EP1545608A4 - Mammalian ch1 deleted mimetibodies, compositions, methods and uses - Google Patents
Mammalian ch1 deleted mimetibodies, compositions, methods and usesInfo
- Publication number
- EP1545608A4 EP1545608A4 EP03742272A EP03742272A EP1545608A4 EP 1545608 A4 EP1545608 A4 EP 1545608A4 EP 03742272 A EP03742272 A EP 03742272A EP 03742272 A EP03742272 A EP 03742272A EP 1545608 A4 EP1545608 A4 EP 1545608A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mammalian
- compositions
- methods
- deleted mimetibodies
- mimetibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39243102P | 2002-06-28 | 2002-06-28 | |
US392431P | 2002-06-28 | ||
PCT/US2003/020347 WO2004002417A2 (en) | 2002-06-28 | 2003-06-27 | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1545608A2 EP1545608A2 (en) | 2005-06-29 |
EP1545608A4 true EP1545608A4 (en) | 2006-09-13 |
Family
ID=30000868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03742272A Withdrawn EP1545608A4 (en) | 2002-06-28 | 2003-06-27 | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1545608A4 (en) |
JP (1) | JP2006504406A (en) |
CN (1) | CN1735433A (en) |
AU (1) | AU2003280130B2 (en) |
CA (1) | CA2490409A1 (en) |
WO (1) | WO2004002417A2 (en) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
HU228582B1 (en) | 1998-10-23 | 2013-04-29 | Kirin Amgen Inc | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
EP1572079A4 (en) * | 2002-03-29 | 2006-09-06 | Centocor Inc | Mammalian cdr mimetibodies, compositions, methods and uses |
CA2490411A1 (en) * | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
JP4767857B2 (en) * | 2003-09-30 | 2011-09-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Benzimidazole compounds |
UA89481C2 (en) * | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Human epo mimetic hinge core mimetibodies, compositions, methods and uses |
JP2008537873A (en) * | 2004-03-31 | 2008-10-02 | セントカー・インコーポレーテツド | Human GLP-1 mimetibody, compositions, methods and uses |
JP5017116B2 (en) | 2004-09-24 | 2012-09-05 | アムジエン・インコーポレーテツド | Modified Fc molecule |
AU2005289594B2 (en) * | 2004-09-27 | 2012-02-02 | Centocor, Inc. | Srage mimetibody, compositions, methods and uses |
BRPI0518411A2 (en) * | 2004-10-25 | 2008-11-18 | Centocor Inc | Melanocortin receptor binding mimetics, compositions, methods and uses |
AU2005339797A1 (en) * | 2005-03-28 | 2007-07-19 | Centocor, Inc. | Human GLP-1 mimetibodies, compositions, methods and uses |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
CA2648035A1 (en) * | 2006-03-31 | 2007-10-11 | Centocor, Inc. | Human epo mimetic hinge core mimetibodies, compositions, methods and uses for preventing or treating glucose intolerance related conditions or renal disease associated anemia |
WO2008028044A2 (en) | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel |
US8834920B2 (en) | 2006-12-21 | 2014-09-16 | Alza Corporation | Liposome composition for targeting egfr receptor |
US8536113B2 (en) | 2006-12-21 | 2013-09-17 | Janssen Biotech, Inc. | EGFR binding peptides and uses thereof |
US8278415B2 (en) | 2006-12-21 | 2012-10-02 | Centocor, Inc. | Dimeric high affinity EGFR constructs and uses thereof |
WO2008092209A1 (en) * | 2007-02-01 | 2008-08-07 | Arana Therapeutics Limited | Protein construct with improved properties |
CA2701032C (en) | 2007-09-27 | 2021-01-26 | Amgen Inc. | Pharmaceutical formulations |
US8796206B2 (en) | 2007-11-15 | 2014-08-05 | Amgen Inc. | Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration |
