、その医薬組成物及び使用 |
WO2018138029A1 (en) | 2017-01-26 | 2018-08-02 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
WO2018138030A1 (en) | 2017-01-26 | 2018-08-02 | Boehringer Ingelheim International Gmbh | Benzyloxypyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10793530B2 (en) | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
WO2018146008A1 (en) | 2017-02-08 | 2018-08-16 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
US10981900B2 (en) * | 2017-02-28 | 2021-04-20 | Medshine Discovery Inc. | Spiro compound and use thereof |
CN110092774B (zh) * | 2018-01-29 | 2022-04-08 | 中国科学院上海药物研究所 | 芳香丙酸类衍生物、及其制备方法和用途 |
US11458124B2 (en) | 2018-07-12 | 2022-10-04 | UCBBiopharma Srl | Spirocyclic indane analogues as IL-17 modulators |
BR112022008113A2 (pt) | 2019-10-31 | 2022-07-19 | Escape Bio Inc | Formas sólidas de um modulador de receptor s1p |
CN117337282A (zh) * | 2020-12-01 | 2024-01-02 | 艾伯维德国公司 | 作为s1p调节剂的螺环胺衍生物 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962259A (en) | 1973-12-12 | 1976-06-08 | American Hoechst Corporation | 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof |
US3980787A (en) * | 1975-08-25 | 1976-09-14 | American Hoechst Corporation | 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives |
SU1069387A1 (ru) | 1982-07-01 | 1985-11-30 | Институт физико-органической химии и углехимии АН УССР | Дигидрохлорид 5-/ @ -( @ -анизил)- @ -оксиэтил/ 2-(3,4-диметоксифенил)-1-метил-4,5,6,7-тетрагидроимидазо(4,5- @ )пиридина,обладающий спазмолитическим действием |
GB2228432A (en) | 1989-01-13 | 1990-08-29 | Grayston Central Services | Multi-role machine for heating and coating pipe welds. |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
JPH03206042A (ja) | 1990-01-06 | 1991-09-09 | Takeda Chem Ind Ltd | 降圧剤 |
JP2681589B2 (ja) | 1992-12-28 | 1997-11-26 | 日揮株式会社 | 配管溶接継手の熱処理方法 |
JPH072848A (ja) | 1993-04-23 | 1995-01-06 | Sankyo Co Ltd | モルホリンおよびチオモルホリン誘導体 |
GB9522845D0 (en) * | 1995-11-08 | 1996-01-10 | Smithkline Beecham Plc | Novel compounds |
JP3822680B2 (ja) | 1996-08-30 | 2006-09-20 | 新日本製鐵株式会社 | 誘導加熱された接合部の冷却方法および冷却装置 |
TWI243173B (en) * | 1999-11-17 | 2005-11-11 | Akzo Nobel Nv | Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives |
US6380387B1 (en) | 1999-12-06 | 2002-04-30 | Hoffmann-La Roche Inc. | 4-Pyrimidinyl-n-acyl-l phenylalanines |
MXPA02010325A (es) | 2000-04-21 | 2003-04-25 | Shionogi & Co | Derivados de oxadiazol los cuales tienen efectos anticancer. |
FR2822727A1 (fr) | 2001-04-03 | 2002-10-04 | Gesal Ind | Procede d'application d'un revetement resistant aux hautes temperatures, dispositif pour la mise en oeuvre de ce procede et objet pourvu dudit revetement |
JP3649223B2 (ja) | 2003-01-08 | 2005-05-18 | 株式会社日立製作所 | 配管系の熱処理方法および熱処理装置 |
BRPI0411124A (pt) | 2003-06-12 | 2006-07-18 | Btg Int Ltd | hidroxilamina cìclica como compostos psicoativos |
EP1663188B1 (en) | 2003-09-12 | 2016-08-10 | Newron Sweden AB | Treatment of disorders of the nervous system |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
WO2005063745A2 (en) | 2003-12-23 | 2005-07-14 | Arena Pharmaceuticals, Inc. | Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof |
GB0401332D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
BRPI0509307A (pt) * | 2004-03-29 | 2007-09-04 | Pfizer | compostos de alfa aril ou heteroaril metil beta piperidino propanamida como antagonistas do receptor orl1 |
GEP20084550B (en) | 2004-04-30 | 2008-11-25 | Warner Lambert Co | Substituted morpholine compounds for the treatment of central nervous system disorders |
