BR112017019349A2 - compostos antimicrobianos e métodos de fabricação e uso dos mesmos - Google Patents

compostos antimicrobianos e métodos de fabricação e uso dos mesmos

Info

Publication number
BR112017019349A2
BR112017019349A2 BR112017019349A BR112017019349A BR112017019349A2 BR 112017019349 A2 BR112017019349 A2 BR 112017019349A2 BR 112017019349 A BR112017019349 A BR 112017019349A BR 112017019349 A BR112017019349 A BR 112017019349A BR 112017019349 A2 BR112017019349 A2 BR 112017019349A2
Authority
BR
Brazil
Prior art keywords
manufacture
methods
antimicrobial compounds
compounds
antimicrobial
Prior art date
Application number
BR112017019349A
Other languages
English (en)
Inventor
Bhattacharjee Ashoke
M Duffy Erin
Chowdhury Somenath
THAKUR Vinay
Lau Wan
F Kanyo Zoltan
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of BR112017019349A2 publication Critical patent/BR112017019349A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

a presente invenção refere-se em geral ao campo de compostos antimicrobianos e a métodos de fabricação e uso dos mesmos. esses compostos são úteis para tratamento, prevenção, redução do risco e retardo do início de infecções microbianas em humanos e animais.
BR112017019349A 2015-03-11 2016-03-11 compostos antimicrobianos e métodos de fabricação e uso dos mesmos BR112017019349A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131751P 2015-03-11 2015-03-11
PCT/US2016/022216 WO2016145417A1 (en) 2015-03-11 2016-03-11 Antimicrobial compounds and methods of making and using the same

Publications (1)

Publication Number Publication Date
BR112017019349A2 true BR112017019349A2 (pt) 2018-06-05

Family

ID=56879869

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017019349A BR112017019349A2 (pt) 2015-03-11 2016-03-11 compostos antimicrobianos e métodos de fabricação e uso dos mesmos

Country Status (16)

