EA200701406A1 - Приемлемые для лечения вич соединения - Google Patents

Приемлемые для лечения вич соединения

Info

Publication number
EA200701406A1
EA200701406A1 EA200701406A EA200701406A EA200701406A1 EA 200701406 A1 EA200701406 A1 EA 200701406A1 EA 200701406 A EA200701406 A EA 200701406A EA 200701406 A EA200701406 A EA 200701406A EA 200701406 A1 EA200701406 A1 EA 200701406A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
accessible
hiv compounds
hiv
hydroxymethylcytosine
Prior art date
Application number
EA200701406A
Other languages
English (en)
Other versions
EA011039B1 (ru
Inventor
Сяо-Сюн Чжоу
Хун Чжан
Original Assignee
Медивир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05100063A external-priority patent/EP1679076A1/en
Application filed by Медивир Аб filed Critical Медивир Аб
Publication of EA200701406A1 publication Critical patent/EA200701406A1/ru
Publication of EA011039B1 publication Critical patent/EA011039B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Среди прочего предоставлено применение 2',3'-дидезокси-3'-С-гидроксиметилцитозина или его пролекарства или соли для производства лекарственного средства для лечения ВИЧ-инфекции, где обратная транскриптаза ВИЧ несет по меньшей мере одну мутацию, обеспечивающую удаление из возникающей цепи ДНК терминирующего облигатную цепь нуклеозид- или нуклеотидфосфата при помощи опосредованного АТФ или пирофосфатом удаления.
EA200701406A 2004-12-30 2005-12-28 Приемлемые для лечения вич соединения EA011039B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71453604P 2004-12-30 2004-12-30
EP05100063A EP1679076A1 (en) 2005-01-06 2005-01-06 Compounds useful in the treatment of HIV
PCT/EP2005/057196 WO2006070004A1 (en) 2004-12-30 2005-12-28 Compounds useful in the treatment of hiv

Publications (2)

Publication Number Publication Date
EA200701406A1 true EA200701406A1 (ru) 2008-02-28
EA011039B1 EA011039B1 (ru) 2008-12-30

Family

ID=39705001

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701406A EA011039B1 (ru) 2004-12-30 2005-12-28 Приемлемые для лечения вич соединения

Country Status (13)

Country Link
US (1) US7829548B2 (ru)
EP (1) EP1835916B1 (ru)
CN (1) CN101132795B (ru)
AT (1) ATE427110T1 (ru)
AU (1) AU2005321239B2 (ru)
BR (1) BRPI0519306A2 (ru)
CA (1) CA2594229A1 (ru)
DE (1) DE602005013697D1 (ru)
EA (1) EA011039B1 (ru)
ES (1) ES2325088T3 (ru)
HK (1) HK1107518A1 (ru)
WO (1) WO2006070004A1 (ru)
ZA (1) ZA200705835B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0513835D0 (en) * 2005-07-07 2005-08-10 Medivir Ab HIV inhibitors
CN101260135B (zh) * 2008-04-16 2011-05-25 厦门大学 一种高级脂肪酸齐多夫定酯的合成方法
US9187783B2 (en) 2010-10-04 2015-11-17 Genapsys, Inc. Systems and methods for automated reusable parallel biological reactions
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
AU2012262364B2 (en) * 2011-05-27 2016-02-11 Sequencing Health, Inc. Systems and methods for genetic and biological analysis
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
JP6193252B2 (ja) 2011-12-01 2017-09-06 ジナプシス インコーポレイテッド 高効率電子配列決定及び検出のためのシステム並びに方法
US9809852B2 (en) 2013-03-15 2017-11-07 Genapsys, Inc. Systems and methods for biological analysis
EP3080300B1 (en) 2013-12-11 2020-09-02 Genapsys Inc. Systems and methods for biological analysis and computation
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
SG11202002516WA (en) 2017-09-21 2020-04-29 Genapsys Inc Systems and methods for nucleic acid sequencing
CN110890132A (zh) * 2019-11-19 2020-03-17 湖南大学 基于自适应高斯混合模型的癌症突变簇识别方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810907D0 (en) 1988-05-09 1988-06-15 British Telecomm Fluoride glass optical coupler & method of manufacture
FI95384C (fi) 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
US5563257A (en) 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
DE4026265A1 (de) 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
DE4418690A1 (de) 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
EP0763048A1 (en) 1994-05-31 1997-03-19 Medivir Aktiebolag Post exposure prevention of hiv
US5612319A (en) 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
DE19602757A1 (de) 1996-01-26 1997-07-31 Boehringer Mannheim Gmbh Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives

Also Published As

Publication number Publication date
ATE427110T1 (de) 2009-04-15
EP1835916A1 (en) 2007-09-26
EA011039B1 (ru) 2008-12-30
ES2325088T3 (es) 2009-08-25
CA2594229A1 (en) 2006-07-06
US20080176817A1 (en) 2008-07-24
AU2005321239B2 (en) 2009-02-12
HK1107518A1 (en) 2008-04-11
ZA200705835B (en) 2008-05-28
BRPI0519306A2 (pt) 2009-01-06
DE602005013697D1 (de) 2009-05-14
US7829548B2 (en) 2010-11-09
EP1835916B1 (en) 2009-04-01
WO2006070004A1 (en) 2006-07-06
AU2005321239A1 (en) 2006-07-06
CN101132795B (zh) 2011-09-21
CN101132795A (zh) 2008-02-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU