ATE502038T1 - Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen - Google Patents
Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasenInfo
- Publication number
- ATE502038T1 ATE502038T1 AT07834863T AT07834863T ATE502038T1 AT E502038 T1 ATE502038 T1 AT E502038T1 AT 07834863 T AT07834863 T AT 07834863T AT 07834863 T AT07834863 T AT 07834863T AT E502038 T1 ATE502038 T1 AT E502038T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrolases
- azyclic
- compounds
- nucleoside phosphorylases
- amine inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000004157 Hydrolases Human genes 0.000 title 1
- 108090000604 Hydrolases Proteins 0.000 title 1
- 102000009097 Phosphorylases Human genes 0.000 title 1
- 108010073135 Phosphorylases Proteins 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000010722 N-Glycosyl Hydrolases Human genes 0.000 abstract 2
- 108010063372 N-Glycosyl Hydrolases Proteins 0.000 abstract 2
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 abstract 2
- 108700006317 Purine-nucleoside phosphorylases Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010037075 Protozoal infections Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84286706P | 2006-09-07 | 2006-09-07 | |
| PCT/NZ2007/000261 WO2008030119A1 (en) | 2006-09-07 | 2007-09-07 | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502038T1 true ATE502038T1 (de) | 2011-04-15 |
Family
ID=39157466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07834863T ATE502038T1 (de) | 2006-09-07 | 2007-09-07 | Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8853224B2 (de) |
| EP (2) | EP2395005A1 (de) |
| JP (1) | JP5388067B2 (de) |
| KR (1) | KR101433621B1 (de) |
| CN (1) | CN101528749B (de) |
| AT (1) | ATE502038T1 (de) |
| AU (1) | AU2007293774C1 (de) |
| CA (1) | CA2662628C (de) |
| CY (1) | CY1111507T1 (de) |
| DE (1) | DE602007013252D1 (de) |
| DK (1) | DK2057165T3 (de) |
| ES (1) | ES2362805T3 (de) |
| HR (1) | HRP20110408T1 (de) |
| NZ (1) | NZ575365A (de) |
| PL (1) | PL2057165T3 (de) |
| PT (1) | PT2057165E (de) |
| RS (1) | RS51864B (de) |
| SI (1) | SI2057165T1 (de) |
| WO (1) | WO2008030119A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2363766T3 (es) | 2002-08-21 | 2011-08-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibidores de nucleosidasas y fosforilasas de nucleosidos. |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| US8541567B2 (en) * | 2005-07-27 | 2013-09-24 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| US8394950B2 (en) * | 2006-02-22 | 2013-03-12 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
| US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
| EP2049543B1 (de) | 2006-09-07 | 2014-11-05 | Callaghan Innovation Research Limited | Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| US20090247750A1 (en) * | 2008-03-28 | 2009-10-01 | Biocryst Pharmaceuticals, Inc. | Process for preparing nucleoside analogs |
| EP2348854A4 (de) * | 2008-09-22 | 2012-03-14 | Einstein Coll Med | Verfahren und zusammensetzungen für die behandlung von bakteriellen infektionen durch hemmung des »quorum sensing |
| AU2010271532B2 (en) | 2009-07-17 | 2016-03-03 | Albert Einstein College Of Medicine, Inc. | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| AR077898A1 (es) | 2009-08-26 | 2011-09-28 | Nycomed Gmbh | Metilpirrolopirimidincarboxamidas |
| PH12012500734A1 (en) | 2009-10-16 | 2012-11-26 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| JP2013508299A (ja) | 2009-10-16 | 2013-03-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| CN102712647B (zh) | 2009-10-16 | 2018-04-24 | 梅琳塔治疗公司 | 抗微生物化合物和其制备和使用方法 |
| EP2898885B1 (de) | 2010-10-15 | 2017-11-22 | Biocryst Pharmaceuticals, Inc. | Pyrrolopyrimidin-Derivate zur Verwendung bei der Behandlung von viralen Infektionen |
