EA201391536A1 - Противомикробные соединения и способы их получения и применения - Google Patents

Противомикробные соединения и способы их получения и применения

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Publication number
EA201391536A1
EA201391536A1 EA201391536A EA201391536A EA201391536A1 EA 201391536 A1 EA201391536 A1 EA 201391536A1 EA 201391536 A EA201391536 A EA 201391536A EA 201391536 A EA201391536 A EA 201391536A EA 201391536 A1 EA201391536 A1 EA 201391536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
production
application
antimicrobial compounds
compounds
Prior art date
Application number
EA201391536A
Other languages
English (en)
Inventor
Эрин М. Даффи
Ашоке Бхаттачарджи
Шили Чэнь
Зольтан Ф. Канио
Мэттью Шейдемен
Юаньцин Тан
Original Assignee
Мелинта Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мелинта Терапьютикс, Инк. filed Critical Мелинта Терапьютикс, Инк.
Publication of EA201391536A1 publication Critical patent/EA201391536A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение в основном относится к области противомикробных соединений и к способам их получения и применения. Эти соединения пригодны для лечения, профилактики и снижения риска микробных инфекций у людей и животных.
EA201391536A 2011-04-15 2012-04-11 Противомикробные соединения и способы их получения и применения EA201391536A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161476138P 2011-04-15 2011-04-15
US201161535118P 2011-09-15 2011-09-15
US201261610363P 2012-03-13 2012-03-13
PCT/US2012/032994 WO2012173689A2 (en) 2011-04-15 2012-04-11 Antimicrobial compounds and methods of making and using the same

Publications (1)

Publication Number Publication Date
EA201391536A1 true EA201391536A1 (ru) 2014-08-29

Family

ID=47357660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391536A EA201391536A1 (ru) 2011-04-15 2012-04-11 Противомикробные соединения и способы их получения и применения

Country Status (20)

Country Link
US (2) US9221827B2 (ru)
EP (2) EP2697229B1 (ru)
JP (2) JP6317669B2 (ru)
KR (1) KR20140065378A (ru)
CN (2) CN103958514B (ru)
AR (1) AR088781A1 (ru)
AU (3) AU2012271228B2 (ru)
BR (1) BR112013026410A2 (ru)
CA (1) CA2833169A1 (ru)
DK (1) DK2697229T3 (ru)
EA (1) EA201391536A1 (ru)
ES (1) ES2665988T3 (ru)
HU (1) HUE036755T2 (ru)
IL (1) IL228845A0 (ru)
MX (1) MX357903B (ru)
MY (1) MY173518A (ru)
PT (1) PT2697229T (ru)
SG (2) SG10201603027QA (ru)
TW (2) TW201843154A (ru)
WO (1) WO2012173689A2 (ru)

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Also Published As

Publication number Publication date
EP2697229A2 (en) 2014-02-19
IL228845A0 (en) 2013-12-31
EP2697229B1 (en) 2018-04-04
CA2833169A1 (en) 2012-12-20
DK2697229T3 (en) 2018-04-23
AR088781A1 (es) 2014-07-10
HUE036755T2 (hu) 2018-07-30
US20190322668A1 (en) 2019-10-24
JP2014510788A (ja) 2014-05-01
ES2665988T3 (es) 2018-04-30
TWI656123B (zh) 2019-04-11
WO2012173689A2 (en) 2012-12-20
JP2018115206A (ja) 2018-07-26
KR20140065378A (ko) 2014-05-29
US20140163049A1 (en) 2014-06-12
SG10201603027QA (en) 2016-05-30
EP3404028A1 (en) 2018-11-21
JP6317669B2 (ja) 2018-04-25
US9221827B2 (en) 2015-12-29
CN103958514B (zh) 2018-07-03
BR112013026410A2 (pt) 2017-06-27
TW201305172A (zh) 2013-02-01
PT2697229T (pt) 2018-04-13
MX357903B (es) 2018-07-30
SG194489A1 (en) 2013-12-30
WO2012173689A3 (en) 2013-04-04
AU2012271228A1 (en) 2013-11-14
AU2012271228B2 (en) 2017-04-13
CN109053695A (zh) 2018-12-21
MX2013012015A (es) 2014-10-24
MY173518A (en) 2020-01-30
TW201843154A (zh) 2018-12-16
AU2019204745A1 (en) 2019-07-18
AU2017204803A1 (en) 2017-07-27
CN103958514A (zh) 2014-07-30
EP2697229A4 (en) 2014-09-10

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