CY1106476T1 - Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες - Google Patents

Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Info

Publication number
CY1106476T1
CY1106476T1 CY20071100709T CY071100709T CY1106476T1 CY 1106476 T1 CY1106476 T1 CY 1106476T1 CY 20071100709 T CY20071100709 T CY 20071100709T CY 071100709 T CY071100709 T CY 071100709T CY 1106476 T1 CY1106476 T1 CY 1106476T1
Authority
CY
Cyprus
Prior art keywords
antiviral properties
dihydroquinazolines
substituted
substituted dihydroquinazolines
production
Prior art date
Application number
CY20071100709T
Other languages
English (en)
Inventor
Tobias Wunberg
Judith Baumeister
Ulrich Betz
Mario Jeske
Thomas Lampe
Susanne Nikolic
Jurgen REEFSCHLÄGER
Rudolf Schohe-Loop
Frank SÜSSMEIER
Holger Zimmermann
Rolf Grosser
Kerstin Henninger
Guy Hewlett
Jörg Keldenich
Dieter Lang
Peter Nell
Original Assignee
Aicuris Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co. Kg filed Critical Aicuris Gmbh & Co. Kg
Publication of CY1106476T1 publication Critical patent/CY1106476T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Abstract

Η εφεύρεση σχετίζεται με υποκατεστημένες διυδροκιναζολίνες του τύπου (I) και με μεθόδους για την παραγωγή αυτών καθώς και με τη χρήση αυτών για την παραγωγή φαρμάκων για την αντιμετώπιση και/ή πρόληψη παθήσεων, ιδίως για χρήση ως αντι-ιικά μέσα, ιδίως έναντι κυτταρομεγαλοϊών.
CY20071100709T 2003-05-02 2007-05-25 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες CY1106476T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (1)

Publication Number Publication Date
CY1106476T1 true CY1106476T1 (el) 2012-01-25

Family

ID=33305099

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071100709T CY1106476T1 (el) 2003-05-02 2007-05-25 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες
CY2018019C CY2018019I2 (el) 2003-05-02 2018-06-29 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2018019C CY2018019I2 (el) 2003-05-02 2018-06-29 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Country Status (39)

Country Link
US (4) US7196086B2 (el)
EP (1) EP1622880B3 (el)
JP (1) JP4733631B2 (el)
KR (1) KR100927063B1 (el)
CN (1) CN100393706C (el)
AR (1) AR044078A1 (el)
AT (1) ATE355280T1 (el)
AU (1) AU2004233978B2 (el)
BR (1) BRPI0410029B8 (el)
CA (1) CA2524069C (el)
CL (1) CL2004000930A1 (el)
CO (1) CO5700764A2 (el)
CY (2) CY1106476T1 (el)
DE (2) DE10319612A1 (el)
DK (1) DK1622880T6 (el)
EC (1) ECSP056138A (el)
EG (1) EG25273A (el)
ES (1) ES2284007T7 (el)
FR (1) FR18C1029I2 (el)
HK (1) HK1092463A1 (el)
HN (1) HN2004000146A (el)
HU (2) HUS1800018I1 (el)
IL (1) IL171513A (el)
MA (1) MA27794A1 (el)
MX (1) MXPA05011707A (el)
MY (1) MY144616A (el)
NL (1) NL300933I2 (el)
NO (2) NO333265B3 (el)
NZ (1) NZ543317A (el)
PE (1) PE20050145A1 (el)
PL (1) PL1622880T6 (el)
PT (1) PT1622880E (el)
RU (1) RU2360912C2 (el)
SI (1) SI1622880T1 (el)
TW (1) TWI335912B (el)
UA (1) UA82519C2 (el)
UY (1) UY28294A1 (el)
WO (1) WO2004096778A1 (el)
ZA (1) ZA200508710B (el)

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DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
MD4673C1 (ro) * 2013-06-19 2020-11-30 Aicuris Anti-Infective Cures Gmbh Letermovir amorf şi forme preparative farmaceutice solide ale acestuia pentru administrare orală
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
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UY39095A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121437A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
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DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
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Also Published As

Publication number Publication date
FR18C1029I2 (fr) 2020-07-17
UA82519C2 (uk) 2008-04-25
DE10319612A1 (de) 2004-11-18
US20070191387A1 (en) 2007-08-16
HUS1800028I1 (hu) 2018-07-30
USRE46791E1 (en) 2018-04-17
HN2004000146A (es) 2008-06-24
NO333265B1 (no) 2013-04-22
CY2018019I1 (el) 2018-12-12
EG25273A (en) 2011-12-04
CN1784390A (zh) 2006-06-07
PT1622880E (pt) 2007-06-04
MA27794A1 (fr) 2006-03-01
FR18C1029I1 (el) 2018-08-17
PL1622880T6 (pl) 2018-08-31
JP2006525249A (ja) 2006-11-09
IL171513A (en) 2011-11-30
HUS1800018I1 (hu) 2018-05-28
TWI335912B (en) 2011-01-11
ES2284007T3 (es) 2007-11-01
CA2524069A1 (en) 2004-11-11
NO20055649L (no) 2006-01-31
DE502004003052D1 (de) 2007-04-12
RU2005137276A (ru) 2006-07-27
AU2004233978A1 (en) 2004-11-11
PL1622880T3 (pl) 2007-08-31
CY2018019I2 (el) 2018-12-12
BRPI0410029A (pt) 2006-04-25
HK1092463A1 (en) 2007-02-09
US7196086B2 (en) 2007-03-27
DK1622880T6 (da) 2018-06-18
BRPI0410029B8 (pt) 2021-06-15
MY144616A (en) 2011-10-14
BRPI0410029B1 (pt) 2019-12-31
MXPA05011707A (es) 2006-02-13
KR20060009883A (ko) 2006-02-01
KR100927063B1 (ko) 2009-11-13
CL2004000930A1 (es) 2005-03-18
NO333265B3 (no) 2019-06-03
NO20055649D0 (no) 2005-11-30
US8513255B2 (en) 2013-08-20
NZ543317A (en) 2008-05-30
CA2524069C (en) 2011-11-08
SI1622880T1 (sl) 2007-08-31
AR044078A1 (es) 2005-08-24
RU2360912C2 (ru) 2009-07-10
CN100393706C (zh) 2008-06-11
TW200510343A (en) 2005-03-16
NL300933I2 (nl) 2018-04-26
EP1622880B3 (de) 2018-05-23
PE20050145A1 (es) 2005-05-22
AU2004233978B2 (en) 2010-02-11
CO5700764A2 (es) 2006-11-30
ECSP056138A (es) 2006-04-19
UY28294A1 (es) 2004-11-30
ES2284007T7 (es) 2018-06-20
US20050065160A1 (en) 2005-03-24
EP1622880A1 (de) 2006-02-08
ATE355280T1 (de) 2006-03-15
JP4733631B2 (ja) 2011-07-27
EP1622880B1 (de) 2007-02-28
NO2018022I1 (no) 2018-07-04
WO2004096778A1 (de) 2004-11-11
ZA200508710B (en) 2006-12-27
DK1622880T3 (da) 2007-06-25
USRE49698E1 (en) 2023-10-17

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