CY1122805T1 - Ενωσεις και μεθοδοι για την αγωγη βακτηριακων λοιμωξεων - Google Patents

Ενωσεις και μεθοδοι για την αγωγη βακτηριακων λοιμωξεων

Info

Publication number
CY1122805T1
CY1122805T1 CY20201100217T CY201100217T CY1122805T1 CY 1122805 T1 CY1122805 T1 CY 1122805T1 CY 20201100217 T CY20201100217 T CY 20201100217T CY 201100217 T CY201100217 T CY 201100217T CY 1122805 T1 CY1122805 T1 CY 1122805T1
Authority
CY
Cyprus
Prior art keywords
compounds
bacterial infections
methods
treating bacterial
formula
Prior art date
Application number
CY20201100217T
Other languages
English (en)
Inventor
Gregory Steven Basarab
Madhusudhan Reddy Gowravaram
Sheila Irene Hauck
Fei Zhou
Original Assignee
Entasis Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entasis Therapeutics Limited filed Critical Entasis Therapeutics Limited
Publication of CY1122805T1 publication Critical patent/CY1122805T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Αποκαλύπτονται ενώσεις του τύπου (Ι), φαρμακευτικά αποδεκτά άλατα αυτών και χρήσεις των ενώσεων του τύπου (Ι) για την αγωγή βακτηριακών λοιμώξεων.
CY20201100217T 2013-01-23 2020-03-12 Ενωσεις και μεθοδοι για την αγωγη βακτηριακων λοιμωξεων CY1122805T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361755537P 2013-01-23 2013-01-23
US201361859910P 2013-07-30 2013-07-30
PCT/GB2014/050164 WO2014114929A1 (en) 2013-01-23 2014-01-22 Compounds and methods for treating bacterial infections

Publications (1)

Publication Number Publication Date
CY1122805T1 true CY1122805T1 (el) 2021-05-05

Family

ID=50033593

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100217T CY1122805T1 (el) 2013-01-23 2020-03-12 Ενωσεις και μεθοδοι για την αγωγη βακτηριακων λοιμωξεων

Country Status (31)

Country Link
US (4) US8889671B2 (el)
EP (1) EP2948461B1 (el)
JP (1) JP6285960B2 (el)
KR (1) KR102149567B1 (el)
CN (1) CN105229012B (el)
AR (1) AR094565A1 (el)
AU (1) AU2014208965B2 (el)
BR (1) BR112015017519B1 (el)
CA (1) CA2897887C (el)
CY (1) CY1122805T1 (el)
DK (1) DK2948461T3 (el)
EA (1) EA026901B1 (el)
ES (1) ES2780824T3 (el)
HK (1) HK1218293A1 (el)
HR (1) HRP20200401T1 (el)
HU (1) HUE048990T2 (el)
IL (1) IL239860A0 (el)
LT (1) LT2948461T (el)
ME (1) ME03676B (el)
MX (1) MX360650B (el)
MY (1) MY192765A (el)
NZ (1) NZ710091A (el)
PH (1) PH12015501588A1 (el)
PL (1) PL2948461T3 (el)
PT (1) PT2948461T (el)
RS (1) RS60078B1 (el)
SG (1) SG11201505462YA (el)
SI (1) SI2948461T1 (el)
TW (1) TWI603973B (el)
UY (1) UY35274A (el)
WO (1) WO2014114929A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040528B2 (en) * 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
US8889671B2 (en) * 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
EP3148546A1 (en) * 2014-05-29 2017-04-05 Entasis Therapeutics Limited Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
CN108136211A (zh) * 2015-10-29 2018-06-08 马里兰大学派克分院 用于抑制人宫颈内膜中的细菌感染的组合物和方法
CN106632298B (zh) * 2015-11-03 2021-06-01 上海科胜药物研发有限公司 一种泰地唑胺的制备方法及其中间体
MY201325A (en) 2017-06-01 2024-02-16 Bristol Myers Squibb Co Substituted nitrogen containing compounds
WO2018233670A1 (zh) * 2017-06-22 2018-12-27 中国科学院上海药物研究所 苯并异噁唑螺嘧啶三酮类化合物及制备方法和用途
CN109111466B (zh) * 2017-06-22 2022-08-02 中国科学院上海药物研究所 苯并异噁唑螺嘧啶三酮类化合物及制备方法和用途
CN109111465B (zh) * 2017-06-22 2021-01-12 中国科学院上海药物研究所 噻唑烷酮螺嘧啶三酮类化合物及制备方法和用途
CN108060207B (zh) * 2017-12-29 2021-10-15 河南科技大学 一种基于微量天然化合物的最小杀菌浓度测定方法
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN111559985A (zh) * 2020-05-13 2020-08-21 河南科技大学第一附属医院 具有杀菌作用的噁唑酮类化合物及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0759570B2 (ja) 1986-05-06 1995-06-28 三井東圧化学株式会社 2−オキサゾリジノン類の製造方法
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
DE602004019548D1 (de) 2003-08-15 2009-04-02 Astrazeneca Ab Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)
WO2005066119A2 (en) 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
CA2606847A1 (en) 2005-05-09 2006-11-16 Warner-Lambert Company Llc Antibacterial agents
DOP2006000268A (es) 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
CL2007003332A1 (es) * 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
WO2009004382A2 (en) 2007-07-02 2009-01-08 Astrazeneca Ab 3-spiropyrimidinetrione-quinoline derivatives and their use as antibacterial agents
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
BRPI0920180B1 (pt) 2008-10-14 2021-10-26 Entasis Therapeutics Limited Compostos herecíclicos substituídos, uso dos mesmos e composiçâo farmacêutica compreendendo os ditos compostos
US8952149B2 (en) 2012-09-26 2015-02-10 Zoetis Llc Tricyclic tetrahydroquinoline antibacterial agents
US8889671B2 (en) * 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections

Also Published As

Publication number Publication date
ES2780824T3 (es) 2020-08-27
CN105229012A (zh) 2016-01-06
NZ710091A (en) 2019-08-30
AU2014208965A1 (en) 2015-07-30
US20170128458A1 (en) 2017-05-11
PL2948461T3 (pl) 2020-09-07
AU2014208965B2 (en) 2017-07-27
BR112015017519A2 (pt) 2017-11-21
IL239860A0 (en) 2015-08-31
US9187495B2 (en) 2015-11-17
AR094565A1 (es) 2015-08-12
JP2016506922A (ja) 2016-03-07
BR112015017519B1 (pt) 2021-01-19
JP6285960B2 (ja) 2018-02-28
PH12015501588B1 (en) 2015-10-05
KR102149567B1 (ko) 2020-08-28
CA2897887C (en) 2021-09-07
PH12015501588A1 (en) 2015-10-05
EA026901B1 (ru) 2017-05-31
SI2948461T1 (sl) 2020-06-30
US9839641B2 (en) 2017-12-12
HK1218293A1 (zh) 2017-02-10
UY35274A (es) 2014-07-31
US8889671B2 (en) 2014-11-18
RS60078B1 (sr) 2020-05-29
EP2948461B1 (en) 2019-12-25
WO2014114929A1 (en) 2014-07-31
US20160130281A1 (en) 2016-05-12
EP2948461A1 (en) 2015-12-02
SG11201505462YA (en) 2015-08-28
TW201443063A (zh) 2014-11-16
KR20150107875A (ko) 2015-09-23
MX360650B (es) 2018-11-12
EA201591362A1 (ru) 2015-11-30
US9540394B2 (en) 2017-01-10
ME03676B (me) 2020-10-20
HUE048990T2 (hu) 2020-09-28
US20140206677A1 (en) 2014-07-24
TWI603973B (zh) 2017-11-01
MY192765A (en) 2022-09-07
MX2015009479A (es) 2016-03-04
PT2948461T (pt) 2020-03-31
CA2897887A1 (en) 2014-07-31
US20150203513A1 (en) 2015-07-23
LT2948461T (lt) 2020-03-25
CN105229012B (zh) 2017-07-18
HRP20200401T1 (hr) 2020-06-12
DK2948461T3 (en) 2020-02-17

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