PL3393496T3 - Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych - Google Patents
Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnychInfo
- Publication number
- PL3393496T3 PL3393496T3 PL16880108.2T PL16880108T PL3393496T3 PL 3393496 T3 PL3393496 T3 PL 3393496T3 PL 16880108 T PL16880108 T PL 16880108T PL 3393496 T3 PL3393496 T3 PL 3393496T3
- Authority
- PL
- Poland
- Prior art keywords
- neurological
- agonist
- therapy
- long
- neurodegenerative conditions
- Prior art date
Links
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 title 1
- GNZCSGYHILBXLL-UHFFFAOYSA-N n-tert-butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine Chemical compound ClC1=C(Cl)C=C2N=C(S(C)(=O)=O)C(NC(C)(C)C)=NC2=C1 GNZCSGYHILBXLL-UHFFFAOYSA-N 0.000 title 1
- 230000000626 neurodegenerative effect Effects 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562387319P | 2015-12-23 | 2015-12-23 | |
PCT/US2016/068378 WO2017112889A1 (en) | 2015-12-23 | 2016-12-22 | Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3393496T3 true PL3393496T3 (pl) | 2024-04-22 |
Family
ID=59091242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL16880108.2T PL3393496T3 (pl) | 2015-12-23 | 2016-12-22 | Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych |
Country Status (13)
Country | Link |
---|---|
US (2) | US11123405B2 (pl) |
EP (1) | EP3393496B1 (pl) |
JP (2) | JP7026044B2 (pl) |
KR (1) | KR102508651B1 (pl) |
CN (1) | CN108697768B (pl) |
AU (1) | AU2016379403B2 (pl) |
CA (1) | CA3009506A1 (pl) |
DK (1) | DK3393496T5 (pl) |
EA (1) | EA201891469A1 (pl) |
ES (1) | ES2968038T3 (pl) |
LT (1) | LT3393496T (pl) |
PL (1) | PL3393496T3 (pl) |
WO (1) | WO2017112889A1 (pl) |
Families Citing this family (7)
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EP4005587A4 (en) * | 2019-07-29 | 2023-08-09 | Peptron, Inc. | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF LEVODOPA-INDUCED DYSKINESIA OR SUPPRESSION OF THEIR PROGRESSION |
BR112022001595A2 (pt) * | 2019-07-29 | 2022-03-22 | Peptron Inc | Composição farmacêutica para tratamento ou inibição da progressão da discinesia induzida por levodopa |
WO2021089678A1 (en) * | 2019-11-06 | 2021-05-14 | Novo Nordisk A/S | Glp-1 receptor agonists in dementia |
JP2024500410A (ja) * | 2020-12-16 | 2024-01-09 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 老化脳機能低下を逆転する方法 |
CN113350488B (zh) * | 2021-07-16 | 2023-07-14 | 中国药科大学 | 口服降糖肽ohp在制备抗神经退行性疾病药物方面的应用 |
WO2023028554A1 (en) * | 2021-08-25 | 2023-03-02 | Neuraly, Inc. | Glp-1r agonists for use in a treatment of neurological impairment associated with viral infection |
TW202410918A (zh) * | 2022-05-27 | 2024-03-16 | 韓商D&D製藥科技股份有限公司 | 用於治療神經病症之組合物及方法 |
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GB201404002D0 (en) | 2014-03-06 | 2014-04-23 | Imp Innovations Ltd | Novel compounds |
EP3152238A4 (en) | 2014-06-06 | 2018-01-03 | The California Institute for Biomedical Research | Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof |
GB2528436A (en) | 2014-07-15 | 2016-01-27 | Lancaster Univ Business Entpr Ltd | Treatment of neurological diseases |
WO2016011335A1 (en) | 2014-07-17 | 2016-01-21 | Jerome Schentag | Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems |
WO2016083499A1 (en) | 2014-11-27 | 2016-06-02 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
JP6691125B2 (ja) | 2014-12-17 | 2020-04-28 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
EP3280723B1 (en) | 2015-04-08 | 2021-01-06 | Polyphor AG | Backbone-cyclized peptidomimetics |
WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
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WO2016205488A1 (en) | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
CN106110325A (zh) | 2016-06-08 | 2016-11-16 | 上海朗安生物技术有限公司 | 一种新型 glp‑1 受体激动剂的制备方法及其在神经退行性疾病治疗领域的应用 |
US20210353710A1 (en) * | 2020-03-05 | 2021-11-18 | The Johns Hopkins University | Glp-1r agonist and methods of treatment |
-
2016
- 2016-12-22 CN CN201680082156.6A patent/CN108697768B/zh active Active
- 2016-12-22 LT LTEPPCT/US2016/068378T patent/LT3393496T/lt unknown
- 2016-12-22 US US16/065,445 patent/US11123405B2/en active Active
- 2016-12-22 PL PL16880108.2T patent/PL3393496T3/pl unknown
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- 2016-12-22 WO PCT/US2016/068378 patent/WO2017112889A1/en active Application Filing
- 2016-12-22 CA CA3009506A patent/CA3009506A1/en active Pending
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EP3393496A4 (en) | 2019-07-31 |
WO2017112889A1 (en) | 2017-06-29 |
DK3393496T5 (da) | 2024-09-16 |
JP7026044B2 (ja) | 2022-02-25 |
KR20180096733A (ko) | 2018-08-29 |
AU2016379403A1 (en) | 2018-07-19 |
JP2020059735A (ja) | 2020-04-16 |
KR102508651B1 (ko) | 2023-03-13 |
AU2016379403B2 (en) | 2020-03-12 |
LT3393496T (lt) | 2023-12-11 |
DK3393496T3 (en) | 2023-11-13 |
CN108697768B (zh) | 2022-07-22 |
EP3393496A1 (en) | 2018-10-31 |
EP3393496B1 (en) | 2023-10-11 |
US11123405B2 (en) | 2021-09-21 |
EA201891469A1 (ru) | 2018-12-28 |
US20180369340A1 (en) | 2018-12-27 |
US20220111010A1 (en) | 2022-04-14 |
CA3009506A1 (en) | 2017-06-29 |
JP2019500369A (ja) | 2019-01-10 |
ES2968038T3 (es) | 2024-05-06 |
CN108697768A (zh) | 2018-10-23 |
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