HK1249758A1 - 抗微生物化合物及其製備和使用方法 - Google Patents

抗微生物化合物及其製備和使用方法

Info

Publication number
HK1249758A1
HK1249758A1 HK18109253.3A HK18109253A HK1249758A1 HK 1249758 A1 HK1249758 A1 HK 1249758A1 HK 18109253 A HK18109253 A HK 18109253A HK 1249758 A1 HK1249758 A1 HK 1249758A1
Authority
HK
Hong Kong
Prior art keywords
making
methods
same
antimicrobial compounds
antimicrobial
Prior art date
Application number
HK18109253.3A
Other languages
English (en)
Inventor
Ashoke Bhattacharjee
Erin M Duffy
Zoltan F Kanyo
Somenath Chowdhury
Vinay Thakur
Wan LAU
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of HK1249758A1 publication Critical patent/HK1249758A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK18109253.3A 2015-03-11 2018-07-17 抗微生物化合物及其製備和使用方法 HK1249758A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131751P 2015-03-11 2015-03-11
PCT/US2016/022216 WO2016145417A1 (en) 2015-03-11 2016-03-11 Antimicrobial compounds and methods of making and using the same

Publications (1)

Publication Number Publication Date
HK1249758A1 true HK1249758A1 (zh) 2018-11-09

Family

ID=56879869

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109253.3A HK1249758A1 (zh) 2015-03-11 2018-07-17 抗微生物化合物及其製備和使用方法

Country Status (16)

