ECSP056138A - Dihidroquinazolinas sustituidas - Google Patents

Dihidroquinazolinas sustituidas

Info

Publication number
ECSP056138A
ECSP056138A EC2005006138A ECSP056138A ECSP056138A EC SP056138 A ECSP056138 A EC SP056138A EC 2005006138 A EC2005006138 A EC 2005006138A EC SP056138 A ECSP056138 A EC SP056138A EC SP056138 A ECSP056138 A EC SP056138A
Authority
EC
Ecuador
Prior art keywords
substituted
dihydroquinazolins
preparation
prophylaxis
medicaments
Prior art date
Application number
EC2005006138A
Other languages
English (en)
Inventor
Tobias Wunberg
Judith Baumeister
Ulrich Betz
Mario Jeske
Thomas Lampe
Susanne Nikolic
Juergen Reefschlaeger
Frank Suessmeier
Holger Zimmermann
Rolf Grosser
Kerstin Henninger
Guy Hewlett
Joerg Keldenich
Dieter Lang
Peter Nell
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of ECSP056138A publication Critical patent/ECSP056138A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a dihidroquinazolinas sustituidas y a procedimientos para su preparación así como a su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente para el uso como agente antiviral, especialmente contra citomegalovirus..
EC2005006138A 2003-05-02 2005-11-01 Dihidroquinazolinas sustituidas ECSP056138A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline

Publications (1)

Publication Number Publication Date
ECSP056138A true ECSP056138A (es) 2006-04-19

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006138A ECSP056138A (es) 2003-05-02 2005-11-01 Dihidroquinazolinas sustituidas

Country Status (39)

Country Link
US (4) US7196086B2 (es)
EP (1) EP1622880B3 (es)
JP (1) JP4733631B2 (es)
KR (1) KR100927063B1 (es)
CN (1) CN100393706C (es)
AR (1) AR044078A1 (es)
AT (1) ATE355280T1 (es)
AU (1) AU2004233978B2 (es)
BR (1) BRPI0410029B8 (es)
CA (1) CA2524069C (es)
CL (1) CL2004000930A1 (es)
CO (1) CO5700764A2 (es)
CY (2) CY1106476T1 (es)
DE (2) DE10319612A1 (es)
DK (1) DK1622880T6 (es)
EC (1) ECSP056138A (es)
EG (1) EG25273A (es)
ES (1) ES2284007T7 (es)
FR (1) FR18C1029I2 (es)
HK (1) HK1092463A1 (es)
HN (1) HN2004000146A (es)
HU (2) HUS1800018I1 (es)
IL (1) IL171513A (es)
MA (1) MA27794A1 (es)
MX (1) MXPA05011707A (es)
MY (1) MY144616A (es)
NL (1) NL300933I2 (es)
NO (2) NO333265B3 (es)
NZ (1) NZ543317A (es)
PE (1) PE20050145A1 (es)
PL (1) PL1622880T6 (es)
PT (1) PT1622880E (es)
RU (1) RU2360912C2 (es)
SI (1) SI1622880T1 (es)
TW (1) TWI335912B (es)
UA (1) UA82519C2 (es)
UY (1) UY28294A1 (es)
WO (1) WO2004096778A1 (es)
ZA (1) ZA200508710B (es)

Families Citing this family (31)

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Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
UA117755C2 (uk) * 2013-06-19 2018-09-25 Айкуріс Анти-Інфектів Курес Гмбх Аморфний летермовір і тверді фармацевтичні препарати, що містять його, призначені для перорального введення
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
WO2018028556A1 (zh) * 2016-08-08 2018-02-15 南京明德新药研发股份有限公司 抗hcmv病毒化合物
CN111741960B (zh) * 2018-02-08 2021-06-25 南京明德新药研发有限公司 一种3,4-二氢噻吩并[3,2-d]嘧啶类化合物的晶型及其制备方法
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
CN112996789A (zh) 2018-09-12 2021-06-18 诺华股份有限公司 抗病毒吡啶并吡嗪二酮化合物
WO2021061898A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
UY39098A (es) * 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39097A (es) * 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用

