AR049014A1 - Mimeticuerpos de glp-1 humanos , composiciones y usos - Google Patents
Mimeticuerpos de glp-1 humanos , composiciones y usosInfo
- Publication number
- AR049014A1 AR049014A1 ARP050101276A ARP050101276A AR049014A1 AR 049014 A1 AR049014 A1 AR 049014A1 AR P050101276 A ARP050101276 A AR P050101276A AR P050101276 A ARP050101276 A AR P050101276A AR 049014 A1 AR049014 A1 AR 049014A1
- Authority
- AR
- Argentina
- Prior art keywords
- glp
- mimicibody
- variant
- methods
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere al menos un mimeticuerpo de GLP-1 humano novedoso o la porcion o variante especificada, que incluye los ácidos nucleicos aislados que codifican a al menos un mimeticuerpo de GLP-1 o una porcion o variante especificada, mimeticuerpo de GLP-1 o porciones o variantes especificadas, vectores, células huésped, animales o plantas transgénicos, y métodos para producir y usar los mismos, incluyendo composiciones terapéuticas, métodos y dispositivos. Reivindicacion 1: Al menos un ácido nucleico de mimeticuerpo de GLP-1 con CH1 suprimida, que comprende al menos un polinucleotido que codifica la secuencia de aminoácidos SEC ID NOS:2 o 4 o un polinucleotido complementario del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55798304P | 2004-03-31 | 2004-03-31 | |
US61298104P | 2004-09-24 | 2004-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049014A1 true AR049014A1 (es) | 2006-06-21 |
Family
ID=35125618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101276A AR049014A1 (es) | 2004-03-31 | 2005-03-31 | Mimeticuerpos de glp-1 humanos , composiciones y usos |
Country Status (17)
Country | Link |
---|---|
US (1) | US20070135338A1 (es) |
EP (1) | EP1750754A4 (es) |
JP (1) | JP2008537873A (es) |
KR (1) | KR20070004078A (es) |
AR (1) | AR049014A1 (es) |
AU (1) | AU2005231359A1 (es) |
BR (1) | BRPI0509528A (es) |
CA (1) | CA2563379A1 (es) |
CR (1) | CR8706A (es) |
EA (2) | EA011583B1 (es) |
IL (1) | IL178432A0 (es) |
MX (1) | MXPA06011425A (es) |
NO (1) | NO20064953L (es) |
SG (1) | SG151315A1 (es) |
TW (1) | TW200602491A (es) |
WO (1) | WO2005097175A2 (es) |
ZA (1) | ZA200709266B (es) |
Families Citing this family (57)
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US20090042781A1 (en) * | 2004-06-28 | 2009-02-12 | Novo Nordisk A/S | Methods for Treating Diabetes |
US7910101B2 (en) | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
DE602005026970D1 (de) * | 2004-10-25 | 2011-04-28 | Centocor Ortho Biotech Inc | Melanocortin-rezeptor-bindende mimetibodies, zusammensetzungen, verfahren und verwendungen |
CN101415439A (zh) * | 2004-12-22 | 2009-04-22 | 森托科尔公司 | Glp-1激动剂、组合物、方法和用途 |
TW200643033A (en) * | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
JP2008546373A (ja) * | 2005-03-28 | 2008-12-25 | セントカー・インコーポレーテツド | ヒトglp−1ミメティボディ、組成物、方法および用途 |
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9284375B2 (en) * | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
CA2605024C (en) | 2005-04-15 | 2018-05-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
EP1920061A4 (en) * | 2005-07-27 | 2009-05-13 | Wang Qinghua | GLP / 1 / EXENDIN 4 IGG FC FUSION CONSTRUCTS FOR THE TREATMENT OF DIABETES |
ES2336575T3 (es) | 2005-09-22 | 2010-04-14 | Biocompatibles Uk Limited | Polipeptidos de fusion glp-1 (peptido-1 similar al glucagon) con resistencia aumentada a la peptidasa. |
CA2627444A1 (en) * | 2005-10-24 | 2007-06-14 | Centocor, Inc. | Glp-2 mimetibodies, polypeptides, compositions, methods and uses |
CA2634784A1 (en) * | 2005-12-22 | 2007-07-05 | Centocor, Inc. | Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses |
US20100034819A1 (en) * | 2006-03-31 | 2010-02-11 | Centocor Inc. | Human epo mimetic hinge core mimetibodies, compositions, methods and uses for preventing or treating glucose intolerance related conditions on renal disease associated anemia |
DE602006009631D1 (de) | 2006-05-10 | 2009-11-19 | Biocompatibles Uk Ltd | GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung |
US20090325873A1 (en) | 2006-07-18 | 2009-12-31 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
WO2008028117A2 (en) | 2006-08-31 | 2008-03-06 | Centocor, Inc. | Glp-2 mimetibodies, polypeptides, compositions, methods and uses |
AR064623A1 (es) * | 2006-12-21 | 2009-04-15 | Centocor Inc | Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos |
EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
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EP2282770B1 (en) * | 2008-06-04 | 2018-03-07 | MacroGenics, Inc. | Antibodies with altered binding to fcrn and methods of using same |
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MX2011012043A (es) * | 2009-05-13 | 2012-03-29 | Protein Delivery Solutions Llc | Sistema farmaceutico para suministro transmembrana. |
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AU2010318542B2 (en) | 2009-10-29 | 2015-08-27 | Janssen Biotech Inc. | Antibody glycosylation variants |
ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
PL2498801T3 (pl) | 2009-11-13 | 2018-08-31 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę |
US9150656B2 (en) | 2010-03-04 | 2015-10-06 | Macrogenics, Inc. | Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
ES2667100T3 (es) | 2010-08-02 | 2018-05-09 | Macrogenics, Inc. | Diacuerpos covalentes y sus usos |
HUE031181T2 (en) | 2010-08-30 | 2017-06-28 | Sanofi Aventis Deutschland | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
AU2012259162C1 (en) | 2011-05-21 | 2020-05-21 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
CN107266558A (zh) | 2011-09-06 | 2017-10-20 | 诺沃—诺迪斯克有限公司 | Glp‑1衍生物 |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
SI2968520T1 (sl) | 2013-03-14 | 2022-01-31 | Macrogenics, Inc. | Bispecifične molekule, ki so imunoreaktivne z imunskimi efektorskimi celicami, ki izražajo aktivacijski receptor |
MY181626A (en) | 2013-04-03 | 2020-12-29 | Sanofi Sa | Treatment of diabetes mellitus by long-acting formulations of insulins |
UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
AU2015323860B2 (en) | 2014-09-29 | 2021-05-27 | Duke University | Bispecific molecules comprising an HIV-1 envelope targeting arm |
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KR102514317B1 (ko) | 2016-04-15 | 2023-03-27 | 마크로제닉스, 인크. | 신규 b7-h3-결합 분자, 그것의 항체 약물 콘쥬게이트 및 그것의 사용 방법 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
EP4125829A2 (en) * | 2020-03-25 | 2023-02-08 | The General Hospital Corporation | Compositions and methods for diabetes treatment |
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2005
- 2005-03-28 AU AU2005231359A patent/AU2005231359A1/en not_active Abandoned
- 2005-03-28 US US11/091,181 patent/US20070135338A1/en not_active Abandoned
- 2005-03-28 MX MXPA06011425A patent/MXPA06011425A/es not_active Application Discontinuation
- 2005-03-28 EP EP05730437A patent/EP1750754A4/en not_active Withdrawn
- 2005-03-28 BR BRPI0509528-0A patent/BRPI0509528A/pt not_active Application Discontinuation
- 2005-03-28 EA EA200601603A patent/EA011583B1/ru not_active IP Right Cessation
- 2005-03-28 WO PCT/US2005/010456 patent/WO2005097175A2/en active Application Filing
- 2005-03-28 CA CA002563379A patent/CA2563379A1/en not_active Abandoned
- 2005-03-28 KR KR1020067022887A patent/KR20070004078A/ko not_active Application Discontinuation
- 2005-03-28 SG SG200902141-1A patent/SG151315A1/en unknown
- 2005-03-28 JP JP2007506454A patent/JP2008537873A/ja active Pending
- 2005-03-30 TW TW094109910A patent/TW200602491A/zh unknown
- 2005-03-31 AR ARP050101276A patent/AR049014A1/es unknown
- 2005-12-22 EA EA200702093A patent/EA200702093A1/ru unknown
-
2006
- 2006-10-03 IL IL178432A patent/IL178432A0/en unknown
- 2006-10-25 CR CR8706A patent/CR8706A/es not_active Application Discontinuation
- 2006-10-30 NO NO20064953A patent/NO20064953L/no not_active Application Discontinuation
-
2007
- 2007-10-26 ZA ZA200709266A patent/ZA200709266B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CR8706A (es) | 2009-01-16 |
BRPI0509528A (pt) | 2007-08-07 |
AU2005231359A1 (en) | 2005-10-20 |
MXPA06011425A (es) | 2007-03-12 |
EP1750754A4 (en) | 2010-09-22 |
EP1750754A2 (en) | 2007-02-14 |
WO2005097175A3 (en) | 2009-11-19 |
SG151315A1 (en) | 2009-04-30 |
JP2008537873A (ja) | 2008-10-02 |
TW200602491A (en) | 2006-01-16 |
EA011583B1 (ru) | 2009-04-28 |
IL178432A0 (en) | 2007-02-11 |
ZA200709266B (en) | 2009-05-27 |
NO20064953L (no) | 2006-12-18 |
WO2005097175A2 (en) | 2005-10-20 |
EA200601603A1 (ru) | 2007-08-31 |
EA200702093A1 (ru) | 2009-06-30 |
US20070135338A1 (en) | 2007-06-14 |
KR20070004078A (ko) | 2007-01-05 |
CA2563379A1 (en) | 2005-10-20 |
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