Country Link
US (1) US10947237B2 (zh)
EP (1) EP3268370A4 (zh)
JP (1) JP2018507881A (zh)
KR (1) KR20180015114A (zh)
CN (1) CN107922418A (zh)
AU (1) AU2016228584A1 (zh)
BR (1) BR112017019349A2 (zh)
CA (1) CA2979342A1 (zh)
EA (1) EA201792006A1 (zh)
HK (1) HK1249758A1 (zh)
IL (1) IL254398A0 (zh)
MA (1) MA42055A (zh)
MX (1) MX2017011616A (zh)
PH (1) PH12017501646A1 (zh)
SG (1) SG11201707346RA (zh)
WO (1) WO2016145417A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012004341A (es) 2009-10-16 2012-10-05 Rib X Pharmaceuticals Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
US10106543B2 (en) 2013-09-09 2018-10-23 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2016094307A1 (en) 2014-12-08 2016-06-16 The Research Foundation For The State University Of New York Anti-fungals targeting the synthesis of fungal shingolipids
EP3452479A1 (en) * 2016-05-06 2019-03-13 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
US10934295B2 (en) * 2016-05-06 2021-03-02 BioVersys AG Antimicrobials and methods of making and using same
RU2019110875A (ru) 2016-09-13 2020-10-15 Аллерган, Инк. Небелковые композиции клостридиального токсина
US11414378B2 (en) 2017-06-16 2022-08-16 The Research Foundation For The State University Of New York Anti-fungals compounds targeting the synthesis of fungal sphingolipids
US20210147422A1 (en) * 2017-06-19 2021-05-20 BioVersys AG Antimicrobials and methods of making and using same
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
US10588551B2 (en) * 2018-03-28 2020-03-17 Dexcom, Inc. Sensor cable support device including mechanical connectors
US20210253589A1 (en) * 2018-06-06 2021-08-19 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
US20210253577A1 (en) * 2018-06-06 2021-08-19 BioVersys AG Biodefense agents
EP3911643A1 (en) * 2019-01-16 2021-11-24 Curza Global LLC Antimicrobial compounds and methods
JP2022518229A (ja) * 2019-01-16 2022-03-14 カーザ グローバル， エルエルシー 抗菌化合物及び方法
EP4058146A1 (en) * 2019-11-13 2022-09-21 Curza Global LLC Antimicrobial compounds and methods
TW202339706A (zh) * 2021-12-06 2023-10-16 美商普萊萃歐治療公司 含醯胺的ｌｏｎｐ１抑制劑化合物、用途及方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624731A (en) 1953-01-06 S-phenylpyrimidkn e x derivativesx
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US3673184A (en) 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US4361557A (en) 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0067610A1 (en) 1981-06-16 1982-12-22 Beecham Group Plc Penicillins, a process for their preparation and compositions containing them
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ZA835684B (en) 1982-08-27 1985-03-27 Roussel Uclaf Imidazo(1,2-a)pyrimidines
US5332835A (en) 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
JPS6191184A (ja) 1984-10-08 1986-05-09 Morishita Seiyaku Kk ２−アニリノ−５−（１ｈ−テトラゾ−ル−５−イル）ピリミジン−４（３ｈ）−オン誘導体
DE3446812A1 (de) 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
JP2873340B2 (ja) 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
JP2549931B2 (ja) 1990-01-12 1996-10-30 株式会社大塚製薬工場 ピリミドベンズイミダゾール誘導体
JP2991382B2 (ja) 1990-07-18 1999-12-20 大日本製薬株式会社 縮合三環式化合物およびその塩
US5208141A (en) 1990-10-09 1993-05-04 Konica Corporation Silver halide color photographic light-sensitive material
JP2811230B2 (ja) 1990-10-17 1998-10-15 コニカ株式会社 新規な写真用カプラー
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
HU218381B (hu) 1993-05-12 2000-08-28 E.I. Du Pont De Nemours And Co. 4-(3H)-kinazolin-származékok, azokat hatóanyagként tartalmazó fungicid készítmények és eljárás a készítmények alkalmazására
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TW424090B (en) 1995-08-18 2001-03-01 Nat Science Council Pyrimidines as folate antimetabolites with selective activity against human brain cancer
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
US6110925A (en) 1997-08-07 2000-08-29 Research Corporation Technologies, Inc. Antibiotic for methicillin resistant bacteria
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
ATE284407T1 (de) 1997-11-07 2004-12-15 Isis Pharmaceuticals Inc Pyrimidinderivate als markierte bindungspartner
DE19838998A1 (de) 1998-08-27 2000-03-09 Bayer Ag Neue Naturstoffderivate
SE9903894D0 (sv) 1999-10-28 1999-10-28 New Pharma Research Ab Novel compounds
EP1113008A1 (en) 1999-12-29 2001-07-04 Pfizer Products Inc. 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents
KR100358083B1 (ko) 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
PT1411954E (pt) 2000-10-18 2011-03-16 Pharmasset Inc Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal
DE10061541A1 (de) 2000-12-11 2002-06-20 Bayer Ag Arylamino-Dihydropyrimidinone
DE10061538A1 (de) 2000-12-11 2002-06-20 Bayer Ag Ureido-Dihydropyrimidinone
DE10061537A1 (de) 2000-12-11 2002-06-20 Bayer Ag beta-Alanin-Derivate
DE10061542A1 (de) 2000-12-11 2002-06-13 Bayer Ag Alkanoylamino-pyrimidine
JP2004515548A (ja) 2000-12-14 2004-05-27 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン
US6900215B2 (en) 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
CA2436665C (en) 2001-01-29 2012-01-10 Bio-Rad Laboratories, Inc. Nucleic acid derivatives
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US20030207804A1 (en) 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
US20030158403A1 (en) 2001-07-03 2003-08-21 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
WO2003004602A2 (en) 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
DE10133277A1 (de) 2001-07-09 2003-01-23 Bayer Ag ß-Alanin-Derivate
DE10141271A1 (de) 2001-08-23 2003-03-06 Bayer Ag Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung
JP4306206B2 (ja) 2001-09-04 2009-07-29 住友化学株式会社 イミダゾ［１，２−ａ］ピリミジン、その用途およびその製造中間体
DE10208256A1 (de) 2002-02-26 2003-09-04 Bayer Ag Piperidinouracile
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
CN1649829A (zh) 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
AU2003225705A1 (en) 2003-03-07 2004-09-30 Ribapharm Inc. Cytidine analogs and methods of use
CN1860121A (zh) 2003-07-30 2006-11-08 S.A.L.V.A.T.实验室有限公司 用于预防和治疗癌症的取代咪唑并嘧啶
WO2005019228A1 (en) 2003-08-12 2005-03-03 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
TW200509938A (en) 2003-08-26 2005-03-16 Teijin Pharma Ltd Pyrrolopyrimidine thion derivatives
TW200524880A (en) 2003-10-21 2005-08-01 Sankyo Co Pyrimidine compounds
US20070248543A1 (en) 2004-06-30 2007-10-25 Zgene A/S Chicken Deoxycytidine and Deoxyadenosine Kinase Enzymes and Their Use
WO2007014308A1 (en) 2005-07-27 2007-02-01 Achillion Pharmaceuticals, Inc. 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
CN101360720A (zh) 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
ATE496766T1 (de) 2006-03-03 2011-02-15 Fujifilm Corp Härtbare zusammensetzung, tintenzusammensetzung, tintenstrahlaufzeichnungsverfahren und flachdruckplatte
JP2007270087A (ja) 2006-03-31 2007-10-18 Fujifilm Corp 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版
WO2007101871A1 (de) 2006-03-08 2007-09-13 Basf Se Substituierte imidazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
KR20080003599A (ko) 2006-07-03 2008-01-08 에스케이케미칼주식회사 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법
AU2007270276A1 (en) 2006-07-03 2008-01-10 Sk Chemicals Co., Ltd. Salts of pyrrolopyrimidinone derivatives and process for preparing the same
US20100112561A1 (en) 2006-08-25 2010-05-06 Stefan Lutz Fluorescent nucleoside analogues
EP2057165B1 (en) 2006-09-07 2011-03-16 Industrial Research Limited Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
EP1964841A1 (en) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine and their use as pharmaceuticals
WO2008106224A1 (en) 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
JP2010520292A (ja) 2007-03-07 2010-06-10 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド 複素環式部分を含有するメタロプロテアーゼ阻害剤
JP2008222557A (ja) 2007-03-08 2008-09-25 Kotobuki Seiyaku Kk ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物
MX2009013016A (es) 2007-05-30 2010-02-17 Schering Plough Ltd Un procedimiento para preparar compuestos de aminodiol oxazolina-protegidos utiles como intermediarios para florfenicol.
ES2602615T3 (es) 2007-06-12 2017-02-21 Achaogen, Inc. Agentes antibacterianos
JP2010529194A (ja) 2007-06-13 2010-08-26 ノースイースタン・ユニバーシティ 抗生物質
GB0724342D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
US20100190747A1 (en) 2009-01-27 2010-07-29 Hideo Suzuki Fused ring compound and use thereof
EP2669290A1 (en) 2009-03-02 2013-12-04 Alnylam Pharmaceuticals Inc. Nucleic Acid Chemical Modifications
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
WO2011045415A2 (en) 2009-10-15 2011-04-21 Guerbet New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
MX2012004341A (es) 2009-10-16 2012-10-05 Rib X Pharmaceuticals Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
EA201270566A1 (ru) * 2009-10-16 2012-11-30 Риб-Экс Фармасьютикалз, Инк. Противомикробные соединения и способы их получения и применения
TWI629277B (zh) 2009-10-16 2018-07-11 梅林塔療法公司 抗微生物性化合物，及製法及其用途
CA2829993A1 (en) 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
CA2833169A1 (en) 2011-04-15 2012-12-20 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
US10106543B2 (en) * 2013-09-09 2018-10-23 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.

