BRPI0411124A - hidroxilamina cìclica como compostos psicoativos - Google Patents

hidroxilamina cìclica como compostos psicoativos

Info

Publication number
BRPI0411124A
BRPI0411124A BRPI0411124-9A BRPI0411124A BRPI0411124A BR PI0411124 A BRPI0411124 A BR PI0411124A BR PI0411124 A BRPI0411124 A BR PI0411124A BR PI0411124 A BRPI0411124 A BR PI0411124A
Authority
BR
Brazil
Prior art keywords
represent
hydroxylamine
cyclically
psychoactive compounds
unsaturated ring
Prior art date
Application number
BRPI0411124-9A
Other languages
English (en)
Inventor
Philip Parsons
Silvia Transciatti
Sergio Rosini
Michael Annis
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0313628A external-priority patent/GB0313628D0/en
Priority claimed from GB0328439A external-priority patent/GB0328439D0/en
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Publication of BRPI0411124A publication Critical patent/BRPI0411124A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"HIDROXILAMINA CìCLICA COMO COMPOSTOS PSICOATIVOS". Um composto de fórmula (I), na qual X representa O ou CH~ 2~; R¬ 3¬ e R¬ 4¬ cada independentemente, representam um anel insaturado ou saturado com cinco ou seis membros selecionado a partir de: fórmula (II) , (III) e (IV) ; ou R representa um anel insaturado com cinco ou seis membros oxo-substituído selecionado a partir de: (V) e (VI); onde R¬ 1¬ e R¬ 2¬ juntos representarem um grupo oxo, ou R¬ 1¬ e R¬ 2¬, cada, representarem hidrogênio, metóxi ou etóxi, ou R¬ 1¬ e R¬ 2¬ juntos com o átomo de carbono interjacente representam um anel 1,3-dioxolano ou 1,2-dioxano, ligado via posição 2 e opcionalmente possuindo um ou mais grupos metila ou etila; ou um seu sal, é apropriado para o tratamento de ansiedade e depressão.
BRPI0411124-9A 2003-06-12 2004-06-01 hidroxilamina cìclica como compostos psicoativos BRPI0411124A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0313628A GB0313628D0 (en) 2003-06-12 2003-06-12 Psychoactive compounds
GB0328439A GB0328439D0 (en) 2003-12-08 2003-12-08 Psychoactive compounds
PCT/GB2004/002324 WO2004111021A1 (en) 2003-06-12 2004-06-01 Cyclic hydroxylamine as psychoactive compounds

Publications (1)

Publication Number Publication Date
BRPI0411124A true BRPI0411124A (pt) 2006-07-18

Family

ID=33554147

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411124-9A BRPI0411124A (pt) 2003-06-12 2004-06-01 hidroxilamina cìclica como compostos psicoativos

Country Status (20)

Country Link
US (4) US7842689B2 (pt)
EP (1) EP1631557B1 (pt)
JP (1) JP4648899B2 (pt)
KR (1) KR20060018253A (pt)
AT (1) ATE348818T1 (pt)
AU (1) AU2004247462B2 (pt)
BR (1) BRPI0411124A (pt)
CA (1) CA2526209A1 (pt)
DE (1) DE602004003810T2 (pt)
DK (1) DK1631557T3 (pt)
ES (1) ES2278321T3 (pt)
HK (1) HK1087123A1 (pt)
MX (1) MXPA05013464A (pt)
NO (1) NO20060178L (pt)
NZ (1) NZ544028A (pt)
PL (1) PL1631557T3 (pt)
PT (1) PT1631557E (pt)
RU (1) RU2006101055A (pt)
SI (1) SI1631557T1 (pt)
WO (1) WO2004111021A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20060258A1 (it) * 2006-02-13 2007-08-14 Abiogen Pharma Spa Procedimento per la preparazione di 2-4 idrossi-3-morfolini-2-cicloesenone
UY32858A (es) * 2009-08-31 2011-03-31 Abbott Healthcare Products Bv Derivados de (tio)morfolina como moduladores de sip
EP2345639A1 (en) * 2009-12-24 2011-07-20 ABIOGEN PHARMA S.p.A. Cyclic hydroxylamine derivatives, their preparation and use as antioxidants
TW201643169A (zh) 2010-07-09 2016-12-16 艾伯維股份有限公司 作為s1p調節劑的螺-哌啶衍生物
TW201206893A (en) * 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
TWI522361B (zh) 2010-07-09 2016-02-21 艾伯維公司 作為s1p調節劑的稠合雜環衍生物
EP2808023A1 (en) * 2013-05-30 2014-12-03 Université Pierre et Marie Curie (Paris 6) New drug for the treatment and/or prevention of depressive disorders
AU2020373047A1 (en) 2019-10-31 2022-05-19 ESCAPE Bio, Inc. Solid forms of an S1P-receptor modulator

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
DK140584A (da) 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
CA2187114C (en) * 1989-05-24 2002-03-19 Sven Hernestam Method of preparation of delmopinol using substituted isoxazolidines and isoxazolines
GB2264299B (en) * 1992-02-19 1995-07-26 British Tech Group Iso-oxazolidine derivatives
JP3118061B2 (ja) * 1992-03-12 2000-12-18 高砂香料工業株式会社 光学活性ヒドロキシルアミンの製造法
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
IL112099A (en) 1993-12-23 1999-07-14 Ortho Pharma Corp N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them
JP2001502311A (ja) * 1996-10-07 2001-02-20 メルク シヤープ エンド ドーム リミテツド 抗鬱及び／又は抗不安薬としてのｃｎｓ浸透性ｎｋ―１受容体拮抗薬
EP0991622A1 (en) * 1997-06-27 2000-04-12 MERCK SHARP & DOHME LTD. Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents

Also Published As

Publication number Publication date
US20090312329A1 (en) 2009-12-17
NZ544028A (en) 2009-07-31
PL1631557T3 (pl) 2007-05-31
US20100256150A1 (en) 2010-10-07
DK1631557T3 (da) 2007-05-07
US20120015947A1 (en) 2012-01-19
WO2004111021A1 (en) 2004-12-23
KR20060018253A (ko) 2006-02-28
NO20060178L (no) 2006-01-11
AU2004247462B2 (en) 2010-09-02
MXPA05013464A (es) 2006-03-17
SI1631557T1 (sl) 2007-06-30
AU2004247462A1 (en) 2004-12-23
HK1087123A1 (en) 2006-10-06
US7842690B2 (en) 2010-11-30
RU2006101055A (ru) 2006-07-10
DE602004003810D1 (de) 2007-02-01
CA2526209A1 (en) 2004-12-23
US8053432B2 (en) 2011-11-08
ATE348818T1 (de) 2007-01-15
JP4648899B2 (ja) 2011-03-09
US20060142286A1 (en) 2006-06-29
EP1631557B1 (en) 2006-12-20
DE602004003810T2 (de) 2007-10-11
EP1631557A1 (en) 2006-03-08
US7842689B2 (en) 2010-11-30
PT1631557E (pt) 2007-03-30
JP2006527242A (ja) 2006-11-30
ES2278321T3 (es) 2007-08-01

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: BTG INTERNATIONAL LIMITED (GB)

Free format text: ENDERECO DO DEPOSITANTE ALTERADO CONFORME SOLICITADO NA PETICAO NO 020110103158/RJ DE 04/10/2011.

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.