CY1114617T1 - Αμινοτετραϋδροπυρανια ως αναστολεις διπεπτιδυλο πεπτιδασης-iv για την αγωγη ή προληψη διαβητη - Google Patents

Αμινοτετραϋδροπυρανια ως αναστολεις διπεπτιδυλο πεπτιδασης-iv για την αγωγη ή προληψη διαβητη

Info

Publication number
CY1114617T1
CY1114617T1 CY20131100966T CY131100966T CY1114617T1 CY 1114617 T1 CY1114617 T1 CY 1114617T1 CY 20131100966 T CY20131100966 T CY 20131100966T CY 131100966 T CY131100966 T CY 131100966T CY 1114617 T1 CY1114617 T1 CY 1114617T1
Authority
CY
Cyprus
Prior art keywords
prevention
dyprophany
aminotetra
diplomatic
diabetes
Prior art date
Application number
CY20131100966T
Other languages
English (en)
Inventor
Tesfaye Biftu
Ping Chen
Jason M Cox
Ann E Weber
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41559521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114617(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1114617T1 publication Critical patent/CY1114617T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Η παρούσα εφεύρεση εστιάζεται σε νέα υποκατεστημένα αμινοτετραϋδροπυράνια του δομικού τύπου Ι τα οποία είναι αναστολείς του ενζύμου διπεπτιδυλο πεπτιδάση-IV και τα οποία είναι χρήσιμα στην αγωγή ή πρόληψη παθήσεων στις οποίες εμπλέκεται το ένζυμο διπεπτιδυλο πεπτιδάση-IV, όπως διαβήτη και ιδίως διαβήτη τύπου 2. Η εφεύρεση επίσης εστιάζεται σε φαρμακευτικές συνθέσεις που περιλαμβάνουν αυτές τις ενώσεις και στη χρήση αυτών των ενώσεων και συνθέσεων στην πρόληψη ή αγωγή παθήσεων στις οποίες εμπλέκεται το ένζυμο διπεπτιδυλο πεπτιδάση-ΙV.
CY20131100966T 2008-11-13 2013-10-31 Αμινοτετραϋδροπυρανια ως αναστολεις διπεπτιδυλο πεπτιδασης-iv για την αγωγη ή προληψη διαβητη CY1114617T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19917908P 2008-11-13 2008-11-13
EP20090756204 EP2358717B1 (en) 2008-11-13 2009-11-11 Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
CY1114617T1 true CY1114617T1 (el) 2016-10-05

Family

ID=41559521

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100966T CY1114617T1 (el) 2008-11-13 2013-10-31 Αμινοτετραϋδροπυρανια ως αναστολεις διπεπτιδυλο πεπτιδασης-iv για την αγωγη ή προληψη διαβητη

Country Status (40)

Country Link
US (8) US8143289B2 (el)
EP (4) EP2676960B1 (el)
JP (2) JP4854825B1 (el)
KR (2) KR101454093B1 (el)
CN (1) CN102272136B (el)
AR (1) AR074306A1 (el)
AU (1) AU2009314191B2 (el)
BR (1) BRPI0921375B8 (el)
CA (1) CA2742783C (el)
CL (1) CL2011001082A1 (el)
CO (1) CO6382129A2 (el)
CR (1) CR20110257A (el)
CY (1) CY1114617T1 (el)
DK (1) DK2358717T3 (el)
DO (1) DOP2011000128A (el)
EA (1) EA018613B1 (el)
EC (1) ECSP11011044A (el)
ES (1) ES2432191T3 (el)
GE (1) GEP20135724B (el)
HK (1) HK1154849A1 (el)
HN (1) HN2011001256A (el)
HR (1) HRP20130924T1 (el)
IL (2) IL212485A (el)
JO (1) JO2870B1 (el)
MA (1) MA32887B1 (el)
MX (1) MX2011005044A (el)
MY (1) MY150787A (el)
NI (1) NI201100081A (el)
NZ (1) NZ592826A (el)
PA (1) PA8848201A1 (el)
PE (1) PE20120027A1 (el)
PL (1) PL2358717T3 (el)
PT (1) PT2358717E (el)
RS (1) RS52946B (el)
SI (1) SI2358717T1 (el)
SV (1) SV2011003903A (el)
TN (1) TN2011000201A1 (el)
TW (1) TWI398443B (el)
UA (1) UA101414C2 (el)
WO (1) WO2010056708A1 (el)

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