WO2009094551A1 (en) | 2008-01-25 | 2009-07-30 | Amgen Inc. | Ferroportin antibodies and methods of use |
ES2487846T3 (en) | 2008-05-01 | 2014-08-25 | Amgen, Inc. | Anti-hepcindin antibodies and methods of use |
DK2329259T3 (en) | 2008-08-29 | 2016-05-09 | Janssen Biotech Inc | MARKERS AND PROCEDURES FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISEASES USING A 20-GEN PANEL |
EP2352998A4 (en) | 2008-11-07 | 2011-09-21 | Centocor Ortho Biotech Inc | Markers and methods for assessing and treating lupus patients susceptible to photoprovocation |
CN104922669A (en) | 2008-11-13 | 2015-09-23 | 通用医疗公司 | Methods and compositions for regulating iron homeostasis by modulation bmp-6 |
AU2010310457B2 (en) | 2009-10-23 | 2015-07-02 | Amgen Inc. | Vial adapter and system |
US8450086B2 (en) | 2009-11-17 | 2013-05-28 | Centocor Ortho Biotech Inc. | Bacterial membrane protein secretion |
CA2781019A1 (en) | 2009-11-17 | 2011-05-26 | Janssen Biotech, Inc. | Display of disulfide linked dimeric proteins on filamentous phage |
EP2536435B1 (en) | 2010-02-18 | 2017-11-15 | Janssen Biotech, Inc. | Monkey homolog of human interferon omega |
WO2011130533A1 (en) | 2010-04-16 | 2011-10-20 | Centocor Ortho Biotech Inc. | Engineered plant cysteine proteases and their uses |
RS54291B2 (en) | 2010-06-07 | 2023-12-29 | Amgen Inc | Drug delivery device |
JP6126991B2 (en) | 2010-09-27 | 2017-05-10 | ヤンセン バイオテツク,インコーポレーテツド | Antibody binding to human type II collagen |
MX341790B (en) | 2011-03-31 | 2016-09-02 | Amgen Inc | Vial adapter and system. |
CA3145238A1 (en) | 2011-04-20 | 2012-10-26 | Amgen Inc. | Autoinjector apparatus |
CA2851521C (en) | 2011-10-14 | 2020-09-22 | Amgen Inc. | Injector and method of assembly |
AU2013348071B2 (en) | 2012-11-21 | 2018-05-24 | Amgen Inc. | Drug delivery device |
CA2904357C (en) | 2013-03-15 | 2020-09-22 | Intrinsic Lifesciences Llc | Anti-hepcidin antibodies and uses thereof |
EP2968760B1 (en) | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
WO2014143815A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
JP2016514456A (en) * | 2013-03-15 | 2016-05-23 | オメロス コーポレーション | Method for producing bioactive peptide-carrying antibody and composition comprising the same |
TWI592183B (en) | 2013-03-15 | 2017-07-21 | 安美基公司 | Body contour adaptable autoinjector device |
LT2976117T (en) | 2013-03-22 | 2021-02-25 | Amgen Inc. | Injector and method of assembly |
BR112016008946B1 (en) | 2013-10-24 | 2022-12-27 | Amgen Inc | INJECTORS AND METHOD FOR ASSEMBLING THE INJECTORS |
EP3501575B1 (en) | 2013-10-24 | 2021-12-01 | Amgen Inc. | Drug delivery system with temperature-sensitive-control |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
EP3139977B1 (en) | 2014-05-07 | 2021-02-17 | Amgen Inc. | Autoinjector with shock reducing elements |
SG11201609966SA (en) | 2014-06-03 | 2016-12-29 | Amgen Inc | Drug delivery system and method of use |
US10323088B2 (en) | 2014-09-22 | 2019-06-18 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
MX2021014323A (en) | 2014-10-14 | 2023-02-02 | Amgen Inc | Drug injection device with visual and audio indicators. |
EP3689394A1 (en) | 2014-12-19 | 2020-08-05 | Amgen Inc. | Drug delivery device with live button or user interface field |
EP3848072A1 (en) | 2014-12-19 | 2021-07-14 | Amgen Inc. | Drug delivery device with proximity sensor |
EP3556411B1 (en) | 2015-02-17 | 2021-06-30 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
EP3261690B1 (en) | 2015-02-27 | 2021-12-15 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
US11351308B2 (en) | 2015-12-09 | 2022-06-07 | Amgen Inc. | Auto-injector with signaling cap |
WO2017120178A1 (en) | 2016-01-06 | 2017-07-13 | Amgen Inc. | Auto-injector with signaling electronics |
ES2814287T3 (en) | 2016-03-15 | 2021-03-26 | Amgen Inc | Reduce the likelihood of glass breakage in drug delivery devices |
WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
WO2017197222A1 (en) | 2016-05-13 | 2017-11-16 | Amgen Inc. | Vial sleeve assembly |
WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
EP3478342A1 (en) | 2016-07-01 | 2019-05-08 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
WO2018034784A1 (en) | 2016-08-17 | 2018-02-22 | Amgen Inc. | Drug delivery device with placement detection |
WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
AU2018210301A1 (en) | 2017-01-17 | 2019-08-01 | Amgen Inc. | Injection devices and related methods of use and assembly |
US11369736B2 (en) | 2017-02-17 | 2022-06-28 | Amgen Inc. | Cannula insertion and retraction mechanisms |
CA3048520A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
JP2020508803A (en) | 2017-03-06 | 2020-03-26 | アムジエン・インコーポレーテツド | Drug delivery device with anti-actuation feature |
SG11201908058UA (en) | 2017-03-07 | 2019-09-27 | Amgen Inc | Needle insertion by overpressure |
KR102619150B1 (en) | 2017-03-09 | 2023-12-27 | 암겐 인코포레이티드 | Insertion mechanism for drug delivery device |
JP2020511499A (en) | 2017-03-20 | 2020-04-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Method for in vitro glycosylation of erythropoiesis stimulating proteins |
SI3600491T1 (en) | 2017-03-28 | 2023-11-30 | Amgen Inc. | Plunger rod and syringe assembly system and method |
AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
CN110709121B (en) | 2017-06-08 | 2022-06-24 | 安进公司 | Torque-driven drug delivery device |
MX2019015472A (en) | 2017-06-22 | 2020-02-19 | Amgen Inc | Device activation impact/shock reduction. |
WO2018237225A1 (en) | 2017-06-23 | 2018-12-27 | Amgen Inc. | Electronic drug delivery device comprising a cap activated by a switch assembly |
EP3651832B1 (en) | 2017-07-14 | 2023-12-13 | Amgen Inc. | Needle insertion-retraction system having dual torsion spring system |
MA49626A (en) | 2017-07-21 | 2020-05-27 | Amgen Inc | GAS PERMEABLE SEALING ELEMENT FOR DRUG CONTAINER AND ASSEMBLY PROCEDURES |
EP3658203B1 (en) | 2017-07-25 | 2022-08-31 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
MA49676A (en) | 2017-07-25 | 2020-06-03 | Amgen Inc | DRUG ADMINISTRATION DEVICE EQUIPPED WITH A CONTAINER ACCESS SYSTEM AND ASSOCIATED ASSEMBLY PROCEDURE |
WO2019032482A2 (en) | 2017-08-09 | 2019-02-14 | Amgen Inc. | Hydraulic-pneumatic pressurized chamber drug delivery system |
EP3668567A1 (en) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Wearable injector with sterile adhesive patch |
US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
MA50611A (en) | 2017-10-04 | 2020-08-12 | Amgen Inc | FLOW ADAPTER FOR A DRUG DELIVERY DEVICE |
WO2019070552A1 (en) | 2017-10-06 | 2019-04-11 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
US11464903B2 (en) | 2017-10-09 | 2022-10-11 | Amgen Inc. | Drug delivery device with drive assembly and related method of assembly |
MA50527A (en) | 2017-11-03 | 2020-09-09 | Amgen Inc | SYSTEM AND APPROACHES TO STERILIZE A DRUG DELIVERY DEVICE |
EP3707075A1 (en) | 2017-11-06 | 2020-09-16 | Amgen Inc. | Fill-finish assemblies and related methods |
EP3706830B1 (en) | 2017-11-06 | 2024-08-07 | Amgen Inc. | Drug delivery device with placement and flow sensing |
CN111225696B (en) | 2017-11-10 | 2023-07-18 | 安进公司 | Plunger for a drug delivery device |
AU2018368340B2 (en) | 2017-11-16 | 2024-03-07 | Amgen Inc. | Door latch mechanism for drug delivery device |
AU2018368338B2 (en) | 2017-11-16 | 2024-07-25 | Amgen Inc. | Autoinjector with stall and end point detection |
US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
WO2020023220A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation |
MA53375A (en) | 2018-07-24 | 2021-06-02 | Amgen Inc | ADMINISTRATION DEVICES FOR THE ADMINISTRATION OF MEDICINES |
MA53379A (en) | 2018-07-24 | 2021-06-02 | Amgen Inc | ADMINISTRATION DEVICES FOR THE ADMINISTRATION OF MEDICINES |
US12115360B2 (en) | 2018-07-24 | 2024-10-15 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
US12109389B2 (en) | 2018-07-31 | 2024-10-08 | Amgen Inc. | Fluid path assembly for a drug delivery device |
US20210346601A1 (en) | 2018-09-24 | 2021-11-11 | Amgen Inc. | Interventional dosing systems and methods |
AU2019350660B2 (en) | 2018-09-28 | 2024-09-26 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
CN117159846A (en) | 2018-10-02 | 2023-12-05 | 安进公司 | Injection system for drug delivery with internal force transfer |
CA3112214A1 (en) | 2018-10-05 | 2020-04-09 | Amgen Inc. | Drug delivery device having dose indicator |
MA53912A (en) | 2018-10-15 | 2022-01-19 | Amgen Inc | DRUG DELIVERY DEVICE INCLUDING A DAMPENING MECHANISM |
MX2021002791A (en) | 2018-10-15 | 2021-05-12 | Amgen Inc | Platform assembly process for drug delivery device. |
US11213620B2 (en) | 2018-11-01 | 2022-01-04 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
EP3873563A1 (en) | 2018-11-01 | 2021-09-08 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
TWI831847B (en) | 2018-11-01 | 2024-02-11 | 美商安進公司 | Drug delivery devices with partial needle retraction and methods for operating the same |
CA3137360A1 (en) | 2019-04-24 | 2020-10-29 | Amgen Inc. | Syringe sterilization verification assemblies and methods |
WO2021041067A2 (en) | 2019-08-23 | 2021-03-04 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
US20240208680A1 (en) | 2021-05-21 | 2024-06-27 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
WO2024094457A1 (en) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Method for producing glycoprotein compositions |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
WO2000024782A2 (en) * | 1998-10-23 | 2000-05-04 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
US20020012989A1 (en) * | 1993-02-01 | 2002-01-31 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
WO2002046227A2 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
WO2002046238A2 (en) * | 2000-12-05 | 2002-06-13 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
WO2003084477A2 (en) * | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
FR2374910A1 (en) | 1976-10-23 | 1978-07-21 | Choay Sa | PREPARATION BASED ON HEPARIN, INCLUDING LIPOSOMES, PROCESS FOR OBTAINING IT AND MEDICINAL PRODUCTS CONTAINING SUCH PREPARATIONS |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US5149636A (en) | 1982-03-15 | 1992-09-22 | Trustees Of Columbia University In The City Of New York | Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products |
US5169762A (en) | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
SE448277B (en) | 1985-04-12 | 1987-02-09 | Draco Ab | INDICATOR DEVICE WITH A DOSAGE DEVICE FOR MEDICINAL PRODUCTS |