Country Link
US (1) US10947237B2 (pt)
EP (1) EP3268370A4 (pt)
JP (1) JP2018507881A (pt)
KR (1) KR20180015114A (pt)
CN (1) CN107922418A (pt)
AU (1) AU2016228584A1 (pt)
BR (1) BR112017019349A2 (pt)
CA (1) CA2979342A1 (pt)
EA (1) EA201792006A1 (pt)
HK (1) HK1249758A1 (pt)
IL (1) IL254398A0 (pt)
MA (1) MA42055A (pt)
MX (1) MX2017011616A (pt)
PH (1) PH12017501646A1 (pt)
SG (1) SG11201707346RA (pt)
WO (1) WO2016145417A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
US20180141897A1 (en) 2014-12-08 2018-05-24 The Research Foundation For The State University Of New York Anti-fungals targeting the synthesis of fungal shingolipids
US11098047B2 (en) * 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
WO2017193023A1 (en) * 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
AU2017326253B2 (en) 2016-09-13 2021-10-21 Allergan, Inc. Stabilized non-protein clostridial toxin compositions
EP3638649A4 (en) 2017-06-16 2021-03-17 The Research Foundation for The State University of New York FUNGUSKID AGENTS AGAINST THE SYNTHESIS OF FUNGAL SHINGOLIPIDS
WO2018236692A1 (en) * 2017-06-19 2018-12-27 Duffy Erin M ANTIMICROBIAL AGENTS AND METHODS OF PREPARATION AND USE
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
JP7395493B2 (ja) * 2018-03-28 2023-12-11 デックスコム・インコーポレーテッド 機械コネクタを含むセンサケーブル支持装置
WO2019234509A2 (en) * 2018-06-06 2019-12-12 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
WO2019234508A1 (en) * 2018-06-06 2019-12-12 BioVersys AG Biodefense agents
CN113924292A (zh) * 2019-01-16 2022-01-11 库扎环球有限责任公司 抗微生物化合物和方法
CN113825748A (zh) * 2019-01-16 2021-12-21 库扎环球有限责任公司 抗微生物化合物和方法
CA3158103A1 (en) * 2019-11-13 2021-05-20 Curza Global, Llc Antimicrobial compounds and methods
TW202342060A (zh) * 2021-12-06 2023-11-01 美商普萊萃歐治療公司 Lonp1抑制劑化合物、用途及方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624731A (en) 1953-01-06 S-phenylpyrimidkn e x derivativesx
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US3673184A (en) 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US4361557A (en) 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0067610A1 (en) 1981-06-16 1982-12-22 Beecham Group Plc Penicillins, a process for their preparation and compositions containing them
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ZA835684B (en) 1982-08-27 1985-03-27 Roussel Uclaf Imidazo(1,2-a)pyrimidines
US5332835A (en) 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
JPS6191184A (ja) 1984-10-08 1986-05-09 Morishita Seiyaku Kk 2−アニリノ−5−(1h−テトラゾ−ル−5−イル)ピリミジン−4(3h)−オン誘導体
DE3446812A1 (de) 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
JP2873340B2 (ja) 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質tan―1057,その製造法および用途
JP2549931B2 (ja) 1990-01-12 1996-10-30 株式会社大塚製薬工場 ピリミドベンズイミダゾール誘導体
JP2991382B2 (ja) 1990-07-18 1999-12-20 大日本製薬株式会社 縮合三環式化合物およびその塩
US5208141A (en) 1990-10-09 1993-05-04 Konica Corporation Silver halide color photographic light-sensitive material
JP2811230B2 (ja) 1990-10-17 1998-10-15 コニカ株式会社 新規な写真用カプラー
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
PL174704B1 (pl) 1993-05-12 1998-09-30 Du Pont Nowe 4(3H)-chinazolinony i środek grzybobójczy do zwalczania mączniaka pszenicy
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TW424090B (en) 1995-08-18 2001-03-01 Nat Science Council Pyrimidines as folate antimetabolites with selective activity against human brain cancer
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
US6110925A (en) 1997-08-07 2000-08-29 Research Corporation Technologies, Inc. Antibiotic for methicillin resistant bacteria
CA2309340C (en) 1997-11-07 2006-02-21 Isis Pharmaceuticals Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
DE19838998A1 (de) 1998-08-27 2000-03-09 Bayer Ag Neue Naturstoffderivate
SE9903894D0 (sv) 1999-10-28 1999-10-28 New Pharma Research Ab Novel compounds
EP1113008A1 (en) 1999-12-29 2001-07-04 Pfizer Products Inc. 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents
KR100358083B1 (ko) 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
DE10061538A1 (de) 2000-12-11 2002-06-20 Bayer Ag Ureido-Dihydropyrimidinone
DE10061541A1 (de) 2000-12-11 2002-06-20 Bayer Ag Arylamino-Dihydropyrimidinone
DE10061537A1 (de) 2000-12-11 2002-06-20 Bayer Ag beta-Alanin-Derivate
DE10061542A1 (de) 2000-12-11 2002-06-13 Bayer Ag Alkanoylamino-pyrimidine
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
US6900215B2 (en) 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
EP1363640B1 (en) 2001-01-29 2010-04-28 Bio-Rad Laboratories, Inc. Nucleic acid derivatives
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US20030207804A1 (en) 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
JP2005504020A (ja) 2001-07-03 2005-02-10 アイシス・ファーマシューティカルス・インコーポレーテッド ヌクレアーゼ耐性キメラオリゴヌクレオチド
US20030158403A1 (en) 2001-07-03 2003-08-21 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
DE10133277A1 (de) 2001-07-09 2003-01-23 Bayer Ag ß-Alanin-Derivate
DE10141271A1 (de) 2001-08-23 2003-03-06 Bayer Ag Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung
JP4306206B2 (ja) 2001-09-04 2009-07-29 住友化学株式会社 イミダゾ[1,2−a]ピリミジン、その用途およびその製造中間体
DE10208256A1 (de) 2002-02-26 2003-09-04 Bayer Ag Piperidinouracile
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
WO2003077828A2 (en) 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
WO2004080466A1 (en) 2003-03-07 2004-09-23 Ribapharm Inc. Cytidine analogs and methods of use
EA009038B1 (ru) 2003-07-30 2007-10-26 Лабораториос С.А.Л.В.А.Т., С.А. Замещенные имидазопиримидины для предупреждения и лечения рака
KR20060069836A (ko) 2003-08-12 2006-06-22 아칠리온 파르마세우티칼스 인코포레이티드 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물
MXPA06002001A (es) 2003-08-26 2006-06-20 Teijin Pharma Ltd Derivados pirrolopirimidinona.
TW200524880A (en) 2003-10-21 2005-08-01 Sankyo Co Pyrimidine compounds
EP1781788A2 (en) 2004-06-30 2007-05-09 ZGene A/S Chicken deoxycytidine and deoxyadenosine kinase enzymes and their use
ATE482219T1 (de) 2005-07-27 2010-10-15 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel
CN101360720A (zh) 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
JP2007270087A (ja) 2006-03-31 2007-10-18 Fujifilm Corp 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版
ATE496766T1 (de) 2006-03-03 2011-02-15 Fujifilm Corp Härtbare zusammensetzung, tintenzusammensetzung, tintenstrahlaufzeichnungsverfahren und flachdruckplatte
WO2007101871A1 (de) 2006-03-08 2007-09-13 Basf Se Substituierte imidazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
AU2007270276A1 (en) 2006-07-03 2008-01-10 Sk Chemicals Co., Ltd. Salts of pyrrolopyrimidinone derivatives and process for preparing the same
KR20080003599A (ko) 2006-07-03 2008-01-08 에스케이케미칼주식회사 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법
US20100112561A1 (en) 2006-08-25 2010-05-06 Stefan Lutz Fluorescent nucleoside analogues
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
WO2008143729A2 (en) 2007-02-28 2008-11-27 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
EP1964841A1 (en) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine and their use as pharmaceuticals
US20080221094A1 (en) 2007-03-07 2008-09-11 Harald Bluhm Metalloprotease inhibitors containing a squaramide moiety
JP2008222557A (ja) 2007-03-08 2008-09-25 Kotobuki Seiyaku Kk ピロロ[3,2−d]ピリミジン誘導体及びこれを有効成分とする医薬組成物
PE20090758A1 (es) 2007-05-30 2009-06-24 Schering Plough Ltd Un proceso para la preparacion de compuestos de aminodiol protegidos con oxazolina, utiles como intermediarios para florfenicol
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
US20110046142A1 (en) 2007-06-13 2011-02-24 Northeastern University Antibiotic compounds
GB0724342D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
WO2010087467A1 (en) 2009-01-27 2010-08-05 Takeda Pharmaceutical Company Limited Delta-5-desaturase inhibitors
US8975389B2 (en) 2009-03-02 2015-03-10 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
EP2501696B1 (en) 2009-10-15 2016-12-28 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
KR101972992B1 (ko) 2009-10-16 2019-04-29 멜린타 서브시디어리 코프. 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
TW201726630A (zh) 2009-10-16 2017-08-01 梅林塔療法公司 抗微生物性化合物及其製造與使用方法
WO2012125832A2 (en) 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
CA2833169A1 (en) 2011-04-15 2012-12-20 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス,インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
AU2014315050A1 (en) * 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same

