HUP0402378A2 - Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402378A2 HUP0402378A2 HU0402378A HUP0402378A HUP0402378A2 HU P0402378 A2 HUP0402378 A2 HU P0402378A2 HU 0402378 A HU0402378 A HU 0402378A HU P0402378 A HUP0402378 A HU P0402378A HU P0402378 A2 HUP0402378 A2 HU P0402378A2
- Authority
- HU
- Hungary
- Prior art keywords
- together form
- groups
- inflammatory cytokines
- spirocyclic
- atoms
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgyát gyulladáskeltő citokinokat gátló (I) általánosképletű vegyületek - ahol R éter- vagy amino kötésű csoport; R1: a)szubsztituált vagy szubsztituálatlan aril; vagy b) szubsztituált vagyszubsztituálatian heteroaril-csoport; két azonos szénatomon levő R2csoport együtt 4-7 atomos spirociklikus gyűrűt képez, a maradék R2csoportok jelentése: a) hidrogénatom; b) -O (CH2)jR8; c) -(CH2)jNR9aR9b; d) - (CH2)jCO2R10; e) - (CH2)jOCO2R10; f) -(CH2)jCON(R10)2 általános képletű csoport; vagy g) két R2 csoportegyütt karbonilcsoportot képez; R8, R9a, R9b és R10 jelentésehidrogénatom, 1-4 szénatomos alkilcsoport és ezek keverékei; R9a ésR9b együtt 3-7 atomos karbociklikus vagy heterociklikus gyűrűt képez;két R10 csoport együtt 3-7 atomos karbociklikus vagy heterociklikusgyűrűt képez; j értéke 0-5 közötti; n értéke 3-5 közötti-, enantiomerés diasztereomer formák, gyógyászatilag elfogadható sóik és ezekettartalmazó gyógyszerkészítmények képezik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32362501P | 2001-09-20 | 2001-09-20 | |
PCT/US2002/030133 WO2003024973A1 (en) | 2001-09-20 | 2002-09-20 | Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0402378A2 true HUP0402378A2 (hu) | 2005-02-28 |
HUP0402378A3 HUP0402378A3 (en) | 2008-10-28 |
Family
ID=23259997
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402500A HUP0402500A3 (en) | 2001-09-20 | 2002-09-20 | Heterocondenzated pyrazol-3-one compounds which inhibit the release of inflammatory cytokines and pharmaceutical compositions containing them |
HU0402378A HUP0402378A3 (en) | 2001-09-20 | 2002-09-20 | Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones controlling inflammatory cytokines and pharmaceutical compositions containing them |
HU0500752A HUP0500752A2 (en) | 2001-09-20 | 2002-09-20 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402500A HUP0402500A3 (en) | 2001-09-20 | 2002-09-20 | Heterocondenzated pyrazol-3-one compounds which inhibit the release of inflammatory cytokines and pharmaceutical compositions containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500752A HUP0500752A2 (en) | 2001-09-20 | 2002-09-20 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Country Status (33)
Country | Link |
---|---|
US (2) | US6566357B1 (hu) |
EP (3) | EP1427727B1 (hu) |
JP (3) | JP2005504082A (hu) |
KR (4) | KR100623879B1 (hu) |
CN (3) | CN1250551C (hu) |
AR (3) | AR037237A1 (hu) |
AT (3) | ATE287887T1 (hu) |
AU (2) | AU2002334641B2 (hu) |
BR (3) | BR0212905A (hu) |
CA (3) | CA2461071A1 (hu) |
CO (3) | CO5560590A2 (hu) |
CY (1) | CY1106398T1 (hu) |
CZ (3) | CZ2004345A3 (hu) |
DE (3) | DE60218704T2 (hu) |
DK (2) | DK1427728T3 (hu) |
EG (2) | EG24363A (hu) |
ES (3) | ES2282459T3 (hu) |
HK (2) | HK1071366A1 (hu) |
HU (3) | HUP0402500A3 (hu) |
IL (3) | IL160682A0 (hu) |
MA (3) | MA27066A1 (hu) |
MX (3) | MXPA04002570A (hu) |
MY (2) | MY129069A (hu) |
NO (2) | NO20041594L (hu) |
NZ (3) | NZ531122A (hu) |
PE (3) | PE20030446A1 (hu) |
PL (3) | PL370415A1 (hu) |
PT (3) | PT1427728E (hu) |
RU (3) | RU2272040C2 (hu) |
SA (1) | SA03230529B1 (hu) |
SK (3) | SK1492004A3 (hu) |
WO (3) | WO2003024970A1 (hu) |
ZA (3) | ZA200401260B (hu) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7087615B2 (en) | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
US6849627B2 (en) | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
US6677337B2 (en) * | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
PL379544A1 (pl) * | 2002-09-09 | 2006-10-02 | Amgen Inc. | 1,4,5-podstawione pochodne 1,2-dihydro-pirazol-3-onu i 3-alkoksy 1H-pirazolu jako środki obniżające poziom TNF-alfa oraz interleukin do leczenia stanów zapalnych |
BRPI0408444A (pt) * | 2003-04-03 | 2006-04-04 | Merck Patent Gmbh | derivados de 1-n-(fenil)-2-n-(fenil) pirazolidina-1,2-dicarboxamida como inibidores de fator xa de coagulação para o tratamento de trombose |
GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
CA2647256A1 (en) * | 2006-04-18 | 2007-10-25 | Abbott Laboratories | Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
RU2011151603A (ru) * | 2009-05-19 | 2013-06-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭсСи | Соединения и способы борьбы с грибами |
