FR3001895B1 - Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes - Google Patents
Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobesInfo
- Publication number
- FR3001895B1 FR3001895B1 FR1351199A FR1351199A FR3001895B1 FR 3001895 B1 FR3001895 B1 FR 3001895B1 FR 1351199 A FR1351199 A FR 1351199A FR 1351199 A FR1351199 A FR 1351199A FR 3001895 B1 FR3001895 B1 FR 3001895B1
- Authority
- FR
- France
- Prior art keywords
- isoelectric point
- anionic compound
- compound carrying
- hydrophobic radicals
- injectable solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne une composition sous forme d'une solution aqueuse injectable, dont le pH est compris entre 6,6 et 7,8, comprenant au moins : a) une insuline basale dont le point isoélectrique pI est compris entre 5,8 et 8,5 ; b) un composé anionique porteur de charges carboxylates et de radicaux hydrophobes. Dans un mode de réalisation, les compositions selon l'invention comprennent en outre une insuline prandiale.
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1351199A FR3001895B1 (fr) | 2013-02-12 | 2013-02-12 | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
PCT/FR2013/052733 WO2014076422A1 (fr) | 2012-11-13 | 2013-11-13 | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
SG10201703742SA SG10201703742SA (en) | 2012-11-13 | 2013-11-13 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
BR112015010797-4A BR112015010797A2 (pt) | 2012-11-13 | 2013-11-13 | compostos aniônicos substituídos, e, composição farmacêutica |
JP2015542337A JP2016505523A (ja) | 2012-11-13 | 2013-11-13 | 離散数の糖単位から構成される主骨格から成る置換されたアニオン性化合物 |
EP13801655.5A EP2920200A1 (fr) | 2012-11-13 | 2013-11-13 | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
CA2889345A CA2889345A1 (fr) | 2012-11-13 | 2013-11-13 | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
KR1020207029334A KR20200121381A (ko) | 2012-11-13 | 2013-11-13 | 개별 갯수의 사카라이드 단위로 이루어지는 백본으로 이루어지는 치환된 음이온성 화합물 |
SG11201503598QA SG11201503598QA (en) | 2012-11-13 | 2013-11-13 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
CN202010210296.5A CN111494638A (zh) | 2012-11-13 | 2013-11-13 | 由离散数个糖单元组成的骨架组成的经取代阴离子化合物 |
MX2015005423A MX2015005423A (es) | 2012-11-13 | 2013-11-13 | Compuestos anionicos sustituidos que consisten de un esqueleto formado por un numero discreto de unidades sacaridicas. |
CN201380059136.3A CN104903341B (zh) | 2012-11-13 | 2013-11-13 | 由离散数个糖单元组成的骨架组成的经取代阴离子化合物 |
KR1020157015765A KR20150084056A (ko) | 2012-11-13 | 2013-11-13 | 개별 갯수의 사카라이드 단위로 이루어지는 백본으로 이루어지는 치환된 음이온성 화합물 |
AU2013346623A AU2013346623A1 (en) | 2012-11-13 | 2013-11-13 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
US14/079,437 US20140187499A1 (en) | 2012-11-13 | 2013-11-13 | Substituted anionic compounds consisting of a backbone made up of a discrete number of saccharide units |
SG10202112306UA SG10202112306UA (en) | 2012-11-13 | 2013-11-13 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
EA201590937A EA201590937A1 (ru) | 2012-11-13 | 2013-11-13 | Замещенные анионные соединения, имеющие скелет, образованный из небольшого числа сахаридных звеньев |
EP14703898.8A EP2956128A1 (fr) | 2013-02-12 | 2014-02-12 | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris entre 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
US14/179,212 US20140235536A1 (en) | 2013-02-12 | 2014-02-12 | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is comprised in 5.8 and 8.5 and an anionic compound bearing carboxylate charges and hydrophobic radicals |
PCT/EP2014/052763 WO2014124994A1 (fr) | 2013-02-12 | 2014-02-12 | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris entre 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
IL238303A IL238303B (en) | 2012-11-13 | 2015-04-15 | Modified anionic compounds containing a skeleton composed of a distinct number of saccharide units |
SA515360426A SA515360426B1 (ar) | 2012-11-13 | 2015-05-12 | مركبات أنيونية بها استبدال تكوِّن سلسلة رئيسية تتكون من عدد منفصل من وحدات سكاريد |
HK16101679.8A HK1213907A1 (zh) | 2012-11-13 | 2016-02-17 | 由離散數個糖單元組成的骨架組成的經取代陰離子化合物 |
US15/950,527 US20180236085A1 (en) | 2013-02-12 | 2018-04-11 | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is comprised in 5.8 and 8.5 and an anionic compound bearing carboxylate charges and hydrophobic radicals |
AU2018204764A AU2018204764A1 (en) | 2012-11-13 | 2018-06-29 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
IL261726A IL261726A (en) | 2012-11-13 | 2018-09-12 | Modified anionic compounds containing a skeleton composed of a distinct number of saccharide units |
