FR18C1029I2 - Dihydroquinazolines substituees a proprietes antivirales - Google Patents

Dihydroquinazolines substituees a proprietes antivirales

Info

Publication number
FR18C1029I2
FR18C1029I2 FR18C1029C FR18C1029C FR18C1029I2 FR 18C1029 I2 FR18C1029 I2 FR 18C1029I2 FR 18C1029 C FR18C1029 C FR 18C1029C FR 18C1029 C FR18C1029 C FR 18C1029C FR 18C1029 I2 FR18C1029 I2 FR 18C1029I2
Authority
FR
France
Prior art keywords
antiviral properties
dihydroquinazolines
substituted
substituted dihydroquinazolines
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C1029C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aicuris Anti Infectives Cures GmbH
Original Assignee
Aicuris Anti Infectives Cures GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Anti Infectives Cures GmbH filed Critical Aicuris Anti Infectives Cures GmbH
Publication of FR18C1029I1 publication Critical patent/FR18C1029I1/fr
Application granted granted Critical
Publication of FR18C1029I2 publication Critical patent/FR18C1029I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
FR18C1029C 2003-05-02 2018-07-06 Dihydroquinazolines substituees a proprietes antivirales Active FR18C1029I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (fr) 2003-05-02 2004-04-17 Dihydroquinazolines substituees a proprietes antivirales

Publications (2)

Publication Number Publication Date
FR18C1029I1 FR18C1029I1 (fr) 2018-08-17
FR18C1029I2 true FR18C1029I2 (fr) 2020-07-17

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C1029C Active FR18C1029I2 (fr) 2003-05-02 2018-07-06 Dihydroquinazolines substituees a proprietes antivirales

Country Status (39)

Country Link
US (4) US7196086B2 (fr)
EP (1) EP1622880B3 (fr)
JP (1) JP4733631B2 (fr)
KR (1) KR100927063B1 (fr)
CN (1) CN100393706C (fr)
AR (1) AR044078A1 (fr)
AT (1) ATE355280T1 (fr)
AU (1) AU2004233978B2 (fr)
BR (1) BRPI0410029B8 (fr)
CA (1) CA2524069C (fr)
CL (1) CL2004000930A1 (fr)
CO (1) CO5700764A2 (fr)
CY (2) CY1106476T1 (fr)
DE (2) DE10319612A1 (fr)
DK (1) DK1622880T6 (fr)
EC (1) ECSP056138A (fr)
EG (1) EG25273A (fr)
ES (1) ES2284007T7 (fr)
FR (1) FR18C1029I2 (fr)
HK (1) HK1092463A1 (fr)
HN (1) HN2004000146A (fr)
HU (2) HUS1800018I1 (fr)
IL (1) IL171513A (fr)
MA (1) MA27794A1 (fr)
MX (1) MXPA05011707A (fr)
MY (1) MY144616A (fr)
NL (1) NL300933I2 (fr)
NO (2) NO333265B3 (fr)
NZ (1) NZ543317A (fr)
PE (1) PE20050145A1 (fr)
PL (1) PL1622880T6 (fr)
PT (1) PT1622880E (fr)
RU (1) RU2360912C2 (fr)
SI (1) SI1622880T1 (fr)
TW (1) TWI335912B (fr)
UA (1) UA82519C2 (fr)
UY (1) UY28294A1 (fr)
WO (1) WO2004096778A1 (fr)
ZA (1) ZA200508710B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
PT3010891T (pt) * 2013-06-19 2019-06-21 Aicuris Anti Infective Cures Gmbh Letermovir amorfo e suas formulações farmacêuticas sólidas para administração oral
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (fr) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Nouveaux procédés de production de composés de quinazoline substitués à l'aide de catalyseurs de liaison hydrogène
WO2018028556A1 (fr) * 2016-08-08 2018-02-15 南京明德新药研发股份有限公司 Composé du virus anti-hcmv
JP7076845B2 (ja) * 2018-02-08 2022-05-30 フェーノ・セラピューティクス・カンパニー・リミテッド ３，４－ジヒドロチエノ［３，２－ｄ］ピリミジン系化合物の結晶形およびその調製方法
EP3527209A1 (fr) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Dérivés pharmaceutiques de noyau hétérobicyclique 6,5
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds
UY39098A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
UY39096A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8- fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
UY39095A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121437A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
EP3906929A1 (fr) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir pour son utilisation dans la prévention et le traitement des infections à coronavirus
WO2022038457A1 (fr) 2020-08-17 2022-02-24 Lupin Limited Procédé de précipitation de letermovir amorphe
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (fr) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 Intermédiaire de letermovir et son procédé de préparation
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
WO1999041253A1 (fr) 1998-02-17 1999-08-19 Tularik Inc. Antiviraux derives de pyrimidine
WO2000063194A1 (fr) 1999-04-19 2000-10-26 Shionogi & Co., Ltd. Derives de sulfonamide possedant des noyaux oxadiazole
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
CA2417106C (fr) 2000-07-31 2007-09-18 F. Hoffmann-La Roche Ag Derives de la piperazine
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
BR0209054A (pt) 2001-04-19 2004-04-20 Bayer Ag Arilsulfonamidas como agentes antivirais
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
EP1848698B1 (fr) * 2005-01-25 2013-03-13 Prolexys Pharmaceuticals, Inc. Dérivés de quinoxaline en tant qu'agents contre des tumeurs
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
KR100962723B1 (ko) 2005-07-21 2010-06-09 에프. 호프만-라 로슈 아게 단백질 티로신 포스파타제1ｂ 억제제로서의피리도[2,3-ｄ]피리미딘-2,4-다이아민 화합물
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
PT3010891T (pt) * 2013-06-19 2019-06-21 Aicuris Anti Infective Cures Gmbh Letermovir amorfo e suas formulações farmacêuticas sólidas para administração oral

Also Published As

Publication number Publication date
AU2004233978B2 (en) 2010-02-11
RU2360912C2 (ru) 2009-07-10
DK1622880T3 (da) 2007-06-25
CY1106476T1 (el) 2012-01-25
EP1622880B1 (fr) 2007-02-28
CA2524069C (fr) 2011-11-08
MXPA05011707A (es) 2006-02-13
NL300933I2 (nl) 2018-04-26
JP4733631B2 (ja) 2011-07-27
US20070191387A1 (en) 2007-08-16
CY2018019I1 (el) 2018-12-12
WO2004096778A1 (fr) 2004-11-11
NO20055649D0 (no) 2005-11-30
USRE49698E1 (en) 2023-10-17
US7196086B2 (en) 2007-03-27
PT1622880E (pt) 2007-06-04
AU2004233978A1 (en) 2004-11-11
EP1622880A1 (fr) 2006-02-08
UY28294A1 (es) 2004-11-30
RU2005137276A (ru) 2006-07-27
NO333265B3 (no) 2019-06-03
NO20055649L (no) 2006-01-31
BRPI0410029B1 (pt) 2019-12-31
BRPI0410029B8 (pt) 2021-06-15
DE502004003052D1 (de) 2007-04-12
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
FR18C1029I1 (fr) 2018-08-17
ES2284007T7 (es) 2018-06-20
CN100393706C (zh) 2008-06-11
US8513255B2 (en) 2013-08-20
US20050065160A1 (en) 2005-03-24
AR044078A1 (es) 2005-08-24
TW200510343A (en) 2005-03-16
MY144616A (en) 2011-10-14
CL2004000930A1 (es) 2005-03-18
SI1622880T1 (sl) 2007-08-31
NO2018022I1 (no) 2018-07-04
PL1622880T3 (pl) 2007-08-31
UA82519C2 (uk) 2008-04-25
EP1622880B3 (fr) 2018-05-23
ES2284007T3 (es) 2007-11-01
HN2004000146A (es) 2008-06-24
HK1092463A1 (en) 2007-02-09
TWI335912B (en) 2011-01-11
ECSP056138A (es) 2006-04-19
CY2018019I2 (el) 2018-12-12
ZA200508710B (en) 2006-12-27
EG25273A (en) 2011-12-04
USRE46791E1 (en) 2018-04-17
DK1622880T6 (da) 2018-06-18
NZ543317A (en) 2008-05-30
MA27794A1 (fr) 2006-03-01
DE10319612A1 (de) 2004-11-18
NO333265B1 (no) 2013-04-22
HUS1800028I1 (hu) 2018-07-30
IL171513A (en) 2011-11-30
CA2524069A1 (fr) 2004-11-11
CN1784390A (zh) 2006-06-07
PL1622880T6 (pl) 2018-08-31
HUS1800018I1 (hu) 2018-05-28
BRPI0410029A (pt) 2006-04-25
KR100927063B1 (ko) 2009-11-13
KR20060009883A (ko) 2006-02-01
CO5700764A2 (es) 2006-11-30
PE20050145A1 (es) 2005-05-22

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