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DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
CN1297447A (zh) 1998-02-17 2001-05-30 图拉列克股份有限公司 抗病毒嘧啶衍生物
CA2367395A1 (en) 1999-04-19 2000-10-26 Shionogi & Co., Ltd. Cyclic amine derivatives and use thereof
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
CN1277828C (zh) * 2000-07-31 2006-10-04 霍夫曼-拉罗奇有限公司 哌嗪衍生物
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
US7115612B2 (en) 2001-04-19 2006-10-03 Bayer Aktiengesellschaft Arylsulfonamides as antiviral agents
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
ES2409686T3 (es) * 2005-01-25 2013-06-27 Prolexys Pharmaceuticals, Inc. Derivados de quinoxalina como agentes antitumorales
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE602006010564D1 (de) * 2005-07-21 2009-12-31 Hoffmann La Roche Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
UA117755C2 (uk) * 2013-06-19 2018-09-25 Айкуріс Анти-Інфектів Курес Гмбх Аморфний летермовір і тверді фармацевтичні препарати, що містять його, призначені для перорального введення

Also Published As

Publication number Publication date
ATE355280T1 (de) 2006-03-15
AU2004233978A1 (en) 2004-11-11
EP1622880B1 (de) 2007-02-28
CL2004000930A1 (es) 2005-03-18
ES2284007T3 (es) 2007-11-01
UA82519C2 (uk) 2008-04-25
IL171513A (en) 2011-11-30
DK1622880T3 (da) 2007-06-25
TWI335912B (en) 2011-01-11
HK1092463A1 (en) 2007-02-09
JP2006525249A (ja) 2006-11-09
BRPI0410029A (pt) 2006-04-25
PT1622880E (pt) 2007-06-04
MY144616A (en) 2011-10-14
PE20050145A1 (es) 2005-05-22
WO2004096778A1 (de) 2004-11-11
CN100393706C (zh) 2008-06-11
RU2005137276A (ru) 2006-07-27
NO2018022I1 (no) 2018-07-04
RU2360912C2 (ru) 2009-07-10
USRE46791E1 (en) 2018-04-17
CA2524069C (en) 2011-11-08
EG25273A (en) 2011-12-04
EP1622880B3 (de) 2018-05-23
HN2004000146A (es) 2008-06-24
PL1622880T6 (pl) 2018-08-31
NL300933I2 (nl) 2018-04-26
PL1622880T3 (pl) 2007-08-31
DE10319612A1 (de) 2004-11-18
DE502004003052D1 (de) 2007-04-12
CN1784390A (zh) 2006-06-07
FR18C1029I2 (fr) 2020-07-17
ZA200508710B (en) 2006-12-27
US20050065160A1 (en) 2005-03-24
DK1622880T6 (da) 2018-06-18
NO333265B1 (no) 2013-04-22
FR18C1029I1 (es) 2018-08-17
NO20055649L (no) 2006-01-31
MA27794A1 (fr) 2006-03-01
SI1622880T1 (sl) 2007-08-31
USRE49698E1 (en) 2023-10-17
MXPA05011707A (es) 2006-02-13
BRPI0410029B1 (pt) 2019-12-31
NZ543317A (en) 2008-05-30
CA2524069A1 (en) 2004-11-11
US7196086B2 (en) 2007-03-27
US20070191387A1 (en) 2007-08-16
AU2004233978B2 (en) 2010-02-11
NO333265B3 (no) 2019-06-03
HUS1800018I1 (hu) 2018-05-28
AR044078A1 (es) 2005-08-24
KR20060009883A (ko) 2006-02-01
KR100927063B1 (ko) 2009-11-13
EP1622880A1 (de) 2006-02-08
JP4733631B2 (ja) 2011-07-27
CY1106476T1 (el) 2012-01-25
NO20055649D0 (no) 2005-11-30
TW200510343A (en) 2005-03-16
BRPI0410029B8 (pt) 2021-06-15
CY2018019I1 (el) 2018-12-12
US8513255B2 (en) 2013-08-20
CY2018019I2 (el) 2018-12-12
HUS1800028I1 (hu) 2018-07-30
ES2284007T7 (es) 2018-06-20
CO5700764A2 (es) 2006-11-30
UY28294A1 (es) 2004-11-30

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