| US9290501B2 (en) | 2010-11-29 | 2016-03-22 | Albert Einstein College Of Medicine, Inc. | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
| WO2012071896A1 (en) * | 2010-11-30 | 2012-06-07 | Wuxi Adessonanotech Co., Limited | Novel agents for reworkable epoxy resins |
| CN103958514B (zh) | 2011-04-15 | 2018-07-03 | 梅琳塔治疗公司 | 抗微生物化合物及制备和使用所述化合物的方法 |
| WO2012150866A1 (en) * | 2011-05-03 | 2012-11-08 | Industrial Research Limited | Phosphoribosyltransferase inhibitors and uses thereof |
| DK2741765T3 (en) | 2011-08-10 | 2016-06-13 | Adocia | Injectable solution of at least one type of basal insulin |
| CN107583039A (zh) | 2012-01-09 | 2018-01-16 | 阿道恰公司 | Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液 |
| US11186575B2 (en) | 2012-08-07 | 2021-11-30 | Alber Einslein College of Medicine | Treatment of helicobacter pylori infections |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| FR3001895B1 (fr) | 2013-02-12 | 2015-07-03 | Adocia | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
| US9616129B2 (en) | 2013-06-22 | 2017-04-11 | Nitor Therapeutics | Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency |
| PT3019503T (pt) | 2013-07-12 | 2017-11-27 | Gilead Sciences Inc | Compostos carbamoílpiridona- policíclicos e seu uso para o tratamento de infecções por hiv |
| NO2865735T3 (de) | 2013-07-12 | 2018-07-21 | ||
| EP3038623A4 (de) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimikrobielle verbindungen und verfahren zur herstellung und verwendung davon |
| MX2016002975A (es) | 2013-09-09 | 2016-10-21 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
| EP3104707B1 (de) | 2014-02-12 | 2020-07-15 | Albert Einstein College of Medicine, Inc. | Behandlung von infektionen mit h. pylori mittels mtan-inhibitoren |
| BR112017019349A2 (pt) | 2015-03-11 | 2018-06-05 | Melinta Therapeutics Inc | compostos antimicrobianos e métodos de fabricação e uso dos mesmos |
| US10512649B2 (en) | 2016-03-06 | 2019-12-24 | Biocryst Pharmaceuticals, Inc. | Methods and compositions for treatment of zika virus infection |
| EP3835285A1 (de) * | 2016-03-15 | 2021-06-16 | Shionogi & Co., Ltd | Verfahren zur herstellung eines phenoxyethanolderivats |
| US11098047B2 (en) | 2016-05-06 | 2021-08-24 | BioVersys AG | Antimicrobials and methods of making and using same |
| CN113045484B (zh) * | 2019-12-27 | 2024-01-26 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法 |
| CN111320634A (zh) * | 2020-04-14 | 2020-06-23 | 浙江工业大学 | 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法 |
| GB202218782D0 (en) | 2022-12-13 | 2023-01-25 | Mehrling Thomas | Purine nucleoside phosphorylase inhibitor for metabolic syndrome |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0920777A (ja) * | 1995-06-30 | 1997-01-21 | Nippon Paper Ind Co Ltd | 新規なプリンヌクレオシド誘導体、その製造方法及びその誘導体を有効成分とする酵素阻害剤 |
| WO1997031008A1 (en) | 1996-02-23 | 1997-08-28 | Industrial Research Limited | Enzyme detection/assay method and substrates |
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| US6228741B1 (en) | 1998-01-13 | 2001-05-08 | Texas Instruments Incorporated | Method for trench isolation of semiconductor devices |
| SI2077268T1 (sl) | 1999-04-08 | 2017-07-31 | Victoria Link Limited | Postopek za pripravo inhibitorjev nukleozidnega metabolizma |
| US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
| US7109331B2 (en) | 2000-08-29 | 2006-09-19 | Industrial Research Limited | 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors |
| US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
| JP2002296365A (ja) * | 2001-03-29 | 2002-10-09 | Seiko Epson Corp | 電子機器、電子制御式機械時計、電子機器の制御方法 |
| TW200306191A (en) | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
| US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| ES2363766T3 (es) | 2002-08-21 | 2011-08-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibidores de nucleosidasas y fosforilasas de nucleosidos. |
