PA8772101A1 - Imidazol-triazolopirimidinas sustituidas - Google Patents
Imidazol-triazolopirimidinas sustituidasInfo
- Publication number
- PA8772101A1 PA8772101A1 PA20088772101A PA8772101A PA8772101A1 PA 8772101 A1 PA8772101 A1 PA 8772101A1 PA 20088772101 A PA20088772101 A PA 20088772101A PA 8772101 A PA8772101 A PA 8772101A PA 8772101 A1 PA8772101 A1 PA 8772101A1
- Authority
- PA
- Panama
- Prior art keywords
- triazolopirimidinas
- imidazol
- replaced
- preparation
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
LA INVENCION SE REFIERE A IMIDAZO- Y TRIAZOLOPIRIMIDINAS SUSTITUIDAS, A PROCEDIMIENTOS PARA SU PREPARACION Y A SU USO PARA LA PREPARACION DE MEDICAMENTOS PARA EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES, EN PARTICULAR DE TRASTORNOS HEMATOLOGICOS, PREFERIBLEMENTE DE LEUCOPENIAS Y NEUTROPENIAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007012645A DE102007012645A1 (de) | 2007-03-16 | 2007-03-16 | Substituierte Imidazo- und Triazolopyrimidine |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8772101A1 true PA8772101A1 (es) | 2009-02-09 |
Family
ID=39688187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088772101A PA8772101A1 (es) | 2007-03-16 | 2008-03-10 | Imidazol-triazolopirimidinas sustituidas |
Country Status (13)
Country | Link |
---|---|
US (2) | US8273752B2 (es) |
EP (1) | EP2137188B1 (es) |
JP (1) | JP5400626B2 (es) |
AR (1) | AR065719A1 (es) |
CA (1) | CA2680697C (es) |
CL (1) | CL2008000703A1 (es) |
DE (1) | DE102007012645A1 (es) |
ES (1) | ES2387223T3 (es) |
PA (1) | PA8772101A1 (es) |
PE (1) | PE20081806A1 (es) |
TW (1) | TW200904819A (es) |
UY (1) | UY30956A1 (es) |
WO (1) | WO2008113469A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007012645A1 (de) | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
DE102008023801A1 (de) * | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
DE102008035552A1 (de) * | 2008-07-30 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Pyridine und ihre Verwendung |
EP2396331B1 (en) * | 2009-02-13 | 2013-10-16 | Bayer Intellectual Property GmbH | Fused pyrimidines as akt inhibitors |
JP5503930B2 (ja) * | 2009-09-18 | 2014-05-28 | 住友化学株式会社 | 3−アミノ−1−tert−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩 |
TWI402268B (zh) * | 2009-09-24 | 2013-07-21 | Hoffmann La Roche | 新穎之咪唑并吡啶衍生物 |
US8748582B2 (en) | 2009-10-15 | 2014-06-10 | Monash University | Affinity ligands and methods for protein purification |
CA2787714C (en) | 2010-01-22 | 2019-04-09 | Joaquin Pastor Fernandez | Inhibitors of pi3 kinase |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011111705A1 (ja) * | 2010-03-12 | 2011-09-15 | 日本曹達株式会社 | t-ブトキシカルボニルアミン化合物の製造方法 |
NZ603446A (en) * | 2010-04-14 | 2014-05-30 | Array Biopharma Inc | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
WO2011141713A1 (en) | 2010-05-13 | 2011-11-17 | Centro Nacional De Investigaciones Oncologicas (Cnio) | New bicyclic compounds as pi3-k and mtor inhibitors |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
US8703946B2 (en) | 2010-12-08 | 2014-04-22 | Vanderbilt University | Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
MX2014004473A (es) * | 2011-10-12 | 2015-04-14 | Array Biopharma Inc | Imidazo [1,2-c] pirimidinas 5,7-substituidas. |
WO2015123408A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
CA2939082C (en) | 2014-02-13 | 2022-06-07 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
LT3105226T (lt) | 2014-02-13 | 2019-11-11 | Incyte Corp | Ciklopropilaminai, kaip lsd1 inhibitoriai |
WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
ES2738416T3 (es) | 2014-03-19 | 2020-01-22 | Boehringer Ingelheim Int | Inhibidores heteroarílicos de SYK |
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US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
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WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
EP3626720A1 (en) | 2015-04-03 | 2020-03-25 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
MX2018001706A (es) | 2015-08-12 | 2018-09-06 | Incyte Corp | Sales de un inhibidor de dimetilasa 1 especifica para lisina (lsd1). |
BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
UA125559C2 (uk) | 2016-04-22 | 2022-04-20 | Інсайт Корпорейшн | Композиції інгібітора lsd1 |
CR20200441A (es) | 2018-02-27 | 2021-03-15 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b |
CA3100731A1 (en) * | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
CR20240054A (es) | 2018-07-05 | 2024-02-26 | Incyte Corp | DERIVADOS DE PIRAZINA FUSIONADOS COMO INHIBIDORES DE A2A/A2B (Div. 2021-71) |
US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
MX2021005047A (es) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1. |
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
EP3883576A4 (en) * | 2018-11-20 | 2022-06-22 | Merck Sharp & Dohme Corp. | SUBSTITUTED AMINOTRIAZOLOPYRIMIDINES AND AMINO-TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
CN112624968B (zh) * | 2021-01-18 | 2022-03-08 | 阿里生物新材料(常州)有限公司 | 一种5-氨基-3-氰基吡啶甲酸甲酯盐酸盐的合成方法 |
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CA2136228A1 (en) * | 1992-05-21 | 1993-11-25 | Masao Hisadome | Use for treating thrombocytopenia, use for treating erythropenia and optically active fused pyrazole compound |
JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
US20030078232A1 (en) | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
DE60236322D1 (de) * | 2001-12-07 | 2010-06-17 | Vertex Pharma | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
NZ539165A (en) * | 2002-09-04 | 2008-03-28 | Schering Corp | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
EP1678180B1 (en) * | 2003-10-10 | 2007-08-08 | Pfizer Products Incorporated | Substituted 2h-[1,2,4]triazolo 4,3-a pyrazines as gsk-3 inhibitors |
DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
DE102007012645A1 (de) | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
DE102008023801A1 (de) * | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
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2007
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2008
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- 2008-03-04 WO PCT/EP2008/001682 patent/WO2008113469A2/de active Application Filing
- 2008-03-04 EP EP08716201A patent/EP2137188B1/de not_active Not-in-force
- 2008-03-04 US US12/529,711 patent/US8273752B2/en not_active Expired - Fee Related
- 2008-03-04 JP JP2009553944A patent/JP5400626B2/ja not_active Expired - Fee Related
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- 2008-03-13 AR ARP080101031A patent/AR065719A1/es unknown
- 2008-03-14 TW TW097108955A patent/TW200904819A/zh unknown
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2012
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US9051323B2 (en) | 2015-06-09 |
JP5400626B2 (ja) | 2014-01-29 |
US20100113441A1 (en) | 2010-05-06 |
EP2137188B1 (de) | 2012-06-06 |
ES2387223T3 (es) | 2012-09-18 |
CA2680697A1 (en) | 2008-09-25 |
DE102007012645A1 (de) | 2008-09-18 |
CA2680697C (en) | 2016-09-20 |
JP2010521506A (ja) | 2010-06-24 |
EP2137188A2 (de) | 2009-12-30 |
AR065719A1 (es) | 2009-06-24 |
PE20081806A1 (es) | 2009-02-07 |
CL2008000703A1 (es) | 2008-09-26 |
WO2008113469A3 (de) | 2008-11-13 |
WO2008113469A8 (de) | 2009-09-24 |
WO2008113469A2 (de) | 2008-09-25 |
UY30956A1 (es) | 2008-10-31 |
US8273752B2 (en) | 2012-09-25 |
US20130040946A1 (en) | 2013-02-14 |
TW200904819A (en) | 2009-02-01 |
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