CY1111507T1 - Ακυκλικοι αμινικοι αναστολεις των νουκλεοζιτικων φωσφορυλασων και υδρολασων - Google Patents

Ακυκλικοι αμινικοι αναστολεις των νουκλεοζιτικων φωσφορυλασων και υδρολασων

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Publication number
CY1111507T1
CY1111507T1 CY20111100525T CY111100525T CY1111507T1 CY 1111507 T1 CY1111507 T1 CY 1111507T1 CY 20111100525 T CY20111100525 T CY 20111100525T CY 111100525 T CY111100525 T CY 111100525T CY 1111507 T1 CY1111507 T1 CY 1111507T1
Authority
CY
Cyprus
Prior art keywords
phosphorilases
nucleozytic
hypolases
aminic
acyclic
Prior art date
Application number
CY20111100525T
Other languages
English (en)
Inventor
Keith Clinch
Gary Brian Evans
Richard Hubert Furneaux
Peter Michael Kelly
Vern L Schramm
Peter Charles Tyler
Anthony David Woolhouse
Shivali Ashwin Gulab
Original Assignee
Industrial Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Research Limited filed Critical Industrial Research Limited
Publication of CY1111507T1 publication Critical patent/CY1111507T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Η εφεύρεση αναφέρεται σε ενώσεις του γενικού τύπου (I) οι οποίες είναι αναστολείς των πουρινονουκλεοζιτικών φωσφορυλασών (ΡΝΡ) και/ή νουκλεοζιτικών υδρολασών (ΝΗ). Η εφεύρεση αναφέρεται επίσης στη χρήση αυτών των ενώσεων στη θεραπεία νόσων και λοιμώξεων συμπεριλαμβανομένου του καρκίνου, βακτηριακών λοιμώξεων από πρωτόζωα και νόσου που διαμεσολαβείται από κύτταρα Τ και σε φαρμακευτικές συνθέσεις οι οποίες περιέχουν τις ενώσεις.
CY20111100525T 2006-09-07 2011-05-31 Ακυκλικοι αμινικοι αναστολεις των νουκλεοζιτικων φωσφορυλασων και υδρολασων CY1111507T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84286706P 2006-09-07 2006-09-07
EP07834863A EP2057165B1 (en) 2006-09-07 2007-09-07 Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases

Publications (1)

Publication Number Publication Date
CY1111507T1 true CY1111507T1 (el) 2015-08-05

Family

ID=39157466

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100525T CY1111507T1 (el) 2006-09-07 2011-05-31 Ακυκλικοι αμινικοι αναστολεις των νουκλεοζιτικων φωσφορυλασων και υδρολασων

Country Status (20)

Country Link
US (1) US8853224B2 (el)
EP (2) EP2395005A1 (el)
JP (1) JP5388067B2 (el)
KR (1) KR101433621B1 (el)
CN (1) CN101528749B (el)
AT (1) ATE502038T1 (el)
AU (1) AU2007293774C1 (el)
CA (1) CA2662628C (el)
CY (1) CY1111507T1 (el)
DE (1) DE602007013252D1 (el)
DK (1) DK2057165T3 (el)
ES (1) ES2362805T3 (el)
HK (1) HK1131612A1 (el)
HR (1) HRP20110408T1 (el)
NZ (1) NZ575365A (el)
PL (1) PL2057165T3 (el)
PT (1) PT2057165E (el)
RS (1) RS51864B (el)
SI (1) SI2057165T1 (el)
WO (1) WO2008030119A1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2330042C2 (ru) 2002-08-21 2008-07-27 Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити Ингибиторы нуклеозидфосфорилаз и нуклеозидаз
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1924684A4 (en) 2005-07-27 2009-02-11 Einstein Coll Med STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES
WO2007097643A1 (en) * 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
US8383636B2 (en) 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
CN101600711A (zh) 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
US20090247750A1 (en) * 2008-03-28 2009-10-01 Biocryst Pharmaceuticals, Inc. Process for preparing nucleoside analogs
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
CA2768291C (en) 2009-07-17 2018-03-27 Albert Einstein College Of Medicine Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
AR077898A1 (es) 2009-08-26 2011-09-28 Nycomed Gmbh Metilpirrolopirimidincarboxamidas
EP2488532B1 (en) 2009-10-16 2018-05-09 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
CA2777741A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
WO2011047319A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
AU2011315902B2 (en) 2010-10-15 2016-11-17 Biocryst Pharmaceuticals, Inc. (A Us Corporation) Methods and compositions for inhibition of polymerase
WO2012074912A1 (en) * 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
CA2819759C (en) * 2010-11-30 2019-09-10 Connora Technologies, Inc. Novel agents for reworkable epoxy resins
EA201391536A1 (ru) * 2011-04-15 2014-08-29 Мелинта Терапьютикс, Инк. Противомикробные соединения и способы их получения и применения
WO2012150866A1 (en) * 2011-05-03 2012-11-08 Industrial Research Limited Phosphoribosyltransferase inhibitors and uses thereof
MX2014001190A (es) 2011-08-10 2014-05-12 Adocia Solucion inyectable de al menos insulina basal.
CN107583039A (zh) 2012-01-09 2018-01-16 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
US11186575B2 (en) 2012-08-07 2021-11-30 Alber Einslein College of Medicine Treatment of helicobacter pylori infections
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
FR3001895B1 (fr) 2013-02-12 2015-07-03 Adocia Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes
US9616129B2 (en) 2013-06-22 2017-04-11 Nitor Therapeutics Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
NO2865735T3 (el) 2013-07-12 2018-07-21
HUE037347T2 (hu) 2013-07-12 2018-08-28 Gilead Sciences Inc Policiklusos karmaboilpiridon vegyületek és alkalmazásuk HIV fertõzések kezelésére
SG11201601654TA (en) 2013-09-09 2016-04-28 Melinta Therapeutics Inc Antimicrobial compunds and methods of making and using the same
WO2015035421A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2015123101A1 (en) 2014-02-12 2015-08-20 Albert Einstein College Of Medicine Of Yeshiva University Treatment of h. pylori infections using mtan inhibitors
US10947237B2 (en) 2015-03-11 2021-03-16 BioVersys AG Antimicrobial compounds and methods of making and using the same
WO2017155886A1 (en) 2016-03-06 2017-09-14 Biocryst Pharmaceuticals, Inc. Methods and compositions for treatment of zika virus infection
EA039048B1 (ru) 2016-03-15 2021-11-26 Сионоги Энд Ко., Лтд. Способ получения производных феноксиэтанола
EP3452479A1 (en) 2016-05-06 2019-03-13 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
CN113045484B (zh) * 2019-12-27 2024-01-26 南京药石科技股份有限公司 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法
CN111320634A (zh) * 2020-04-14 2020-06-23 浙江工业大学 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0920777A (ja) 1995-06-30 1997-01-21 Nippon Paper Ind Co Ltd 新規なプリンヌクレオシド誘導体、その製造方法及びその誘導体を有効成分とする酵素阻害剤
US6379911B2 (en) 1996-02-23 2002-04-30 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US6228741B1 (en) 1998-01-13 2001-05-08 Texas Instruments Incorporated Method for trench isolation of semiconductor devices
CN1196704C (zh) 1999-04-08 2005-04-13 工业研究有限公司 制备核苷代谢抑制剂的方法及中间体化合物
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
WO2002018371A1 (en) 2000-08-29 2002-03-07 Industrial Research Limited Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
JP2002296365A (ja) * 2001-03-29 2002-10-09 Seiko Epson Corp 電子機器、電子制御式機械時計、電子機器の制御方法
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
RU2330042C2 (ru) 2002-08-21 2008-07-27 Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити Ингибиторы нуклеозидфосфорилаз и нуклеозидаз
GB0301736D0 (en) 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
AU2005269541A1 (en) 2004-07-27 2006-02-09 Biocryst Pharmaceuticals, Inc. Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
EP1924684A4 (en) 2005-07-27 2009-02-11 Einstein Coll Med STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
BRPI0620643A2 (pt) 2005-12-23 2011-12-20 Novartis Ag compostos de heterocìclicos condensados úteis como inibidores de dpp-iv, formulações farmacêuticas, produtos e usos dos compostos
AU2007218334A1 (en) 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
US8383636B2 (en) 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
WO2008039324A1 (en) 2006-09-26 2008-04-03 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
CN101600711A (zh) 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
US20110190265A1 (en) 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
CA2768291C (en) 2009-07-17 2018-03-27 Albert Einstein College Of Medicine Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
US8853224B2 (en) 2014-10-07
JP2010502696A (ja) 2010-01-28
DE602007013252D1 (de) 2011-04-28
HRP20110408T1 (hr) 2011-06-30
DK2057165T3 (da) 2011-06-27
RS51864B (en) 2012-02-29
PL2057165T3 (pl) 2011-08-31
WO2008030119A9 (en) 2009-09-24
CN101528749B (zh) 2013-07-31
CA2662628C (en) 2016-02-09
ES2362805T3 (es) 2011-07-13
SI2057165T1 (sl) 2011-07-29
WO2008030119A1 (en) 2008-03-13
ATE502038T1 (de) 2011-04-15
US20110130412A1 (en) 2011-06-02
AU2007293774C1 (en) 2014-12-18
AU2007293774A1 (en) 2008-03-13
EP2057165A1 (en) 2009-05-13
CA2662628A1 (en) 2008-03-13
EP2057165A4 (en) 2009-09-02
EP2395005A1 (en) 2011-12-14
HK1131612A1 (en) 2010-01-29
JP5388067B2 (ja) 2014-01-15
EP2057165B1 (en) 2011-03-16
KR101433621B1 (ko) 2014-08-27
NZ575365A (en) 2012-02-24
CN101528749A (zh) 2009-09-09
PT2057165E (pt) 2011-05-12
KR20090069281A (ko) 2009-06-30
AU2007293774B2 (en) 2013-07-04

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