CY1125603T1 - Χημικες ενωσεις - Google Patents
Χημικες ενωσειςInfo
- Publication number
- CY1125603T1 CY1125603T1 CY20221100667T CY221100667T CY1125603T1 CY 1125603 T1 CY1125603 T1 CY 1125603T1 CY 20221100667 T CY20221100667 T CY 20221100667T CY 221100667 T CY221100667 T CY 221100667T CY 1125603 T1 CY1125603 T1 CY 1125603T1
- Authority
- CY
- Cyprus
- Prior art keywords
- moiety
- amino acid
- chemical compounds
- naturally occurring
- phosphoramido
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 abstract 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 abstract 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229960000684 cytarabine Drugs 0.000 abstract 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 abstract 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 abstract 1
- 229960005277 gemcitabine Drugs 0.000 abstract 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 150000008039 phosphoramides Chemical class 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Περιγράφονται φωσφοραμιδικά παράγωγα των νουκλεοτιδίων και η χρήση τους στη θεραπεία του καρκίνου. Τα τμήματα βάσεως, για παράδειγμα, καθεμίας από δεοξυουριδίνη, κυταραβίνη, γεμσιταβίνη και κιτιδίνη μπορούν να υποκατασταθούν στη θέση 5. Το φωσφοραμιδικό τμήμα έχει προσαρτήσει στο άτομο Ρ ένα τμήμα αρυλ-Ο και ένα τμήμα α-αμινοξέος. Το τμήμα α-αμινοξέος μπορεί να αντιστοιχεί ή να προέρχεται από ένα φυσικώς απαντώμενο ή ένα μη φυσικώς απαντώμενο αμινοξύ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0317009.9A GB0317009D0 (en) | 2003-07-21 | 2003-07-21 | Chemical compounds |
EP21180706.0A EP3904365B1 (en) | 2003-07-21 | 2004-07-20 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1125603T1 true CY1125603T1 (el) | 2023-06-09 |
Family
ID=27772362
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100875T CY1117960T1 (el) | 2003-07-21 | 2016-09-05 | Φωσφοραμιδικα νουκλεοτιδια ως αντικαρκινικοι παραγοντες |
CY20181100460T CY1120202T1 (el) | 2003-07-21 | 2018-05-03 | Χημικες ενωσεις |
CY20191100124T CY1121218T1 (el) | 2003-07-21 | 2019-01-30 | Χημικες ενωσεις |
CY20221100667T CY1125603T1 (el) | 2003-07-21 | 2022-10-07 | Χημικες ενωσεις |
CY2023008C CY2023008I1 (el) | 2003-07-21 | 2023-02-28 | Χημικες ενωσεις |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100875T CY1117960T1 (el) | 2003-07-21 | 2016-09-05 | Φωσφοραμιδικα νουκλεοτιδια ως αντικαρκινικοι παραγοντες |
CY20181100460T CY1120202T1 (el) | 2003-07-21 | 2018-05-03 | Χημικες ενωσεις |
CY20191100124T CY1121218T1 (el) | 2003-07-21 | 2019-01-30 | Χημικες ενωσεις |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2023008C CY2023008I1 (el) | 2003-07-21 | 2023-02-28 | Χημικες ενωσεις |
Country Status (20)
Country | Link |
---|---|
US (2) | USRE47589E1 (el) |
EP (5) | EP2955190B1 (el) |
JP (1) | JP4923216B2 (el) |
AU (1) | AU2004261455B2 (el) |
CA (1) | CA2518115C (el) |
CY (5) | CY1117960T1 (el) |
DK (4) | DK3904365T3 (el) |
ES (4) | ES2708570T3 (el) |
FI (1) | FIC20230013I1 (el) |
FR (1) | FR23C1014I2 (el) |
GB (1) | GB0317009D0 (el) |
HU (4) | HUE030374T2 (el) |
MX (1) | MXPA05012606A (el) |
NO (1) | NO333603B1 (el) |
NZ (1) | NZ541974A (el) |
PL (4) | PL3040340T3 (el) |
PT (4) | PT3040340T (el) |
SI (2) | SI3040340T1 (el) |
TR (1) | TR201901246T4 (el) |
WO (1) | WO2005012327A2 (el) |
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