Also Published As

Publication number Publication date
AU2016228584A1 (en) 2017-10-05
MA42055A (fr) 2018-03-14
SG11201707346RA (en) 2017-10-30
EP3268370A1 (en) 2018-01-17
IL254398A0 (en) 2017-11-30
BR112017019349A2 (pt) 2018-06-05
MX2017011616A (es) 2018-04-11
PH12017501646A1 (en) 2018-03-12
US20180065966A1 (en) 2018-03-08
EA201792006A1 (ru) 2018-04-30
KR20180015114A (ko) 2018-02-12
JP2018507881A (ja) 2018-03-22
US10947237B2 (en) 2021-03-16
WO2016145417A1 (en) 2016-09-15
CA2979342A1 (en) 2016-09-15
CN107922418A (zh) 2018-04-17
EP3268370A4 (en) 2018-08-22

Similar Documents

Publication Publication Date Title
HK1249758A1 (zh) 抗微生物化合物及其製備和使用方法
IL264258B (en) Diazahetero-bicyclic substituted compounds and their use
SG11201706029VA (en) Anti-senescence compounds and uses thereof
HK1246780A1 (zh) 氮雜-吡啶酮化合物及其用途
ZA201705456B (en) Benzoxaborole compounds and uses thereof
IL292488B1 (en) Pyridineamine-pyridone and pyrimidineamine-pyridone compounds
GB201608779D0 (en) Methods and compounds
GB201504763D0 (en) Compounds and uses
GB201616439D0 (en) Compounds and uses
GB201608776D0 (en) Methods and compounds
GB2575196B (en) Thieno pyridimine compounds and manufacture of the same
IL253459B (en) Isoergoline compounds and their uses
GB201718875D0 (en) Autophagy-inhibiting compounds and uses thereof
IL292482B2 (en) Azaindolylpyridone and diazaindolylpyridone compounds
GB201700404D0 (en) Compounds and composistions
GB201614224D0 (en) Compounds and uses thereof
IL265617B (en) 1-phenylpropanone compounds and their use
IL258458B (en) Peroxyhemiacetal profragrant and proflavor compounds
GB201719043D0 (en) Methods and compounds
GB2543375B (en) Compounds and their uses
GB201613134D0 (en) Novel compounds and their use
GB201514770D0 (en) Compounds and their use
GB201513318D0 (en) Novel compounds and their use