MXPA05012606A - Fosforamidatos de nucleosidos como agentes anticancerigenos. - Google Patents

Fosforamidatos de nucleosidos como agentes anticancerigenos.

Info

Publication number
MXPA05012606A
MXPA05012606A MXPA05012606A MXPA05012606A MXPA05012606A MX PA05012606 A MXPA05012606 A MX PA05012606A MX PA05012606 A MXPA05012606 A MX PA05012606A MX PA05012606 A MXPA05012606 A MX PA05012606A MX PA05012606 A MXPA05012606 A MX PA05012606A
Authority
MX
Mexico
Prior art keywords
moiety
amino acid
chemical compounds
alpha
naturally occurring
Prior art date
Application number
MXPA05012606A
Other languages
English (en)
Inventor
Christopher Mcguigan
Original Assignee
Univ Cardiff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27772362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05012606(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Cardiff filed Critical Univ Cardiff
Publication of MXPA05012606A publication Critical patent/MXPA05012606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En la presente invencion se describen a derivados de fosforamidato de nucleotidos y a su uso en el tratamiento se cancer. Las porciones base de, por ejemplo, cada uno de desoxiuridina, citarabina, gemcitabina y citidina pueden ser sustituidas en la posicion 5. La porcion de fosforamidato tiene unidas al atomo de P una porcion de arilo-O y una porcion de (-aminoacido. La porcion de (-aminoacido puede corresponder a o se deriva de cualquier aminoacido de origen natural o de origen no natural.
MXPA05012606A 2003-07-21 2004-07-20 Fosforamidatos de nucleosidos como agentes anticancerigenos. MXPA05012606A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317009.9A GB0317009D0 (en) 2003-07-21 2003-07-21 Chemical compounds
PCT/GB2004/003148 WO2005012327A2 (en) 2003-07-21 2004-07-20 Nucleotide phosphoramidates as anticancer agents

Publications (1)

Publication Number Publication Date
MXPA05012606A true MXPA05012606A (es) 2006-02-08

Family

ID=27772362

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05012606A MXPA05012606A (es) 2003-07-21 2004-07-20 Fosforamidatos de nucleosidos como agentes anticancerigenos.

Country Status (20)

Country Link
US (2) USRE47589E1 (es)
EP (5) EP2955190B1 (es)
JP (1) JP4923216B2 (es)
AU (1) AU2004261455B2 (es)
CA (1) CA2518115C (es)
CY (5) CY1117960T1 (es)
DK (4) DK2955190T3 (es)
ES (4) ES2589738T3 (es)
FI (1) FIC20230013I1 (es)
FR (1) FR23C1014I2 (es)
GB (1) GB0317009D0 (es)
HU (4) HUE030374T2 (es)
MX (1) MXPA05012606A (es)
NO (1) NO333603B1 (es)
NZ (1) NZ541974A (es)
PL (4) PL3040340T3 (es)
PT (4) PT3904365T (es)
SI (2) SI2955190T1 (es)
TR (1) TR201901246T4 (es)
WO (1) WO2005012327A2 (es)

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US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8809265B2 (en) 2011-10-21 2014-08-19 Abbvie Inc. Methods for treating HCV
US8853176B2 (en) 2011-10-21 2014-10-07 Abbvie Inc. Methods for treating HCV
US11192914B2 (en) 2016-04-28 2021-12-07 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto

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