ATE444741T1 - Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung - Google Patents
Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendungInfo
- Publication number
- ATE444741T1 ATE444741T1 AT06009678T AT06009678T ATE444741T1 AT E444741 T1 ATE444741 T1 AT E444741T1 AT 06009678 T AT06009678 T AT 06009678T AT 06009678 T AT06009678 T AT 06009678T AT E444741 T1 ATE444741 T1 AT E444741T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- spherical microcapsules
- diseases
- conditions associated
- glp
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06009678A EP1854455B1 (de) | 2006-05-10 | 2006-05-10 | GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE444741T1 true ATE444741T1 (de) | 2009-10-15 |
Family
ID=37773605
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06009678T ATE444741T1 (de) | 2006-05-10 | 2006-05-10 | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
AT07724702T ATE502628T1 (de) | 2006-05-10 | 2007-04-27 | Sphärische oder nichtsphärische mikrokapseln mit glp-1-peptiden, ihre herstellung und verwendung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07724702T ATE502628T1 (de) | 2006-05-10 | 2007-04-27 | Sphärische oder nichtsphärische mikrokapseln mit glp-1-peptiden, ihre herstellung und verwendung |
Country Status (13)
Country | Link |
---|---|
US (2) | US8790705B2 (de) |
EP (3) | EP1854455B1 (de) |
JP (1) | JP5209608B2 (de) |
CN (1) | CN101489539A (de) |
AT (2) | ATE444741T1 (de) |
AU (1) | AU2007247511B2 (de) |
CA (1) | CA2649902A1 (de) |
DE (2) | DE602006009631D1 (de) |
DK (1) | DK2015736T3 (de) |
ES (1) | ES2363810T3 (de) |
PL (1) | PL2015736T3 (de) |
PT (1) | PT2015736E (de) |
WO (1) | WO2007128443A2 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1767545B1 (de) | 2005-09-22 | 2009-11-11 | Biocompatibles UK Limited | Fusionspolypeptide vom glp-1 (glucagon-like peptide-1) mit erhöhten peptidaseresistenz |
DE602006009631D1 (de) | 2006-05-10 | 2009-11-19 | Biocompatibles Uk Ltd | GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung |
EP1972349A1 (de) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | Mit Polymer(en) konjugierte GLP-1-Fusionspeptide, ihre Herstellung und Verwendung |
EP1975176A1 (de) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Neue GLP-1-Fusionspeptide, ihre Herstellung und Verwendung |
WO2009007979A2 (en) * | 2007-07-11 | 2009-01-15 | Technion Research & Development Foundation Ltd. | Encapsulated mesenchymal stem cells and uses thereof |
EP2163243A1 (de) * | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Behandlung akuter Herzinfarkte mithilfe eingekapselter Zellen, welche GLP-1-Peptide oder deren Analoga kodieren und absondern |
EP2251028A1 (de) * | 2009-05-12 | 2010-11-17 | Biocompatibles Uk Ltd. | Behandlung von Augenerkrankungen unter Verwendung eingekapselter Zellen, die einen antiangiogenetischen Faktor und/oder einen neuroprotektiven Faktor codieren und sekretieren |
US20120020931A1 (en) | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
US20140004201A1 (en) * | 2010-09-15 | 2014-01-02 | Biocompatibles Uk Ltd. | Treatment of Vascular Diseases Using Encapsulated Cells Encoding and Secreting GLP-1, or a Fragment or Variant Thereof |
WO2012099974A2 (en) | 2011-01-19 | 2012-07-26 | Fractyl Laboratories, Inc. | Devices and methods for the treatment of tissue |
WO2012130567A1 (en) * | 2011-03-29 | 2012-10-04 | Beta-Cell Nv | Method for encapsulated therapeutic products and uses thereof |
US9388385B2 (en) | 2011-05-19 | 2016-07-12 | Mesoblast, Inc. | Methods for treating obesity and/or metabolic syndrome |
KR101335176B1 (ko) * | 2011-12-12 | 2013-11-29 | 테고사이언스 (주) | 상처 치유용 드레싱재제 |
KR102245697B1 (ko) | 2012-02-27 | 2021-04-28 | 프랙틸 래브러토리스 인코포레이티드 | 조직의 치료를 위한 열 절제 시스템,장치 및 방법 |
WO2015077571A1 (en) * | 2013-11-22 | 2015-05-28 | Fractyl Laboratories, Inc. | Systems, devices and methods for the creation of a therapeutic restriction in the gastrointestinal tract |
KR102231179B1 (ko) | 2012-04-19 | 2021-03-22 | 프랙틸 래브러토리스 인코포레이티드 | 조직 팽창 디바이스들, 시스템들, 및 방법들 |