Also Published As

Publication number Publication date
KR20180015114A (ko) 2018-02-12
CA2979342A1 (en) 2016-09-15
HK1249758A1 (zh) 2018-11-09
AU2016228584A1 (en) 2017-10-05
SG11201707346RA (en) 2017-10-30
MX2017011616A (es) 2018-04-11
WO2016145417A1 (en) 2016-09-15
US20180065966A1 (en) 2018-03-08
US10947237B2 (en) 2021-03-16
JP2018507881A (ja) 2018-03-22
EP3268370A1 (en) 2018-01-17
PH12017501646A1 (en) 2018-03-12
EA201792006A1 (ru) 2018-04-30
EP3268370A4 (en) 2018-08-22
MA42055A (fr) 2018-03-14
IL254398A0 (en) 2017-11-30
CN107922418A (zh) 2018-04-17

Similar Documents

Publication Publication Date Title
BR112017019349A2 (pt) compostos antimicrobianos e métodos de fabricação e uso dos mesmos
PH12016500453A1 (en) Antimicrobial compounds and methods of making and using the same
EA201890201A1 (ru) Антибактериальные соединения
HK1220624A1 (zh) 抗微生物劑的組合物和製劑、它們的方法以及用於治療微生物感染的方法
EA201990043A1 (ru) Антибактериальные соединения
MD3209381T2 (ro) Compoziții care conțin tulpini bacteriene
EA201391536A1 (ru) Противомикробные соединения и способы их получения и применения
GB2609346B (en) Treating & preventing microbial infections
BR112017007543A2 (pt) peptídeos com propriedades anti-inflamatórias
EP3390357A4 (en) BIARYLMONOBACTAM COMPOUNDS AND CORRESPONDING METHODS OF USE FOR THE TREATMENT OF BACTERIAL INFECTIONS
EA201990044A1 (ru) Гетероциклические соединения в качестве антибактериальных средств
CY1122805T1 (el) Ενωσεις και μεθοδοι για την αγωγη βακτηριακων λοιμωξεων
EP3374350A4 (en) HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
EP3280722B8 (en) Antimicrobial peptides and their use for the treatment of topical infections
IL271863B (en) Compounds and their use for the treatment of microbial infections
TR201901906T4 (tr) Yeni bakteriyofaj ve bunu içeren antibakteriyel bileşim.
MX2018013545A (es) Antimicrobianos y metodos de preparacion y uso de los mismos.
MX2017005249A (es) Compuestos para usarse en el tratamiento antihelmintico.
BR112018000056A2 (pt) bactérias oxidantes de amônia para tratamento de acne
EP3617204A4 (en) INDOLAMINE-2,3-DIOXYGENASE INHIBITOR AND APPLICATION
MX2017001047A (es) Compuestos para usar en el tratamiento antihelmintico.
EP3327000A4 (en) NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING THE SAME AS ACTIVE INGREDIENT
MX2020005056A (es) Emulsiones para el tratamiento tópico de infecciones dérmicas y de mucosas.
IN2013MU03216A (pt)
DK3432900T3 (da) Mælkesyrebakteriesammensæting til behandling af bakterielle vaginale infektioner forårsaget af gardnerella vaginalis og, hvis de forefindes, samtidige svampeinfektioner

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]