TW200602491A - Human GLP-1 mimetibodies, compositions, methods and uses - Google Patents
Human GLP-1 mimetibodies, compositions, methods and usesInfo
- Publication number
- TW200602491A TW200602491A TW094109910A TW94109910A TW200602491A TW 200602491 A TW200602491 A TW 200602491A TW 094109910 A TW094109910 A TW 094109910A TW 94109910 A TW94109910 A TW 94109910A TW 200602491 A TW200602491 A TW 200602491A
- Authority
- TW
- Taiwan
- Prior art keywords
- methods
- compositions
- mimetibodies
- human glp
- glp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55798304P | 2004-03-31 | 2004-03-31 | |
US61298104P | 2004-09-24 | 2004-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200602491A true TW200602491A (en) | 2006-01-16 |
Family
ID=35125618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094109910A TW200602491A (en) | 2004-03-31 | 2005-03-30 | Human GLP-1 mimetibodies, compositions, methods and uses |
Country Status (17)
Country | Link |
---|---|
US (1) | US20070135338A1 (zh) |
EP (1) | EP1750754A4 (zh) |
JP (1) | JP2008537873A (zh) |
KR (1) | KR20070004078A (zh) |
AR (1) | AR049014A1 (zh) |
AU (1) | AU2005231359A1 (zh) |
BR (1) | BRPI0509528A (zh) |
CA (1) | CA2563379A1 (zh) |
CR (1) | CR8706A (zh) |
EA (2) | EA011583B1 (zh) |
IL (1) | IL178432A0 (zh) |
MX (1) | MXPA06011425A (zh) |
NO (1) | NO20064953L (zh) |
SG (1) | SG151315A1 (zh) |
TW (1) | TW200602491A (zh) |
WO (1) | WO2005097175A2 (zh) |
ZA (1) | ZA200709266B (zh) |
Families Citing this family (57)
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EP1906991A2 (en) * | 2004-06-28 | 2008-04-09 | Novo Nordisk A/S | Use of glp-1 receptor agonists and/or dpp-iv inhibitors in combination with proton pump inhibitors and ppar agonists for the preparation of a medicament for the treatment of diabetes type i, diabetes type ii and impaired pancreatic beta-cell function |
US7910101B2 (en) | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
EP1812046B1 (en) * | 2004-10-25 | 2011-03-16 | Centocor Ortho Biotech Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
MX2007007602A (es) * | 2004-12-22 | 2007-12-07 | Johnson & Johnson | Agonistas del peptido 1 similar al glucagon, composiciones, metodos y usos. |
TW200643033A (en) * | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
AU2005339797A1 (en) * | 2005-03-28 | 2007-07-19 | Centocor, Inc. | Human GLP-1 mimetibodies, compositions, methods and uses |
EP1868650B1 (en) * | 2005-04-15 | 2018-10-03 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
CA2658673A1 (en) | 2005-07-27 | 2008-02-01 | Gerald J. Prud'homme | Composition and method for prevention and treatment of type i and type ii diabetes |
DK1767545T3 (da) | 2005-09-22 | 2010-03-15 | Biocompatibles Uk Ltd | GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens |
US20070212355A1 (en) * | 2005-10-24 | 2007-09-13 | Baker Audrey E | GLP-2 Mimetibodies, Polypeptides, Compositions, Methods and Uses |
CA2634784A1 (en) * | 2005-12-22 | 2007-07-05 | Centocor, Inc. | Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses |
WO2007115148A2 (en) * | 2006-03-31 | 2007-10-11 | Centocor, Inc. | Human mimetic epo hinge core mimetibodies |
ATE444741T1 (de) | 2006-05-10 | 2009-10-15 | Biocompatibles Uk Ltd | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
BRPI0714334A2 (pt) * | 2006-07-18 | 2013-05-14 | Centocor Inc | mimeticorpos de glp-1 humano aperfeiÇoados, composiÇÕes, mÉtodos e usos |
US7812121B2 (en) | 2006-08-31 | 2010-10-12 | Baker Audrey E | GLP-2 mimetibodies, polypeptides, compositions, methods and uses |
AR064623A1 (es) | 2006-12-21 | 2009-04-15 | Centocor Inc | Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos |
EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
WO2009151717A2 (en) | 2008-04-02 | 2009-12-17 | Macrogenics, Inc. | Bcr-complex-specific antibodies and methods of using same |
EP2214700A4 (en) * | 2007-11-02 | 2012-08-22 | Janssen Biotech Inc | HALF-SYNTHETIC GLP-1 PEPTIDE FUSION CONSTRUCTS, METHOD AND USES |
ES2675730T3 (es) * | 2008-06-04 | 2018-07-12 | Macrogenics, Inc. | Anticuerpos con unión alterada a FcRn y métodos de uso de los mismos |
US20110129522A1 (en) * | 2008-07-21 | 2011-06-02 | Transpharma Medical Ltd. | Transdermal system for extended delivery of incretins and incretn mimetic peptides |