EP2879605A4 (de) | 2012-07-30 | 2016-04-06 | Fractyl Lab Inc | Stromablationssysteme, vorrichtungen und verfahren zur behandlung von gewebe |
WO2014026055A1 (en) | 2012-08-09 | 2014-02-13 | Fractyl Laboratories Inc. | Ablation systems, devices and methods for the treatment of tissue |
EP2903626A4 (de) | 2012-10-05 | 2016-10-19 | Fractyl Lab Inc | Verfahren, systeme und vorrichtungen zur durchführung mehrerer behandlungen eines patienten |
WO2014197632A2 (en) | 2013-06-04 | 2014-12-11 | Fractyl Laboratories, Inc. | Methods, systems and devices for reducing the luminal surface area of the gastrointestinal tract |
CN104805058A (zh) * | 2014-01-23 | 2015-07-29 | 上海欧易生物医学科技有限公司 | 一种稳定表达外源性glp-1基因的人脐带源间充质干细胞株 |
US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
US9844641B2 (en) | 2014-07-16 | 2017-12-19 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
WO2016011269A1 (en) | 2014-07-16 | 2016-01-21 | Fractyl Laboratories, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
TWI726889B (zh) * | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
EP3393496B1 (de) | 2015-12-23 | 2023-10-11 | The Johns Hopkins University | Langwirkender glp-1r-agonist als therapie neurologischer und neurodegenerativer erkrankungen |
CN109929806B (zh) * | 2017-12-19 | 2020-05-08 | 北京吉源生物科技有限公司 | 一种表达glp1和fgf21的干细胞及其用途 |
CN111803617A (zh) * | 2020-07-16 | 2020-10-23 | 卡杜兰(广州)生命基因工程科技有限公司 | 一种内载微囊的干细胞系统与制备方法 |
US20220389071A9 (en) * | 2020-09-22 | 2022-12-08 | Yang Wei | Long-lasting glp1 analogue drug for type-2 diabetes |
CN113493764B (zh) * | 2021-07-27 | 2023-01-24 | 新乡医学院 | 一种体外诱导小鼠耳朵间充质干细胞分化为脂肪细胞的方法 |
WO2023028554A1 (en) * | 2021-08-25 | 2023-03-02 | Neuraly, Inc. | Glp-1r agonists for use in a treatment of neurological impairment associated with viral infection |
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2006
- 2006-05-10 DE DE602006009631T patent/DE602006009631D1/de not_active Expired - Fee Related
- 2006-05-10 EP EP06009678A patent/EP1854455B1/de not_active Not-in-force
- 2006-05-10 AT AT06009678T patent/ATE444741T1/de not_active IP Right Cessation
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2007
- 2007-04-27 AT AT07724702T patent/ATE502628T1/de active
- 2007-04-27 JP JP2009508185A patent/JP5209608B2/ja not_active Expired - Fee Related
- 2007-04-27 PL PL07724702T patent/PL2015736T3/pl unknown
- 2007-04-27 CN CNA2007800260098A patent/CN101489539A/zh active Pending
- 2007-04-27 ES ES07724702T patent/ES2363810T3/es active Active
- 2007-04-27 US US12/300,087 patent/US8790705B2/en not_active Expired - Fee Related
- 2007-04-27 WO PCT/EP2007/003775 patent/WO2007128443A2/en active Application Filing
- 2007-04-27 AU AU2007247511A patent/AU2007247511B2/en not_active Ceased
- 2007-04-27 PT PT07724702T patent/PT2015736E/pt unknown
- 2007-04-27 EP EP07724702A patent/EP2015736B1/de not_active Not-in-force
- 2007-04-27 CA CA002649902A patent/CA2649902A1/en not_active Abandoned
- 2007-04-27 DK DK07724702.1T patent/DK2015736T3/da active
- 2007-04-27 DE DE602007013385T patent/DE602007013385D1/de active Active
- 2007-04-27 EP EP09014514A patent/EP2174655A1/de not_active Withdrawn
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- 2012-10-16 US US13/653,277 patent/US20140105991A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101489539A (zh) | 2009-07-22 |
AU2007247511A1 (en) | 2007-11-15 |
EP2174655A1 (de) | 2010-04-14 |
JP5209608B2 (ja) | 2013-06-12 |
ES2363810T3 (es) | 2011-08-17 |
EP1854455A1 (de) | 2007-11-14 |
EP2015736B1 (de) | 2011-03-23 |
ATE502628T1 (de) | 2011-04-15 |
US8790705B2 (en) | 2014-07-29 |
US20140105991A1 (en) | 2014-04-17 |
DK2015736T3 (da) | 2011-06-14 |
JP2009536166A (ja) | 2009-10-08 |
DE602007013385D1 (de) | 2011-05-05 |
EP1854455B1 (de) | 2009-10-07 |
WO2007128443A2 (en) | 2007-11-15 |
PT2015736E (pt) | 2011-05-30 |
CA2649902A1 (en) | 2007-11-15 |
US20100068289A1 (en) | 2010-03-18 |
AU2007247511B2 (en) | 2012-12-06 |
EP2015736A2 (de) | 2009-01-21 |
WO2007128443A3 (en) | 2008-05-22 |
PL2015736T3 (pl) | 2011-09-30 |
DE602006009631D1 (de) | 2009-11-19 |
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