AU2020203078A AU2020203078A1 (en) | 2012-11-13 | 2020-05-10 | Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1351199A FR3001895B1 (fr) | 2013-02-12 | 2013-02-12 | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3001895A1 FR3001895A1 (fr) | 2014-08-15 |
FR3001895B1 true FR3001895B1 (fr) | 2015-07-03 |
Family
ID=48521179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1351199A Expired - Fee Related FR3001895B1 (fr) | 2012-11-13 | 2013-02-12 | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
Country Status (4)
Country | Link |
---|---|
US (2) | US20140235536A1 (fr) |
EP (1) | EP2956128A1 (fr) |
FR (1) | FR3001895B1 (fr) |
WO (1) | WO2014124994A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2814461B1 (fr) | 2012-01-09 | 2019-07-24 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue |
US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
FR3052072A1 (fr) | 2016-06-07 | 2017-12-08 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
FR3070264A1 (fr) | 2017-08-24 | 2019-03-01 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
FR3083089A1 (fr) | 2018-06-29 | 2020-01-03 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
FR3083088B1 (fr) | 2018-06-29 | 2020-10-02 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
EP3720472A1 (fr) | 2017-12-06 | 2020-10-14 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
MA51127A (fr) | 2017-12-07 | 2021-03-17 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
WO2019110773A1 (fr) | 2017-12-07 | 2019-06-13 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
SG11202005322RA (en) | 2017-12-07 | 2020-07-29 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid carrying carboxylate charges and hydrophobic radicals |
US20200179489A1 (en) | 2018-12-07 | 2020-06-11 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3482551D1 (de) | 1983-10-26 | 1990-07-26 | Kanebo Ltd | Proteinhaltiges emulgiermittel, dessen herstellung und dieses enthaltende emulgierte kosmetische zusammensetzung. |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
SK2432004A3 (sk) | 2001-12-20 | 2005-04-01 | Eli Lilly And Company | Inzulínová zlúčenina s protrahovaným účinkom |
FR2840614B1 (fr) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
CA2518776A1 (fr) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Analogues de l'insuline ayant une action prolongee |
JP2009533471A (ja) | 2006-04-12 | 2009-09-17 | バイオデル, インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
SI2057165T1 (sl) | 2006-09-07 | 2011-07-29 | Ind Res Ltd Gracefield Res Ct | Acikliäśni aminski zaviralci nukleozidnih fosforilaz in hidrolaz |
US8575096B2 (en) | 2007-08-13 | 2013-11-05 | Novo Nordisk A/S | Rapid acting insulin analogues |
PL2597103T3 (pl) * | 2007-11-16 | 2017-04-28 | Novo Nordisk A/S | Stabilne kompozycje farmaceutyczne zawierające liraglutyd i degludec |
US8759322B2 (en) | 2008-11-05 | 2014-06-24 | National University Corporation Tokyo Medical And Dental University | Hyaluronic acid derivative and pharmaceutical composition thereof |
EP2388723A1 (fr) | 2010-05-18 | 2011-11-23 | University College Cork-National University of Ireland, Cork | Procédé d'évaluation de l'état allergique d'une personne |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
EP2389945A1 (fr) | 2010-05-28 | 2011-11-30 | Sanofi-Aventis Deutschland GmbH | Composition pharmaceutique comprenant de l'AVE0010 et de l'insuline glargine |
RU2578460C2 (ru) * | 2011-08-10 | 2016-03-27 | Адосиа | Приемлемый для инъекций раствор по меньшей мере одного базального инсулина |
FR2985429B1 (fr) * | 2012-01-09 | 2016-07-29 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue obtenu par un procede de polymerisation controle |
EP2814461B1 (fr) * | 2012-01-09 | 2019-07-24 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue |
FR2985428B1 (fr) * | 2012-01-09 | 2016-05-27 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue |
-
2013
- 2013-02-12 FR FR1351199A patent/FR3001895B1/fr not_active Expired - Fee Related
-
2014
- 2014-02-12 US US14/179,212 patent/US20140235536A1/en not_active Abandoned
- 2014-02-12 WO PCT/EP2014/052763 patent/WO2014124994A1/fr active Application Filing
- 2014-02-12 EP EP14703898.8A patent/EP2956128A1/fr not_active Withdrawn
-
2018
- 2018-04-11 US US15/950,527 patent/US20180236085A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2014124994A1 (fr) | 2014-08-21 |
EP2956128A1 (fr) | 2015-12-23 |
US20140235536A1 (en) | 2014-08-21 |
US20180236085A1 (en) | 2018-08-23 |
FR3001895A1 (fr) | 2014-08-15 |
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