US4740587A (en) | 1985-07-18 | 1988-04-26 | The Salk Institute For Biological Studies | Inhibin and method of purifying same |
US4721672A (en) | 1985-08-28 | 1988-01-26 | President And Fellows Of Harvard College | CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression |
US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
SE453566B (en) | 1986-03-07 | 1988-02-15 | Draco Ab | POWDER INHALATOR DEVICE |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
AU610083B2 (en) | 1986-08-18 | 1991-05-16 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
DE3631229A1 (en) | 1986-09-13 | 1988-03-24 | Basf Ag | MONOCLONAL ANTIBODIES AGAINST HUMAN TUMORNESCROSE FACTOR (TNF) AND THEIR USE |
EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
US5075236A (en) | 1987-04-24 | 1991-12-24 | Teijin Limited | Method of detecting kawasaki disease using anti-tumor necrosis antibody |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
US5231166A (en) | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5266491A (en) | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
EP0486526B2 (en) | 1989-08-07 | 2001-03-07 | Peptech Limited | Tumour necrosis factor binding ligands |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5210026A (en) | 1990-08-20 | 1993-05-11 | American Cyanamid Company | Human mk gene and method of expression |
GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
US5268465A (en) | 1991-01-18 | 1993-12-07 | The Johns Hopkins University | Purification and molecular cloning of nitric oxide synthase |
US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
GEP20033082B (en) | 1991-03-15 | 2003-10-27 | Amgen Inc | Pegylation of Polypeptides |
US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
DE69233690T2 (en) | 1991-07-02 | 2008-01-24 | Nektar Therapeutics, San Carlos | Delivery device for nebulous drugs |
US5976835A (en) | 1992-03-19 | 1999-11-02 | The Rockefeller University | Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
US5315000A (en) | 1992-05-14 | 1994-05-24 | Children's Hospital Medical Center | Gene encoding for a L5/3 growth factor and its CDNA |
AU4829593A (en) | 1992-09-23 | 1994-04-12 | Fisons Plc | Inhalation device |
PL172758B1 (en) | 1992-10-19 | 1997-11-28 | Dura Pharma Inc | Dry powder inhaler |
US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US6143289A (en) | 1992-12-09 | 2000-11-07 | Indiana University Foundation | Compositions of myeloid-cell-suppressive chemokines |
US5849695A (en) | 1993-01-13 | 1998-12-15 | The Regents Of The University Of California | Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals |
DK0680451T3 (en) | 1993-01-19 | 1999-07-19 | Glaxo Group Ltd | Aerosol dispenser as well as process of its manufacture |
WO1994018317A1 (en) | 1993-02-12 | 1994-08-18 | The Board Of Trustees Of The Leland Stanford Junior University | Regulated transcription of targeted genes and other biological events |
US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5880096A (en) | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5786331A (en) | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US6174995B1 (en) | 1994-08-23 | 2001-01-16 | Haodong Li | Human chemokines, CKβ4 and CKβ10/MCP-4 |
EP0741144B1 (en) | 1994-11-11 | 2002-07-24 | Noboru Kaneko | Antiannexin-v monoclonal antibody, process for producing the same, and use therof |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
US6284535B1 (en) | 1995-09-07 | 2001-09-04 | The Trustees Of Columbia University In The City Of New York | Splice variants of the heregulin gene, nARIA and uses thereof |
