HUP0402500A2 - Gyulladáskeltő citokinok kibocsátását gátló heterokondenzált pirazol-3-on vegyületek és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Gyulladáskeltő citokinok kibocsátását gátló heterokondenzált pirazol-3-on vegyületek és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402500A2 HUP0402500A2 HU0402500A HUP0402500A HUP0402500A2 HU P0402500 A2 HUP0402500 A2 HU P0402500A2 HU 0402500 A HU0402500 A HU 0402500A HU P0402500 A HUP0402500 A HU P0402500A HU P0402500 A2 HUP0402500 A2 HU P0402500A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- compounds
- inflammatory cytokines
- amino
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 title 1
- -1 amino- Chemical group 0.000 abstract 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgyát gyulladáskeltő citokinok extracelluláriskibocsátását gátló általános képletű vegyületek - ahol R H,szubsztituált aminocsoport vagy éterkötéssel kapcsolódó csoport, R1 a)szubsztituált vagy szubsztituálatlan aril-; b) szubsztituált vagyszubsztituálatlan heteroaril-csoport; R2a és R2b egymástól függetlenülhidrogénatom, éterkötéssel kapcsolódó csoport, amino-, karbamoil-,oxikarbonil-, karboxi-oxi csoport, vagy amino-, karbamoil-,oxikarbonil-, karboxi-oxi csoporttal szubsztituált alkilcsoport, vagyegyütt kettőskötést vagy karbonilcsoportot képezhetnek: vagy R2a ésR2b együtt 4-8 atomos szubsztituált vagy szubsztituálatlan i)karbociklikus; ii) heterociklikus; iii) aril-; iv) heteroaril-; v)biciklikus vagy vi) heterobiciklikus gyűrűt képez - összes enantiomerés diasztereomer formáik, gyógyszerészetileg elfogadható sóik és azezeket tartalmazó gyógyszerkészítmények képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32362501P | 2001-09-20 | 2001-09-20 | |
| PCT/US2002/030134 WO2003024970A1 (en) | 2001-09-20 | 2002-09-20 | Compounds which inhibit the release of inflammatory cytokines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0402500A2 true HUP0402500A2 (hu) | 2005-03-29 |
| HUP0402500A3 HUP0402500A3 (en) | 2008-10-28 |
Family
ID=23259997
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402378A HUP0402378A3 (en) | 2001-09-20 | 2002-09-20 | Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones controlling inflammatory cytokines and pharmaceutical compositions containing them |
| HU0402500A HUP0402500A3 (en) | 2001-09-20 | 2002-09-20 | Heterocondenzated pyrazol-3-one compounds which inhibit the release of inflammatory cytokines and pharmaceutical compositions containing them |
| HU0500752A HUP0500752A2 (en) | 2001-09-20 | 2002-09-20 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402378A HUP0402378A3 (en) | 2001-09-20 | 2002-09-20 | Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones controlling inflammatory cytokines and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500752A HUP0500752A2 (en) | 2001-09-20 | 2002-09-20 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US6566357B1 (hu) |
| EP (3) | EP1427728B1 (hu) |
| JP (3) | JP2005504082A (hu) |
| KR (4) | KR100623879B1 (hu) |
| CN (3) | CN1250551C (hu) |
| AR (3) | AR037237A1 (hu) |
| AT (3) | ATE356126T1 (hu) |
| AU (2) | AU2002334641B2 (hu) |
| BR (3) | BR0212905A (hu) |
| CA (3) | CA2461073A1 (hu) |
| CO (3) | CO5560590A2 (hu) |
| CY (1) | CY1106398T1 (hu) |
| CZ (3) | CZ2004361A3 (hu) |
| DE (3) | DE60202782T2 (hu) |
| DK (2) | DK1427732T3 (hu) |
| EG (2) | EG24413A (hu) |
| ES (3) | ES2282459T3 (hu) |
| HK (2) | HK1071366A1 (hu) |
| HU (3) | HUP0402378A3 (hu) |
| IL (3) | IL160741A0 (hu) |
| MA (3) | MA27066A1 (hu) |
| MX (3) | MXPA04002569A (hu) |
| MY (2) | MY129329A (hu) |
| NO (2) | NO20041594L (hu) |
| NZ (3) | NZ531123A (hu) |
| PE (3) | PE20030474A1 (hu) |
| PL (3) | PL370362A1 (hu) |
| PT (3) | PT1427727E (hu) |
| RU (3) | RU2272040C2 (hu) |
| SA (1) | SA03230529B1 (hu) |
| SK (3) | SK1502004A3 (hu) |
| WO (3) | WO2003024973A1 (hu) |
| ZA (3) | ZA200401260B (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849627B2 (en) | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7087615B2 (en) | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| US6677337B2 (en) * | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
| CA2497007A1 (en) * | 2002-09-09 | 2004-03-18 | Amgen Inc. | 1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivatives s tnf-alpha and interleukin lowering agents for the treatment of inflammations |
| ATE361296T1 (de) * | 2003-04-03 | 2007-05-15 | Merck Patent Gmbh | Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| AU2007238071B2 (en) * | 2006-04-18 | 2012-06-07 | Abbvie Inc. | Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| DK2432767T3 (da) * | 2009-05-19 | 2013-09-30 | Dow Agrosciences Llc | Forbindelser og fremgangsmåder til at kontrollere svampe |
| EP3308059B1 (en) | 2015-06-15 | 2021-05-26 | Cummins, Inc. | Combustion chamber elasticity device |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| CN107033090B (zh) * | 2017-05-16 | 2019-05-07 | 无锡捷化医药科技有限公司 | 一种1,2,3,4-四氢噌啉的制备方法 |
| RU2721684C1 (ru) * | 2019-09-06 | 2020-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты |
| EP4422621A1 (en) * | 2021-10-27 | 2024-09-04 | Merck Sharp & Dohme LLC | Spirotricycle ripk1 inhibitors and methods of uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1054291A (hu) * | 1963-02-26 | |||
| GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
| CH529154A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
| US5358924A (en) * | 1991-03-21 | 1994-10-25 | Bayer Aktiengesellschaft | 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use |
| PT1481970E (pt) * | 1999-09-07 | 2006-07-31 | Syngenta Participations Ag | Novos herbicidas |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
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2002
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
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- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
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- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
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- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
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- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
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- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active IP Right Cessation
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active IP Right Cessation
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Application Discontinuation
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
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- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en active IP Right Grant
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Application Discontinuation
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Application Discontinuation
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en active IP Right Grant
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- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
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- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
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2003
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2004
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- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
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- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
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2005
- 2005-05-18 HK HK05104163A patent/HK1071366A1/xx not_active IP Right Cessation
- 2005-05-24 HK HK05104374A patent/HK1071565A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown
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| Date | Code | Title | Description |
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| FD9A | Lapse of provisional protection due to non-payment of fees |