MA27066A1 - 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES. - Google Patents
6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES.Info
- Publication number
- MA27066A1 MA27066A1 MA27569A MA27569A MA27066A1 MA 27066 A1 MA27066 A1 MA 27066A1 MA 27569 A MA27569 A MA 27569A MA 27569 A MA27569 A MA 27569A MA 27066 A1 MA27066 A1 MA 27066A1
- Authority
- MA
- Morocco
- Prior art keywords
- inflammatory cytokines
- taken together
- hydrogen
- pyrazolo
- pyrazol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES QUI CONTROLENT LES CYTOKINES INFLAMMATOIRES THE PROCTER & GAMBLE COMPANY Invention de: CLARK Michael Philip LAUFER-SWEILER Matthew John DJUNG Jane Fra-Jine NATCHUS Michael George DE Biswanath Priorité: demande de brevet déposée aux Etats-Unis le 20 septembre 2002 sous le no. 60/323,625 La présente invention concerne des composés qui sont à même d'empêcher la libération extracellulaire de cytokines inflammatoires; lesdits composés comprenant toutes les formes énantiomères et diastéréomères et leurs sels acceptables au plan pharmaceutique ont la formule (I) dans laquelle R comprend des éthers ou des aminés; R1 est a) un groupe aryle substitué ou non substitué; ou b) un groupe hétéroaryle substitué ou non substitué; chaque unité R2 est choisie indépendamment dans le groupe constitué des suivants : a) l'hydrogène; b) -(CH2)jO(CH2)nR8; c) -(CH2)jNR9aR9b; d) -(CH2)jCO2R10; e) -(CH2)jOCO2R10; f) -(CH2)jCON(R10)2; g) -(CH2)jOCON(R10)2; h) deux unités R2 peuvent être prises conjointement pour former une unité carbonyle; i) et leurs mélanges; R8, R9a, R9b et R10 sont chacun indépendamment l'hydrogène, un groupe alkyle en C1-C4 et leurs mélanges; R9a et R9b peuvent être pris conjointement pour former un cycle carbocyclique ou hétérocyclique comprenant 3 à 7 atomes; deux unités R10 peuvent être pris conjointement pour former un cycle carbocyclique ou hétérocyclique comprenant 3 à 7 atomes; j est un indice de 0 à 5, n est un indice de 0 à 5; Z est O, S, NR11 ou NOR11; R11 est l'hydrogène ou un groupe alkyle en C1-C4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32362501P | 2001-09-20 | 2001-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27066A1 true MA27066A1 (fr) | 2004-12-20 |
Family
ID=23259997
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27569A MA27066A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES. |
| MA27567A MA27064A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones spirocycliques regulant les cytokines inflammatoires. |
| MA27568A MA27065A1 (fr) | 2001-09-20 | 2004-03-10 | Composes inhibant la liberation des cytokines inflammatoires. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27567A MA27064A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones spirocycliques regulant les cytokines inflammatoires. |
| MA27568A MA27065A1 (fr) | 2001-09-20 | 2004-03-10 | Composes inhibant la liberation des cytokines inflammatoires. |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US6821971B2 (fr) |
| EP (3) | EP1427727B1 (fr) |
| JP (3) | JP2005504081A (fr) |
| KR (4) | KR20060036125A (fr) |
| CN (3) | CN1257905C (fr) |
| AR (3) | AR037145A1 (fr) |
| AT (3) | ATE332901T1 (fr) |
| AU (2) | AU2002327690B2 (fr) |
| BR (3) | BR0212716A (fr) |
| CA (3) | CA2461073A1 (fr) |
| CO (3) | CO5560590A2 (fr) |
| CY (1) | CY1106398T1 (fr) |
| CZ (3) | CZ2004358A3 (fr) |
| DE (3) | DE60213108T2 (fr) |
| DK (2) | DK1427728T3 (fr) |
| EG (2) | EG24363A (fr) |
| ES (3) | ES2237691T3 (fr) |
| HK (2) | HK1071366A1 (fr) |
| HU (3) | HUP0402378A3 (fr) |
| IL (3) | IL160741A0 (fr) |
| MA (3) | MA27066A1 (fr) |
| MX (3) | MXPA04002574A (fr) |
| MY (2) | MY129329A (fr) |
| NO (2) | NO20041594L (fr) |
| NZ (3) | NZ531063A (fr) |
| PE (3) | PE20030430A1 (fr) |
| PL (3) | PL370415A1 (fr) |
| PT (3) | PT1427727E (fr) |
| RU (3) | RU2278864C2 (fr) |
| SA (1) | SA03230529B1 (fr) |
| SK (3) | SK1492004A3 (fr) |
| WO (3) | WO2003024971A1 (fr) |
| ZA (3) | ZA200401260B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US6849627B2 (en) | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7087615B2 (en) | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| US6677337B2 (en) * | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
| ES2283811T3 (es) * | 2002-09-09 | 2007-11-01 | Amgen Inc. | Derivados de 1,2-dihidro-pirazol-3-ona y 3-alcoxi-1h-pirazol sustituidos 1,4,5- para la utilizacion como agentes reductores de tnf-alfa e interleukina en el tratamiento de inflamaciones. |
| DE502004003688D1 (de) * | 2003-04-03 | 2007-06-14 | Merck Patent Gmbh | Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen |
| GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| CA2647256A1 (fr) * | 2006-04-18 | 2007-10-25 | Abbott Laboratories | Antagonistes du sous-type 1 du recepteur vanilloide (vr1) et utilisations de ceux-ci |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| JP2012527461A (ja) * | 2009-05-19 | 2012-11-08 | ダウ アグロサイエンシィズ エルエルシー | 真菌を防除するための化合物および方法 |
| WO2016205284A1 (fr) | 2015-06-15 | 2016-12-22 | Cummins Inc. | Dispositif d'élasticité pour chambre de combustion |
| WO2017151409A1 (fr) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Méthodes de chimiothérapie |
| CN107033090B (zh) * | 2017-05-16 | 2019-05-07 | 无锡捷化医药科技有限公司 | 一种1,2,3,4-四氢噌啉的制备方法 |
| RU2721684C1 (ru) * | 2019-09-06 | 2020-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты |
| WO2023076133A1 (fr) * | 2021-10-27 | 2023-05-04 | Merck Sharp & Dohme Llc | Inhibiteurs de ripk1 spirotricycliques et leurs procédés d'utilisation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1054291A (fr) * | 1963-02-26 | |||
| GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
| CH529153A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
| US5358924A (en) * | 1991-03-21 | 1994-10-25 | Bayer Aktiengesellschaft | 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use |
| HU229958B1 (hu) * | 1999-09-07 | 2015-03-30 | Syngenta Participations Ag | Herbicid vegyületek, ezeket tartalmazó készítmények, eljárás a vegyületek előállítására, valamint eljárás gyomnövények irtására |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
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2002
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 CA CA002461073A patent/CA2461073A1/fr not_active Abandoned
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 EP EP02763692A patent/EP1427727B1/fr not_active Expired - Lifetime
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/fr active IP Right Grant
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Application Discontinuation
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Application Discontinuation
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active IP Right Cessation
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/fr not_active Application Discontinuation
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 CA CA002461072A patent/CA2461072A1/fr not_active Abandoned
- 2002-09-20 EP EP02763693A patent/EP1427728B1/fr not_active Expired - Lifetime
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 CA CA002461071A patent/CA2461071A1/fr not_active Abandoned
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/fr active IP Right Grant
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/fr not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active IP Right Cessation
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
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2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
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2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
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2005
- 2005-05-18 HK HK05104163A patent/HK1071366A1/xx not_active IP Right Cessation
- 2005-05-24 HK HK05104374A patent/HK1071565A1/xx not_active IP Right Cessation
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2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown
Also Published As
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| MA26952A1 (fr) | Derives d'imidazole a noyau aryle ou heteroaryle condense, utiles comme agents anti-inflammatoires et analgesiques. | |
| MA25035A1 (fr) | Derives de 3-azabicyclo [3,1,0] hexane nouveaux, procede pour leur preparation et compositions les contenant | |
| MA27654A1 (fr) | DERIVES HEXAHYDROPYRAZINO [1,2-a]-4,7-DIONE SUBSTITUES, METHODE POUR LEUR PRODUCTION ET LEUR UTILISATION EN TANT QUE MEDICAMENTS | |
| TNSN97190A1 (fr) | Derives d'amines bicycliques. | |
| MA27573A1 (fr) | Sinomenine et derives de sinomenine, synthese et utilisation. | |
| TNSN00228A1 (fr) | Derives de benzimidazole nouveaux, et compositions les contenant | |
| MA28271A1 (fr) | Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité | |
| MA27775A1 (fr) | Composes organiques | |
| MA31504B1 (fr) | Acides benzoylamino-indan-2-carboxyliques substitues et composes apparentes | |
| MA27897A1 (fr) | Compose de glucocorticosteroide specifique presentant une active anti-inflammatoire | |
| TNSN99142A1 (fr) | Derives de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procede pour leur preparation. | |
| MA26996A1 (fr) | Derives de glutaramide a substituant n-phenpropylcyclopentyle, servant d'inhibiteurs de nep pour un trouble d'eveil sexuel feminin | |
| TNSN07178A1 (fr) | N-sulfonylaminobenzyl-2-phenoxy-acetamides substitues | |
| MA29984B1 (fr) | Antagonistes du recepteur de crf et procedes correspondants | |
| MA26717A1 (fr) | Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| ATE297381T1 (de) | Ether-muskarinantagonisten | |
| MA30767B1 (fr) | Composes azabicycliques en tant qu'inhibiteurs de reabsorption de monoamines | |
| EA200500006A1 (ru) | Лекарственное средство для лечения нейродегенеративных заболеваний | |
| TNSN01126A1 (fr) | Imidazoles substitues nouveaux, procede pour leur preparation et compositions les contenant | |
| HUP0301032A2 (hu) | Ciklin-dependens kinázok N-{5-[(5-alkil-2-oxazolil)-metil-tio]-2-tiazolil}-karboxamid inhibitorai, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| SE8204817L (sv) | Tetrazinderivat | |
| MA28286A1 (fr) | Dérivés de 1-N-phenyl-amino-1H-imidazole et compositions pharmaceutiques les contenant | |
| RU95113107A (ru) | Новые пирролокарбазолы |