AU2001284564A1 - Nucleoside metabolism inhibitors - Google Patents

Nucleoside metabolism inhibitors

Info

Publication number
AU2001284564A1
AU2001284564A1 AU2001284564A AU8456401A AU2001284564A1 AU 2001284564 A1 AU2001284564 A1 AU 2001284564A1 AU 2001284564 A AU2001284564 A AU 2001284564A AU 8456401 A AU8456401 A AU 8456401A AU 2001284564 A1 AU2001284564 A1 AU 2001284564A1
Authority
AU
Australia
Prior art keywords
metabolism inhibitors
nucleoside metabolism
nucleoside
inhibitors
metabolism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284564A
Inventor
Richard Hubert Furneaux
Vern L. Schramm
Peter Charles Tyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industrial Research Ltd
Albert Einstein College of Medicine
Original Assignee
IND RES Ltd
Industrial Research Ltd
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND RES Ltd, Industrial Research Ltd, Albert Einstein College of Medicine filed Critical IND RES Ltd
Publication of AU2001284564A1 publication Critical patent/AU2001284564A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
AU2001284564A 2000-08-29 2001-08-24 Nucleoside metabolism inhibitors Abandoned AU2001284564A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ506613 2000-08-29
NZ50661300 2000-08-29
PCT/NZ2001/000174 WO2002018371A1 (en) 2000-08-29 2001-08-24 Nucleoside metabolism inhibitors

Publications (1)

Publication Number Publication Date
AU2001284564A1 true AU2001284564A1 (en) 2002-03-13

Family

ID=19928075

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284564A Abandoned AU2001284564A1 (en) 2000-08-29 2001-08-24 Nucleoside metabolism inhibitors

Country Status (4)

Country Link
US (2) US7109331B2 (en)
JP (1) JP2004507534A (en)
AU (1) AU2001284564A1 (en)
WO (1) WO2002018371A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
EP1165564B1 (en) * 1999-04-08 2009-03-11 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
US7109331B2 (en) * 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ATE505474T1 (en) 2002-08-21 2011-04-15 Einstein Coll Med INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
MXPA06002001A (en) * 2003-08-26 2006-06-20 Teijin Pharma Ltd Pyrrolopyrimidinone derivative.
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
US8541567B2 (en) * 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
ITRM20050611A1 (en) * 2005-12-06 2007-06-07 Angeletti P Ist Richerche Bio AZANUCLEOSID DERIVATIVES WITH ANTIVIRAL ACTIVITY.
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8394950B2 (en) * 2006-02-22 2013-03-12 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
WO2007097647A1 (en) * 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
US20110092521A1 (en) * 2006-02-24 2011-04-21 Richard Hubert Furneaux Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
CN101094080B (en) * 2006-06-22 2012-06-20 华为技术有限公司 Charging method for system of putting call through immediately after connection
US8853224B2 (en) 2006-09-07 2014-10-07 Industrial Research Limited Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
CA2662626C (en) * 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
PT2114925E (en) * 2006-12-22 2012-05-29 Einstein Coll Med Azetidine analogues of nucleosidase and phosphorylase inhibitors
KR20160029870A (en) 2008-04-21 2016-03-15 오토노미, 인코포레이티드 Auris formulations for treating otic diseases and conditions
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
WO2010033236A2 (en) 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (en) 2009-07-17 2016-02-16 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
CN103391777A (en) 2011-02-02 2013-11-13 普林斯顿大学理事会 Sirtuin modulators as virus production modulators
US9682093B2 (en) 2012-03-30 2017-06-20 Charles R. Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (en) * 2012-04-18 2014-12-03 Biocryst Pharm Inc INHIBITING COMPOUNDS OF VIRAL POLYMERASE RNA ACTIVITY
WO2014205194A1 (en) 2013-06-22 2014-12-24 Nitor Therapeutics Compositions and methods for potentiating immune response for the treatment of infectious diseases and cancer
WO2018005830A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
CN113209165A (en) * 2017-11-01 2021-08-06 苏州颐华生物医药技术股份有限公司 Piper laetispicum extract and preparation method and application thereof
CA3229752A1 (en) 2021-08-20 2023-02-23 Shionogi & Co., Ltd. Nucleoside derivatives and prodrugs thereof having viral growth inhibitory action

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914086A (en) * 1987-12-18 1990-04-03 University Patents, Inc. Method for treating African human and veterinary trypanosomiases
WO1997031008A1 (en) * 1996-02-23 1997-08-28 Industrial Research Limited Enzyme detection/assay method and substrates
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
EP1165564B1 (en) 1999-04-08 2009-03-11 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
US7109331B2 (en) * 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US6458799B1 (en) * 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US6660719B2 (en) * 2001-12-17 2003-12-09 Biocryst Pharmaceuticals Inc. Inhibiting T-Cell proliferation
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases

Also Published As

Publication number Publication date
US7109331B2 (en) 2006-09-19
US20040053944A1 (en) 2004-03-18
US20070015772A1 (en) 2007-01-18
WO2002018371A1 (en) 2002-03-07
JP2004507534A (en) 2004-03-11

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