DK2349324T3 (en) | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
RU2744176C2 (ru) * | 2008-12-19 | 2021-03-03 | Макродженикс, Инк. | Ковалентные диантитела и их применение |
BRPI1010639A2 (pt) * | 2009-05-13 | 2016-03-15 | Protein Delivery Solutions Llc | sistema farmacêutico para distribuição transmembrana |
US9096877B2 (en) | 2009-10-07 | 2015-08-04 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
WO2011044589A2 (en) * | 2009-10-09 | 2011-04-14 | Board Of Regents, The University Of Texas System | Photokinetic ocular drug delivery methods and apparatus |
AU2010318542B2 (en) | 2009-10-29 | 2015-08-27 | Janssen Biotech Inc. | Antibody glycosylation variants |
JP5973918B2 (ja) | 2009-11-13 | 2016-08-23 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Glp−1アゴニスト及びメチオニンを含む薬学的組成物 |
KR101836070B1 (ko) | 2009-11-13 | 2018-03-09 | 사노피-아벤티스 도이칠란트 게엠베하 | Glp-1 작용제, 인슐린 및 메티오닌을 포함하는 약제학적 조성물 |
CN106279416B (zh) | 2010-03-04 | 2019-08-30 | 宏观基因有限公司 | 与b7-h3反应性的抗体、其免疫学活性片段及其用途 |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
CN103154025B (zh) | 2010-08-02 | 2015-07-01 | 宏观基因有限公司 | 共价双抗体及其用途 |
PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
JP6145088B2 (ja) | 2011-05-21 | 2017-06-07 | マクロジェニクス,インコーポレーテッド | 脱免疫化血清結合ドメイン及び血清半減期を延長するためのその使用 |
CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
US9758560B2 (en) | 2011-09-06 | 2017-09-12 | Novo Nordisk A/S | GLP-1 derivatives |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
JP6676521B2 (ja) | 2013-03-14 | 2020-04-08 | マクロジェニクス,インコーポレーテッド | 二重特異性分子、薬学的組成物及びそれらの使用 |
EP3517122A1 (en) | 2013-04-03 | 2019-07-31 | Sanofi | Treatment of diabetes mellitus by long-acting formulations of insulins |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
WO2016054101A1 (en) | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
CN107206058A (zh) | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
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TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
US20230149478A1 (en) * | 2020-03-25 | 2023-05-18 | The General Hospital Corporation | Compositions and methods for diabetes treatment |
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-
2005
- 2005-03-28 SG SG200902141-1A patent/SG151315A1/en unknown
- 2005-03-28 BR BRPI0509528-0A patent/BRPI0509528A/pt not_active Application Discontinuation
- 2005-03-28 AU AU2005231359A patent/AU2005231359A1/en not_active Abandoned
- 2005-03-28 MX MXPA06011425A patent/MXPA06011425A/es not_active Application Discontinuation
- 2005-03-28 EA EA200601603A patent/EA011583B1/ru not_active IP Right Cessation
- 2005-03-28 JP JP2007506454A patent/JP2008537873A/ja active Pending
- 2005-03-28 EP EP05730437A patent/EP1750754A4/en not_active Withdrawn
- 2005-03-28 CA CA002563379A patent/CA2563379A1/en not_active Abandoned
- 2005-03-28 KR KR1020067022887A patent/KR20070004078A/ko not_active Application Discontinuation
- 2005-03-28 US US11/091,181 patent/US20070135338A1/en not_active Abandoned
- 2005-03-28 WO PCT/US2005/010456 patent/WO2005097175A2/en active Application Filing
- 2005-03-30 TW TW094109910A patent/TW200602491A/zh unknown
- 2005-03-31 AR ARP050101276A patent/AR049014A1/es unknown
- 2005-12-22 EA EA200702093A patent/EA200702093A1/ru unknown
-
2006
- 2006-10-03 IL IL178432A patent/IL178432A0/en unknown
- 2006-10-25 CR CR8706A patent/CR8706A/es not_active Application Discontinuation
- 2006-10-30 NO NO20064953A patent/NO20064953L/no not_active Application Discontinuation
-
2007
- 2007-10-26 ZA ZA200709266A patent/ZA200709266B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20070135338A1 (en) | 2007-06-14 |
WO2005097175A3 (en) | 2009-11-19 |
MXPA06011425A (es) | 2007-03-12 |
KR20070004078A (ko) | 2007-01-05 |
EP1750754A4 (en) | 2010-09-22 |
NO20064953L (no) | 2006-12-18 |
EP1750754A2 (en) | 2007-02-14 |
CA2563379A1 (en) | 2005-10-20 |
AR049014A1 (es) | 2006-06-21 |
EA200601603A1 (ru) | 2007-08-31 |
EA011583B1 (ru) | 2009-04-28 |
JP2008537873A (ja) | 2008-10-02 |
EA200702093A1 (ru) | 2009-06-30 |
IL178432A0 (en) | 2007-02-11 |
SG151315A1 (en) | 2009-04-30 |
BRPI0509528A (pt) | 2007-08-07 |
AU2005231359A1 (en) | 2005-10-20 |
WO2005097175A2 (en) | 2005-10-20 |
ZA200709266B (en) | 2009-05-27 |
CR8706A (es) | 2009-01-16 |
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