AR061930A1 - Mimeticuerpos de glp-1 humanos, composiciones, metodos y usos - Google Patents
Mimeticuerpos de glp-1 humanos, composiciones, metodos y usosInfo
- Publication number
- AR061930A1 AR061930A1 ARP070103214A ARP070103214A AR061930A1 AR 061930 A1 AR061930 A1 AR 061930A1 AR P070103214 A ARP070103214 A AR P070103214A AR P070103214 A ARP070103214 A AR P070103214A AR 061930 A1 AR061930 A1 AR 061930A1
- Authority
- AR
- Argentina
- Prior art keywords
- glp
- methods
- mimicibody
- specified portion
- deleted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Al menos, un mimeticuerpo de GLP-1 humano mejorado o porcion o variante especificada, que incluyen ácidos nucleicos aislados que codifican al menos un mimeticuerpo de GLP-1 o porcion o variante especificada, mimeticuerpo de GLP-1 o porcion o variantes especificadas, vectores, células hospedantes, animales transgénicos o plantas, y métodos de elaboracion y utilizacion de los mismos, incluyendo composiciones, métodos y dispositivos terapéuticos. Reivindicacion 1: Al menos un ácido nucleico de mimeticuerpo delecionado GLP-1 CH1, que comprende al menos un polinucleotido que codifica la secuencia de amino ácidos de ID SEC N°s: 2 o 4, o un polinucleotido complementario a los mismos, dicho mimeticuerpo delecionado GLP-1 CH1 tiene al menos una actividad biologica de GLP-1 in vitro o ?n vivo y comprende además al menos un sitio de glicosilacion unido a N.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83170406P | 2006-07-18 | 2006-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061930A1 true AR061930A1 (es) | 2008-10-01 |
Family
ID=38596585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103214A AR061930A1 (es) | 2006-07-18 | 2007-07-18 | Mimeticuerpos de glp-1 humanos, composiciones, metodos y usos |
Country Status (18)
Country | Link |
---|---|
US (2) | US20090325873A1 (es) |
EP (1) | EP2049567A2 (es) |
JP (1) | JP2010500868A (es) |
KR (1) | KR20090039787A (es) |
CN (1) | CN101535341A (es) |
AR (1) | AR061930A1 (es) |
AU (1) | AU2007275294A1 (es) |
BR (1) | BRPI0714334A2 (es) |
CA (1) | CA2658286A1 (es) |
CR (1) | CR10619A (es) |
EA (1) | EA200970131A1 (es) |
EC (1) | ECSP099079A (es) |
MX (1) | MX2009000748A (es) |
NO (1) | NO20090780L (es) |
TW (1) | TW200821386A (es) |
UY (1) | UY30494A1 (es) |
WO (1) | WO2008011446A2 (es) |
ZA (1) | ZA200901132B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003002136A2 (en) * | 2001-06-28 | 2003-01-09 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
EP2207808B1 (en) | 2007-11-02 | 2013-05-08 | Novartis AG | Improved nogo-a binding molecules and pharmaceutical use thereof |
EP2298801A4 (en) * | 2008-06-17 | 2011-08-03 | Otsuka Chemical Co Ltd | GLYCOSYLATED GLP-1 PEPTIDE |
JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
EP2373681B1 (en) | 2008-12-10 | 2017-01-18 | Glaxosmithkline LLC | Pharmaceutical compositions of albiglutide |
WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
SG176000A1 (en) * | 2009-05-13 | 2011-12-29 | Protein Delivery Solutions Llc | Pharmaceutical system for trans-membrane delivery |
CN102595897A (zh) | 2009-09-02 | 2012-07-18 | 默沙东公司 | 作为用于糖尿病的治疗或预防的二肽基肽酶-iv抑制剂的氨基四氢吡喃 |
EP2538783B1 (en) | 2010-02-22 | 2016-06-01 | Merck Sharp & Dohme Corp. | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
WO2011130533A1 (en) | 2010-04-16 | 2011-10-20 | Centocor Ortho Biotech Inc. | Engineered plant cysteine proteases and their uses |
EP2566502A4 (en) * | 2010-05-04 | 2013-10-09 | Glaxosmithkline Llc | METHODS OF TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND PROVIDING CARDIOVASCULAR PROTECTION |
EP2571876B1 (en) | 2010-05-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
EP2663647A4 (en) | 2011-01-14 | 2015-08-19 | Redwood Bioscience Inc | POLYPEPTIDE IMMUNOGLOBULINS WITH ALDEHYDIC MARKING AND THEIR USE METHOD |
US20150057220A1 (en) | 2012-04-16 | 2015-02-26 | Kaneq Pharma Inc. | Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors |
CN103204944B (zh) * | 2013-03-26 | 2014-05-28 | 江苏健德生物药业有限公司 | 用于治疗糖尿病的长效免疫融合蛋白 |
JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール.ピー.シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
WO2019036859A1 (zh) * | 2017-08-21 | 2019-02-28 | 中国科学院动物研究所 | 分泌glp-1及其衍生物的蛋白表达系统及其制备方法和用途 |
TWI783890B (zh) | 2017-08-24 | 2022-11-11 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
TWI639987B (zh) * | 2017-10-11 | 2018-11-01 | 奇美醫療財團法人奇美醫院 | 具有位置感知的穿刺輔助教學裝置 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
CR20210193A (es) | 2018-10-22 | 2021-06-15 | Janssen Pharmaceutica Nv | Proteínas de fusión de péptido similar al glucagón 1 (glp1)-factor de diferenciación de crecimiento 15 (gdf15) y usos de estas |
KR20220143037A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 이의 용도 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118666A (en) * | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US6406697B1 (en) * | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
US5512549A (en) * | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
DE69737479T4 (de) | 1996-08-30 | 2010-05-06 | Novo Nordisk A/S | Glp-1 derivate |
US6849719B2 (en) * | 1997-09-17 | 2005-02-01 | Human Genome Sciences, Inc. | Antibody to an IL-17 receptor like protein |
JP2000319297A (ja) * | 1999-03-30 | 2000-11-21 | Noguchi Inst | 酵素的に安定な複合糖ペプチドの調製法 |
SI1180121T1 (en) | 1999-05-17 | 2004-04-30 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
ATE346093T1 (de) * | 2000-06-16 | 2006-12-15 | Lilly Co Eli | Analoge des glucagon ähnlichen peptid-1 |
CA2434237C (en) * | 2000-12-07 | 2012-05-15 | Eli Lilly And Company | Glp-1 fusion proteins |
CN1363654A (zh) * | 2001-07-19 | 2002-08-14 | 上海华谊生物技术有限公司 | 生产促胰岛素分泌肽glp-1(7-36)的基因工程菌以及生产glp-1(7-36)的方法 |
EP1575499A2 (en) * | 2002-06-28 | 2005-09-21 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
AU2003272970B2 (en) * | 2002-10-11 | 2009-05-28 | Sanwa Kagaku Kenkyusho Co. Ltd. | GLP-1 derivatives and transmicosal absorption preparations thereof |
EP1644416A4 (en) | 2003-06-30 | 2007-08-29 | Centocor Inc | ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
MXPA06011425A (es) | 2004-03-31 | 2007-03-12 | Johnson & Johnson | Memiticuerpos de peptido-1 similar a glucagon de humano, composiciones, metodos y usos. |
-
2007
- 2007-07-18 EP EP07799669A patent/EP2049567A2/en not_active Withdrawn
- 2007-07-18 KR KR1020097003122A patent/KR20090039787A/ko not_active Application Discontinuation
- 2007-07-18 AR ARP070103214A patent/AR061930A1/es unknown
- 2007-07-18 CA CA002658286A patent/CA2658286A1/en not_active Abandoned
- 2007-07-18 BR BRPI0714334-6A patent/BRPI0714334A2/pt not_active IP Right Cessation
- 2007-07-18 AU AU2007275294A patent/AU2007275294A1/en not_active Abandoned
- 2007-07-18 US US12/305,034 patent/US20090325873A1/en not_active Abandoned
- 2007-07-18 US US11/779,316 patent/US8071103B2/en not_active Expired - Fee Related
- 2007-07-18 WO PCT/US2007/073752 patent/WO2008011446A2/en active Application Filing
- 2007-07-18 EA EA200970131A patent/EA200970131A1/ru unknown
- 2007-07-18 MX MX2009000748A patent/MX2009000748A/es unknown
- 2007-07-18 TW TW096126255A patent/TW200821386A/zh unknown
- 2007-07-18 CN CNA2007800342628A patent/CN101535341A/zh active Pending
- 2007-07-18 JP JP2009520970A patent/JP2010500868A/ja active Pending
- 2007-07-19 UY UY30494A patent/UY30494A1/es unknown
-
2009
- 2009-01-19 EC EC2009009079A patent/ECSP099079A/es unknown
- 2009-02-17 ZA ZA200901132A patent/ZA200901132B/xx unknown
- 2009-02-18 NO NO20090780A patent/NO20090780L/no not_active Application Discontinuation
- 2009-02-18 CR CR10619A patent/CR10619A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2658286A1 (en) | 2008-01-24 |
ECSP099079A (es) | 2009-02-27 |
UY30494A1 (es) | 2008-01-31 |
CN101535341A (zh) | 2009-09-16 |
US8071103B2 (en) | 2011-12-06 |
JP2010500868A (ja) | 2010-01-14 |
CR10619A (es) | 2009-06-04 |
EA200970131A1 (ru) | 2009-08-28 |
KR20090039787A (ko) | 2009-04-22 |
WO2008011446A3 (en) | 2008-09-18 |
WO2008011446A2 (en) | 2008-01-24 |
MX2009000748A (es) | 2009-03-31 |
US20080044411A1 (en) | 2008-02-21 |
AU2007275294A1 (en) | 2008-01-24 |
US20090325873A1 (en) | 2009-12-31 |
BRPI0714334A2 (pt) | 2013-05-14 |
EP2049567A2 (en) | 2009-04-22 |
ZA200901132B (en) | 2010-10-27 |
TW200821386A (en) | 2008-05-16 |
NO20090780L (no) | 2009-04-03 |
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