GB9526100D0 (en) | 1995-12-20 | 1996-02-21 | Intersurgical Ltd | Nebulizer |
JP2000503565A (en) | 1996-01-03 | 2000-03-28 | グラクソ、グループ、リミテッド | Inhaler |
US5700774A (en) | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
IL118003A0 (en) | 1996-04-23 | 1996-08-04 | Yeda Res & Dev | Novel vip fragments and pharmaceutical compositions comprising them |
US6271347B1 (en) | 1996-04-26 | 2001-08-07 | Merck & Co., Inc. | Eosinophil eotaxin receptor |
DE69737229T2 (en) | 1996-06-07 | 2008-01-31 | Takeda Pharmaceutical Co. Ltd. | PEPTIDE WITH CORTISTATIN OR SOMATOSTATIN ACTIVITY, METHOD FOR THE PRODUCTION THEREOF AND ITS USE |
DE69714698T2 (en) | 1996-06-10 | 2002-12-05 | Sucampo Ag, Zug | Endothelin antagonists |
US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
WO1998009940A1 (en) | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
CA2218456A1 (en) | 1996-10-15 | 1998-04-15 | The Rockefeller University | Purified stat proteins and methods of purifying thereof |
HU222666B1 (en) | 1996-11-15 | 2003-09-29 | Genentech, Inc. | Purification of neurotrophins |
ATE318515T1 (en) | 1996-11-19 | 2006-03-15 | Univ Georgetown | METHOD FOR INHIBITING HEREGULIN AND ITS RECEPTOR AND USE FOR INHIBITING CANCER CELLS |
US5948892A (en) | 1996-12-16 | 1999-09-07 | Amgen Inc. | Analogs of macrophage stimulating protein |
US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US6136558A (en) | 1997-02-10 | 2000-10-24 | Genentech, Inc. | Heregulin variants |
US5921447A (en) | 1997-02-13 | 1999-07-13 | Glaxo Wellcome Inc. | Flow-through metered aerosol dispensing apparatus and method of use thereof |
IT1292017B1 (en) | 1997-05-28 | 1999-01-25 | Dompe Spa | PHARMACEUTICAL COMPOSITIONS CONTAINING MACROPHAGE STIMULATING PROTEIN FOR THE TREATMENT OF NERVOUS SYSTEM PATHOLOGIES |
IL120943A (en) | 1997-05-29 | 2004-03-28 | Univ Ben Gurion | Transdermal delivery system |
US6265535B1 (en) | 1997-05-30 | 2001-07-24 | The Trustees Of The University Of Pennsylvania | Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses |
AR016551A1 (en) | 1997-07-30 | 2001-07-25 | Smithkline Beecham Corp | DERIVATIVES OF 2-OXINDOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES |
US6180084B1 (en) * | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
-
2003
- 2003-06-27 EP EP03742272A patent/EP1545608A4/en not_active Withdrawn
- 2003-06-27 AU AU2003280130A patent/AU2003280130B2/en not_active Ceased
- 2003-06-27 WO PCT/US2003/020347 patent/WO2004002417A2/en active Application Filing
- 2003-06-27 CA CA002490409A patent/CA2490409A1/en not_active Abandoned
- 2003-06-27 JP JP2004517981A patent/JP2006504406A/en active Pending
- 2003-06-30 CN CNA038201100A patent/CN1735433A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020012989A1 (en) * | 1993-02-01 | 2002-01-31 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
WO2000024782A2 (en) * | 1998-10-23 | 2000-05-04 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
WO2002046238A2 (en) * | 2000-12-05 | 2002-06-13 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
WO2002046227A2 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
WO2003084477A2 (en) * | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
Non-Patent Citations (14)
Title |
---|
BES CEDRIC ET AL: "Efficient CD4 binding and immunosuppressive properties of the 13B8.2 monoclonal antibody are displayed by its CDR-H1-derived peptide CB1", FEBS LETTERS, vol. 508, no. 1, 9 November 2001 (2001-11-09), pages 67 - 74, XP004322279, ISSN: 0014-5793 * |