GB0409744D0 (en) | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
WO2006047195A2 (en) | 2004-10-22 | 2006-05-04 | Merck & Co., Inc. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists |
JP4491334B2 (ja) | 2004-12-01 | 2010-06-30 | 日立Geニュークリア・エナジー株式会社 | 配管の熱処理方法および装置 |
GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
JP4599250B2 (ja) | 2005-08-10 | 2010-12-15 | 株式会社東芝 | 高周波誘導加熱時外面温度制御方法および当該制御装置 |
JP2007063642A (ja) | 2005-09-01 | 2007-03-15 | Hitachi Ltd | 残留応力改善方法と高周波誘導加熱用コイル |
MY146564A (en) * | 2005-11-10 | 2012-08-30 | Msd Kk | Aza-substituted spiro derivatives |
WO2007057775A1 (en) | 2005-11-21 | 2007-05-24 | Pfizer Limited | Spiropiperidine derivatives |
WO2007076070A2 (en) * | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
AU2007209380B2 (en) | 2006-01-27 | 2011-12-08 | F. Hoffmann-La Roche Ag | Use of 4-imidazole derivatives for CNS disorders |
AU2007209381A1 (en) | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Use of substituted 2-imidazole of imidazoline derivatives |
ES2462240T3 (es) | 2006-02-28 | 2014-05-22 | Dart Neuroscience (Cayman) Ltd | Piperazinas terapéuticas como inhibidores de PDE4 |
GB0608452D0 (en) * | 2006-04-27 | 2006-06-07 | Glaxo Group Ltd | Novel compounds |
US20100009969A1 (en) | 2006-07-27 | 2010-01-14 | Ucb Pharma, S.A. | Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands |
CN101511783A (zh) | 2006-09-08 | 2009-08-19 | 诺瓦提斯公司 | 用于治疗淋巴细胞相互作用介导的疾病的n-联芳(杂)芳基磺酰胺衍生物 |
TW200838497A (en) * | 2006-12-21 | 2008-10-01 | Abbott Lab | Sphingosine-1-phosphate receptor agonist and antagonist compounds |
US8575167B2 (en) | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
EP2121648A2 (en) | 2007-03-21 | 2009-11-25 | EPIX Pharmaceuticals, Inc. | S1p receptor modulating compounds and use thereof |
EA200901389A1 (ru) | 2007-04-23 | 2010-04-30 | Новартис Аг | Производные фталазина и изохинолина с модулирующим действием на s1p рецепторы |
WO2009084501A1 (ja) | 2007-12-27 | 2009-07-09 | Asahi Kasei Pharma Corporation | スルタム誘導体 |
WO2009092764A1 (en) | 2008-01-24 | 2009-07-30 | Ucb Pharma, S.A. | Compounds comprising a cyclobutoxy group |
CA2712897A1 (en) | 2008-01-30 | 2009-08-06 | Pharmacopeia, Inc. | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
MX2010008382A (es) * | 2008-01-30 | 2010-11-25 | Cephalon Inc | Derivados de piperidina espirociclicos substituidos, como ligandos de receptores de histamina-3 (h3). |
US20090321144A1 (en) | 2008-06-30 | 2009-12-31 | Wyble Kevin J | Protecting an element from excessive surface wear by localized hardening |
UY32858A (es) | 2009-08-31 | 2011-03-31 | Abbott Healthcare Products Bv | Derivados de (tio)morfolina como moduladores de sip |
AR080133A1 (es) | 2010-02-04 | 2012-03-14 | Esteve Labor Dr | Clorhidrato de 4-(-2-((5-metil-1-(2-naftalenil)-1h-pirazol-3-il)oxi)etil)morfolina y formas cristalinas del mismo |
CN101812058B (zh) | 2010-04-13 | 2012-03-21 | 湖南大学 | 吲哚美辛2-芳基吗啉乙酯及其制备方法与应用 |
TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
US10179971B2 (en) | 2014-03-21 | 2019-01-15 | Iogen Energy Corporation | Method for processing a cellulosic feedstock at high consistency |
US20210139503A1 (en) | 2019-10-31 | 2021-05-13 | ESCAPE Bio, Inc. | Processes for preparing an s1p-receptor modulator |
BR112022008113A2 (pt) | 2019-10-31 | 2022-07-19 | Escape Bio Inc | Formas sólidas de um modulador de receptor s1p |
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