TR201901246T4 - Kimyasal bileşikler. - Google Patents

Kimyasal bileşikler. Download PDF

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Publication number
TR201901246T4
TR201901246T4 TR2019/01246T TR201901246T TR201901246T4 TR 201901246 T4 TR201901246 T4 TR 201901246T4 TR 2019/01246 T TR2019/01246 T TR 2019/01246T TR 201901246 T TR201901246 T TR 201901246T TR 201901246 T4 TR201901246 T4 TR 201901246T4
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compound
compound according
group
formula
alkyl group
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TR2019/01246T
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Mcguigan Christopher
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NuCana plc
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Publication of TR201901246T4 publication Critical patent/TR201901246T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nükleotidlerin fosforamidat türevleri ve bunların kanser tedavisindeki kullanımları açıklanır. Örneğin deoksiüridin, sitarabin, gemsitabin ve sitidinden her birinin baz kısımları, 5-konumunda sübstitüe edilebilir. Fosforamidat kısmında, P atomuna aril-O ve bir ±-amino asit kısmı ekli olabilir. ±-amino asit kısmı, doğal olarak görülen veya doğal olarak görülmeyen amino asitten herhangi birine karşılık gelebilir veya bunlardan birinden derive edilebilir.

Claims (1)

  1. ISTEMLER . Forrnüle (I) sahip olan bir kimyasal bilesik: R, bir Ci-C16 dallanmis veya dallanmamis asiklik alkil grubu, bir C3- Ciz siklik alkil grubu, bir fenil grubu veya bir naftil grubu ve bir benzil grubundan seçilir; ve burada R sübsititüe edilmez; R' ve R" bagimsiz olarak H, metil (-CH3), benzil (-CH2C6H5) ve sekonder bütilden (-CHZCH(CH3)2 seçilir veya R' ve R" baglandiklari C atomu ile birlikte bir C5-6 halkasi saglar; X ve Y”nin her ikisi F”dir; Ar, naftil veya fenildir; ve ayni veya farkli olabilen bir, iki, üç veya dört sübstitüent, Ar üzerinde mevcut olabilir ve halojen,-N02; -NH2; -C1_3alkil; gruptan seçilir; Z H7dir; n 07d1r, Z' -NH2°dir ve konum 3 ile konum 4 arasinda bir çift bag mevcuttur; veya formül (I) üzerinde farmasötik olarak kabul edilebilir bir tuz, ester veya bu tür esterin tuzudur. . Istem 1,6 göre bir bilesiktir, burada R bir Ci-Cs, dallanmis veya dallanmamis asiklik alkil grubudur. Istem l”e göre bir bilesiktir, burada R, C5-C7 siklik alkil grubudur. Istem 1”e göre bir bilesiktir, burada R bir benzil grubudur. Istemler 1 ila 4”ten herhangi birine göre bir bilesiktir, burada R' ve R'”den biri H'dir ve R' ve R'"den biri metildir. Istemler 1 ila 55ten herhangi birinin bir bilesigidir, burada Ar naftildir. Istemler `l ila 6ldan herhangi birinin bir bilesigidir, burada Ar fenildir. Istemler 1 ila 7”den herhangi birinin bir bilesigidir, burada Ar sübstitüe edilmez. Istemler 1 ila Tden herhangi birinin bir bilesigidir, burada Ar üzerinde sübstitüentler F, Cl, CF3 ve NOzeden seçilebilir. Kanser profilaksisi veya tedavisinin bir yönteminde kullanilmaya yönelik istemler 1 ila 9,dan herhangi birine göre bir bilesiktir. Farmasötik olarak kabul edilebilir bir tasiyici, seyreltici veya eksipiyan ile kombinasyon içerisinde istemler 1 ila 9'dan herhangi birine göre bir bilesigi içeren farmasötik bir bilesimdir. Farinasötik olarak kabul edilebilir bir eksipiyan, tasiyici veya seyreltici ile istemler 1 ila 9,dan herhangi birine göre bir bilesigin kombine edilmesi adimini içeren, farmasötik bir bilesimin hazirlanmasina yönelik bir yöntemdir. Istein 1°e göre bir formül (l) bilesiginin hazirlanmasina yönelik bir prosestir, proses bir formül (III) bilesiginin: burada Ar, n, Q, R, R', R", X, Y, Z ve Z' istem 1°de açiklanan anlamlara sahiptir ve konum 3 ile konum 4 arasinda bir çift bag mevcuttur.15
TR2019/01246T 2003-07-21 2004-07-20 Kimyasal bileşikler. TR201901246T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0317009.9A GB0317009D0 (en) 2003-07-21 2003-07-21 Chemical compounds

Publications (1)

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TR201901246T4 true TR201901246T4 (tr) 2019-02-21

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TR2019/01246T TR201901246T4 (tr) 2003-07-21 2004-07-20 Kimyasal bileşikler.

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US (2) USRE47589E1 (tr)
EP (5) EP2955190B1 (tr)
JP (1) JP4923216B2 (tr)
AU (1) AU2004261455B2 (tr)
CA (1) CA2518115C (tr)
CY (5) CY1117960T1 (tr)
DK (4) DK2955190T3 (tr)
ES (4) ES2589738T3 (tr)
FI (1) FIC20230013I1 (tr)
FR (1) FR23C1014I2 (tr)
GB (1) GB0317009D0 (tr)
HU (4) HUE030374T2 (tr)
MX (1) MXPA05012606A (tr)
NO (1) NO333603B1 (tr)
NZ (1) NZ541974A (tr)
PL (4) PL3040340T3 (tr)
PT (4) PT3904365T (tr)
SI (2) SI2955190T1 (tr)
TR (1) TR201901246T4 (tr)
WO (1) WO2005012327A2 (tr)

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