CASARES SOFIA ET AL: "Foreign peptides expressed in engineered chimeric self molecules", BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS INTERCEPT LTD. {A}, P. O. BOX 716, ANDOVER SP10 1YG, ENGLAND SERIES : BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS (ISSN 0264-8725), 1998, pages 159 - 198, XP009069478, ISSN: 1-898298-54-8 * |
HAYDEN M S ET AL: "Antibody engineering", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, vol. 9, no. 2, April 1997 (1997-04-01), pages 201 - 212, XP004327252, ISSN: 0952-7915 * |
HAYDEN M S ET AL: "SINGLE-CHAIN MONO- AND BISPECIFIC ANTIBODY DERIVATIVES WITH NOVEL BIOLOGICAL PROPERTIES AND ANTITUMOUR ACTIVITY FROM A COS CELL TRANSIENT EXPRESSION SYSTEM", THERAPEUTIC IMMUNOLOGY, BLACKWELL SCIENTIFIC PUBL. LONDON, GB, vol. 1, no. 1, January 1994 (1994-01-01), pages 3 - 15, XP009023719, ISSN: 0967-0149 * |
HUFTON-SE ET AL: "Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 475, no. 3, 23 June 2000 (2000-06-23), pages 225 - 231, XP004337267, ISSN: 0014-5793 * |
IGARASHI T ET AL: "Structure of a mouse immunoglobulin G that lacks the entire CH1 domain: protein sequencing and small-angle X-ray scattering studies.", BIOCHEMISTRY. 19 JUN 1990, vol. 29, no. 24, 19 June 1990 (1990-06-19), pages 5727 - 5733, XP002389674, ISSN: 0006-2960 * |
JACOBIN MARIE-JOSEE ET AL: "Human IgG monoclonal anti-alphaIIbbeta3-binding fragments derived from immunized donors using phage display.", JOURNAL OF IMMUNOLOGY, vol. 168, no. 4, 15 February 2002 (2002-02-15), pages 2035 - 2045, XP002389673, ISSN: 0022-1767 * |
LAMBERT MIREILLE ET AL: "Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: Contribution of both outside-in and inside-out signals", JOURNAL OF CELL SCIENCE, vol. 113, no. 12, June 2000 (2000-06-01), pages 2207 - 2219, XP002389675, ISSN: 0021-9533 * |
LIVNAH O ET AL: "FUNCTIONAL MIMICRY OF A PROTEIN HORMONE BY A PEPTIDE AGONIST: THE EPO RECEPTOR COMPLEX AT 2.8 AA", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 273, 26 July 1996 (1996-07-26), pages 464 - 471, XP002021035, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.464 * |
MONNET CELINE ET AL: "Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 6, 5 February 1999 (1999-02-05), pages 3789 - 3796, XP002283342, ISSN: 0021-9258 * |
SAGOT MARIE-ASTRID ET AL: "A monoclonal antibody directed against the neurokinin-1 receptor contains a peptide sequence with similar hydropathy and functional properties to substance P, the natural ligand for the receptor", MOLECULAR IMMUNOLOGY, vol. 37, no. 8, June 2000 (2000-06-01), pages 423 - 433, XP002389672, ISSN: 0161-5890 * |
See also references of WO2004002417A2 * |
WELLS J A: "HORMONE MIMICRY", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 273, 26 July 1996 (1996-07-26), pages 449/450, XP000999487, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.449 * |
WRIGHTON N C ET AL: "Small peptides as potent mimetics of the protein hormone erythropoietin", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, no. 273, 1 July 1996 (1996-07-01), pages 458 - 463, XP002074894, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.458 * |
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EP1545608A2 (en) | 2005-06-29 |
CN1735433A (en) | 2006-02-15 |
CA2490409A1 (en) | 2004-01-08 |
AU2003280130B2 (en) | 2009-06-11 |
WO2004002417A3 (en) | 2004-11-04 |
WO2004002417A2 (en) | 2004-01-08 |
JP2006504406A (en) | 2006-02-09 |
AU2003280130A1 (en) | 2004-01-19 |
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