| GB0301736D0 (en) | 2003-01-24 | 2003-02-26 | Xenova Ltd | Pharmaceutical compounds |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| WO2006014913A2 (en) | 2004-07-27 | 2006-02-09 | Biocryst Pharmaceuticals, Inc. | Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase |
| NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| US8541567B2 (en) | 2005-07-27 | 2013-09-24 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| US20090192138A1 (en) | 2005-12-23 | 2009-07-30 | Daniel Kaspar Baeschlin | compounds |
| US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
| JP2009528996A (ja) | 2006-02-24 | 2009-08-13 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法 |
| EP2049543B1 (de) | 2006-09-07 | 2014-11-05 | Callaghan Innovation Research Limited | Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase |
| US20100062995A1 (en) | 2006-09-26 | 2010-03-11 | Schramm Vern L | Transition state structure of human 5'methylthioadenosine phosphorylase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| EP2348854A4 (de) | 2008-09-22 | 2012-03-14 | Einstein Coll Med | Verfahren und zusammensetzungen für die behandlung von bakteriellen infektionen durch hemmung des »quorum sensing |
| AU2010271532B2 (en) | 2009-07-17 | 2016-03-03 | Albert Einstein College Of Medicine, Inc. | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
-
2007
- 2007-09-07 CN CN2007800402949A patent/CN101528749B/zh active Active
- 2007-09-07 DK DK07834863.8T patent/DK2057165T3/da active
- 2007-09-07 NZ NZ575365A patent/NZ575365A/en unknown
- 2007-09-07 CA CA2662628A patent/CA2662628C/en active Active
- 2007-09-07 EP EP11158228A patent/EP2395005A1/de not_active Withdrawn
- 2007-09-07 PL PL07834863T patent/PL2057165T3/pl unknown
- 2007-09-07 US US12/310,708 patent/US8853224B2/en active Active
- 2007-09-07 RS RS20110192A patent/RS51864B/sr unknown
- 2007-09-07 WO PCT/NZ2007/000261 patent/WO2008030119A1/en not_active Ceased
- 2007-09-07 HR HR20110408T patent/HRP20110408T1/hr unknown
- 2007-09-07 SI SI200730602T patent/SI2057165T1/sl unknown
- 2007-09-07 AT AT07834863T patent/ATE502038T1/de active
- 2007-09-07 ES ES07834863T patent/ES2362805T3/es active Active
- 2007-09-07 PT PT07834863T patent/PT2057165E/pt unknown
- 2007-09-07 JP JP2009527314A patent/JP5388067B2/ja active Active
- 2007-09-07 AU AU2007293774A patent/AU2007293774C1/en active Active
- 2007-09-07 EP EP07834863A patent/EP2057165B1/de active Active
- 2007-09-07 DE DE602007013252T patent/DE602007013252D1/de active Active
- 2007-09-07 KR KR1020097006628A patent/KR101433621B1/ko active Active
-
2011
- 2011-05-31 CY CY20111100525T patent/CY1111507T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ575365A (en) | 2012-02-24 |
| RS51864B (sr) | 2012-02-29 |
| DK2057165T3 (da) | 2011-06-27 |
| PL2057165T3 (pl) | 2011-08-31 |
| DE602007013252D1 (de) | 2011-04-28 |
| HK1131612A1 (en) | 2010-01-29 |
| KR101433621B1 (ko) | 2014-08-27 |
| HRP20110408T1 (hr) | 2011-06-30 |
| US8853224B2 (en) | 2014-10-07 |
| US20110130412A1 (en) | 2011-06-02 |
| CA2662628C (en) | 2016-02-09 |
| CA2662628A1 (en) | 2008-03-13 |
| JP2010502696A (ja) | 2010-01-28 |
| WO2008030119A9 (en) | 2009-09-24 |
| CN101528749A (zh) | 2009-09-09 |
| AU2007293774A1 (en) | 2008-03-13 |
| PT2057165E (pt) | 2011-05-12 |
| EP2057165B1 (de) | 2011-03-16 |
| WO2008030119A1 (en) | 2008-03-13 |
| AU2007293774B2 (en) | 2013-07-04 |
| CY1111507T1 (el) | 2015-08-05 |
| EP2057165A1 (de) | 2009-05-13 |
| JP5388067B2 (ja) | 2014-01-15 |
| EP2057165A4 (de) | 2009-09-02 |
| AU2007293774C1 (en) | 2014-12-18 |
| EP2395005A1 (de) | 2011-12-14 |
| SI2057165T1 (sl) | 2011-07-29 |
| ES2362805T3 (es) | 2011-07-13 |
| KR20090069281A (ko) | 2009-06-30 |
| CN101528749B (zh) | 2013-07-31 |
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