EA201070040A1 - Новые соединения, соединения, которые влияют на клеточные везикулярные системы, фармацевтические композиции и их применение - Google Patents
Новые соединения, соединения, которые влияют на клеточные везикулярные системы, фармацевтические композиции и их применениеInfo
- Publication number
- EA201070040A1 EA201070040A1 EA201070040A EA201070040A EA201070040A1 EA 201070040 A1 EA201070040 A1 EA 201070040A1 EA 201070040 A EA201070040 A EA 201070040A EA 201070040 A EA201070040 A EA 201070040A EA 201070040 A1 EA201070040 A1 EA 201070040A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- connections
- pharmaceutical compositions
- hydrogen
- independently
- compounds
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Данное изобретение касается соединений, приемлемых для лечения состояний болезни и влияния на клеточные везикулярные системы, особенно на образование и/или функционирование липидных капель, причем указанное соединение имеет общую формулу I, где каждый Х независимо является водородом, галогеном, -С-алкильной, -С-алкенильной, -С-алкинильной, -С-циклоалкильной, арильной, аралкильной, адамантильной, гетероциклической, гидроксильной, гидроксиалкильной или -N-(R, R) группой; n является 0, 1, 2, 3 или 4; Rи R, каждый независимо, могут быть водородом, прямой или разветвленной алкильной, циклоалкильной, арильной, аралкильной, гетероциклической группой, где каждая является незамещенной или замещенной галогеном; или Rи Rвместе с азотом между ними формируют 5- или 6-членное кольцо; А является одинарной связью, -О-, -S-, -CH- или -NH-; Y является О или S; Z является О или S; R' и R'', каждый независимо, являются метилом, этилом, изопропилом, изобутилом, sec-бутилом или terc-бутилом; при условии что все Хне могут быть фтором, и А быть одинарной связью, и Y, а также Z быть О, и R', а также R'' быть изопропилом, и Rи Rбыть водородом в одно и то же время. Данное изобретение далее касается фармацевтических композиций, включающих такие соединения, и применения таких соединений для лечения состояний болезни
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0700433A HUP0700433A2 (en) | 2007-06-21 | 2007-06-21 | Compounds influencing development or functioning of cellular vesicular systems particularly lipid droplets, pharmaceutical compositions containing these compounds and use them for treatment of illnesses |
PCT/HU2008/000075 WO2008155594A2 (en) | 2007-06-21 | 2008-06-20 | Phthalimide derivatives that influence cellular vesicular systems, pharmaceutical compositions, and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201070040A1 true EA201070040A1 (ru) | 2010-06-30 |
Family
ID=89987602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070040A EA201070040A1 (ru) | 2007-06-21 | 2008-06-20 | Новые соединения, соединения, которые влияют на клеточные везикулярные системы, фармацевтические композиции и их применение |
Country Status (10)
Country | Link |
---|---|
US (1) | US8232299B2 (ru) |
EP (1) | EP2373618A2 (ru) |
JP (1) | JP2010530410A (ru) |
CN (1) | CN101784523A (ru) |
AU (1) | AU2008264918A1 (ru) |
BR (1) | BRPI0813501A2 (ru) |
CA (1) | CA2691522A1 (ru) |
EA (1) | EA201070040A1 (ru) |
HU (1) | HUP0700433A2 (ru) |
WO (1) | WO2008155594A2 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP1000688A2 (en) * | 2010-12-23 | 2012-08-28 | Avidin Kft | Use of trifluoro-phthalimides in the treatment of cancer |
WO2014136911A1 (ja) * | 2013-03-06 | 2014-09-12 | Jx日鉱日石エネルギー株式会社 | 摩擦調整剤および潤滑油組成物 |
US20170283408A1 (en) * | 2014-09-19 | 2017-10-05 | Yen-Ta Lu | Benzo-heterocyclic compounds and their applications |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673699A (en) * | 1984-11-19 | 1987-06-16 | Mobay Corporation | Flame retardant molding compositions |
-
2007
- 2007-06-21 HU HU0700433A patent/HUP0700433A2/hu unknown
-
2008
- 2008-06-20 JP JP2010512785A patent/JP2010530410A/ja not_active Withdrawn
- 2008-06-20 BR BRPI0813501-0A2A patent/BRPI0813501A2/pt not_active Application Discontinuation
- 2008-06-20 EA EA201070040A patent/EA201070040A1/ru unknown
- 2008-06-20 CN CN200880103820A patent/CN101784523A/zh active Pending
- 2008-06-20 CA CA002691522A patent/CA2691522A1/en not_active Abandoned
- 2008-06-20 AU AU2008264918A patent/AU2008264918A1/en not_active Abandoned
- 2008-06-20 US US12/452,206 patent/US8232299B2/en not_active Expired - Fee Related
- 2008-06-20 WO PCT/HU2008/000075 patent/WO2008155594A2/en active Application Filing
- 2008-06-20 EP EP08776241A patent/EP2373618A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US8232299B2 (en) | 2012-07-31 |
WO2008155594A2 (en) | 2008-12-24 |
WO2008155594A3 (en) | 2009-02-12 |
EP2373618A2 (en) | 2011-10-12 |
HU0700433D0 (en) | 2007-08-28 |
JP2010530410A (ja) | 2010-09-09 |
US20100184762A1 (en) | 2010-07-22 |
BRPI0813501A2 (pt) | 2015-01-06 |
CN101784523A (zh) | 2010-07-21 |
AU2008264918A1 (en) | 2008-12-24 |
HUP0700433A2 (en) | 2009-03-30 |
CA2691522A1 (en) | 2008-12-24 |
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