EP3308059B1 (en) | 2015-06-15 | 2021-05-26 | Cummins, Inc. | Combustion chamber elasticity device |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
CN107033090B (zh) * | 2017-05-16 | 2019-05-07 | 无锡捷化医药科技有限公司 | 一种1,2,3,4-四氢噌啉的制备方法 |
RU2721684C1 (ru) * | 2019-09-06 | 2020-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты |
WO2023076133A1 (en) * | 2021-10-27 | 2023-05-04 | Merck Sharp & Dohme Llc | Spirotricycle ripk1 inhibitors and methods of uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1054291A (hu) | 1963-02-26 | |||
GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
CH529153A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
US5358924A (en) * | 1991-03-21 | 1994-10-25 | Bayer Aktiengesellschaft | 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use |
DK1481970T3 (da) * | 1999-09-07 | 2006-07-31 | Syngenta Participations Ag | Nye herbicider |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2002
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active IP Right Cessation
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en active IP Right Grant
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en active IP Right Grant
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Application Discontinuation
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 EP EP02763693A patent/EP1427728B1/en not_active Expired - Lifetime
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active IP Right Cessation
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Application Discontinuation
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Application Discontinuation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
-
2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
-
2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
-
2005
- 2005-05-18 HK HK05104163A patent/HK1071366A1/xx not_active IP Right Cessation
- 2005-05-24 HK HK05104374A patent/HK1071565A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0402378A2 (hu) | Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítmények | |
HUP0203575A2 (hu) | Th2 differenciálódás inhibitorokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0300138A2 (en) | Cyclic amine derivatives as ccr5 antagonists, their production and use and pharmaceutical compositions containing them | |
HUP0204474A2 (hu) | 1H-imidazopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0001848A2 (hu) | NOS gátló 6-fenil-piridil-2-amin származékok | |
HUP0401898A2 (hu) | 3-Szubsztituált-4-pirimidon-származékok, ezeket tartalmazó gyógyászati készítmények és intermedierjeik | |
CA2475432A1 (en) | 2,4,6-triamino-1,3,5-triazine derivative | |
WO2003055441A3 (en) | Medicaments | |
HUP0302167A2 (hu) | Metabotropikus glutamát receptor antagonista hatású kinolinszármazékok, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
HUP0300974A2 (hu) | Ciklin-dependens kinázok N-{5-[(5--alkil-2-oxazolil)-metil-tio]-2-tiazolil}-karboxamid inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0003921A2 (hu) | VLA-4 által közvetített leukocitaadhéziót gátló szulfonilezett dipeptidszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
HUP0401982A2 (hu) | Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0400828A2 (hu) | Kondenzált heterociklikus aminopirimidinek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
HUP0301607A2 (hu) | Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0102851A2 (hu) | Parazitaellenes artemizinin-származékok (endoperoxidok), eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0004595A2 (hu) | Aciklikus metalloproteáz inhibitorok | |
HUP0302226A2 (hu) | Foszfodiészteráz inhibitorokként alkalmazható szubsztituált pirrolopiridinon-származékok, ezek intermedierjei és a vegyületeket tartalmazó gyógyszerkészítmények | |
HUP0402235A2 (hu) | 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények | |
IL113778A0 (en) | Condensed-indan derivatives pharmaceutical compositions containing the same and methods for the preparation thereof | |
NO20015446L (no) | Kinolin-derivater som inhibitorer for MEK-enzymer | |
MY140749A (en) | Novel piperidine compound | |
AU2001269540A1 (en) | Serotonin reuptake inhibitors | |
HUP0301587A2 (hu) | Foszfodiészteráz V gátló hatású 5-amino-alkil-pirazolo[4,3-d]pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárások az elżállításaikra | |
AU7582094A (en) | New 1,2,3,4-tetrahydronaphthalene compounds, process for their preparation and the pharmaceutical compositions which contain them | |
HUP0102931A2 (hu) | Új N-(triazolil-metil)-piperazin-származékok mint neurokininreceptor-antagonisták |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |